Reviewed,
UniProtKB/Swiss-Prot Q3TP92 (DULRD_MOUSE)
Last modified
June 16, 2009.
Version 28.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Serine/threonine-protein phosphatase dullard EC=3.1.3.16 | ||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 244 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Serine/threonine phosphatase which may be required for proper nuclear membrane morphology. Involved in LPIN1 dephosphorylation. May antagonize BMP signaling By similarity. |
| Catalytic activity | A phosphoprotein + H2O = a protein + phosphate. |
| Subcellular location | Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Nucleus membrane; Single-pass membrane protein By similarity. |
| Sequence similarities | Belongs to the dullard family. Contains 1 FCP1 homology domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Membrane Nucleus |
| Domain | Transmembrane |
| Molecular function | Hydrolase Protein phosphatase |
| Gene Ontology (GO) | |
| Biological process | nuclear envelope organization Inferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | endoplasmic reticulum membrane Inferred from sequence or structural similarity. Source: UniProtKB integral to membraneInferred from electronic annotation. Source: UniProtKB-KW nuclear membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein serine/threonine phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Lung. |
| [2] | The mouse genome sequencing consortium Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor. |
| [4] | "Molecular cloning and characterization of dullard: a novel gene required for neural development." Satow R., Chan T.C., Asashima M. Biochem. Biophys. Res. Commun. 295:85-91(2002) [PubMed: 12083771] [Abstract] Cited for: IDENTIFICATION. |
Cross-references
Sequence databases | |
|---|---|
| AK164602 mRNA. Translation: BAE37845.1. AL596185 Genomic DNA. Translation: CAI35161.1. BC018265 mRNA. Translation: AAH18265.1. | |
| IPI | IPI00754944. |
| RefSeq | NP_080293.1. XP_001480287.1. |
| UniGene | Mm.41678 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q3TP92. |
Proteomic databases | |
| PRIDE | Q3TP92. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000018559. Mus musculus. [Contig view] |
| GeneID | 100048221. 67181. |
| KEGG | mmu:100048221. mmu:67181. |
Organism-specific databases | |
| MGI | MGI:1914431. Dullard. |
Phylogenomic databases | |
| HOGENOM | Q3TP92. |
| HOVERGEN | Q3TP92. |
| OMA | Q3TP92. DKLDNNR. |
Enzyme and pathway databases | |
| BRENDA | 3.1.3.16. 244. |
Gene expression databases | |
| ArrayExpress | Q3TP92. |
| Bgee | Q3TP92. |
| CleanEx | MM_DULLARD. |
Family and domain databases | |
| InterPro | IPR011948. Dullard. IPR004274. NIF. [Graphical view] |
| Pfam | PF03031. NIF. 1 hit. [Graphical view] |
| SMART | SM00577. CPDc. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR02251. HIF-SF_euk. 1 hit. |
| PROSITE | PS50969. FCP1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 461641. |
| SOURCE | Search... |
Entry information
| Entry name | DULRD_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q3TP92 Secondary accession number(s): Q5NCW4, Q8VEL4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


