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Protein

Protein FAM172A

Gene

Fam172a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM172A
Gene namesi
Name:Fam172a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1915925 Fam172a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000032093219 – 417Protein FAM172AAdd BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ3TNH5
MaxQBiQ3TNH5
PaxDbiQ3TNH5
PeptideAtlasiQ3TNH5
PRIDEiQ3TNH5

PTM databases

iPTMnetiQ3TNH5
PhosphoSitePlusiQ3TNH5

Expressioni

Gene expression databases

BgeeiENSMUSG00000064138
CleanExiMM_1110033M05RIK
ExpressionAtlasiQ3TNH5 baseline and differential
GenevisibleiQ3TNH5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000133140

Structurei

3D structure databases

ProteinModelPortaliQ3TNH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi414 – 417Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the UPF0528 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3967 Eukaryota
ENOG410ZNS0 LUCA
GeneTreeiENSGT00530000063907
HOGENOMiHOG000046503
HOVERGENiHBG107877
InParanoidiQ3TNH5
OMAiDSAHNIW
OrthoDBiEOG091G08MK
PhylomeDBiQ3TNH5
TreeFamiTF315960

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
SUPFAMiSSF53474 SSF53474, 2 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TNH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSISLSSLIF LPIWINMAQM QQGGSNETEQ TAALKDLLSR IDLDELMKKD
60 70 80 90 100
EPPFDFPDTL EGFEYAFNEK GQLRHIKTGE PFVFNYREDL HRWNQKRYEA
110 120 130 140 150
LGEIITRYVY ELLESDCNLK KISIPVDATE SEPKSFIFMS EDALTNPQKL
160 170 180 190 200
MVLIHGSGVV RAGQWARRLI INEDLDSGTQ IPFIKRAMDE GYGVIVLNPN
210 220 230 240 250
ENYIEVEKQK MHKQSSSSDG TDEPAGKRER RDKVSKETKK RRDFYEKYRN
260 270 280 290 300
PQKEKEMMQL FIRENGSPEE HAVYVWDHFI AQAAAENVFF VAHSYGGLAF
310 320 330 340 350
VELMIQREAD VKSKVTAVAL TDSVHNVWHQ EAGKTIREWM RENCCNWVSS
360 370 380 390 400
SEPLDTSVES MLPDCPRVSA GTDRHELTSW KSFPSIFKFF AEASEAKSSS
410
QKPALTRRSH RIKHEEL
Length:417
Mass (Da):48,072
Last modified:February 26, 2008 - v2
Checksum:i8FBE7D0873DA8109
GO
Isoform 2 (identifier: Q3TNH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Note: No experimental confirmation available.
Show »
Length:279
Mass (Da):31,975
Checksum:i0AB4FE1707A3D22B
GO
Isoform 3 (identifier: Q3TNH5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
     126-189: Missing.

Note: No experimental confirmation available.
Show »
Length:307
Mass (Da):35,840
Checksum:i605B0CD185BBD4B9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0317501 – 138Missing in isoform 2. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_0317511 – 46Missing in isoform 3. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_031752126 – 189Missing in isoform 3. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK165273 mRNA Translation: BAE38114.1
AK166285 mRNA Translation: BAE38682.1
AC167171 Genomic DNA No translation available.
AC154584 Genomic DNA No translation available.
AC154548 Genomic DNA No translation available.
CT025642 Genomic DNA No translation available.
CCDSiCCDS49317.1 [Q3TNH5-1]
CCDS49319.1 [Q3TNH5-3]
RefSeqiNP_001156892.1, NM_001163420.1 [Q3TNH5-3]
NP_612185.1, NM_138312.1 [Q3TNH5-1]
UniGeneiMm.343005

Genome annotation databases

EnsembliENSMUST00000099358; ENSMUSP00000096960; ENSMUSG00000064138 [Q3TNH5-3]
ENSMUST00000163257; ENSMUSP00000133140; ENSMUSG00000064138 [Q3TNH5-1]
GeneIDi68675
KEGGimmu:68675
UCSCiuc007rgy.2 mouse [Q3TNH5-1]
uc007rha.2 mouse [Q3TNH5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiF172A_MOUSE
AccessioniPrimary (citable) accession number: Q3TNH5
Secondary accession number(s): Q3TLW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: March 28, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

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