SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3TNH5

- F172A_MOUSE

UniProt

Q3TNH5 - F172A_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Protein FAM172A
Gene
Fam172a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM172A
Gene namesi
Name:Fam172a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1915925. Fam172a.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 417399Protein FAM172A
PRO_0000320932Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi26 – 261N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ3TNH5.
PaxDbiQ3TNH5.
PRIDEiQ3TNH5.

PTM databases

PhosphoSiteiQ3TNH5.

Expressioni

Gene expression databases

BgeeiQ3TNH5.
CleanExiMM_1110033M05RIK.
GenevestigatoriQ3TNH5.

Structurei

3D structure databases

ProteinModelPortaliQ3TNH5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi414 – 4174Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Belongs to the UPF0528 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG263064.
GeneTreeiENSGT00530000063907.
HOGENOMiHOG000046503.
HOVERGENiHBG107877.
InParanoidiQ3TNH5.
OMAiEEHVLYV.
OrthoDBiEOG71K64J.
PhylomeDBiQ3TNH5.
TreeFamiTF315960.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR019154. Arb2_domain.
[Graphical view]
PfamiPF09757. Arb2. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3TNH5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSISLSSLIF LPIWINMAQM QQGGSNETEQ TAALKDLLSR IDLDELMKKD    50
EPPFDFPDTL EGFEYAFNEK GQLRHIKTGE PFVFNYREDL HRWNQKRYEA 100
LGEIITRYVY ELLESDCNLK KISIPVDATE SEPKSFIFMS EDALTNPQKL 150
MVLIHGSGVV RAGQWARRLI INEDLDSGTQ IPFIKRAMDE GYGVIVLNPN 200
ENYIEVEKQK MHKQSSSSDG TDEPAGKRER RDKVSKETKK RRDFYEKYRN 250
PQKEKEMMQL FIRENGSPEE HAVYVWDHFI AQAAAENVFF VAHSYGGLAF 300
VELMIQREAD VKSKVTAVAL TDSVHNVWHQ EAGKTIREWM RENCCNWVSS 350
SEPLDTSVES MLPDCPRVSA GTDRHELTSW KSFPSIFKFF AEASEAKSSS 400
QKPALTRRSH RIKHEEL 417
Length:417
Mass (Da):48,072
Last modified:February 26, 2008 - v2
Checksum:i8FBE7D0873DA8109
GO
Isoform 2 (identifier: Q3TNH5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Note: No experimental confirmation available.

Show »
Length:279
Mass (Da):31,975
Checksum:i0AB4FE1707A3D22B
GO
Isoform 3 (identifier: Q3TNH5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
     126-189: Missing.

Note: No experimental confirmation available.

Show »
Length:307
Mass (Da):35,840
Checksum:i605B0CD185BBD4B9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 138138Missing in isoform 2.
VSP_031750Add
BLAST
Alternative sequencei1 – 4646Missing in isoform 3.
VSP_031751Add
BLAST
Alternative sequencei126 – 18964Missing in isoform 3.
VSP_031752Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK165273 mRNA. Translation: BAE38114.1.
AK166285 mRNA. Translation: BAE38682.1.
AC167171 Genomic DNA. No translation available.
AC154584 Genomic DNA. No translation available.
AC154548 Genomic DNA. No translation available.
CT025642 Genomic DNA. No translation available.
CCDSiCCDS49317.1. [Q3TNH5-1]
CCDS49319.1. [Q3TNH5-3]
RefSeqiNP_001156892.1. NM_001163420.1. [Q3TNH5-3]
NP_612185.1. NM_138312.1. [Q3TNH5-1]
UniGeneiMm.343005.

Genome annotation databases

EnsembliENSMUST00000099358; ENSMUSP00000096960; ENSMUSG00000064138. [Q3TNH5-3]
ENSMUST00000163257; ENSMUSP00000133140; ENSMUSG00000064138. [Q3TNH5-1]
GeneIDi68675.
KEGGimmu:68675.
UCSCiuc007rgy.2. mouse. [Q3TNH5-1]
uc007rha.2. mouse. [Q3TNH5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK165273 mRNA. Translation: BAE38114.1 .
AK166285 mRNA. Translation: BAE38682.1 .
AC167171 Genomic DNA. No translation available.
AC154584 Genomic DNA. No translation available.
AC154548 Genomic DNA. No translation available.
CT025642 Genomic DNA. No translation available.
CCDSi CCDS49317.1. [Q3TNH5-1 ]
CCDS49319.1. [Q3TNH5-3 ]
RefSeqi NP_001156892.1. NM_001163420.1. [Q3TNH5-3 ]
NP_612185.1. NM_138312.1. [Q3TNH5-1 ]
UniGenei Mm.343005.

3D structure databases

ProteinModelPortali Q3TNH5.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q3TNH5.

Proteomic databases

MaxQBi Q3TNH5.
PaxDbi Q3TNH5.
PRIDEi Q3TNH5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000099358 ; ENSMUSP00000096960 ; ENSMUSG00000064138 . [Q3TNH5-3 ]
ENSMUST00000163257 ; ENSMUSP00000133140 ; ENSMUSG00000064138 . [Q3TNH5-1 ]
GeneIDi 68675.
KEGGi mmu:68675.
UCSCi uc007rgy.2. mouse. [Q3TNH5-1 ]
uc007rha.2. mouse. [Q3TNH5-3 ]

Organism-specific databases

CTDi 83989.
MGIi MGI:1915925. Fam172a.

Phylogenomic databases

eggNOGi NOG263064.
GeneTreei ENSGT00530000063907.
HOGENOMi HOG000046503.
HOVERGENi HBG107877.
InParanoidi Q3TNH5.
OMAi EEHVLYV.
OrthoDBi EOG71K64J.
PhylomeDBi Q3TNH5.
TreeFami TF315960.

Miscellaneous databases

NextBioi 327674.
PROi Q3TNH5.
SOURCEi Search...

Gene expression databases

Bgeei Q3TNH5.
CleanExi MM_1110033M05RIK.
Genevestigatori Q3TNH5.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR019154. Arb2_domain.
[Graphical view ]
Pfami PF09757. Arb2. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 2 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Mammary gland and Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiF172A_MOUSE
AccessioniPrimary (citable) accession number: Q3TNH5
Secondary accession number(s): Q3TLW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi