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Protein

Sulfhydryl oxidase 2

Gene

Qsox2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins (By similarity).By similarity

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

FADCuratedNote: Binds 1 FAD per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85NucleophileBy similarity1
Active sitei88NucleophileBy similarity1
Binding sitei420FADBy similarity1
Binding sitei427FADBy similarity1
Binding sitei431FADBy similarity1
Binding sitei472FADBy similarity1
Binding sitei476FADBy similarity1
Binding sitei521FADBy similarity1
Binding sitei524FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi499 – 506FADBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidase 2 (EC:1.8.3.2)
Alternative name(s):
Quiescin Q6-like protein 1
Gene namesi
Name:Qsox2
Synonyms:Qscn6l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2387194 Qsox2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei656 – 676HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000024953939 – 692Sulfhydryl oxidase 2Add BLAST654

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi85 ↔ 88Redox-activePROSITE-ProRule annotation
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi412 ↔ 424PROSITE-ProRule annotation
Disulfide bondi470 ↔ 473PROSITE-ProRule annotation
Disulfide bondi530 ↔ 533PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ3TMX7
MaxQBiQ3TMX7
PaxDbiQ3TMX7
PeptideAtlasiQ3TMX7
PRIDEiQ3TMX7

PTM databases

iPTMnetiQ3TMX7
PhosphoSitePlusiQ3TMX7

Expressioni

Gene expression databases

BgeeiENSMUSG00000036327
CleanExiMM_QSOX2
GenevisibleiQ3TMX7 MM

Interactioni

Protein-protein interaction databases

BioGridi230654, 1 interactor
STRINGi10090.ENSMUSP00000037128

Structurei

3D structure databases

ProteinModelPortaliQ3TMX7
SMRiQ3TMX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 172ThioredoxinPROSITE-ProRule annotationAdd BLAST119
Domaini415 – 524ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd BLAST110

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1731 Eukaryota
ENOG410XVJT LUCA
GeneTreeiENSGT00390000008045
HOGENOMiHOG000231631
HOVERGENiHBG080360
InParanoidiQ3TMX7
KOiK10758
OMAiLQTMRRY
OrthoDBiEOG091G038J
PhylomeDBiQ3TMX7
TreeFamiTF316749

Family and domain databases

Gene3Di1.20.120.310, 1 hit
InterProiView protein in InterPro
IPR036774 ERV/ALR_sulphydryl_oxid_sf
IPR017905 ERV/ALR_sulphydryl_oxidase
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF04777 Evr1_Alr, 1 hit
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF69000 SSF69000, 1 hit
PROSITEiView protein in PROSITE
PS51324 ERV_ALR, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TMX7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAARAVARD PGAYARQPPS LRAARLPRLL FLLAVVAAVG PREGGGARLY
60 70 80 90 100
REGSDAVWLL DSGSVRSATG NSSAAWLVQF HSSWCGHCIG YAPTWRALAA
110 120 130 140 150
DVRDWAAAIR VAALDCAEEK NQDVCRTYDI HFYPTFRYFK AFTKEFTTGE
160 170 180 190 200
NFKGPDRELR TVRQTMIDFL QNHTEGTWPP ACPPLDPIQS SDILSFMDSH
210 220 230 240 250
SGQYHAIVFE SNGSYVGREV ILDLIPYENI MVSRALDTDK AFLGTLGITS
260 270 280 290 300
VPSCYLIYPN GSHGLVNVAK PLRSFFSSHL KSLPDVRKKS LFLPEKSNKE
310 320 330 340 350
EKSEVVVWKE FDRAKLYTAD LESGLHYLLR VELAAHRSLA GAQLKTFRDF
360 370 380 390 400
VTVVAKLFPG RPAVKKLLET LQEWLANLPL DKIPYNAILD LVNNKMQISG
410 420 430 440 450
IFLTSHVKWV GCQGSRLELR GYPCSLWKLF HTLTVQASTH PEALAGTGFE
460 470 480 490 500
GHPQAVLQAI RRYIRTFFGC KECGEHFEEM AKESMDSVKT PDQAVLWLWR
510 520 530 540 550
KHNMVNSRLA GHLSEDPKFP KVPWPTPDLC PACHEEIKGL DSWNEGQVLL
560 570 580 590 600
FLKQHYSRDN LVDAYSVDQG SPGEWEAQGR EQEEGKGLNP SGKSWRHHDT
610 620 630 640 650
GSLRPPHILG PRTDLSKSLH HRLDLRLQSP QGPQALKEAK AVVPFLGVGF
660 670 680 690
SSLDMSLCVV LYVASSLFLM IMYFFFRVRS KRWKVRLYHP AV
Length:692
Mass (Da):77,775
Last modified:October 11, 2005 - v1
Checksum:i3BDC7058817484A1
GO
Isoform 2 (identifier: Q3TMX7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-666: EWEAQGREQE...LCVVLYVASS → SVLRARPWLG...WSVSLRIGPI
     667-692: Missing.

Note: No experimental confirmation available.
Show »
Length:639
Mass (Da):71,477
Checksum:iB61C2ECE6ABC6477
GO
Isoform 3 (identifier: Q3TMX7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.

Note: No experimental confirmation available.
Show »
Length:527
Mass (Da):59,568
Checksum:i56976D2DF52B8BD2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0205001 – 165Missing in isoform 3. 1 PublicationAdd BLAST165
Alternative sequenceiVSP_020501574 – 666EWEAQ…YVASS → SVLRARPWLGQMARLSHVNL LPHFPVEEVSSLKPGVLCLK TNKPRSSLGVSKDEHSWSVS LRIGPI in isoform 2. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_020502667 – 692Missing in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042036 mRNA Translation: BAC31140.1 Sequence problems.
AK140324 mRNA Translation: BAE24335.1
AK157992 mRNA Translation: BAE34304.1
AK165642 mRNA Translation: BAE38312.1
AL773595 Genomic DNA No translation available.
BC030934 mRNA Translation: AAH30934.1
CCDSiCCDS15798.1 [Q3TMX7-2]
RefSeqiNP_001289885.1, NM_001302956.1 [Q3TMX7-1]
NP_705787.1, NM_153559.3 [Q3TMX7-2]
UniGeneiMm.116769

Genome annotation databases

EnsembliENSMUST00000036187; ENSMUSP00000037128; ENSMUSG00000036327 [Q3TMX7-2]
ENSMUST00000091263; ENSMUSP00000088807; ENSMUSG00000036327 [Q3TMX7-3]
GeneIDi227638
KEGGimmu:227638
UCSCiuc008iuj.2 mouse [Q3TMX7-2]
uc008iuk.2 mouse [Q3TMX7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiQSOX2_MOUSE
AccessioniPrimary (citable) accession number: Q3TMX7
Secondary accession number(s): A2ALE0
, A2ALE1, Q3TZA5, Q8C9I4, Q8K0M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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