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Protein
Submitted name:

Uncharacterized protein

Gene

Capn5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei81PROSITE-ProRule annotation1
Active sitei252PROSITE-ProRule annotation1
Active sitei284PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteasePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:Capn5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1100859. Capn5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiQ3TPL4.
PRIDEiQ3TPL4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035547.
ExpressionAtlasiQ3TPL4. baseline and differential.
GenevisibleiQ3TPL4. MM.

Structurei

3D structure databases

ProteinModelPortaliQ3TPL4.
SMRiQ3TPL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 343Calpain catalyticInterPro annotationAdd BLAST318

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
HOVERGENiHBG001095.
KOiK08574.
OMAiRPKDICE.
OrthoDBiEOG091G030A.
PhylomeDBiQ3TPL4.

Family and domain databases

CDDicd04046. C2_Calpain. 1 hit.
cd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
Gene3Di2.60.40.150. 1 hit.
InterProiView protein in InterPro
IPR033884. C2_Calpain.
IPR000008. C2_dom.
IPR035892. C2_domain_sf.
IPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR036213. Calpain_III_sf.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
PfamiView protein in Pfam
PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
PRINTSiPR00704. CALPAIN.
SMARTiView protein in SMART
SM00239. C2. 1 hit.
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiView protein in PROSITE
PS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3TPL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSCAKAYED QNYSALKRAC LRKKVLFEDP LFPATDDSLY YKGTPGPTVR
60 70 80 90 100
WKRPKDICDD PRLFVDGISS HDLHQGQVGN CWFVAACSSL ASRESLWQKV
110 120 130 140 150
IPDWKEQEWN PEKPDSYAGI FHFNFWRFGE WVDVIVDDRL PTVNNQLIYC
160 170 180 190 200
HSNSKNEFWC ALVEKAYAKL AGCYQALDGG NTADALVDFT GGVSEPIDLT
210 220 230 240 250
EGDLATDEAK RNQLFERVLK VHSRGGLISA SIKAVTAADM EARLACGLVK
260 270 280 290 300
GHAYAVTDVR KVRLGHGLLA FFKSEKLDMI RLRNPWGERE WTGPWSDTSE
310 320 330 340 350
EWQKVSKSER EKMGVTVQDD GEFWMTFEDM CRYFTDIIKC RLINTSYLSI
360 370 380 390 400
HKTWEEARLH GAWTRHEDPQ QNRSGGCINH KDTFFQNPQY VFEVKKPEDE
410 420 430 440 450
VLISIQQRPK RSTRREGKGE NLAIGFDIYK VEENRQYRMH SLQHKAASSI
460 470 480 490 500
YINSRSVFLR TELPEGRYVI IPTTFEPGHT GEFLLRVFTD VPSNCRELRL
510 520 530 540 550
DEPPRTCWSS LCGYPQQVAQ VHVLGAAGLK DSPTGANSYV IIKCEGEKVR
560 570 580 590 600
SAVQRGTSTP EYNVKGIFYR KKLAQPITVQ VWNHRVLKDE FLGQVHLKTA
610 620 630 640
PDDLQDLHTL HLQDRSSRQP SDLPGIVAVR VLCSASLTAV
Length:640
Mass (Da):72,955
Last modified:October 11, 2005 - v1
Checksum:i7F1DA3E299FEC02D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK164293 mRNA. Translation: BAE37722.1.
RefSeqiNP_001288179.1. NM_001301250.1.
NP_031628.1. NM_007602.4.
UniGeneiMm.326847.

Genome annotation databases

GeneIDi12337.
KEGGimmu:12337.

Similar proteinsi

Entry informationi

Entry nameiQ3TPL4_MOUSE
AccessioniPrimary (citable) accession number: Q3TPL4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: October 25, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)