ID   Q3TNZ7_MOUSE            Unreviewed;       633 AA.
AC   Q3TNZ7;
DT   11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2005, sequence version 1.
DT   27-MAR-2024, entry version 112.
DE   RecName: Full=Collagen alpha-1(XII) chain {ECO:0008006|Google:ProtNLM};
DE   Flags: Fragment;
GN   Name=Col12a1 {ECO:0000313|MGI:MGI:88448};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE37940.1};
RN   [1] {ECO:0000313|EMBL:BAE37940.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE37940.1};
RC   TISSUE=Head {ECO:0000313|EMBL:BAE37940.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2] {ECO:0000313|EMBL:BAE37940.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE37940.1};
RC   TISSUE=Head {ECO:0000313|EMBL:BAE37940.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT   full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [3] {ECO:0000313|EMBL:BAE37940.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE37940.1};
RC   TISSUE=Head {ECO:0000313|EMBL:BAE37940.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA   Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA   Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA   Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA   Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA   Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT   pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [4] {ECO:0000313|EMBL:BAE37940.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE37940.1};
RC   TISSUE=Head {ECO:0000313|EMBL:BAE37940.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [5] {ECO:0000313|EMBL:BAE37940.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE37940.1};
RC   TISSUE=Head {ECO:0000313|EMBL:BAE37940.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [6] {ECO:0000313|EMBL:BAE37940.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE37940.1};
RC   TISSUE=Head {ECO:0000313|EMBL:BAE37940.1};
RA   Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA   Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA   Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA   Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA   Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:BAE37940.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE37940.1};
RC   TISSUE=Head {ECO:0000313|EMBL:BAE37940.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [8] {ECO:0000313|EMBL:BAE37940.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE37940.1};
RC   TISSUE=Head {ECO:0000313|EMBL:BAE37940.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK164846; BAE37940.1; -; mRNA.
DR   AlphaFoldDB; Q3TNZ7; -.
DR   PeptideAtlas; Q3TNZ7; -.
DR   AGR; MGI:88448; -.
DR   MGI; MGI:88448; Col12a1.
DR   ChiTaRS; Col12a1; mouse.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0031012; C:extracellular matrix; IEA:UniProt.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   CDD; cd00063; FN3; 3.
DR   CDD; cd01482; vWA_collagen_alphaI-XII-like; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR048287; TSPN-like_N.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR   PANTHER; PTHR24020:SF17; COLLAGEN ALPHA-1(XII) CHAIN; 1.
DR   Pfam; PF00041; fn3; 3.
DR   Pfam; PF00092; VWA; 1.
DR   PRINTS; PR00453; VWFADOMAIN.
DR   SMART; SM00060; FN3; 3.
DR   SMART; SM00210; TSPN; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 2.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50853; FN3; 3.
DR   PROSITE; PS50234; VWFA; 1.
DR   Genevisible; Q3TNZ7; MM.
PE   2: Evidence at transcript level;
KW   Collagen {ECO:0000256|ARBA:ARBA00023119};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          1..81
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          82..170
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          171..258
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          287..460
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          255..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        261..275
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAE37940.1"
FT   NON_TER         633
FT                   /evidence="ECO:0000313|EMBL:BAE37940.1"
SQ   SEQUENCE   633 AA;  70192 MW;  36A5056DE67B5E0D CRC64;
     TTNSLSVAWD HADGPVQQYR IIYSPTVGDP IDEYTTVPGR RNNVILQPLQ PDTPYKITVI
     AIYEDGDGGH LTGNGRTVGL LPPQNIHIFD EWYTRFRVSW DPSPSPVLGY KIVYKPVGSN
     EPMEAFVGEV TSYTLHNLNP STTYDVSVYA QYDSGLSVPL TDQGTTLYLN VTDLKTYQVG
     WDTFCVKWSP HRAATSYRLK LSPADGTRGQ EITVRGSETS HCFTGLSPEA EYGVTVFVQT
     PNLEGPGVPI KEQTTVKPTE APTEPPTPSP PPTIPPARDV CKGAKADIVF LTDASWSIGD
     DNFNKVVKFI FNTVGAFDEV NPAGIQVSFV QYSDEVKSEF KLNTYNDKAL ALGALQNIRY
     RGGNTRTGKA LTFIKEKVLT WESGMRKNVP KVLVVVTDGR SQDEVKKAAF VIQQSGFSVF
     VVGVADVDYN ELANIASKPS ERHVFIVDDF ESFEKIEDNL ITFVCETATS SCPLIYLDGY
     TSPGFKMLEA YNLTEKNFAS VQGVSLESGS FPSYSAYRLQ KNAFINQPTA ELHPNGLPPS
     YTIILLFRLL PETPSDPFAI WQITDRDYRP QVGVIADPSS KTLSFFNKDT RGEVQTVTFD
     TDEVKTLFYG SFHKVHIVVT SKSVKIYIDC YEI
//