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Q3TNA1 (XYLB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Xylulose kinase

Short name=Xylulokinase
EC=2.7.1.17
Gene names
Name:Xylb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis By similarity.

Catalytic activity

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the FGGY kinase family.

Sequence caution

The sequence AAH25442.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551Xylulose kinase
PRO_0000230986

Regions

Nucleotide binding456 – 4572ATP By similarity

Sites

Binding site1141Substrate By similarity
Binding site1851Substrate By similarity
Binding site2951Substrate By similarity
Binding site2961Substrate By similarity
Binding site3701ATP By similarity
Binding site4601ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3TNA1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: CED895069FBFD97B

FASTA55159,544
        10         20         30         40         50         60 
MDARTHRRAA GTPRALAERA GRRCCLGWDF STQQVKVVAV DAELNVFYED SVHFDRDLPE 

        70         80         90        100        110        120 
FGTQGGVHVH KDRLTVTSPV LMWVQALDLI LGKMKSSGFD FSQVLALSGA GQQHGSVYWK 

       130        140        150        160        170        180 
TGASLALSSL SPALPLHQQL QSCFSISDCP IWMDSSTTAQ CHQLEAAVGG AQALSCLTGS 

       190        200        210        220        230        240 
RAYERFTGNQ IAKLFQKNPE AYSHSERISL VSSFAASLFL GGYSPIDYSD GSGMNLLQIQ 

       250        260        270        280        290        300 
EKVWSQACLD VCAPHLEEKL GSPVPSCSVV GTISSYYVQR YGFPPGCKVV AFSGDNPASL 

       310        320        330        340        350        360 
AGMRLEEGDI AVSLGTSDTL FLWLQKPMPA LEGHIFCNPV DPQHYMALLC FKNGSLMREK 

       370        380        390        400        410        420 
IRDESASCSW NKFSKALKST AMGNNGNLGF YFDVMEITPE IIGRHRFNAE NMEVSAFPGD 

       430        440        450        460        470        480 
VEIRALIEGQ FMAKRIHAEG LGYRVMPKTK ILATGGASHN KDILQVLADV FGAPVYVIDT 

       490        500        510        520        530        540 
TSSACVGSAY RAFHGLAGGT GVAFSEVVKS APQPSLAATP NPGASQVYAA LLPRYSALEQ 

       550 
RILSTAQRPL E 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Kidney.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Brain and Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK143476 mRNA. Translation: BAE25393.1.
AK165440 mRNA. Translation: BAE38188.1.
AK165518 mRNA. Translation: BAE38233.1.
BC025442 mRNA. Translation: AAH25442.1. Different initiation.
BC138244 mRNA. Translation: AAI38245.1.
BC138247 mRNA. Translation: AAI38248.1.
CCDSCCDS23614.1.
RefSeqNP_001028381.1. NM_001033209.3.
NP_001186497.1. NM_001199568.1.
UniGeneMm.219497.

3D structure databases

ProteinModelPortalQ3TNA1.
SMRQ3TNA1. Positions 22-544.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ3TNA1. 1 interaction.
MINTMINT-4118544.

PTM databases

PhosphoSiteQ3TNA1.

Proteomic databases

MaxQBQ3TNA1.
PaxDbQ3TNA1.
PRIDEQ3TNA1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000039610; ENSMUSP00000047254; ENSMUSG00000035769.
GeneID102448.
KEGGmmu:102448.
UCSCuc009sat.2. mouse.

Organism-specific databases

CTD9942.
MGIMGI:2142985. Xylb.

Phylogenomic databases

eggNOGCOG1070.
GeneTreeENSGT00390000010821.
HOGENOMHOG000174850.
HOVERGENHBG053124.
InParanoidB2RR66.
KOK00854.
OMAGSYSPID.
OrthoDBEOG751NFS.
PhylomeDBQ3TNA1.
TreeFamTF313643.

Gene expression databases

ArrayExpressQ3TNA1.
BgeeQ3TNA1.
CleanExMM_XYLB.
GenevestigatorQ3TNA1.

Family and domain databases

InterProIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio355490.
PROQ3TNA1.
SOURCESearch...

Entry information

Entry nameXYLB_MOUSE
AccessionPrimary (citable) accession number: Q3TNA1
Secondary accession number(s): B2RR66, Q8R156
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot