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Q3TNX8

- Q3TNX8_MOUSE

UniProt

Q3TNX8 - Q3TNX8_MOUSE

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Protein
Submitted name: A disintegrin and metalloproteinase with thrombospondin motifs 4
Gene
Adamts4
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. metalloendopeptidase activity Source: MGI
  2. metallopeptidase activity Source: MGI
  3. protein binding Source: MGI
  4. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. defense response to bacterium Source: MGI
  2. proteolysis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
A disintegrin and metalloproteinase with thrombospondin motifs 4Imported
Gene namesi
Name:Adamts4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1339949. Adamts4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. proteinaceous extracellular matrix Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Expressioni

Gene expression databases

GenevestigatoriQ3TNX8.

Family & Domainsi

Sequence similaritiesi

Contains 1 peptidase M12B domain.UniRule annotation
Contains peptidase M12B domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00650000092972.
HOGENOMiHOG000004799.
HOVERGENiHBG004313.
InParanoidiQ3TNX8.
KOiK07764.
OMAiHAGCDRI.
TreeFamiTF331949.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 1 hit.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TNX8-1 [UniParc]FASTAAdd to Basket

« Hide

MASIHPSCSP GTMSQMGLHP RRGLTGHWLQ RFQPCLPLHT VQWRRLLLLA    50
FLLSLAWPAS PLPREEEIVF PEKLNGSSIL PGSGVPARLL YRLPAFGEML 100
LLELEQDPGV QVEGLTVQYL GQAPEMLGGA EPGTYLTGTI NGDPESVASL 150
HWDGGALLGV LQYRGAELHL QPLEGGALNS AGGPGAHILR RKSPASSQGP 200
MCTVKAPSGS PSPISRRTKR FASLSRFVET LVVADDKMAA FHGTGLKRYL 250
LTVMAAAAKA FKHPSIRNPV NLVVTRLVIL GSGQEGPQVG PSAAQTLRSF 300
CTWQRGLNTP NDSDPDHFDT AILFTRQDLC GVSTCDTLGM ADVGTVCDPA 350
RSCAIVEDDG LQSAFTAAHE LGHVFNMLHD NSKPCTNLNG QGGSSRHVMA 400
PVMAHVDPEE PWSPCSARFI TDFLDNGYGH CLLDKPEAPL HLPATFPGKD 450
YDADRQCQLT FGPDSSHCPQ LPPPCAALWC SGHLNGHAMC QTKHSPWADG 500
TPCGSSQACM GGRCLHVDQL KDFNVPQAGG WGPWGPWGDC SRTCGGGVQF 550
SSRDCTRPVP RNGGKYCEGR RTRFRSCNTE NCPHGSALTF REEQCAAYNH 600
RTDLFKSFPG PMDWVPRYTG VAPRDQCKLT CQARALGYYY VLEPRVADGT 650
PCSPDTSSVC VQGRCIHAGC DRIIGSKKKF DKCMVCGGDG SRCSKQSGSF 700
KKFRYGYSDV VTIPAGATHI LVRQQGGSGL KSIYLALKLS DGSYALNGEY 750
TLMPSPTDVV LPGAVSLRYS GATAASETLS GHGPLAQPLT LQVLVAGNPQ 800
NARLRYSFFV PRPVPSTPRP PPQDWLQRRA EILKILRKRP WAGRK 845
Length:845
Mass (Da):91,239
Last modified:October 11, 2005 - v1
Checksum:iB496C3190D1A9225
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC084821 Genomic DNA. No translation available.
AK164900 mRNA. Translation: BAE37959.1.
RefSeqiNP_766433.1. NM_172845.2.
UniGeneiMm.491147.

Genome annotation databases

EnsembliENSMUST00000006570; ENSMUSP00000006570; ENSMUSG00000006403.
GeneIDi240913.
KEGGimmu:240913.
UCSCiuc007dnn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC084821 Genomic DNA. No translation available.
AK164900 mRNA. Translation: BAE37959.1 .
RefSeqi NP_766433.1. NM_172845.2.
UniGenei Mm.491147.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006570 ; ENSMUSP00000006570 ; ENSMUSG00000006403 .
GeneIDi 240913.
KEGGi mmu:240913.
UCSCi uc007dnn.1. mouse.

Organism-specific databases

CTDi 9507.
MGIi MGI:1339949. Adamts4.

Phylogenomic databases

GeneTreei ENSGT00650000092972.
HOGENOMi HOG000004799.
HOVERGENi HBG004313.
InParanoidi Q3TNX8.
KOi K07764.
OMAi HAGCDRI.
TreeFami TF331949.

Miscellaneous databases

NextBioi 384802.
SOURCEi Search...

Gene expression databases

Genevestigatori Q3TNX8.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
InterProi IPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR000884. Thrombospondin_1_rpt.
[Graphical view ]
Pfami PF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 1 hit.
[Graphical view ]
PRINTSi PR01857. ADAMTSFAMILY.
SMARTi SM00209. TSP1. 1 hit.
[Graphical view ]
SUPFAMi SSF82895. SSF82895. 1 hit.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3TNX8_MOUSE
AccessioniPrimary (citable) accession number: Q3TNX8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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