Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q3TP59

- Q3TP59_MOUSE

UniProt

Q3TP59 - Q3TP59_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Thbs1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. extracellular matrix binding Source: MGI
    3. heparin binding Source: MGI
    4. low-density lipoprotein particle binding Source: Ensembl
    5. phosphatidylserine binding Source: Ensembl

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. blood vessel morphogenesis Source: MGI
    3. cell adhesion Source: InterPro
    4. cell cycle arrest Source: Ensembl
    5. cell migration Source: Ensembl
    6. cellular response to growth factor stimulus Source: Ensembl
    7. cellular response to tumor necrosis factor Source: Ensembl
    8. chronic inflammatory response Source: Ensembl
    9. endocardial cushion development Source: MGI
    10. engulfment of apoptotic cell Source: Ensembl
    11. growth plate cartilage development Source: MGI
    12. immune response Source: Ensembl
    13. inflammatory response Source: MGI
    14. negative regulation of angiogenesis Source: MGI
    15. negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: Ensembl
    16. negative regulation of apoptotic process Source: Ensembl
    17. negative regulation of blood vessel endothelial cell migration Source: Ensembl
    18. negative regulation of cell-matrix adhesion Source: Ensembl
    19. negative regulation of cGMP-mediated signaling Source: Ensembl
    20. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    21. negative regulation of dendritic cell antigen processing and presentation Source: Ensembl
    22. negative regulation of endothelial cell proliferation Source: Ensembl
    23. negative regulation of fibrinolysis Source: Ensembl
    24. negative regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
    25. negative regulation of interleukin-12 production Source: Ensembl
    26. negative regulation of nitric oxide mediated signal transduction Source: Ensembl
    27. negative regulation of plasma membrane long-chain fatty acid transport Source: Ensembl
    28. negative regulation of plasminogen activation Source: Ensembl
    29. outflow tract morphogenesis Source: MGI
    30. peptide cross-linking Source: Ensembl
    31. positive regulation of angiogenesis Source: Ensembl
    32. positive regulation of blood vessel endothelial cell migration Source: Ensembl
    33. positive regulation of cell-substrate adhesion Source: MGI
    34. positive regulation of chemotaxis Source: Ensembl
    35. positive regulation of endothelial cell apoptotic process Source: Ensembl
    36. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    37. positive regulation of fibroblast migration Source: Ensembl
    38. positive regulation of macrophage activation Source: Ensembl
    39. positive regulation of protein kinase B signaling Source: Ensembl
    40. positive regulation of reactive oxygen species metabolic process Source: Ensembl
    41. positive regulation of transforming growth factor beta production Source: Ensembl
    42. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    43. positive regulation of translation Source: Ensembl
    44. positive regulation of tumor necrosis factor biosynthetic process Source: Ensembl
    45. response to calcium ion Source: Ensembl
    46. response to drug Source: Ensembl
    47. response to glucose Source: Ensembl
    48. response to magnesium ion Source: Ensembl
    49. response to mechanical stimulus Source: Ensembl
    50. response to testosterone Source: Ensembl
    51. sprouting angiogenesis Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_196644. Syndecan interactions.
    REACT_211817. O-glycosylation of TSR domain-containing proteins.
    REACT_216309. Integrin cell surface interactions.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:Thbs1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:98737. Thbs1.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular space Source: MGI
    3. extracellular vesicular exosome Source: Ensembl
    4. fibrinogen complex Source: Ensembl
    5. platelet alpha granule Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ3TP59.
    BgeeiQ3TP59.
    GenevestigatoriQ3TP59.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG000636.
    InParanoidiQ3TP59.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    4.10.1080.10. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR028499. Thrombospondin-1.
    IPR003367. Thrombospondin_3-like_rpt.
    IPR017897. Thrombospondin_3_rpt.
    IPR008859. Thrombospondin_C.
    IPR028974. TSP_type-3_rpt.
    [Graphical view]
    PANTHERiPTHR10199:SF78. PTHR10199:SF78. 1 hit.
    PfamiPF02412. TSP_3. 1 hit.
    PF05735. TSP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF103647. SSF103647. 1 hit.
    SSF49899. SSF49899. 1 hit.
    PROSITEiPS51234. TSP3. 2 hits.
    PS51236. TSP_CTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q3TP59-1 [UniParc]FASTAAdd to Basket

    « Hide

    NCRLVPNPDQ KDSDGDGRGD ACKDDFDHDN VPDIDDICPE NFDISETDFR    50
    QFQMIPLDPK GTSQNDPNWV VRHQGKELVQ TVNCDPGLAV GYDEFNAVDF 100
    SGTFFINTER DDDYAGFVFG YQSSSRFYVV MWKQVTQSYW DTNPTRAQGY 150
    SGLSVKVVNS TTGPGEHLRN ALWHTGNTPG QVRTLWHDPR HIGWKDFTAY 200
    RWRLSHRPKT GYIRVVMYEG KKIMADSGPI YDKTYAGGRL GLFVFSQEMV 250
    FFSDMKYECR DS 262
    Length:262
    Mass (Da):30,023
    Last modified:October 11, 2005 - v1
    Checksum:iD50A1635AA01426F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK164691 mRNA. Translation: BAE37878.1.
    UniGeneiMm.4159.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK164691 mRNA. Translation: BAE37878.1 .
    UniGenei Mm.4159.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:98737. Thbs1.

    Phylogenomic databases

    HOVERGENi HBG000636.
    InParanoidi Q3TP59.

    Enzyme and pathway databases

    Reactomei REACT_196644. Syndecan interactions.
    REACT_211817. O-glycosylation of TSR domain-containing proteins.
    REACT_216309. Integrin cell surface interactions.

    Miscellaneous databases

    ChiTaRSi THBS1. mouse.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3TP59.
    Bgeei Q3TP59.
    Genevestigatori Q3TP59.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    4.10.1080.10. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR028499. Thrombospondin-1.
    IPR003367. Thrombospondin_3-like_rpt.
    IPR017897. Thrombospondin_3_rpt.
    IPR008859. Thrombospondin_C.
    IPR028974. TSP_type-3_rpt.
    [Graphical view ]
    PANTHERi PTHR10199:SF78. PTHR10199:SF78. 1 hit.
    Pfami PF02412. TSP_3. 1 hit.
    PF05735. TSP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103647. SSF103647. 1 hit.
    SSF49899. SSF49899. 1 hit.
    PROSITEi PS51234. TSP3. 2 hits.
    PS51236. TSP_CTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.

    Entry informationi

    Entry nameiQ3TP59_MOUSE
    AccessioniPrimary (citable) accession number: Q3TP59
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)