Slc9a1

Functionⁱ

GO - Molecular functionⁱ

sodium:proton antiporter activity Source: InterPro

GO - Biological processⁱ

regulation of pH Source: InterPro

Keywordsⁱ

Biological process	AntiportUniRule annotation, Ion transport, Sodium transportUniRule annotation, Transport
Ligand	Sodium

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sodium/hydrogen exchangerUniRule annotation
Gene namesⁱ	Name:Slc9a1Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:102462. Slc9a1.

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	136 – 153	HelicalSequence analysisAdd BLAST	18
Transmembraneⁱ	159 – 181	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	193 – 220	HelicalSequence analysisAdd BLAST	28
Transmembraneⁱ	232 – 250	HelicalSequence analysisAdd BLAST	19
Transmembraneⁱ	262 – 281	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	296 – 322	HelicalSequence analysisAdd BLAST	27
Transmembraneⁱ	329 – 346	HelicalSequence analysisAdd BLAST	18
Transmembraneⁱ	352 – 371	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	392 – 411	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	417 – 441	HelicalSequence analysisAdd BLAST	25
Transmembraneⁱ	453 – 472	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	484 – 507	HelicalSequence analysisAdd BLAST	24

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	Q3TN68.
PeptideAtlas More...PeptideAtlasⁱ	Q3TN68.
PRIDEⁱ	Q3TN68.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000028854.
Genevisibleⁱ	Q3TN68. MM.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3TN68.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	110 – 507	Na_H_ExchangerInterPro annotationAdd BLAST		398

Sequence similaritiesⁱ

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG1966. Eukaryota. COG0025. LUCA.
HOVERGENⁱ	HBG052615.
KEGG Orthology (KO) More...KOⁱ	K05742.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006153. Cation/H_exchanger. IPR018422. Cation/H_exchanger_CPA1. IPR001970. Na/H_exchanger_1. IPR004709. NaH_exchanger.
PANTHERⁱ	PTHR10110. PTHR10110. 1 hit. PTHR10110:SF143. PTHR10110:SF143. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00999. Na_H_Exchanger. 1 hit.
PRINTSⁱ	PR01084. NAHEXCHNGR. PR01085. NAHEXCHNGR1.
TIGRFAMsⁱ	TIGR00840. b_cpa1. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q3TN68-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMLRWSGVWG FHPPRIFPSL LVVVALVGLL PVLRSHGLQH SPTASTIRGS 
        60         70         80         90        100
EPPRERSIGD VTTAPSEPLH RPDDHNLTNL IIEHGGKPSR KAFPVLDIDY 
       110        120        130        140        150
PHVRTPFEIS LWILLACLMK IGFHVIPTIS SIVPESCLLI VVGLLVGGLI 
       160        170        180        190        200
KGVGETPPFL QSDVFFLFLL PPIILDAGYF LPLRQFTENL GTILIFAVVG 
       210        220        230        240        250
TLWNAFFLGG LLYAVCLVGG EQINNIGLLD TLLFGSIISA VDPVAVLAVF 
       260        270        280        290        300
EEIHINELLH ILVFGESLLN DAVTVVLYHL FEEFASYDSV GISDIFLGFL 
       310        320        330        340        350
SFFVVALGGV FVGVVYGVIA AFTSRFTSHI RVIEPLFVFL YSYMAYLSAE 
       360        370        380        390        400
LFHLSGIMAL IASGVVMRPY VEANISHKSH TTIKYFLKMW SSVSETLIFI 
       410        420        430        440        450
FLGVSTVAGS HQWNWTFVIS TLLFCLIARV LGVLVLTWFI NKFRIVKLTP 
       460        470        480        490        500
KDQFIIAYGG LRGAIAFSLG YLLDKKHFPM CDLFLTAIIT VIFFTVFVQG 
       510        520        530        540 
MTIRPLVDLL AVKKKQETKR SINEEIHTQF LDHLLTGIED ICGHYGHHH

Length:549

Mass (Da):60,990

Last modified:October 11, 2005 - v1

Checksum:ⁱ1E7D33BCA98FD8E1

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	549	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK165501 mRNA. Translation: BAE38221.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_058677.1. NM_016981.2.
UniGeneⁱ	Mm.4312.

Genome annotation databases

GeneIDⁱ	20544.
KEGGⁱ	mmu:20544.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK165501 mRNA. Translation: BAE38221.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_058677.1. NM_016981.2.
UniGeneⁱ	Mm.4312.

3D structure databases

ProteinModelPortalⁱ	Q3TN68.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PaxDbⁱ	Q3TN68.
PeptideAtlas More...PeptideAtlasⁱ	Q3TN68.
PRIDEⁱ	Q3TN68.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	20544.
KEGGⁱ	mmu:20544.

Organism-specific databases

CTDⁱ	6548.
MGIⁱ	MGI:102462. Slc9a1.

Phylogenomic databases

eggNOGⁱ	KOG1966. Eukaryota. COG0025. LUCA.
HOVERGENⁱ	HBG052615.
KEGG Orthology (KO) More...KOⁱ	K05742.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000028854.
Genevisibleⁱ	Q3TN68. MM.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006153. Cation/H_exchanger. IPR018422. Cation/H_exchanger_CPA1. IPR001970. Na/H_exchanger_1. IPR004709. NaH_exchanger.
PANTHERⁱ	PTHR10110. PTHR10110. 1 hit. PTHR10110:SF143. PTHR10110:SF143. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00999. Na_H_Exchanger. 1 hit.
PRINTSⁱ	PR01084. NAHEXCHNGR. PR01085. NAHEXCHNGR1.
TIGRFAMsⁱ	TIGR00840. b_cpa1. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q3TN68_MOUSE
Accessionⁱ	Q3TN68Primary (citable) accession number: Q3TN68
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 11, 2005
	Last sequence update:	October 11, 2005
	Last modified:	July 5, 2017
	This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3TN68 (Q3TN68_MOUSE)

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Sodium/hydrogen exchanger

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ