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Q3TMX7

- QSOX2_MOUSE

UniProt

Q3TMX7 - QSOX2_MOUSE

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Protein

Sulfhydryl oxidase 2

Gene

Qsox2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins (By similarity).By similarity

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

FADCuratedNote: Binds 1 FAD per subunit.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851NucleophileBy similarity
Active sitei88 – 881NucleophileBy similarity
Binding sitei420 – 4201FADBy similarity
Binding sitei427 – 4271FADBy similarity
Binding sitei431 – 4311FADBy similarity
Binding sitei472 – 4721FADBy similarity
Binding sitei476 – 4761FADBy similarity
Binding sitei521 – 5211FADBy similarity
Binding sitei524 – 5241FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi499 – 5068FADBy similarity

GO - Molecular functioni

  1. thiol oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidase 2 (EC:1.8.3.2)
Alternative name(s):
Quiescin Q6-like protein 1
Gene namesi
Name:Qsox2
Synonyms:Qscn6l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2387194. Qsox2.

Subcellular locationi

Membrane By similarity; Single-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei656 – 67621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838Sequence AnalysisAdd
BLAST
Chaini39 – 692654Sulfhydryl oxidase 2PRO_0000249539Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi85 ↔ 88Redox-activePROSITE-ProRule annotation
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi412 ↔ 424PROSITE-ProRule annotation
Disulfide bondi470 ↔ 473PROSITE-ProRule annotation
Disulfide bondi530 ↔ 533PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ3TMX7.
PaxDbiQ3TMX7.
PRIDEiQ3TMX7.

PTM databases

PhosphoSiteiQ3TMX7.

Expressioni

Gene expression databases

BgeeiQ3TMX7.
CleanExiMM_QSOX2.
GenevestigatoriQ3TMX7.

Structurei

3D structure databases

ProteinModelPortaliQ3TMX7.
SMRiQ3TMX7. Positions 54-562.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 172119ThioredoxinPROSITE-ProRule annotationAdd
BLAST
Domaini415 – 524110ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ERV/ALR sulfhydryl oxidase domain.PROSITE-ProRule annotation
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237986.
GeneTreeiENSGT00390000008045.
HOGENOMiHOG000231631.
HOVERGENiHBG080360.
InParanoidiQ3TMX7.
KOiK10758.
OMAiHCIGYAP.
OrthoDBiEOG73RB9X.
PhylomeDBiQ3TMX7.
TreeFamiTF316749.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3TMX7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAARAVARD PGAYARQPPS LRAARLPRLL FLLAVVAAVG PREGGGARLY
60 70 80 90 100
REGSDAVWLL DSGSVRSATG NSSAAWLVQF HSSWCGHCIG YAPTWRALAA
110 120 130 140 150
DVRDWAAAIR VAALDCAEEK NQDVCRTYDI HFYPTFRYFK AFTKEFTTGE
160 170 180 190 200
NFKGPDRELR TVRQTMIDFL QNHTEGTWPP ACPPLDPIQS SDILSFMDSH
210 220 230 240 250
SGQYHAIVFE SNGSYVGREV ILDLIPYENI MVSRALDTDK AFLGTLGITS
260 270 280 290 300
VPSCYLIYPN GSHGLVNVAK PLRSFFSSHL KSLPDVRKKS LFLPEKSNKE
310 320 330 340 350
EKSEVVVWKE FDRAKLYTAD LESGLHYLLR VELAAHRSLA GAQLKTFRDF
360 370 380 390 400
VTVVAKLFPG RPAVKKLLET LQEWLANLPL DKIPYNAILD LVNNKMQISG
410 420 430 440 450
IFLTSHVKWV GCQGSRLELR GYPCSLWKLF HTLTVQASTH PEALAGTGFE
460 470 480 490 500
GHPQAVLQAI RRYIRTFFGC KECGEHFEEM AKESMDSVKT PDQAVLWLWR
510 520 530 540 550
KHNMVNSRLA GHLSEDPKFP KVPWPTPDLC PACHEEIKGL DSWNEGQVLL
560 570 580 590 600
FLKQHYSRDN LVDAYSVDQG SPGEWEAQGR EQEEGKGLNP SGKSWRHHDT
610 620 630 640 650
GSLRPPHILG PRTDLSKSLH HRLDLRLQSP QGPQALKEAK AVVPFLGVGF
660 670 680 690
SSLDMSLCVV LYVASSLFLM IMYFFFRVRS KRWKVRLYHP AV
Length:692
Mass (Da):77,775
Last modified:October 11, 2005 - v1
Checksum:i3BDC7058817484A1
GO
Isoform 2 (identifier: Q3TMX7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-666: EWEAQGREQE...LCVVLYVASS → SVLRARPWLG...WSVSLRIGPI
     667-692: Missing.

Note: No experimental confirmation available.

Show »
Length:639
Mass (Da):71,477
Checksum:iB61C2ECE6ABC6477
GO
Isoform 3 (identifier: Q3TMX7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.

Note: No experimental confirmation available.

Show »
Length:527
Mass (Da):59,568
Checksum:i56976D2DF52B8BD2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 165165Missing in isoform 3. 1 PublicationVSP_020500Add
BLAST
Alternative sequencei574 – 66693EWEAQ…YVASS → SVLRARPWLGQMARLSHVNL LPHFPVEEVSSLKPGVLCLK TNKPRSSLGVSKDEHSWSVS LRIGPI in isoform 2. 1 PublicationVSP_020501Add
BLAST
Alternative sequencei667 – 69226Missing in isoform 2. 1 PublicationVSP_020502Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042036 mRNA. Translation: BAC31140.1. Sequence problems.
AK140324 mRNA. Translation: BAE24335.1.
AK157992 mRNA. Translation: BAE34304.1.
AK165642 mRNA. Translation: BAE38312.1.
AL773595 Genomic DNA. Translation: CAM20023.1.
AL773595 Genomic DNA. Translation: CAM20024.1.
BC030934 mRNA. Translation: AAH30934.1.
CCDSiCCDS15798.1. [Q3TMX7-2]
RefSeqiNP_705787.1. NM_153559.2. [Q3TMX7-2]
XP_006497965.1. XM_006497902.1. [Q3TMX7-1]
UniGeneiMm.116769.

Genome annotation databases

EnsembliENSMUST00000036187; ENSMUSP00000037128; ENSMUSG00000036327. [Q3TMX7-2]
ENSMUST00000091263; ENSMUSP00000088807; ENSMUSG00000036327. [Q3TMX7-3]
GeneIDi227638.
KEGGimmu:227638.
UCSCiuc008iuj.1. mouse. [Q3TMX7-2]
uc008iuk.1. mouse. [Q3TMX7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042036 mRNA. Translation: BAC31140.1 . Sequence problems.
AK140324 mRNA. Translation: BAE24335.1 .
AK157992 mRNA. Translation: BAE34304.1 .
AK165642 mRNA. Translation: BAE38312.1 .
AL773595 Genomic DNA. Translation: CAM20023.1 .
AL773595 Genomic DNA. Translation: CAM20024.1 .
BC030934 mRNA. Translation: AAH30934.1 .
CCDSi CCDS15798.1. [Q3TMX7-2 ]
RefSeqi NP_705787.1. NM_153559.2. [Q3TMX7-2 ]
XP_006497965.1. XM_006497902.1. [Q3TMX7-1 ]
UniGenei Mm.116769.

3D structure databases

ProteinModelPortali Q3TMX7.
SMRi Q3TMX7. Positions 54-562.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q3TMX7.

Proteomic databases

MaxQBi Q3TMX7.
PaxDbi Q3TMX7.
PRIDEi Q3TMX7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036187 ; ENSMUSP00000037128 ; ENSMUSG00000036327 . [Q3TMX7-2 ]
ENSMUST00000091263 ; ENSMUSP00000088807 ; ENSMUSG00000036327 . [Q3TMX7-3 ]
GeneIDi 227638.
KEGGi mmu:227638.
UCSCi uc008iuj.1. mouse. [Q3TMX7-2 ]
uc008iuk.1. mouse. [Q3TMX7-1 ]

Organism-specific databases

CTDi 169714.
MGIi MGI:2387194. Qsox2.

Phylogenomic databases

eggNOGi NOG237986.
GeneTreei ENSGT00390000008045.
HOGENOMi HOG000231631.
HOVERGENi HBG080360.
InParanoidi Q3TMX7.
KOi K10758.
OMAi HCIGYAP.
OrthoDBi EOG73RB9X.
PhylomeDBi Q3TMX7.
TreeFami TF316749.

Miscellaneous databases

ChiTaRSi Qsox2. mouse.
NextBioi 378712.
PROi Q3TMX7.
SOURCEi Search...

Gene expression databases

Bgeei Q3TMX7.
CleanExi MM_QSOX2.
Genevestigatori Q3TMX7.

Family and domain databases

Gene3Di 1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEi PS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Strain: C57BL/6J.
    Tissue: Adipose tissue, Inner ear and Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiQSOX2_MOUSE
AccessioniPrimary (citable) accession number: Q3TMX7
Secondary accession number(s): A2ALE0
, A2ALE1, Q3TZA5, Q8C9I4, Q8K0M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 11, 2005
Last modified: November 26, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3