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Q3TP59

- Q3TP59_MOUSE

UniProt

Q3TP59 - Q3TP59_MOUSE

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Protein
Submitted name:

Putative uncharacterized protein

Gene
Thbs1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. extracellular matrix binding Source: MGI
  3. heparin binding Source: MGI
  4. low-density lipoprotein particle binding Source: Ensembl
  5. phosphatidylserine binding Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. blood vessel morphogenesis Source: MGI
  3. cell adhesion Source: InterPro
  4. cell cycle arrest Source: Ensembl
  5. cell migration Source: Ensembl
  6. cellular response to growth factor stimulus Source: Ensembl
  7. cellular response to tumor necrosis factor Source: Ensembl
  8. chronic inflammatory response Source: Ensembl
  9. endocardial cushion development Source: MGI
  10. engulfment of apoptotic cell Source: Ensembl
  11. growth plate cartilage development Source: MGI
  12. immune response Source: Ensembl
  13. inflammatory response Source: MGI
  14. negative regulation of angiogenesis Source: MGI
  15. negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: Ensembl
  16. negative regulation of apoptotic process Source: Ensembl
  17. negative regulation of blood vessel endothelial cell migration Source: Ensembl
  18. negative regulation of cell-matrix adhesion Source: Ensembl
  19. negative regulation of cGMP-mediated signaling Source: Ensembl
  20. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  21. negative regulation of dendritic cell antigen processing and presentation Source: Ensembl
  22. negative regulation of endothelial cell proliferation Source: Ensembl
  23. negative regulation of fibrinolysis Source: Ensembl
  24. negative regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
  25. negative regulation of interleukin-12 production Source: Ensembl
  26. negative regulation of nitric oxide mediated signal transduction Source: Ensembl
  27. negative regulation of plasma membrane long-chain fatty acid transport Source: Ensembl
  28. negative regulation of plasminogen activation Source: Ensembl
  29. outflow tract morphogenesis Source: MGI
  30. peptide cross-linking Source: Ensembl
  31. positive regulation of angiogenesis Source: Ensembl
  32. positive regulation of blood vessel endothelial cell migration Source: Ensembl
  33. positive regulation of cell-substrate adhesion Source: MGI
  34. positive regulation of chemotaxis Source: Ensembl
  35. positive regulation of endothelial cell apoptotic process Source: Ensembl
  36. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  37. positive regulation of fibroblast migration Source: Ensembl
  38. positive regulation of macrophage activation Source: Ensembl
  39. positive regulation of protein kinase B signaling Source: Ensembl
  40. positive regulation of reactive oxygen species metabolic process Source: Ensembl
  41. positive regulation of transforming growth factor beta production Source: Ensembl
  42. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  43. positive regulation of translation Source: Ensembl
  44. positive regulation of tumor necrosis factor biosynthetic process Source: Ensembl
  45. response to calcium ion Source: Ensembl
  46. response to drug Source: Ensembl
  47. response to glucose Source: Ensembl
  48. response to magnesium ion Source: Ensembl
  49. response to mechanical stimulus Source: Ensembl
  50. response to testosterone Source: Ensembl
  51. sprouting angiogenesis Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196644. Syndecan interactions.
REACT_211817. O-glycosylation of TSR domain-containing proteins.
REACT_216309. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Thbs1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98737. Thbs1.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: MGI
  3. extracellular vesicular exosome Source: Ensembl
  4. fibrinogen complex Source: Ensembl
  5. platelet alpha granule Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiQ3TP59.
BgeeiQ3TP59.
GenevestigatoriQ3TP59.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000636.
InParanoidiQ3TP59.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
4.10.1080.10. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR028499. Thrombospondin-1.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view]
PANTHERiPTHR10199:SF78. PTHR10199:SF78. 1 hit.
PfamiPF02412. TSP_3. 1 hit.
PF05735. TSP_C. 1 hit.
[Graphical view]
SUPFAMiSSF103647. SSF103647. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS51234. TSP3. 2 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3TP59-1 [UniParc]FASTAAdd to Basket

« Hide

NCRLVPNPDQ KDSDGDGRGD ACKDDFDHDN VPDIDDICPE NFDISETDFR    50
QFQMIPLDPK GTSQNDPNWV VRHQGKELVQ TVNCDPGLAV GYDEFNAVDF 100
SGTFFINTER DDDYAGFVFG YQSSSRFYVV MWKQVTQSYW DTNPTRAQGY 150
SGLSVKVVNS TTGPGEHLRN ALWHTGNTPG QVRTLWHDPR HIGWKDFTAY 200
RWRLSHRPKT GYIRVVMYEG KKIMADSGPI YDKTYAGGRL GLFVFSQEMV 250
FFSDMKYECR DS 262
Length:262
Mass (Da):30,023
Last modified:October 11, 2005 - v1
Checksum:iD50A1635AA01426F
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK164691 mRNA. Translation: BAE37878.1.
UniGeneiMm.4159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK164691 mRNA. Translation: BAE37878.1 .
UniGenei Mm.4159.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:98737. Thbs1.

Phylogenomic databases

HOVERGENi HBG000636.
InParanoidi Q3TP59.

Enzyme and pathway databases

Reactomei REACT_196644. Syndecan interactions.
REACT_211817. O-glycosylation of TSR domain-containing proteins.
REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

ChiTaRSi THBS1. mouse.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3TP59.
Bgeei Q3TP59.
Genevestigatori Q3TP59.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
4.10.1080.10. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR028499. Thrombospondin-1.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view ]
PANTHERi PTHR10199:SF78. PTHR10199:SF78. 1 hit.
Pfami PF02412. TSP_3. 1 hit.
PF05735. TSP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF103647. SSF103647. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEi PS51234. TSP3. 2 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.

Entry informationi

Entry nameiQ3TP59_MOUSE
AccessioniPrimary (citable) accession number: Q3TP59
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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