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Q3TNX8

- Q3TNX8_MOUSE

UniProt

Q3TNX8 - Q3TNX8_MOUSE

Protein
Submitted name:

A disintegrin and metalloproteinase with thrombospondin motifs 4

Gene

Adamts4

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: MGI
    2. metallopeptidase activity Source: MGI
    3. protein binding Source: MGI
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. defense response to bacterium Source: MGI
    2. proteolysis Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    A disintegrin and metalloproteinase with thrombospondin motifs 4Imported
    Gene namesi
    Name:Adamts4Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1339949. Adamts4.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. proteinaceous extracellular matrix Source: InterPro

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ3TNX8.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 peptidase M12B domain.UniRule annotation
    Contains peptidase M12B domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00650000092972.
    HOGENOMiHOG000004799.
    HOVERGENiHBG004313.
    InParanoidiQ3TNX8.
    KOiK07764.
    OMAiHAGCDRI.
    TreeFamiTF331949.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    InterProiIPR010294. ADAM_spacer1.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR013273. Peptidase_M12B_ADAM-TS.
    IPR002870. Peptidase_M12B_N.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view]
    PfamiPF05986. ADAM_spacer1. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    PF00090. TSP_1. 1 hit.
    [Graphical view]
    PRINTSiPR01857. ADAMTSFAMILY.
    SMARTiSM00209. TSP1. 1 hit.
    [Graphical view]
    SUPFAMiSSF82895. SSF82895. 1 hit.
    PROSITEiPS50215. ADAM_MEPRO. 1 hit.
    PS50092. TSP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3TNX8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASIHPSCSP GTMSQMGLHP RRGLTGHWLQ RFQPCLPLHT VQWRRLLLLA    50
    FLLSLAWPAS PLPREEEIVF PEKLNGSSIL PGSGVPARLL YRLPAFGEML 100
    LLELEQDPGV QVEGLTVQYL GQAPEMLGGA EPGTYLTGTI NGDPESVASL 150
    HWDGGALLGV LQYRGAELHL QPLEGGALNS AGGPGAHILR RKSPASSQGP 200
    MCTVKAPSGS PSPISRRTKR FASLSRFVET LVVADDKMAA FHGTGLKRYL 250
    LTVMAAAAKA FKHPSIRNPV NLVVTRLVIL GSGQEGPQVG PSAAQTLRSF 300
    CTWQRGLNTP NDSDPDHFDT AILFTRQDLC GVSTCDTLGM ADVGTVCDPA 350
    RSCAIVEDDG LQSAFTAAHE LGHVFNMLHD NSKPCTNLNG QGGSSRHVMA 400
    PVMAHVDPEE PWSPCSARFI TDFLDNGYGH CLLDKPEAPL HLPATFPGKD 450
    YDADRQCQLT FGPDSSHCPQ LPPPCAALWC SGHLNGHAMC QTKHSPWADG 500
    TPCGSSQACM GGRCLHVDQL KDFNVPQAGG WGPWGPWGDC SRTCGGGVQF 550
    SSRDCTRPVP RNGGKYCEGR RTRFRSCNTE NCPHGSALTF REEQCAAYNH 600
    RTDLFKSFPG PMDWVPRYTG VAPRDQCKLT CQARALGYYY VLEPRVADGT 650
    PCSPDTSSVC VQGRCIHAGC DRIIGSKKKF DKCMVCGGDG SRCSKQSGSF 700
    KKFRYGYSDV VTIPAGATHI LVRQQGGSGL KSIYLALKLS DGSYALNGEY 750
    TLMPSPTDVV LPGAVSLRYS GATAASETLS GHGPLAQPLT LQVLVAGNPQ 800
    NARLRYSFFV PRPVPSTPRP PPQDWLQRRA EILKILRKRP WAGRK 845
    Length:845
    Mass (Da):91,239
    Last modified:October 11, 2005 - v1
    Checksum:iB496C3190D1A9225
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC084821 Genomic DNA. No translation available.
    AK164900 mRNA. Translation: BAE37959.1.
    RefSeqiNP_766433.1. NM_172845.2.
    UniGeneiMm.491147.

    Genome annotation databases

    EnsembliENSMUST00000006570; ENSMUSP00000006570; ENSMUSG00000006403.
    GeneIDi240913.
    KEGGimmu:240913.
    UCSCiuc007dnn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC084821 Genomic DNA. No translation available.
    AK164900 mRNA. Translation: BAE37959.1 .
    RefSeqi NP_766433.1. NM_172845.2.
    UniGenei Mm.491147.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006570 ; ENSMUSP00000006570 ; ENSMUSG00000006403 .
    GeneIDi 240913.
    KEGGi mmu:240913.
    UCSCi uc007dnn.1. mouse.

    Organism-specific databases

    CTDi 9507.
    MGIi MGI:1339949. Adamts4.

    Phylogenomic databases

    GeneTreei ENSGT00650000092972.
    HOGENOMi HOG000004799.
    HOVERGENi HBG004313.
    InParanoidi Q3TNX8.
    KOi K07764.
    OMAi HAGCDRI.
    TreeFami TF331949.

    Miscellaneous databases

    NextBioi 384802.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3TNX8.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    InterProi IPR010294. ADAM_spacer1.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR013273. Peptidase_M12B_ADAM-TS.
    IPR002870. Peptidase_M12B_N.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view ]
    Pfami PF05986. ADAM_spacer1. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    PF00090. TSP_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01857. ADAMTSFAMILY.
    SMARTi SM00209. TSP1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82895. SSF82895. 1 hit.
    PROSITEi PS50215. ADAM_MEPRO. 1 hit.
    PS50092. TSP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    10. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ3TNX8_MOUSE
    AccessioniPrimary (citable) accession number: Q3TNX8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3