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Q3TNA1

- XYLB_MOUSE

UniProt

Q3TNA1 - XYLB_MOUSE

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Protein
Xylulose kinase
Gene
Xylb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis By similarity.

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei114 – 1141Substrate By similarity
Binding sitei185 – 1851Substrate By similarity
Binding sitei295 – 2951Substrate By similarity
Binding sitei296 – 2961Substrate By similarity
Binding sitei370 – 3701ATP By similarity
Binding sitei460 – 4601ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi456 – 4572ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. xylulokinase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-KW
  2. carbohydrate phosphorylation Source: GOC
  3. xylulose metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Xylose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylulose kinase (EC:2.7.1.17)
Short name:
Xylulokinase
Gene namesi
Name:Xylb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2142985. Xylb.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Xylulose kinase
PRO_0000230986Add
BLAST

Proteomic databases

MaxQBiQ3TNA1.
PaxDbiQ3TNA1.
PRIDEiQ3TNA1.

PTM databases

PhosphoSiteiQ3TNA1.

Expressioni

Gene expression databases

ArrayExpressiQ3TNA1.
BgeeiQ3TNA1.
CleanExiMM_XYLB.
GenevestigatoriQ3TNA1.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

IntActiQ3TNA1. 1 interaction.
MINTiMINT-4118544.

Structurei

3D structure databases

ProteinModelPortaliQ3TNA1.
SMRiQ3TNA1. Positions 22-544.

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.

Phylogenomic databases

eggNOGiCOG1070.
GeneTreeiENSGT00390000010821.
HOGENOMiHOG000174850.
HOVERGENiHBG053124.
InParanoidiB2RR66.
KOiK00854.
OMAiGSYSPID.
OrthoDBiEOG751NFS.
PhylomeDBiQ3TNA1.
TreeFamiTF313643.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TNA1-1 [UniParc]FASTAAdd to Basket

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MDARTHRRAA GTPRALAERA GRRCCLGWDF STQQVKVVAV DAELNVFYED    50
SVHFDRDLPE FGTQGGVHVH KDRLTVTSPV LMWVQALDLI LGKMKSSGFD 100
FSQVLALSGA GQQHGSVYWK TGASLALSSL SPALPLHQQL QSCFSISDCP 150
IWMDSSTTAQ CHQLEAAVGG AQALSCLTGS RAYERFTGNQ IAKLFQKNPE 200
AYSHSERISL VSSFAASLFL GGYSPIDYSD GSGMNLLQIQ EKVWSQACLD 250
VCAPHLEEKL GSPVPSCSVV GTISSYYVQR YGFPPGCKVV AFSGDNPASL 300
AGMRLEEGDI AVSLGTSDTL FLWLQKPMPA LEGHIFCNPV DPQHYMALLC 350
FKNGSLMREK IRDESASCSW NKFSKALKST AMGNNGNLGF YFDVMEITPE 400
IIGRHRFNAE NMEVSAFPGD VEIRALIEGQ FMAKRIHAEG LGYRVMPKTK 450
ILATGGASHN KDILQVLADV FGAPVYVIDT TSSACVGSAY RAFHGLAGGT 500
GVAFSEVVKS APQPSLAATP NPGASQVYAA LLPRYSALEQ RILSTAQRPL 550
E 551
Length:551
Mass (Da):59,544
Last modified:October 11, 2005 - v1
Checksum:iCED895069FBFD97B
GO

Sequence cautioni

The sequence AAH25442.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK143476 mRNA. Translation: BAE25393.1.
AK165440 mRNA. Translation: BAE38188.1.
AK165518 mRNA. Translation: BAE38233.1.
BC025442 mRNA. Translation: AAH25442.1. Different initiation.
BC138244 mRNA. Translation: AAI38245.1.
BC138247 mRNA. Translation: AAI38248.1.
CCDSiCCDS23614.1.
RefSeqiNP_001028381.1. NM_001033209.3.
NP_001186497.1. NM_001199568.1.
UniGeneiMm.219497.

Genome annotation databases

EnsembliENSMUST00000039610; ENSMUSP00000047254; ENSMUSG00000035769.
GeneIDi102448.
KEGGimmu:102448.
UCSCiuc009sat.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK143476 mRNA. Translation: BAE25393.1 .
AK165440 mRNA. Translation: BAE38188.1 .
AK165518 mRNA. Translation: BAE38233.1 .
BC025442 mRNA. Translation: AAH25442.1 . Different initiation.
BC138244 mRNA. Translation: AAI38245.1 .
BC138247 mRNA. Translation: AAI38248.1 .
CCDSi CCDS23614.1.
RefSeqi NP_001028381.1. NM_001033209.3.
NP_001186497.1. NM_001199568.1.
UniGenei Mm.219497.

3D structure databases

ProteinModelPortali Q3TNA1.
SMRi Q3TNA1. Positions 22-544.
ModBasei Search...

Protein-protein interaction databases

IntActi Q3TNA1. 1 interaction.
MINTi MINT-4118544.

PTM databases

PhosphoSitei Q3TNA1.

Proteomic databases

MaxQBi Q3TNA1.
PaxDbi Q3TNA1.
PRIDEi Q3TNA1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039610 ; ENSMUSP00000047254 ; ENSMUSG00000035769 .
GeneIDi 102448.
KEGGi mmu:102448.
UCSCi uc009sat.2. mouse.

Organism-specific databases

CTDi 9942.
MGIi MGI:2142985. Xylb.

Phylogenomic databases

eggNOGi COG1070.
GeneTreei ENSGT00390000010821.
HOGENOMi HOG000174850.
HOVERGENi HBG053124.
InParanoidi B2RR66.
KOi K00854.
OMAi GSYSPID.
OrthoDBi EOG751NFS.
PhylomeDBi Q3TNA1.
TreeFami TF313643.

Miscellaneous databases

NextBioi 355490.
PROi Q3TNA1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3TNA1.
Bgeei Q3TNA1.
CleanExi MM_XYLB.
Genevestigatori Q3TNA1.

Family and domain databases

InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Brain and Kidney.

Entry informationi

Entry nameiXYLB_MOUSE
AccessioniPrimary (citable) accession number: Q3TNA1
Secondary accession number(s): B2RR66, Q8R156
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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