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Q3TNA1

- XYLB_MOUSE

UniProt

Q3TNA1 - XYLB_MOUSE

Protein

Xylulose kinase

Gene

Xylb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.By similarity

    Catalytic activityi

    ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei114 – 1141SubstrateBy similarity
    Binding sitei185 – 1851SubstrateBy similarity
    Binding sitei295 – 2951SubstrateBy similarity
    Binding sitei296 – 2961SubstrateBy similarity
    Binding sitei370 – 3701ATPBy similarity
    Binding sitei460 – 4601ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi456 – 4572ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. xylulokinase activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate phosphorylation Source: GOC
    2. D-xylose metabolic process Source: UniProtKB-KW
    3. xylulose metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Xylose metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylulose kinase (EC:2.7.1.17)
    Short name:
    Xylulokinase
    Gene namesi
    Name:Xylb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2142985. Xylb.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Xylulose kinasePRO_0000230986Add
    BLAST

    Proteomic databases

    MaxQBiQ3TNA1.
    PaxDbiQ3TNA1.
    PRIDEiQ3TNA1.

    PTM databases

    PhosphoSiteiQ3TNA1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3TNA1.
    BgeeiQ3TNA1.
    CleanExiMM_XYLB.
    GenevestigatoriQ3TNA1.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    IntActiQ3TNA1. 1 interaction.
    MINTiMINT-4118544.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3TNA1.
    SMRiQ3TNA1. Positions 22-544.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FGGY kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG1070.
    GeneTreeiENSGT00390000010821.
    HOGENOMiHOG000174850.
    HOVERGENiHBG053124.
    InParanoidiB2RR66.
    KOiK00854.
    OMAiGSYSPID.
    OrthoDBiEOG751NFS.
    PhylomeDBiQ3TNA1.
    TreeFamiTF313643.

    Family and domain databases

    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018484. Carb_kinase_FGGY_N.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3TNA1-1 [UniParc]FASTAAdd to Basket

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    MDARTHRRAA GTPRALAERA GRRCCLGWDF STQQVKVVAV DAELNVFYED    50
    SVHFDRDLPE FGTQGGVHVH KDRLTVTSPV LMWVQALDLI LGKMKSSGFD 100
    FSQVLALSGA GQQHGSVYWK TGASLALSSL SPALPLHQQL QSCFSISDCP 150
    IWMDSSTTAQ CHQLEAAVGG AQALSCLTGS RAYERFTGNQ IAKLFQKNPE 200
    AYSHSERISL VSSFAASLFL GGYSPIDYSD GSGMNLLQIQ EKVWSQACLD 250
    VCAPHLEEKL GSPVPSCSVV GTISSYYVQR YGFPPGCKVV AFSGDNPASL 300
    AGMRLEEGDI AVSLGTSDTL FLWLQKPMPA LEGHIFCNPV DPQHYMALLC 350
    FKNGSLMREK IRDESASCSW NKFSKALKST AMGNNGNLGF YFDVMEITPE 400
    IIGRHRFNAE NMEVSAFPGD VEIRALIEGQ FMAKRIHAEG LGYRVMPKTK 450
    ILATGGASHN KDILQVLADV FGAPVYVIDT TSSACVGSAY RAFHGLAGGT 500
    GVAFSEVVKS APQPSLAATP NPGASQVYAA LLPRYSALEQ RILSTAQRPL 550
    E 551
    Length:551
    Mass (Da):59,544
    Last modified:October 11, 2005 - v1
    Checksum:iCED895069FBFD97B
    GO

    Sequence cautioni

    The sequence AAH25442.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK143476 mRNA. Translation: BAE25393.1.
    AK165440 mRNA. Translation: BAE38188.1.
    AK165518 mRNA. Translation: BAE38233.1.
    BC025442 mRNA. Translation: AAH25442.1. Different initiation.
    BC138244 mRNA. Translation: AAI38245.1.
    BC138247 mRNA. Translation: AAI38248.1.
    CCDSiCCDS23614.1.
    RefSeqiNP_001028381.1. NM_001033209.3.
    NP_001186497.1. NM_001199568.1.
    UniGeneiMm.219497.

    Genome annotation databases

    EnsembliENSMUST00000039610; ENSMUSP00000047254; ENSMUSG00000035769.
    GeneIDi102448.
    KEGGimmu:102448.
    UCSCiuc009sat.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK143476 mRNA. Translation: BAE25393.1 .
    AK165440 mRNA. Translation: BAE38188.1 .
    AK165518 mRNA. Translation: BAE38233.1 .
    BC025442 mRNA. Translation: AAH25442.1 . Different initiation.
    BC138244 mRNA. Translation: AAI38245.1 .
    BC138247 mRNA. Translation: AAI38248.1 .
    CCDSi CCDS23614.1.
    RefSeqi NP_001028381.1. NM_001033209.3.
    NP_001186497.1. NM_001199568.1.
    UniGenei Mm.219497.

    3D structure databases

    ProteinModelPortali Q3TNA1.
    SMRi Q3TNA1. Positions 22-544.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q3TNA1. 1 interaction.
    MINTi MINT-4118544.

    PTM databases

    PhosphoSitei Q3TNA1.

    Proteomic databases

    MaxQBi Q3TNA1.
    PaxDbi Q3TNA1.
    PRIDEi Q3TNA1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000039610 ; ENSMUSP00000047254 ; ENSMUSG00000035769 .
    GeneIDi 102448.
    KEGGi mmu:102448.
    UCSCi uc009sat.2. mouse.

    Organism-specific databases

    CTDi 9942.
    MGIi MGI:2142985. Xylb.

    Phylogenomic databases

    eggNOGi COG1070.
    GeneTreei ENSGT00390000010821.
    HOGENOMi HOG000174850.
    HOVERGENi HBG053124.
    InParanoidi B2RR66.
    KOi K00854.
    OMAi GSYSPID.
    OrthoDBi EOG751NFS.
    PhylomeDBi Q3TNA1.
    TreeFami TF313643.

    Miscellaneous databases

    NextBioi 355490.
    PROi Q3TNA1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3TNA1.
    Bgeei Q3TNA1.
    CleanExi MM_XYLB.
    Genevestigatori Q3TNA1.

    Family and domain databases

    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018484. Carb_kinase_FGGY_N.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Brain and Kidney.

    Entry informationi

    Entry nameiXYLB_MOUSE
    AccessioniPrimary (citable) accession number: Q3TNA1
    Secondary accession number(s): B2RR66, Q8R156
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3