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Protein
Submitted name:

Putative uncharacterized protein

Gene

Thbs1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. collagen V binding Source: MGI
  3. extracellular matrix binding Source: MGI
  4. fibrinogen binding Source: MGI
  5. fibroblast growth factor binding Source: MGI
  6. fibronectin binding Source: MGI
  7. heparin binding Source: MGI
  8. integrin binding Source: MGI
  9. laminin binding Source: MGI
  10. low-density lipoprotein particle binding Source: MGI
  11. phosphatidylserine binding Source: MGI

GO - Biological processi

  1. activation of MAPK activity Source: MGI
  2. blood vessel morphogenesis Source: MGI
  3. cell adhesion Source: InterPro
  4. cell cycle arrest Source: MGI
  5. cell migration Source: MGI
  6. cellular response to growth factor stimulus Source: Ensembl
  7. cellular response to nitric oxide Source: MGI
  8. cellular response to tumor necrosis factor Source: Ensembl
  9. chronic inflammatory response Source: Ensembl
  10. endocardial cushion development Source: MGI
  11. engulfment of apoptotic cell Source: MGI
  12. growth plate cartilage development Source: MGI
  13. immune response Source: Ensembl
  14. inflammatory response Source: MGI
  15. negative regulation of angiogenesis Source: MGI
  16. negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: MGI
  17. negative regulation of apoptotic process Source: MGI
  18. negative regulation of blood vessel endothelial cell migration Source: MGI
  19. negative regulation of cell-matrix adhesion Source: MGI
  20. negative regulation of cGMP-mediated signaling Source: MGI
  21. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  22. negative regulation of dendritic cell antigen processing and presentation Source: MGI
  23. negative regulation of endothelial cell chemotaxis Source: MGI
  24. negative regulation of endothelial cell migration Source: MGI
  25. negative regulation of endothelial cell proliferation Source: MGI
  26. negative regulation of fibrinolysis Source: MGI
  27. negative regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  28. negative regulation of interleukin-12 production Source: MGI
  29. negative regulation of nitric oxide mediated signal transduction Source: MGI
  30. negative regulation of plasma membrane long-chain fatty acid transport Source: MGI
  31. negative regulation of plasminogen activation Source: MGI
  32. outflow tract morphogenesis Source: MGI
  33. peptide cross-linking Source: MGI
  34. positive regulation of angiogenesis Source: MGI
  35. positive regulation of blood coagulation Source: MGI
  36. positive regulation of blood vessel endothelial cell migration Source: MGI
  37. positive regulation of cell migration Source: MGI
  38. positive regulation of cell-substrate adhesion Source: MGI
  39. positive regulation of chemotaxis Source: MGI
  40. positive regulation of endothelial cell apoptotic process Source: MGI
  41. positive regulation of endothelial cell migration Source: MGI
  42. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  43. positive regulation of fibroblast migration Source: MGI
  44. positive regulation of macrophage activation Source: MGI
  45. positive regulation of phosphorylation Source: MGI
  46. positive regulation of protein kinase B signaling Source: MGI
  47. positive regulation of reactive oxygen species metabolic process Source: MGI
  48. positive regulation of transforming growth factor beta production Source: Ensembl
  49. positive regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  50. positive regulation of translation Source: MGI
  51. positive regulation of tumor necrosis factor biosynthetic process Source: MGI
  52. regulation of cGMP metabolic process Source: MGI
  53. response to calcium ion Source: MGI
  54. response to drug Source: Ensembl
  55. response to glucose Source: MGI
  56. response to magnesium ion Source: MGI
  57. response to mechanical stimulus Source: Ensembl
  58. response to testosterone Source: Ensembl
  59. sprouting angiogenesis Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196644. Syndecan interactions.
REACT_211817. O-glycosylation of TSR domain-containing proteins.
REACT_216309. Integrin cell surface interactions.
REACT_263353. Signaling by PDGF.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Thbs1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98737. Thbs1.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: MGI
  2. external side of plasma membrane Source: MGI
  3. extracellular matrix Source: MGI
  4. extracellular space Source: MGI
  5. extracellular vesicular exosome Source: MGI
  6. fibrinogen complex Source: MGI
  7. platelet alpha granule Source: MGI
  8. secretory granule Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ3TP59.
ExpressionAtlasiQ3TP59. baseline and differential.
GenevestigatoriQ3TP59.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000636.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
4.10.1080.10. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR028499. Thrombospondin-1.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view]
PANTHERiPTHR10199:SF78. PTHR10199:SF78. 1 hit.
PfamiPF02412. TSP_3. 1 hit.
PF05735. TSP_C. 1 hit.
[Graphical view]
SUPFAMiSSF103647. SSF103647. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS51234. TSP3. 2 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3TP59-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
NCRLVPNPDQ KDSDGDGRGD ACKDDFDHDN VPDIDDICPE NFDISETDFR
60 70 80 90 100
QFQMIPLDPK GTSQNDPNWV VRHQGKELVQ TVNCDPGLAV GYDEFNAVDF
110 120 130 140 150
SGTFFINTER DDDYAGFVFG YQSSSRFYVV MWKQVTQSYW DTNPTRAQGY
160 170 180 190 200
SGLSVKVVNS TTGPGEHLRN ALWHTGNTPG QVRTLWHDPR HIGWKDFTAY
210 220 230 240 250
RWRLSHRPKT GYIRVVMYEG KKIMADSGPI YDKTYAGGRL GLFVFSQEMV
260
FFSDMKYECR DS
Length:262
Mass (Da):30,023
Last modified:October 11, 2005 - v1
Checksum:iD50A1635AA01426F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK164691 mRNA. Translation: BAE37878.1.
UniGeneiMm.4159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK164691 mRNA. Translation: BAE37878.1.
UniGeneiMm.4159.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:98737. Thbs1.

Phylogenomic databases

HOVERGENiHBG000636.

Enzyme and pathway databases

ReactomeiREACT_196644. Syndecan interactions.
REACT_211817. O-glycosylation of TSR domain-containing proteins.
REACT_216309. Integrin cell surface interactions.
REACT_263353. Signaling by PDGF.

Miscellaneous databases

ChiTaRSiThbs1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ3TP59.
ExpressionAtlasiQ3TP59. baseline and differential.
GenevestigatoriQ3TP59.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
4.10.1080.10. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR028499. Thrombospondin-1.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view]
PANTHERiPTHR10199:SF78. PTHR10199:SF78. 1 hit.
PfamiPF02412. TSP_3. 1 hit.
PF05735. TSP_C. 1 hit.
[Graphical view]
SUPFAMiSSF103647. SSF103647. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS51234. TSP3. 2 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.

Entry informationi

Entry nameiQ3TP59_MOUSE
AccessioniPrimary (citable) accession number: Q3TP59
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: February 4, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.