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Q3TMX7

- QSOX2_MOUSE

UniProt

Q3TMX7 - QSOX2_MOUSE

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Protein

Sulfhydryl oxidase 2

Gene
Qsox2, Qscn6l1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

Binds 1 FAD per subunit Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851Nucleophile By similarity
Active sitei88 – 881Nucleophile By similarity
Binding sitei420 – 4201FAD By similarity
Binding sitei427 – 4271FAD By similarity
Binding sitei431 – 4311FAD By similarity
Binding sitei472 – 4721FAD By similarity
Binding sitei476 – 4761FAD By similarity
Binding sitei521 – 5211FAD By similarity
Binding sitei524 – 5241FAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi499 – 5068FAD By similarity

GO - Molecular functioni

  1. thiol oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidase 2 (EC:1.8.3.2)
Alternative name(s):
Quiescin Q6-like protein 1
Gene namesi
Name:Qsox2
Synonyms:Qscn6l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2387194. Qsox2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei656 – 67621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838 Reviewed predictionAdd
BLAST
Chaini39 – 692654Sulfhydryl oxidase 2PRO_0000249539Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi85 ↔ 88Redox-active By similarity
Glycosylationi172 – 1721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi212 – 2121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi260 – 2601N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi412 ↔ 424 By similarity
Disulfide bondi470 ↔ 473 By similarity
Disulfide bondi530 ↔ 533 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ3TMX7.
PaxDbiQ3TMX7.
PRIDEiQ3TMX7.

PTM databases

PhosphoSiteiQ3TMX7.

Expressioni

Gene expression databases

BgeeiQ3TMX7.
CleanExiMM_QSOX2.
GenevestigatoriQ3TMX7.

Structurei

3D structure databases

ProteinModelPortaliQ3TMX7.
SMRiQ3TMX7. Positions 54-562.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 172119ThioredoxinAdd
BLAST
Domaini415 – 524110ERV/ALR sulfhydryl oxidaseAdd
BLAST

Sequence similaritiesi

Contains 1 thioredoxin domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237986.
GeneTreeiENSGT00390000008045.
HOGENOMiHOG000231631.
HOVERGENiHBG080360.
InParanoidiA2ALE0.
KOiK10758.
OMAiHCIGYAP.
OrthoDBiEOG73RB9X.
PhylomeDBiQ3TMX7.
TreeFamiTF316749.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3TMX7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAARAVARD PGAYARQPPS LRAARLPRLL FLLAVVAAVG PREGGGARLY    50
REGSDAVWLL DSGSVRSATG NSSAAWLVQF HSSWCGHCIG YAPTWRALAA 100
DVRDWAAAIR VAALDCAEEK NQDVCRTYDI HFYPTFRYFK AFTKEFTTGE 150
NFKGPDRELR TVRQTMIDFL QNHTEGTWPP ACPPLDPIQS SDILSFMDSH 200
SGQYHAIVFE SNGSYVGREV ILDLIPYENI MVSRALDTDK AFLGTLGITS 250
VPSCYLIYPN GSHGLVNVAK PLRSFFSSHL KSLPDVRKKS LFLPEKSNKE 300
EKSEVVVWKE FDRAKLYTAD LESGLHYLLR VELAAHRSLA GAQLKTFRDF 350
VTVVAKLFPG RPAVKKLLET LQEWLANLPL DKIPYNAILD LVNNKMQISG 400
IFLTSHVKWV GCQGSRLELR GYPCSLWKLF HTLTVQASTH PEALAGTGFE 450
GHPQAVLQAI RRYIRTFFGC KECGEHFEEM AKESMDSVKT PDQAVLWLWR 500
KHNMVNSRLA GHLSEDPKFP KVPWPTPDLC PACHEEIKGL DSWNEGQVLL 550
FLKQHYSRDN LVDAYSVDQG SPGEWEAQGR EQEEGKGLNP SGKSWRHHDT 600
GSLRPPHILG PRTDLSKSLH HRLDLRLQSP QGPQALKEAK AVVPFLGVGF 650
SSLDMSLCVV LYVASSLFLM IMYFFFRVRS KRWKVRLYHP AV 692
Length:692
Mass (Da):77,775
Last modified:October 11, 2005 - v1
Checksum:i3BDC7058817484A1
GO
Isoform 2 (identifier: Q3TMX7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-666: EWEAQGREQE...LCVVLYVASS → SVLRARPWLG...WSVSLRIGPI
     667-692: Missing.

Note: No experimental confirmation available.

Show »
Length:639
Mass (Da):71,477
Checksum:iB61C2ECE6ABC6477
GO
Isoform 3 (identifier: Q3TMX7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.

Note: No experimental confirmation available.

Show »
Length:527
Mass (Da):59,568
Checksum:i56976D2DF52B8BD2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 165165Missing in isoform 3. VSP_020500Add
BLAST
Alternative sequencei574 – 66693EWEAQ…YVASS → SVLRARPWLGQMARLSHVNL LPHFPVEEVSSLKPGVLCLK TNKPRSSLGVSKDEHSWSVS LRIGPI in isoform 2. VSP_020501Add
BLAST
Alternative sequencei667 – 69226Missing in isoform 2. VSP_020502Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK042036 mRNA. Translation: BAC31140.1. Sequence problems.
AK140324 mRNA. Translation: BAE24335.1.
AK157992 mRNA. Translation: BAE34304.1.
AK165642 mRNA. Translation: BAE38312.1.
AL773595 Genomic DNA. Translation: CAM20023.1.
AL773595 Genomic DNA. Translation: CAM20024.1.
BC030934 mRNA. Translation: AAH30934.1.
CCDSiCCDS15798.1. [Q3TMX7-2]
RefSeqiNP_705787.1. NM_153559.2. [Q3TMX7-2]
XP_006497965.1. XM_006497902.1. [Q3TMX7-1]
UniGeneiMm.116769.

Genome annotation databases

EnsembliENSMUST00000036187; ENSMUSP00000037128; ENSMUSG00000036327. [Q3TMX7-2]
ENSMUST00000091263; ENSMUSP00000088807; ENSMUSG00000036327. [Q3TMX7-3]
GeneIDi227638.
KEGGimmu:227638.
UCSCiuc008iuj.1. mouse. [Q3TMX7-2]
uc008iuk.1. mouse. [Q3TMX7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK042036 mRNA. Translation: BAC31140.1 . Sequence problems.
AK140324 mRNA. Translation: BAE24335.1 .
AK157992 mRNA. Translation: BAE34304.1 .
AK165642 mRNA. Translation: BAE38312.1 .
AL773595 Genomic DNA. Translation: CAM20023.1 .
AL773595 Genomic DNA. Translation: CAM20024.1 .
BC030934 mRNA. Translation: AAH30934.1 .
CCDSi CCDS15798.1. [Q3TMX7-2 ]
RefSeqi NP_705787.1. NM_153559.2. [Q3TMX7-2 ]
XP_006497965.1. XM_006497902.1. [Q3TMX7-1 ]
UniGenei Mm.116769.

3D structure databases

ProteinModelPortali Q3TMX7.
SMRi Q3TMX7. Positions 54-562.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q3TMX7.

Proteomic databases

MaxQBi Q3TMX7.
PaxDbi Q3TMX7.
PRIDEi Q3TMX7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036187 ; ENSMUSP00000037128 ; ENSMUSG00000036327 . [Q3TMX7-2 ]
ENSMUST00000091263 ; ENSMUSP00000088807 ; ENSMUSG00000036327 . [Q3TMX7-3 ]
GeneIDi 227638.
KEGGi mmu:227638.
UCSCi uc008iuj.1. mouse. [Q3TMX7-2 ]
uc008iuk.1. mouse. [Q3TMX7-1 ]

Organism-specific databases

CTDi 169714.
MGIi MGI:2387194. Qsox2.

Phylogenomic databases

eggNOGi NOG237986.
GeneTreei ENSGT00390000008045.
HOGENOMi HOG000231631.
HOVERGENi HBG080360.
InParanoidi A2ALE0.
KOi K10758.
OMAi HCIGYAP.
OrthoDBi EOG73RB9X.
PhylomeDBi Q3TMX7.
TreeFami TF316749.

Miscellaneous databases

ChiTaRSi QSOX2. mouse.
NextBioi 378712.
PROi Q3TMX7.
SOURCEi Search...

Gene expression databases

Bgeei Q3TMX7.
CleanExi MM_QSOX2.
Genevestigatori Q3TMX7.

Family and domain databases

Gene3Di 1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEi PS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Strain: C57BL/6J.
    Tissue: Adipose tissue, Inner ear and Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiQSOX2_MOUSE
AccessioniPrimary (citable) accession number: Q3TMX7
Secondary accession number(s): A2ALE0
, A2ALE1, Q3TZA5, Q8C9I4, Q8K0M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi