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Q3TP59 (Q3TP59_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Thbs1 MGI 98737
OrganismMus musculus (Mouse) EMBL BAE37878.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length262 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processactivation of MAPK activity

Inferred from electronic annotation. Source: Ensembl

blood vessel morphogenesis

Inferred from genetic interaction PubMed 20026598. Source: MGI

cell adhesion

Inferred from electronic annotation. Source: InterPro

cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

cell migration

Inferred from electronic annotation. Source: Ensembl

cellular response to growth factor stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to tumor necrosis factor

Inferred from electronic annotation. Source: Ensembl

chronic inflammatory response

Inferred from electronic annotation. Source: Ensembl

endocardial cushion development

Inferred from genetic interaction PubMed 20026598. Source: MGI

engulfment of apoptotic cell

Inferred from electronic annotation. Source: Ensembl

growth plate cartilage development

Inferred from mutant phenotype PubMed 18467703. Source: MGI

immune response

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from mutant phenotype PubMed 15963261. Source: MGI

negative regulation of angiogenesis

Inferred from direct assay PubMed 12498716. Source: MGI

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of blood vessel endothelial cell migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of cGMP-mediated signaling

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell-matrix adhesion

Inferred from electronic annotation. Source: Ensembl

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of dendritic cell antigen processing and presentation

Inferred from electronic annotation. Source: Ensembl

negative regulation of endothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of fibrinolysis

Inferred from electronic annotation. Source: Ensembl

negative regulation of fibroblast growth factor receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-12 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of nitric oxide mediated signal transduction

Inferred from electronic annotation. Source: Ensembl

negative regulation of plasma membrane long-chain fatty acid transport

Inferred from electronic annotation. Source: Ensembl

negative regulation of plasminogen activation

Inferred from electronic annotation. Source: Ensembl

outflow tract morphogenesis

Inferred from genetic interaction PubMed 20026598. Source: MGI

peptide cross-linking

Inferred from electronic annotation. Source: Ensembl

positive regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of blood vessel endothelial cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell-substrate adhesion

Inferred from direct assay PubMed 18757743. Source: MGI

positive regulation of chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of endothelial cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Inferred from electronic annotation. Source: Ensembl

positive regulation of fibroblast migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of macrophage activation

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of reactive oxygen species metabolic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of transforming growth factor beta production

Inferred from electronic annotation. Source: Ensembl

positive regulation of transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of translation

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor biosynthetic process

Inferred from electronic annotation. Source: Ensembl

response to calcium ion

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to glucose

Inferred from electronic annotation. Source: Ensembl

response to magnesium ion

Inferred from electronic annotation. Source: Ensembl

response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

response to testosterone

Inferred from electronic annotation. Source: Ensembl

sprouting angiogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from direct assay PubMed 12498716. Source: MGI

extracellular vesicular exosome

Inferred from electronic annotation. Source: Ensembl

fibrinogen complex

Inferred from electronic annotation. Source: Ensembl

platelet alpha granule

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

extracellular matrix binding

Inferred from direct assay PubMed 18757743. Source: MGI

heparin binding

Inferred from sequence orthology PubMed 8288588. Source: MGI

low-density lipoprotein particle binding

Inferred from electronic annotation. Source: Ensembl

phosphatidylserine binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL BAE37878.1

Sequences

Sequence LengthMass (Da)Tools
Q3TP59 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: D50A1635AA01426F

FASTA26230,023
        10         20         30         40         50         60 
NCRLVPNPDQ KDSDGDGRGD ACKDDFDHDN VPDIDDICPE NFDISETDFR QFQMIPLDPK 

        70         80         90        100        110        120 
GTSQNDPNWV VRHQGKELVQ TVNCDPGLAV GYDEFNAVDF SGTFFINTER DDDYAGFVFG 

       130        140        150        160        170        180 
YQSSSRFYVV MWKQVTQSYW DTNPTRAQGY SGLSVKVVNS TTGPGEHLRN ALWHTGNTPG 

       190        200        210        220        230        240 
QVRTLWHDPR HIGWKDFTAY RWRLSHRPKT GYIRVVMYEG KKIMADSGPI YDKTYAGGRL 

       250        260 
GLFVFSQEMV FFSDMKYECR DS 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE37878.1.
Tissue: Kidney EMBL BAE37878.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE37878.1.
Tissue: Kidney EMBL BAE37878.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE37878.1.
Tissue: Kidney EMBL BAE37878.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE37878.1.
Tissue: Kidney EMBL BAE37878.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE37878.1.
Tissue: Kidney EMBL BAE37878.1.
[6]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE37878.1.
Tissue: Kidney EMBL BAE37878.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE37878.1.
Tissue: Kidney EMBL BAE37878.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE37878.1.
Tissue: Kidney EMBL BAE37878.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK164691 mRNA. Translation: BAE37878.1.
UniGeneMm.4159.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:98737. Thbs1.

Phylogenomic databases

HOVERGENHBG000636.
InParanoidQ3TP59.

Gene expression databases

ArrayExpressQ3TP59.
BgeeQ3TP59.
GenevestigatorQ3TP59.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
4.10.1080.10. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR028499. Thrombospondin-1.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view]
PANTHERPTHR10199:SF78. PTHR10199:SF78. 1 hit.
PfamPF02412. TSP_3. 1 hit.
PF05735. TSP_C. 1 hit.
[Graphical view]
SUPFAMSSF103647. SSF103647. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEPS51234. TSP3. 2 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTHBS1. mouse.
SOURCESearch...

Entry information

Entry nameQ3TP59_MOUSE
AccessionPrimary (citable) accession number: Q3TP59
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)