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Q3TNA1

- XYLB_MOUSE

UniProt

Q3TNA1 - XYLB_MOUSE

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Protein

Xylulose kinase

Gene

Xylb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.By similarity

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei114 – 1141SubstrateBy similarity
Binding sitei185 – 1851SubstrateBy similarity
Binding sitei295 – 2951SubstrateBy similarity
Binding sitei296 – 2961SubstrateBy similarity
Binding sitei370 – 3701ATPBy similarity
Binding sitei460 – 4601ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi456 – 4572ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. xylulokinase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. D-xylose metabolic process Source: UniProtKB-KW
  3. xylulose metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Xylose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylulose kinase (EC:2.7.1.17)
Short name:
Xylulokinase
Gene namesi
Name:Xylb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2142985. Xylb.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Xylulose kinasePRO_0000230986Add
BLAST

Proteomic databases

MaxQBiQ3TNA1.
PaxDbiQ3TNA1.
PRIDEiQ3TNA1.

PTM databases

PhosphoSiteiQ3TNA1.

Expressioni

Gene expression databases

BgeeiQ3TNA1.
CleanExiMM_XYLB.
ExpressionAtlasiQ3TNA1. baseline and differential.
GenevestigatoriQ3TNA1.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiQ3TNA1. 1 interaction.
MINTiMINT-4118544.

Structurei

3D structure databases

ProteinModelPortaliQ3TNA1.
SMRiQ3TNA1. Positions 22-544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiCOG1070.
GeneTreeiENSGT00390000010821.
HOGENOMiHOG000174850.
HOVERGENiHBG053124.
InParanoidiQ3TNA1.
KOiK00854.
OMAiGSYSPID.
OrthoDBiEOG751NFS.
PhylomeDBiQ3TNA1.
TreeFamiTF313643.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TNA1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDARTHRRAA GTPRALAERA GRRCCLGWDF STQQVKVVAV DAELNVFYED
60 70 80 90 100
SVHFDRDLPE FGTQGGVHVH KDRLTVTSPV LMWVQALDLI LGKMKSSGFD
110 120 130 140 150
FSQVLALSGA GQQHGSVYWK TGASLALSSL SPALPLHQQL QSCFSISDCP
160 170 180 190 200
IWMDSSTTAQ CHQLEAAVGG AQALSCLTGS RAYERFTGNQ IAKLFQKNPE
210 220 230 240 250
AYSHSERISL VSSFAASLFL GGYSPIDYSD GSGMNLLQIQ EKVWSQACLD
260 270 280 290 300
VCAPHLEEKL GSPVPSCSVV GTISSYYVQR YGFPPGCKVV AFSGDNPASL
310 320 330 340 350
AGMRLEEGDI AVSLGTSDTL FLWLQKPMPA LEGHIFCNPV DPQHYMALLC
360 370 380 390 400
FKNGSLMREK IRDESASCSW NKFSKALKST AMGNNGNLGF YFDVMEITPE
410 420 430 440 450
IIGRHRFNAE NMEVSAFPGD VEIRALIEGQ FMAKRIHAEG LGYRVMPKTK
460 470 480 490 500
ILATGGASHN KDILQVLADV FGAPVYVIDT TSSACVGSAY RAFHGLAGGT
510 520 530 540 550
GVAFSEVVKS APQPSLAATP NPGASQVYAA LLPRYSALEQ RILSTAQRPL

E
Length:551
Mass (Da):59,544
Last modified:October 11, 2005 - v1
Checksum:iCED895069FBFD97B
GO

Sequence cautioni

The sequence AAH25442.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK143476 mRNA. Translation: BAE25393.1.
AK165440 mRNA. Translation: BAE38188.1.
AK165518 mRNA. Translation: BAE38233.1.
BC025442 mRNA. Translation: AAH25442.1. Different initiation.
BC138244 mRNA. Translation: AAI38245.1.
BC138247 mRNA. Translation: AAI38248.1.
CCDSiCCDS23614.1.
RefSeqiNP_001028381.1. NM_001033209.3.
NP_001186497.1. NM_001199568.1.
UniGeneiMm.219497.

Genome annotation databases

EnsembliENSMUST00000039610; ENSMUSP00000047254; ENSMUSG00000035769.
GeneIDi102448.
KEGGimmu:102448.
UCSCiuc009sat.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK143476 mRNA. Translation: BAE25393.1 .
AK165440 mRNA. Translation: BAE38188.1 .
AK165518 mRNA. Translation: BAE38233.1 .
BC025442 mRNA. Translation: AAH25442.1 . Different initiation.
BC138244 mRNA. Translation: AAI38245.1 .
BC138247 mRNA. Translation: AAI38248.1 .
CCDSi CCDS23614.1.
RefSeqi NP_001028381.1. NM_001033209.3.
NP_001186497.1. NM_001199568.1.
UniGenei Mm.219497.

3D structure databases

ProteinModelPortali Q3TNA1.
SMRi Q3TNA1. Positions 22-544.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q3TNA1. 1 interaction.
MINTi MINT-4118544.

PTM databases

PhosphoSitei Q3TNA1.

Proteomic databases

MaxQBi Q3TNA1.
PaxDbi Q3TNA1.
PRIDEi Q3TNA1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039610 ; ENSMUSP00000047254 ; ENSMUSG00000035769 .
GeneIDi 102448.
KEGGi mmu:102448.
UCSCi uc009sat.2. mouse.

Organism-specific databases

CTDi 9942.
MGIi MGI:2142985. Xylb.

Phylogenomic databases

eggNOGi COG1070.
GeneTreei ENSGT00390000010821.
HOGENOMi HOG000174850.
HOVERGENi HBG053124.
InParanoidi Q3TNA1.
KOi K00854.
OMAi GSYSPID.
OrthoDBi EOG751NFS.
PhylomeDBi Q3TNA1.
TreeFami TF313643.

Miscellaneous databases

NextBioi 355490.
PROi Q3TNA1.
SOURCEi Search...

Gene expression databases

Bgeei Q3TNA1.
CleanExi MM_XYLB.
ExpressionAtlasi Q3TNA1. baseline and differential.
Genevestigatori Q3TNA1.

Family and domain databases

InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Brain and Kidney.

Entry informationi

Entry nameiXYLB_MOUSE
AccessioniPrimary (citable) accession number: Q3TNA1
Secondary accession number(s): B2RR66, Q8R156
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3