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Protein

Protein FAM172A

Gene

Fam172a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM172A
Gene namesi
Name:Fam172a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1915925. Fam172a.

Subcellular locationi

  1. Secreted Curated

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 417399Protein FAM172APRO_0000320932Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ3TNH5.
PaxDbiQ3TNH5.
PRIDEiQ3TNH5.

PTM databases

PhosphoSiteiQ3TNH5.

Expressioni

Gene expression databases

BgeeiQ3TNH5.
CleanExiMM_1110033M05RIK.
ExpressionAtlasiQ3TNH5. baseline and differential.
GenevestigatoriQ3TNH5.

Structurei

3D structure databases

ProteinModelPortaliQ3TNH5.
SMRiQ3TNH5. Positions 265-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi414 – 4174Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the UPF0528 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG263064.
GeneTreeiENSGT00530000063907.
HOGENOMiHOG000046503.
HOVERGENiHBG107877.
InParanoidiQ3TNH5.
OMAiPNENYLE.
OrthoDBiEOG71K64J.
PhylomeDBiQ3TNH5.
TreeFamiTF315960.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR019154. Arb2_domain.
[Graphical view]
PfamiPF09757. Arb2. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TNH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSISLSSLIF LPIWINMAQM QQGGSNETEQ TAALKDLLSR IDLDELMKKD
60 70 80 90 100
EPPFDFPDTL EGFEYAFNEK GQLRHIKTGE PFVFNYREDL HRWNQKRYEA
110 120 130 140 150
LGEIITRYVY ELLESDCNLK KISIPVDATE SEPKSFIFMS EDALTNPQKL
160 170 180 190 200
MVLIHGSGVV RAGQWARRLI INEDLDSGTQ IPFIKRAMDE GYGVIVLNPN
210 220 230 240 250
ENYIEVEKQK MHKQSSSSDG TDEPAGKRER RDKVSKETKK RRDFYEKYRN
260 270 280 290 300
PQKEKEMMQL FIRENGSPEE HAVYVWDHFI AQAAAENVFF VAHSYGGLAF
310 320 330 340 350
VELMIQREAD VKSKVTAVAL TDSVHNVWHQ EAGKTIREWM RENCCNWVSS
360 370 380 390 400
SEPLDTSVES MLPDCPRVSA GTDRHELTSW KSFPSIFKFF AEASEAKSSS
410
QKPALTRRSH RIKHEEL
Length:417
Mass (Da):48,072
Last modified:February 26, 2008 - v2
Checksum:i8FBE7D0873DA8109
GO
Isoform 2 (identifier: Q3TNH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Note: No experimental confirmation available.

Show »
Length:279
Mass (Da):31,975
Checksum:i0AB4FE1707A3D22B
GO
Isoform 3 (identifier: Q3TNH5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
     126-189: Missing.

Note: No experimental confirmation available.

Show »
Length:307
Mass (Da):35,840
Checksum:i605B0CD185BBD4B9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 138138Missing in isoform 2. 1 PublicationVSP_031750Add
BLAST
Alternative sequencei1 – 4646Missing in isoform 3. 1 PublicationVSP_031751Add
BLAST
Alternative sequencei126 – 18964Missing in isoform 3. 1 PublicationVSP_031752Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK165273 mRNA. Translation: BAE38114.1.
AK166285 mRNA. Translation: BAE38682.1.
AC167171 Genomic DNA. No translation available.
AC154584 Genomic DNA. No translation available.
AC154548 Genomic DNA. No translation available.
CT025642 Genomic DNA. No translation available.
CCDSiCCDS49317.1. [Q3TNH5-1]
CCDS49319.1. [Q3TNH5-3]
RefSeqiNP_001156892.1. NM_001163420.1. [Q3TNH5-3]
NP_612185.1. NM_138312.1. [Q3TNH5-1]
UniGeneiMm.343005.

Genome annotation databases

EnsembliENSMUST00000099358; ENSMUSP00000096960; ENSMUSG00000064138. [Q3TNH5-3]
ENSMUST00000163257; ENSMUSP00000133140; ENSMUSG00000064138. [Q3TNH5-1]
GeneIDi68675.
KEGGimmu:68675.
UCSCiuc007rgy.2. mouse. [Q3TNH5-1]
uc007rha.2. mouse. [Q3TNH5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK165273 mRNA. Translation: BAE38114.1.
AK166285 mRNA. Translation: BAE38682.1.
AC167171 Genomic DNA. No translation available.
AC154584 Genomic DNA. No translation available.
AC154548 Genomic DNA. No translation available.
CT025642 Genomic DNA. No translation available.
CCDSiCCDS49317.1. [Q3TNH5-1]
CCDS49319.1. [Q3TNH5-3]
RefSeqiNP_001156892.1. NM_001163420.1. [Q3TNH5-3]
NP_612185.1. NM_138312.1. [Q3TNH5-1]
UniGeneiMm.343005.

3D structure databases

ProteinModelPortaliQ3TNH5.
SMRiQ3TNH5. Positions 265-324.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ3TNH5.

Proteomic databases

MaxQBiQ3TNH5.
PaxDbiQ3TNH5.
PRIDEiQ3TNH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099358; ENSMUSP00000096960; ENSMUSG00000064138. [Q3TNH5-3]
ENSMUST00000163257; ENSMUSP00000133140; ENSMUSG00000064138. [Q3TNH5-1]
GeneIDi68675.
KEGGimmu:68675.
UCSCiuc007rgy.2. mouse. [Q3TNH5-1]
uc007rha.2. mouse. [Q3TNH5-3]

Organism-specific databases

CTDi83989.
MGIiMGI:1915925. Fam172a.

Phylogenomic databases

eggNOGiNOG263064.
GeneTreeiENSGT00530000063907.
HOGENOMiHOG000046503.
HOVERGENiHBG107877.
InParanoidiQ3TNH5.
OMAiPNENYLE.
OrthoDBiEOG71K64J.
PhylomeDBiQ3TNH5.
TreeFamiTF315960.

Miscellaneous databases

NextBioi327674.
PROiQ3TNH5.
SOURCEiSearch...

Gene expression databases

BgeeiQ3TNH5.
CleanExiMM_1110033M05RIK.
ExpressionAtlasiQ3TNH5. baseline and differential.
GenevestigatoriQ3TNH5.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR019154. Arb2_domain.
[Graphical view]
PfamiPF09757. Arb2. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Mammary gland and Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiF172A_MOUSE
AccessioniPrimary (citable) accession number: Q3TNH5
Secondary accession number(s): Q3TLW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: February 4, 2015
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.