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Q3TMX7

- QSOX2_MOUSE

UniProt

Q3TMX7 - QSOX2_MOUSE

Protein

Sulfhydryl oxidase 2

Gene

Qsox2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.By similarity

    Catalytic activityi

    2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

    Cofactori

    Binds 1 FAD per subunit.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei85 – 851NucleophileBy similarity
    Active sitei88 – 881NucleophileBy similarity
    Binding sitei420 – 4201FADBy similarity
    Binding sitei427 – 4271FADBy similarity
    Binding sitei431 – 4311FADBy similarity
    Binding sitei472 – 4721FADBy similarity
    Binding sitei476 – 4761FADBy similarity
    Binding sitei521 – 5211FADBy similarity
    Binding sitei524 – 5241FADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi499 – 5068FADBy similarity

    GO - Molecular functioni

    1. thiol oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfhydryl oxidase 2 (EC:1.8.3.2)
    Alternative name(s):
    Quiescin Q6-like protein 1
    Gene namesi
    Name:Qsox2
    Synonyms:Qscn6l1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2387194. Qsox2.

    Subcellular locationi

    Membrane By similarity; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3838Sequence AnalysisAdd
    BLAST
    Chaini39 – 692654Sulfhydryl oxidase 2PRO_0000249539Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi85 ↔ 88Redox-activePROSITE-ProRule annotation
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi412 ↔ 424PROSITE-ProRule annotation
    Disulfide bondi470 ↔ 473PROSITE-ProRule annotation
    Disulfide bondi530 ↔ 533PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ3TMX7.
    PaxDbiQ3TMX7.
    PRIDEiQ3TMX7.

    PTM databases

    PhosphoSiteiQ3TMX7.

    Expressioni

    Gene expression databases

    BgeeiQ3TMX7.
    CleanExiMM_QSOX2.
    GenevestigatoriQ3TMX7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3TMX7.
    SMRiQ3TMX7. Positions 54-562.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei656 – 67621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 172119ThioredoxinPROSITE-ProRule annotationAdd
    BLAST
    Domaini415 – 524110ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ERV/ALR sulfhydryl oxidase domain.PROSITE-ProRule annotation
    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG237986.
    GeneTreeiENSGT00390000008045.
    HOGENOMiHOG000231631.
    HOVERGENiHBG080360.
    InParanoidiA2ALE0.
    KOiK10758.
    OMAiHCIGYAP.
    OrthoDBiEOG73RB9X.
    PhylomeDBiQ3TMX7.
    TreeFamiTF316749.

    Family and domain databases

    Gene3Di1.20.120.310. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF04777. Evr1_Alr. 1 hit.
    PF00085. Thioredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    SSF69000. SSF69000. 1 hit.
    PROSITEiPS51324. ERV_ALR. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3TMX7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAARAVARD PGAYARQPPS LRAARLPRLL FLLAVVAAVG PREGGGARLY    50
    REGSDAVWLL DSGSVRSATG NSSAAWLVQF HSSWCGHCIG YAPTWRALAA 100
    DVRDWAAAIR VAALDCAEEK NQDVCRTYDI HFYPTFRYFK AFTKEFTTGE 150
    NFKGPDRELR TVRQTMIDFL QNHTEGTWPP ACPPLDPIQS SDILSFMDSH 200
    SGQYHAIVFE SNGSYVGREV ILDLIPYENI MVSRALDTDK AFLGTLGITS 250
    VPSCYLIYPN GSHGLVNVAK PLRSFFSSHL KSLPDVRKKS LFLPEKSNKE 300
    EKSEVVVWKE FDRAKLYTAD LESGLHYLLR VELAAHRSLA GAQLKTFRDF 350
    VTVVAKLFPG RPAVKKLLET LQEWLANLPL DKIPYNAILD LVNNKMQISG 400
    IFLTSHVKWV GCQGSRLELR GYPCSLWKLF HTLTVQASTH PEALAGTGFE 450
    GHPQAVLQAI RRYIRTFFGC KECGEHFEEM AKESMDSVKT PDQAVLWLWR 500
    KHNMVNSRLA GHLSEDPKFP KVPWPTPDLC PACHEEIKGL DSWNEGQVLL 550
    FLKQHYSRDN LVDAYSVDQG SPGEWEAQGR EQEEGKGLNP SGKSWRHHDT 600
    GSLRPPHILG PRTDLSKSLH HRLDLRLQSP QGPQALKEAK AVVPFLGVGF 650
    SSLDMSLCVV LYVASSLFLM IMYFFFRVRS KRWKVRLYHP AV 692
    Length:692
    Mass (Da):77,775
    Last modified:October 11, 2005 - v1
    Checksum:i3BDC7058817484A1
    GO
    Isoform 2 (identifier: Q3TMX7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         574-666: EWEAQGREQE...LCVVLYVASS → SVLRARPWLG...WSVSLRIGPI
         667-692: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:639
    Mass (Da):71,477
    Checksum:iB61C2ECE6ABC6477
    GO
    Isoform 3 (identifier: Q3TMX7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-165: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:527
    Mass (Da):59,568
    Checksum:i56976D2DF52B8BD2
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 165165Missing in isoform 3. 1 PublicationVSP_020500Add
    BLAST
    Alternative sequencei574 – 66693EWEAQ…YVASS → SVLRARPWLGQMARLSHVNL LPHFPVEEVSSLKPGVLCLK TNKPRSSLGVSKDEHSWSVS LRIGPI in isoform 2. 1 PublicationVSP_020501Add
    BLAST
    Alternative sequencei667 – 69226Missing in isoform 2. 1 PublicationVSP_020502Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK042036 mRNA. Translation: BAC31140.1. Sequence problems.
    AK140324 mRNA. Translation: BAE24335.1.
    AK157992 mRNA. Translation: BAE34304.1.
    AK165642 mRNA. Translation: BAE38312.1.
    AL773595 Genomic DNA. Translation: CAM20023.1.
    AL773595 Genomic DNA. Translation: CAM20024.1.
    BC030934 mRNA. Translation: AAH30934.1.
    CCDSiCCDS15798.1. [Q3TMX7-2]
    RefSeqiNP_705787.1. NM_153559.2. [Q3TMX7-2]
    XP_006497965.1. XM_006497902.1. [Q3TMX7-1]
    UniGeneiMm.116769.

    Genome annotation databases

    EnsembliENSMUST00000036187; ENSMUSP00000037128; ENSMUSG00000036327. [Q3TMX7-2]
    ENSMUST00000091263; ENSMUSP00000088807; ENSMUSG00000036327. [Q3TMX7-3]
    GeneIDi227638.
    KEGGimmu:227638.
    UCSCiuc008iuj.1. mouse. [Q3TMX7-2]
    uc008iuk.1. mouse. [Q3TMX7-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK042036 mRNA. Translation: BAC31140.1 . Sequence problems.
    AK140324 mRNA. Translation: BAE24335.1 .
    AK157992 mRNA. Translation: BAE34304.1 .
    AK165642 mRNA. Translation: BAE38312.1 .
    AL773595 Genomic DNA. Translation: CAM20023.1 .
    AL773595 Genomic DNA. Translation: CAM20024.1 .
    BC030934 mRNA. Translation: AAH30934.1 .
    CCDSi CCDS15798.1. [Q3TMX7-2 ]
    RefSeqi NP_705787.1. NM_153559.2. [Q3TMX7-2 ]
    XP_006497965.1. XM_006497902.1. [Q3TMX7-1 ]
    UniGenei Mm.116769.

    3D structure databases

    ProteinModelPortali Q3TMX7.
    SMRi Q3TMX7. Positions 54-562.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q3TMX7.

    Proteomic databases

    MaxQBi Q3TMX7.
    PaxDbi Q3TMX7.
    PRIDEi Q3TMX7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036187 ; ENSMUSP00000037128 ; ENSMUSG00000036327 . [Q3TMX7-2 ]
    ENSMUST00000091263 ; ENSMUSP00000088807 ; ENSMUSG00000036327 . [Q3TMX7-3 ]
    GeneIDi 227638.
    KEGGi mmu:227638.
    UCSCi uc008iuj.1. mouse. [Q3TMX7-2 ]
    uc008iuk.1. mouse. [Q3TMX7-1 ]

    Organism-specific databases

    CTDi 169714.
    MGIi MGI:2387194. Qsox2.

    Phylogenomic databases

    eggNOGi NOG237986.
    GeneTreei ENSGT00390000008045.
    HOGENOMi HOG000231631.
    HOVERGENi HBG080360.
    InParanoidi A2ALE0.
    KOi K10758.
    OMAi HCIGYAP.
    OrthoDBi EOG73RB9X.
    PhylomeDBi Q3TMX7.
    TreeFami TF316749.

    Miscellaneous databases

    ChiTaRSi QSOX2. mouse.
    NextBioi 378712.
    PROi Q3TMX7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3TMX7.
    CleanExi MM_QSOX2.
    Genevestigatori Q3TMX7.

    Family and domain databases

    Gene3Di 1.20.120.310. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF04777. Evr1_Alr. 1 hit.
    PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    SSF69000. SSF69000. 1 hit.
    PROSITEi PS51324. ERV_ALR. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Strain: C57BL/6J.
      Tissue: Adipose tissue, Inner ear and Thymus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiQSOX2_MOUSE
    AccessioniPrimary (citable) accession number: Q3TMX7
    Secondary accession number(s): A2ALE0
    , A2ALE1, Q3TZA5, Q8C9I4, Q8K0M2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3