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Protein
Submitted name:

A disintegrin and metalloproteinase with thrombospondin motifs 4

Gene

Adamts4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. metalloendopeptidase activity Source: MGI
  2. metallopeptidase activity Source: MGI
  3. protease binding Source: MGI
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. defense response to bacterium Source: MGI
  2. proteolysis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
A disintegrin and metalloproteinase with thrombospondin motifs 4Imported
Gene namesi
Name:Adamts4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1339949. Adamts4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: MGI
  2. extracellular space Source: MGI
  3. proteinaceous extracellular matrix Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ3TNX8.

Family & Domainsi

Sequence similaritiesi

Contains 1 peptidase M12B domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118880.
HOGENOMiHOG000004799.
HOVERGENiHBG004313.
KOiK07764.
OMAiHAGCDRI.
TreeFamiTF331949.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 1 hit.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TNX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASIHPSCSP GTMSQMGLHP RRGLTGHWLQ RFQPCLPLHT VQWRRLLLLA
60 70 80 90 100
FLLSLAWPAS PLPREEEIVF PEKLNGSSIL PGSGVPARLL YRLPAFGEML
110 120 130 140 150
LLELEQDPGV QVEGLTVQYL GQAPEMLGGA EPGTYLTGTI NGDPESVASL
160 170 180 190 200
HWDGGALLGV LQYRGAELHL QPLEGGALNS AGGPGAHILR RKSPASSQGP
210 220 230 240 250
MCTVKAPSGS PSPISRRTKR FASLSRFVET LVVADDKMAA FHGTGLKRYL
260 270 280 290 300
LTVMAAAAKA FKHPSIRNPV NLVVTRLVIL GSGQEGPQVG PSAAQTLRSF
310 320 330 340 350
CTWQRGLNTP NDSDPDHFDT AILFTRQDLC GVSTCDTLGM ADVGTVCDPA
360 370 380 390 400
RSCAIVEDDG LQSAFTAAHE LGHVFNMLHD NSKPCTNLNG QGGSSRHVMA
410 420 430 440 450
PVMAHVDPEE PWSPCSARFI TDFLDNGYGH CLLDKPEAPL HLPATFPGKD
460 470 480 490 500
YDADRQCQLT FGPDSSHCPQ LPPPCAALWC SGHLNGHAMC QTKHSPWADG
510 520 530 540 550
TPCGSSQACM GGRCLHVDQL KDFNVPQAGG WGPWGPWGDC SRTCGGGVQF
560 570 580 590 600
SSRDCTRPVP RNGGKYCEGR RTRFRSCNTE NCPHGSALTF REEQCAAYNH
610 620 630 640 650
RTDLFKSFPG PMDWVPRYTG VAPRDQCKLT CQARALGYYY VLEPRVADGT
660 670 680 690 700
PCSPDTSSVC VQGRCIHAGC DRIIGSKKKF DKCMVCGGDG SRCSKQSGSF
710 720 730 740 750
KKFRYGYSDV VTIPAGATHI LVRQQGGSGL KSIYLALKLS DGSYALNGEY
760 770 780 790 800
TLMPSPTDVV LPGAVSLRYS GATAASETLS GHGPLAQPLT LQVLVAGNPQ
810 820 830 840
NARLRYSFFV PRPVPSTPRP PPQDWLQRRA EILKILRKRP WAGRK
Length:845
Mass (Da):91,239
Last modified:October 11, 2005 - v1
Checksum:iB496C3190D1A9225
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084821 Genomic DNA. No translation available.
AK164900 mRNA. Translation: BAE37959.1.
RefSeqiNP_766433.1. NM_172845.2.
UniGeneiMm.491147.

Genome annotation databases

EnsembliENSMUST00000111315; ENSMUSP00000106947; ENSMUSG00000006403.
GeneIDi240913.
KEGGimmu:240913.
UCSCiuc007dnn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084821 Genomic DNA. No translation available.
AK164900 mRNA. Translation: BAE37959.1.
RefSeqiNP_766433.1. NM_172845.2.
UniGeneiMm.491147.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111315; ENSMUSP00000106947; ENSMUSG00000006403.
GeneIDi240913.
KEGGimmu:240913.
UCSCiuc007dnn.1. mouse.

Organism-specific databases

CTDi9507.
MGIiMGI:1339949. Adamts4.

Phylogenomic databases

GeneTreeiENSGT00760000118880.
HOGENOMiHOG000004799.
HOVERGENiHBG004313.
KOiK07764.
OMAiHAGCDRI.
TreeFamiTF331949.

Miscellaneous databases

NextBioi384802.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ3TNX8.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 1 hit.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Ensembl
    Submitted (JAN-2015) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3TNX8_MOUSE
AccessioniPrimary (citable) accession number: Q3TNX8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 29, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.