Reviewed, UniProtKB/Swiss-Prot Q3TNA1 (XYLB_MOUSE)

Names and origin

Protein names

Recommended name:
    Xylulose kinase
      Short name=Xylulokinase
    EC=2.7.1.17

Gene names

Name:

Xylb

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	551 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + D-xylulose = ADP + D-xylulose 5-phosphate.
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Xylose metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW xylulokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 551	551	Xylulose kinase		PRO_0000230986

Sequences

	Sequence		Length	Mass (Da)
	Q3TNA1-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: CED895069FBFD97B	FASTA	551	59,544
	10 20 30 40 50 60 MDARTHRRAA GTPRALAERA GRRCCLGWDF STQQVKVVAV DAELNVFYED SVHFDRDLPE 70 80 90 100 110 120 FGTQGGVHVH KDRLTVTSPV LMWVQALDLI LGKMKSSGFD FSQVLALSGA GQQHGSVYWK 130 140 150 160 170 180 TGASLALSSL SPALPLHQQL QSCFSISDCP IWMDSSTTAQ CHQLEAAVGG AQALSCLTGS 190 200 210 220 230 240 RAYERFTGNQ IAKLFQKNPE AYSHSERISL VSSFAASLFL GGYSPIDYSD GSGMNLLQIQ 250 260 270 280 290 300 EKVWSQACLD VCAPHLEEKL GSPVPSCSVV GTISSYYVQR YGFPPGCKVV AFSGDNPASL 310 320 330 340 350 360 AGMRLEEGDI AVSLGTSDTL FLWLQKPMPA LEGHIFCNPV DPQHYMALLC FKNGSLMREK 370 380 390 400 410 420 IRDESASCSW NKFSKALKST AMGNNGNLGF YFDVMEITPE IIGRHRFNAE NMEVSAFPGD 430 440 450 460 470 480 VEIRALIEGQ FMAKRIHAEG LGYRVMPKTK ILATGGASHN KDILQVLADV FGAPVYVIDT 490 500 510 520 530 540 TSSACVGSAY RAFHGLAGGT GVAFSEVVKS APQPSLAATP NPGASQVYAA LLPRYSALEQ 550 RILSTAQRPL E

References

[1]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Kidney.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 13-551. Strain: FVB/N. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK143476 mRNA. Translation: BAE25393.1. AK165440 mRNA. Translation: BAE38188.1. AK165518 mRNA. Translation: BAE38233.1. BC025442 mRNA. Translation: AAH25442.1. Different initiation.
IPI	IPI00153294.
RefSeq	NP_001028381.1.
UniGene	Mm.219497
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000035769. Mus musculus. [Contig view]
GeneID	102448.
KEGG	mmu:102448.
Organism-specific databases
MGI	MGI:2142985. Xylb.
Phylogenomic databases
HOGENOM	Q3TNA1.
HOVERGEN	Q3TNA1.
OMA	Q3TNA1. FSTQQLK.
Enzyme and pathway databases
BRENDA	2.7.1.17. 244.
Gene expression databases
ArrayExpress	Q3TNA1.
Bgee	Q3TNA1.
CleanEx	MM_XYLB.
GermOnline	ENSMUSG00000035769. Mus musculus.
Family and domain databases
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018484. Carb_kinase_FGGY_N. [Graphical view]
PANTHER	PTHR10196. FGGY_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	355490.
SOURCE	Search...

Entry information

Entry name

XYLB_MOUSE

Accession

Primary (citable) accession number: Q3TNA1
Secondary accession number(s): Q8R156

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 11, 2005
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)