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Q3TNH5 (F172A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM172A
Gene names
Name:Fam172a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the UPF0528 family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q3TNH5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q3TNH5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q3TNH5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
     126-189: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 417399Protein FAM172A
PRO_0000320932

Regions

Motif414 – 4174Prevents secretion from ER Potential

Amino acid modifications

Glycosylation261N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 138138Missing in isoform 2.
VSP_031750
Alternative sequence1 – 4646Missing in isoform 3.
VSP_031751
Alternative sequence126 – 18964Missing in isoform 3.
VSP_031752

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: 8FBE7D0873DA8109

FASTA41748,072
        10         20         30         40         50         60 
MSISLSSLIF LPIWINMAQM QQGGSNETEQ TAALKDLLSR IDLDELMKKD EPPFDFPDTL 

        70         80         90        100        110        120 
EGFEYAFNEK GQLRHIKTGE PFVFNYREDL HRWNQKRYEA LGEIITRYVY ELLESDCNLK 

       130        140        150        160        170        180 
KISIPVDATE SEPKSFIFMS EDALTNPQKL MVLIHGSGVV RAGQWARRLI INEDLDSGTQ 

       190        200        210        220        230        240 
IPFIKRAMDE GYGVIVLNPN ENYIEVEKQK MHKQSSSSDG TDEPAGKRER RDKVSKETKK 

       250        260        270        280        290        300 
RRDFYEKYRN PQKEKEMMQL FIRENGSPEE HAVYVWDHFI AQAAAENVFF VAHSYGGLAF 

       310        320        330        340        350        360 
VELMIQREAD VKSKVTAVAL TDSVHNVWHQ EAGKTIREWM RENCCNWVSS SEPLDTSVES 

       370        380        390        400        410 
MLPDCPRVSA GTDRHELTSW KSFPSIFKFF AEASEAKSSS QKPALTRRSH RIKHEEL 

« Hide

Isoform 2 [UniParc].

Checksum: 0AB4FE1707A3D22B
Show »

FASTA27931,975
Isoform 3 [UniParc].

Checksum: 605B0CD185BBD4B9
Show »

FASTA30735,840

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Strain: C57BL/6J.
Tissue: Mammary gland and Spleen.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK165273 mRNA. Translation: BAE38114.1.
AK166285 mRNA. Translation: BAE38682.1.
AC167171 Genomic DNA. No translation available.
AC154584 Genomic DNA. No translation available.
AC154548 Genomic DNA. No translation available.
CT025642 Genomic DNA. No translation available.
RefSeqNP_001156892.1. NM_001163420.1.
NP_612185.1. NM_138312.1.
UniGeneMm.343005.

3D structure databases

ProteinModelPortalQ3TNH5.
SMRQ3TNH5. Positions 265-324.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ3TNH5.

Proteomic databases

PaxDbQ3TNH5.
PRIDEQ3TNH5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000099358; ENSMUSP00000096960; ENSMUSG00000064138. [Q3TNH5-3]
ENSMUST00000163257; ENSMUSP00000133140; ENSMUSG00000064138. [Q3TNH5-1]
GeneID68675.
KEGGmmu:68675.
UCSCuc007rgy.2. mouse. [Q3TNH5-1]
uc007rha.2. mouse. [Q3TNH5-3]

Organism-specific databases

CTD83989.
MGIMGI:1915925. Fam172a.

Phylogenomic databases

eggNOGNOG263064.
GeneTreeENSGT00530000063907.
HOGENOMHOG000046503.
HOVERGENHBG107877.
InParanoidQ3TNH5.
OMAEEHVLYV.
OrthoDBEOG71K64J.
PhylomeDBQ3TNH5.
TreeFamTF315960.

Gene expression databases

BgeeQ3TNH5.
CleanExMM_1110033M05RIK.
GenevestigatorQ3TNH5.

Family and domain databases

InterProIPR019154. Arb2_domain.
[Graphical view]
PfamPF09757. Arb2. 1 hit.
[Graphical view]
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio327674.
PROQ3TNH5.
SOURCESearch...

Entry information

Entry nameF172A_MOUSE
AccessionPrimary (citable) accession number: Q3TNH5
Secondary accession number(s): Q3TLW0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: April 16, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot