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UniProtKB - Q3TNB8 (Q3TNB8_MOUSE)

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Protein
Submitted name:

FYVE, RhoGEF and PH domain containing 3, isoform CRA_b

Gene

Fgd3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri528 – 584FYVE-typePROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-193648. NRAGE signals death through JNK.
R-MMU-194840. Rho GTPase cycle.
R-MMU-416482. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
FYVE, RhoGEF and PH domain containing 3, isoform CRA_bImported
Submitted name:
FYVE, RhoGEF and PH domain-containing protein 3Imported
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Fgd3Imported
ORF Names:mCG_15640Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1353657. Fgd3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037946.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 337DH (DBL-homology)InterPro annotationAdd BLAST185
Domaini366 – 465PHInterPro annotationAdd BLAST100
Domaini528 – 584FYVE-typeInterPro annotationAdd BLAST57
Domaini612 – 711PHInterPro annotationAdd BLAST100

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri528 – 584FYVE-typePROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4424. Eukaryota.
ENOG410XRXV. LUCA.
GeneTreeiENSGT00750000117280.
HOVERGENiHBG007506.
KOiK05722.
OMAiRQSRVCR.
OrthoDBiEOG091G03FU.
TreeFamiTF316247.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01363. FYVE. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
SMARTiView protein in SMART
SM00064. FYVE. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 1 hit.
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF57903. SSF57903. 2 hits.
PROSITEiView protein in PROSITE
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS50178. ZF_FYVE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3TNB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGRSPSTP QEEAISPLGV LGTGPSSSPL GKLQALPIGP GAHRGAHSSS 
        60         70         80         90        100
APAGDSSTRE PSGAMKIPNR DSGIDSPSSS VASENFPCEE SSEGSPSPAI 
       110        120        130        140        150
LGLPSETASD SRVPQDNPQE EEDSGMGEEP DPKVTLFRPQ EDVSLTQCSD 
       160        170        180        190        200
PQKLLHIAQE LLHTEEAYVK RLHLLDQVFC TKLTEAGIPL EVTTGIFSNI 
       210        220        230        240        250
SSIYRFHGQF LLPELQKRIT EEWDTNPRLG DILQKLAPFL KMYGEYVKNF 
       260        270        280        290        300
DRAMGLVSTW TQRSPQFKDV IHTIQKQEVC GNLTLQHHML EPVQRVPRYE 
       310        320        330        340        350
LLLKDYLKRL PRDAPDRKDA ERSLELISTA ADHSNAAIRK MEKMHKLLEV 
       360        370        380        390        400
YEQLGGEEDI VNPANELIKE GSIQKLSAKN GTTQDRHLFL FNNVMLYCVP 
       410        420        430        440        450
KLRLMGQKLS VREKMDISDL QVQDIVKPNA ACTFIITGRK RSLELQTRTE 
       460        470        480        490        500
EEKKEWIQVI QATVEKHKQK SETFRAFGGA CSQDEEPTLS PDQPVMSTSS 
       510        520        530        540        550
VEPAGVADSN GGTPGIESRK SSSKTRRDKE KPGCKSCGET FNSITKRRYR 
       560        570        580        590        600
CKLCGEVICR KCSEFKAENS KQSRVCRECF LEEPLVPPSP SSETPTELKQ 
       610        620        630        640        650
NAEKPPSVDP RPSLLCGTLN LSDDGTTWNE VWAAIPESDP QVLDLLAGSQ 
       660        670        680        690        700
AGRLLYSIPL SGCNITMPDP EEGLEAGCAW KLHQGSQTWW LSAPSTKLQQ 
       710        720        730 
CWLKALGTAV HGDTAGDRPG ASQPQAPAGT DTP
Length:733
Mass (Da):80,666
Last modified:October 11, 2005 - v1
Checksum:i8B2FBCFCAB475FBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132245 Genomic DNA. No translation available.
AC140284 Genomic DNA. No translation available.
AK157835 mRNA. Translation: BAE34218.1.
AK165413 mRNA. Translation: BAE38171.1.
CH466546 Genomic DNA. Translation: EDL41073.1.
RefSeqiNP_056574.2. NM_015759.2.
XP_006516992.1. XM_006516929.3.
XP_006516993.1. XM_006516930.3.
XP_006516994.1. XM_006516931.3.
UniGeneiMm.291089.

Genome annotation databases

EnsembliENSMUST00000048716; ENSMUSP00000048692; ENSMUSG00000037946.
ENSMUST00000110087; ENSMUSP00000105714; ENSMUSG00000037946.
GeneIDi30938.
KEGGimmu:30938.
UCSCiuc007qjc.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ3TNB8_MOUSE
AccessioniPrimary (citable) accession number: Q3TNB8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 5, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported