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Q3TNH5

- F172A_MOUSE

UniProt

Q3TNH5 - F172A_MOUSE

Protein

Protein FAM172A

Gene

Fam172a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM172A
    Gene namesi
    Name:Fam172a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1915925. Fam172a.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 417399Protein FAM172APRO_0000320932Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ3TNH5.
    PaxDbiQ3TNH5.
    PRIDEiQ3TNH5.

    PTM databases

    PhosphoSiteiQ3TNH5.

    Expressioni

    Gene expression databases

    BgeeiQ3TNH5.
    CleanExiMM_1110033M05RIK.
    GenevestigatoriQ3TNH5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3TNH5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi414 – 4174Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the UPF0528 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG263064.
    GeneTreeiENSGT00530000063907.
    HOGENOMiHOG000046503.
    HOVERGENiHBG107877.
    InParanoidiQ3TNH5.
    OMAiEEHVLYV.
    OrthoDBiEOG71K64J.
    PhylomeDBiQ3TNH5.
    TreeFamiTF315960.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR019154. Arb2_domain.
    [Graphical view]
    PfamiPF09757. Arb2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 2 hits.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3TNH5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSISLSSLIF LPIWINMAQM QQGGSNETEQ TAALKDLLSR IDLDELMKKD    50
    EPPFDFPDTL EGFEYAFNEK GQLRHIKTGE PFVFNYREDL HRWNQKRYEA 100
    LGEIITRYVY ELLESDCNLK KISIPVDATE SEPKSFIFMS EDALTNPQKL 150
    MVLIHGSGVV RAGQWARRLI INEDLDSGTQ IPFIKRAMDE GYGVIVLNPN 200
    ENYIEVEKQK MHKQSSSSDG TDEPAGKRER RDKVSKETKK RRDFYEKYRN 250
    PQKEKEMMQL FIRENGSPEE HAVYVWDHFI AQAAAENVFF VAHSYGGLAF 300
    VELMIQREAD VKSKVTAVAL TDSVHNVWHQ EAGKTIREWM RENCCNWVSS 350
    SEPLDTSVES MLPDCPRVSA GTDRHELTSW KSFPSIFKFF AEASEAKSSS 400
    QKPALTRRSH RIKHEEL 417
    Length:417
    Mass (Da):48,072
    Last modified:February 26, 2008 - v2
    Checksum:i8FBE7D0873DA8109
    GO
    Isoform 2 (identifier: Q3TNH5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-138: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:279
    Mass (Da):31,975
    Checksum:i0AB4FE1707A3D22B
    GO
    Isoform 3 (identifier: Q3TNH5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-46: Missing.
         126-189: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:307
    Mass (Da):35,840
    Checksum:i605B0CD185BBD4B9
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 138138Missing in isoform 2. 1 PublicationVSP_031750Add
    BLAST
    Alternative sequencei1 – 4646Missing in isoform 3. 1 PublicationVSP_031751Add
    BLAST
    Alternative sequencei126 – 18964Missing in isoform 3. 1 PublicationVSP_031752Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK165273 mRNA. Translation: BAE38114.1.
    AK166285 mRNA. Translation: BAE38682.1.
    AC167171 Genomic DNA. No translation available.
    AC154584 Genomic DNA. No translation available.
    AC154548 Genomic DNA. No translation available.
    CT025642 Genomic DNA. No translation available.
    CCDSiCCDS49317.1. [Q3TNH5-1]
    CCDS49319.1. [Q3TNH5-3]
    RefSeqiNP_001156892.1. NM_001163420.1. [Q3TNH5-3]
    NP_612185.1. NM_138312.1. [Q3TNH5-1]
    UniGeneiMm.343005.

    Genome annotation databases

    EnsembliENSMUST00000099358; ENSMUSP00000096960; ENSMUSG00000064138. [Q3TNH5-3]
    ENSMUST00000163257; ENSMUSP00000133140; ENSMUSG00000064138. [Q3TNH5-1]
    GeneIDi68675.
    KEGGimmu:68675.
    UCSCiuc007rgy.2. mouse. [Q3TNH5-1]
    uc007rha.2. mouse. [Q3TNH5-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK165273 mRNA. Translation: BAE38114.1 .
    AK166285 mRNA. Translation: BAE38682.1 .
    AC167171 Genomic DNA. No translation available.
    AC154584 Genomic DNA. No translation available.
    AC154548 Genomic DNA. No translation available.
    CT025642 Genomic DNA. No translation available.
    CCDSi CCDS49317.1. [Q3TNH5-1 ]
    CCDS49319.1. [Q3TNH5-3 ]
    RefSeqi NP_001156892.1. NM_001163420.1. [Q3TNH5-3 ]
    NP_612185.1. NM_138312.1. [Q3TNH5-1 ]
    UniGenei Mm.343005.

    3D structure databases

    ProteinModelPortali Q3TNH5.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q3TNH5.

    Proteomic databases

    MaxQBi Q3TNH5.
    PaxDbi Q3TNH5.
    PRIDEi Q3TNH5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000099358 ; ENSMUSP00000096960 ; ENSMUSG00000064138 . [Q3TNH5-3 ]
    ENSMUST00000163257 ; ENSMUSP00000133140 ; ENSMUSG00000064138 . [Q3TNH5-1 ]
    GeneIDi 68675.
    KEGGi mmu:68675.
    UCSCi uc007rgy.2. mouse. [Q3TNH5-1 ]
    uc007rha.2. mouse. [Q3TNH5-3 ]

    Organism-specific databases

    CTDi 83989.
    MGIi MGI:1915925. Fam172a.

    Phylogenomic databases

    eggNOGi NOG263064.
    GeneTreei ENSGT00530000063907.
    HOGENOMi HOG000046503.
    HOVERGENi HBG107877.
    InParanoidi Q3TNH5.
    OMAi EEHVLYV.
    OrthoDBi EOG71K64J.
    PhylomeDBi Q3TNH5.
    TreeFami TF315960.

    Miscellaneous databases

    NextBioi 327674.
    PROi Q3TNH5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3TNH5.
    CleanExi MM_1110033M05RIK.
    Genevestigatori Q3TNH5.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR019154. Arb2_domain.
    [Graphical view ]
    Pfami PF09757. Arb2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 2 hits.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Strain: C57BL/6J.
      Tissue: Mammary gland and Spleen.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiF172A_MOUSE
    AccessioniPrimary (citable) accession number: Q3TNH5
    Secondary accession number(s): Q3TLW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 71 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3