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Protein
Submitted name:

Putative uncharacterized protein

Gene

Pik3cb

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • 1-phosphatidylinositol-3-kinase activity Source: MGI
  • 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: GO_Central
  • insulin receptor substrate binding Source: MGI
  • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: GO_Central

GO - Biological processi

  • adaptive immune response Source: GO_Central
  • angiogenesis involved in wound healing Source: MGI
  • cell chemotaxis Source: GO_Central
  • cellular calcium ion homeostasis Source: MGI
  • embryonic cleavage Source: MGI
  • endothelial cell proliferation Source: MGI
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: MGI
  • inflammatory response Source: GO_Central
  • innate immune response Source: GO_Central
  • phosphatidylinositol 3-kinase signaling Source: GO_Central
  • phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  • platelet activation Source: MGI
  • positive regulation of gene expression Source: MGI
  • protein phosphorylation Source: GO_Central
  • regulation of cell-matrix adhesion Source: MGI
  • response to wounding Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Pik3cbImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1922019. Pik3cb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ3TNJ8.
ExpressionAtlasiQ3TNJ8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035037.

Family & Domainsi

Sequence similaritiesi

Contains PI3K/PI4K domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG052721.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR015433. PI_Kinase.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3TNJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GKEAMHTCLK QSAYREALSD LQSPLNPCVI LSELYVEKCK YMDSKMKPLW
60 70 80 90 100
LVYSSRAFGE DSVGVIFKNG DDLRQDMLTL QMLRLMDLLW KEAGLDLRML
110 120 130 140 150
PYGCLATGDR SGLIEVVSTS ETIADIQLNS SNVAATAAFN KDALLNWLKE
160 170 180 190 200
YNSGDDLDRA IEEFTLSCAG YCVASYVLGI GDRHSDNIMV KKTGQLFHID
210 220 230 240 250
FGHILGNFKS KFGIKRERVP FILTYDFIHV IQQGKTGNTE KFGRFRQCCE
260 270 280 290 300
DAYLILRRHG NLFITLFALM LTAGLPELTS VKDIQYLKDS LALGKSEEEA
310 320 330
LKQFKQKFDE ALRESWTTKV NWMAHTVRKD YRS
Length:333
Mass (Da):37,854
Last modified:October 11, 2005 - v1
Checksum:iB4D9D96A420C8B19
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK165230 mRNA. Translation: BAE38090.1.
UniGeneiMm.213128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK165230 mRNA. Translation: BAE38090.1.
UniGeneiMm.213128.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035037.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1922019. Pik3cb.

Phylogenomic databases

HOVERGENiHBG052721.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ3TNJ8.
ExpressionAtlasiQ3TNJ8. baseline and differential.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR015433. PI_Kinase.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SpleenImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SpleenImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SpleenImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SpleenImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SpleenImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SpleenImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SpleenImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SpleenImported.

Entry informationi

Entry nameiQ3TNJ8_MOUSE
AccessioniPrimary (citable) accession number: Q3TNJ8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 24, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.