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Protein

Sulfhydryl oxidase 2

Gene

Qsox2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins (By similarity).By similarity

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

FADCuratedNote: Binds 1 FAD per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85NucleophileBy similarity1
Active sitei88NucleophileBy similarity1
Binding sitei420FADBy similarity1
Binding sitei427FADBy similarity1
Binding sitei431FADBy similarity1
Binding sitei472FADBy similarity1
Binding sitei476FADBy similarity1
Binding sitei521FADBy similarity1
Binding sitei524FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi499 – 506FADBy similarity8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidase 2 (EC:1.8.3.2)
Alternative name(s):
Quiescin Q6-like protein 1
Gene namesi
Name:Qsox2
Synonyms:Qscn6l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2387194. Qsox2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei656 – 676HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000024953939 – 692Sulfhydryl oxidase 2Add BLAST654

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi85 ↔ 88Redox-activePROSITE-ProRule annotation
Glycosylationi172N-linked (GlcNAc...)Sequence analysis1
Glycosylationi212N-linked (GlcNAc...)Sequence analysis1
Glycosylationi260N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi412 ↔ 424PROSITE-ProRule annotation
Disulfide bondi470 ↔ 473PROSITE-ProRule annotation
Disulfide bondi530 ↔ 533PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ3TMX7.
MaxQBiQ3TMX7.
PaxDbiQ3TMX7.
PeptideAtlasiQ3TMX7.
PRIDEiQ3TMX7.

PTM databases

iPTMnetiQ3TMX7.
PhosphoSitePlusiQ3TMX7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036327.
CleanExiMM_QSOX2.
GenevisibleiQ3TMX7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037128.

Structurei

3D structure databases

ProteinModelPortaliQ3TMX7.
SMRiQ3TMX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 172ThioredoxinPROSITE-ProRule annotationAdd BLAST119
Domaini415 – 524ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd BLAST110

Sequence similaritiesi

Contains 1 ERV/ALR sulfhydryl oxidase domain.PROSITE-ProRule annotation
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1731. Eukaryota.
ENOG410XVJT. LUCA.
GeneTreeiENSGT00390000008045.
HOGENOMiHOG000231631.
HOVERGENiHBG080360.
InParanoidiQ3TMX7.
KOiK10758.
OMAiHISRIRY.
OrthoDBiEOG091G038J.
PhylomeDBiQ3TMX7.
TreeFamiTF316749.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TMX7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAARAVARD PGAYARQPPS LRAARLPRLL FLLAVVAAVG PREGGGARLY
60 70 80 90 100
REGSDAVWLL DSGSVRSATG NSSAAWLVQF HSSWCGHCIG YAPTWRALAA
110 120 130 140 150
DVRDWAAAIR VAALDCAEEK NQDVCRTYDI HFYPTFRYFK AFTKEFTTGE
160 170 180 190 200
NFKGPDRELR TVRQTMIDFL QNHTEGTWPP ACPPLDPIQS SDILSFMDSH
210 220 230 240 250
SGQYHAIVFE SNGSYVGREV ILDLIPYENI MVSRALDTDK AFLGTLGITS
260 270 280 290 300
VPSCYLIYPN GSHGLVNVAK PLRSFFSSHL KSLPDVRKKS LFLPEKSNKE
310 320 330 340 350
EKSEVVVWKE FDRAKLYTAD LESGLHYLLR VELAAHRSLA GAQLKTFRDF
360 370 380 390 400
VTVVAKLFPG RPAVKKLLET LQEWLANLPL DKIPYNAILD LVNNKMQISG
410 420 430 440 450
IFLTSHVKWV GCQGSRLELR GYPCSLWKLF HTLTVQASTH PEALAGTGFE
460 470 480 490 500
GHPQAVLQAI RRYIRTFFGC KECGEHFEEM AKESMDSVKT PDQAVLWLWR
510 520 530 540 550
KHNMVNSRLA GHLSEDPKFP KVPWPTPDLC PACHEEIKGL DSWNEGQVLL
560 570 580 590 600
FLKQHYSRDN LVDAYSVDQG SPGEWEAQGR EQEEGKGLNP SGKSWRHHDT
610 620 630 640 650
GSLRPPHILG PRTDLSKSLH HRLDLRLQSP QGPQALKEAK AVVPFLGVGF
660 670 680 690
SSLDMSLCVV LYVASSLFLM IMYFFFRVRS KRWKVRLYHP AV
Length:692
Mass (Da):77,775
Last modified:October 11, 2005 - v1
Checksum:i3BDC7058817484A1
GO
Isoform 2 (identifier: Q3TMX7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-666: EWEAQGREQE...LCVVLYVASS → SVLRARPWLG...WSVSLRIGPI
     667-692: Missing.

Note: No experimental confirmation available.
Show »
Length:639
Mass (Da):71,477
Checksum:iB61C2ECE6ABC6477
GO
Isoform 3 (identifier: Q3TMX7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.

Note: No experimental confirmation available.
Show »
Length:527
Mass (Da):59,568
Checksum:i56976D2DF52B8BD2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0205001 – 165Missing in isoform 3. 1 PublicationAdd BLAST165
Alternative sequenceiVSP_020501574 – 666EWEAQ…YVASS → SVLRARPWLGQMARLSHVNL LPHFPVEEVSSLKPGVLCLK TNKPRSSLGVSKDEHSWSVS LRIGPI in isoform 2. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_020502667 – 692Missing in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042036 mRNA. Translation: BAC31140.1. Sequence problems.
AK140324 mRNA. Translation: BAE24335.1.
AK157992 mRNA. Translation: BAE34304.1.
AK165642 mRNA. Translation: BAE38312.1.
AL773595 Genomic DNA. Translation: CAM20023.1.
AL773595 Genomic DNA. Translation: CAM20024.1.
BC030934 mRNA. Translation: AAH30934.1.
CCDSiCCDS15798.1. [Q3TMX7-2]
RefSeqiNP_001289885.1. NM_001302956.1. [Q3TMX7-1]
NP_705787.1. NM_153559.3. [Q3TMX7-2]
UniGeneiMm.116769.

Genome annotation databases

EnsembliENSMUST00000036187; ENSMUSP00000037128; ENSMUSG00000036327. [Q3TMX7-2]
ENSMUST00000091263; ENSMUSP00000088807; ENSMUSG00000036327. [Q3TMX7-3]
GeneIDi227638.
KEGGimmu:227638.
UCSCiuc008iuj.2. mouse. [Q3TMX7-2]
uc008iuk.2. mouse. [Q3TMX7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042036 mRNA. Translation: BAC31140.1. Sequence problems.
AK140324 mRNA. Translation: BAE24335.1.
AK157992 mRNA. Translation: BAE34304.1.
AK165642 mRNA. Translation: BAE38312.1.
AL773595 Genomic DNA. Translation: CAM20023.1.
AL773595 Genomic DNA. Translation: CAM20024.1.
BC030934 mRNA. Translation: AAH30934.1.
CCDSiCCDS15798.1. [Q3TMX7-2]
RefSeqiNP_001289885.1. NM_001302956.1. [Q3TMX7-1]
NP_705787.1. NM_153559.3. [Q3TMX7-2]
UniGeneiMm.116769.

3D structure databases

ProteinModelPortaliQ3TMX7.
SMRiQ3TMX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037128.

PTM databases

iPTMnetiQ3TMX7.
PhosphoSitePlusiQ3TMX7.

Proteomic databases

EPDiQ3TMX7.
MaxQBiQ3TMX7.
PaxDbiQ3TMX7.
PeptideAtlasiQ3TMX7.
PRIDEiQ3TMX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036187; ENSMUSP00000037128; ENSMUSG00000036327. [Q3TMX7-2]
ENSMUST00000091263; ENSMUSP00000088807; ENSMUSG00000036327. [Q3TMX7-3]
GeneIDi227638.
KEGGimmu:227638.
UCSCiuc008iuj.2. mouse. [Q3TMX7-2]
uc008iuk.2. mouse. [Q3TMX7-1]

Organism-specific databases

CTDi169714.
MGIiMGI:2387194. Qsox2.

Phylogenomic databases

eggNOGiKOG1731. Eukaryota.
ENOG410XVJT. LUCA.
GeneTreeiENSGT00390000008045.
HOGENOMiHOG000231631.
HOVERGENiHBG080360.
InParanoidiQ3TMX7.
KOiK10758.
OMAiHISRIRY.
OrthoDBiEOG091G038J.
PhylomeDBiQ3TMX7.
TreeFamiTF316749.

Miscellaneous databases

ChiTaRSiQsox2. mouse.
PROiQ3TMX7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036327.
CleanExiMM_QSOX2.
GenevisibleiQ3TMX7. MM.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQSOX2_MOUSE
AccessioniPrimary (citable) accession number: Q3TMX7
Secondary accession number(s): A2ALE0
, A2ALE1, Q3TZA5, Q8C9I4, Q8K0M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.