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Protein

Trimeric intracellular cation channel type A

Gene

Tmem38a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei122Phosphatidylinositol 4,5-bisphosphate (PIP2)By similarity1
Binding sitei126Phosphatidylinositol 4,5-bisphosphate (PIP2)By similarity1

GO - Molecular functioni

  • calcium-activated potassium channel activity Source: BHF-UCL

Keywordsi

Molecular functionIon channel, Potassium channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Protein family/group databases

TCDBi1.A.62.1.1 the homotrimeric cation channel (tric) family

Names & Taxonomyi

Protein namesi
Recommended name:
Trimeric intracellular cation channel type A
Short name:
TRIC-A
Short name:
TRICA
Alternative name(s):
27 kDa sarcoplasmic reticulum protein
Mitsugumin-33A
SPR-27
Transmembrane protein 38A
Gene namesi
Name:Tmem38a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1921416 Tmem38a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18LumenalCuratedAdd BLAST18
Transmembranei19 – 39Helical;Name=1Sequence analysisAdd BLAST21
Topological domaini40 – 51CytoplasmicCuratedAdd BLAST12
Transmembranei52 – 72Helical;Name=2Sequence analysisAdd BLAST21
Topological domaini73 – 85LumenalCuratedAdd BLAST13
Transmembranei86 – 106Helical;Name=3Sequence analysisAdd BLAST21
Topological domaini107 – 144CytoplasmicCuratedAdd BLAST38
Transmembranei145 – 165Helical;Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 178LumenalCuratedAdd BLAST13
Transmembranei179 – 199Helical;Name=5Sequence analysisAdd BLAST21
Topological domaini200 – 209CytoplasmicCurated10
Transmembranei210 – 230Helical;Name=6Sequence analysisAdd BLAST21
Topological domaini231 – 234LumenalCurated4
Transmembranei235 – 255Helical;Name=7Sequence analysisAdd BLAST21
Topological domaini256 – 298CytoplasmicCuratedAdd BLAST43

Keywords - Cellular componenti

Membrane, Nucleus, Sarcoplasmic reticulum

Pathology & Biotechi

Disruption phenotypei

Mice are viable. Mice lacking Tmem38a and Tmem38b show a weak heartbeat at E9.5 followed by loss of cardiomyocyte viability and embryonic lethality around E10.5.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710691 – 298Trimeric intracellular cation channel type AAdd BLAST298

Proteomic databases

EPDiQ3TMP8
MaxQBiQ3TMP8
PaxDbiQ3TMP8
PeptideAtlasiQ3TMP8
PRIDEiQ3TMP8

PTM databases

iPTMnetiQ3TMP8
PhosphoSitePlusiQ3TMP8

Expressioni

Tissue specificityi

Expressed at high levels in heart and striated muscle. Also detected in brain, lung and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000031791
CleanExiMM_TMEM38A
ExpressionAtlasiQ3TMP8 baseline and differential
GenevisibleiQ3TMP8 MM

Interactioni

Subunit structurei

Homotrimer; trimerization probably requires binding to phosphatidylinositol 4,5-bisphosphate (PIP2).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034244

Structurei

3D structure databases

SMRiQ3TMP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi135 – 143His-richPROSITE-ProRule annotation9

Sequence similaritiesi

Belongs to the TMEM38 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3944 Eukaryota
ENOG410XQ0P LUCA
GeneTreeiENSGT00390000018845
HOGENOMiHOG000037929
HOVERGENiHBG059853
InParanoidiQ3TMP8
OMAiKYEPGAV
OrthoDBiEOG091G0GQP
PhylomeDBiQ3TMP8
TreeFamiTF313483

Family and domain databases

InterProiView protein in InterPro
IPR007866 TRIC_channel
PANTHERiPTHR12454 PTHR12454, 1 hit
PfamiView protein in Pfam
PF05197 TRIC, 1 hit

Sequencei

Sequence statusi: Complete.

Q3TMP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLMSALSLG ELALSFSRVP LFPVFDLSYF IVSIIYLKYE PGAVELSRRH
60 70 80 90 100
PVASWLCAML HCFGSYILAD LLLGEPIIDY FSNSSSILLA SGVWYLIFFC
110 120 130 140 150
PLDLFYKCVC FLPVKLIFVA MKEVVRVRKI AVGIHHAHHH YHHGWFIMIA
160 170 180 190 200
TGWVKGSGVA LLSNVEQLLR GVWKPETNEI LHMSFPTKAS LYGAILFTLQ
210 220 230 240 250
QTRWLPVSKA SLIFVFTMFM VSCKVFLTAT HSHSSPFDIL EGYICPVLFG
260 270 280 290
ATWGGDHHHD NHGAPHGMGL GTQHSGLPAK AKEELGEGSR KKKTKKAD
Length:298
Mass (Da):33,309
Last modified:January 9, 2007 - v2
Checksum:iF35559581DA80BD7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73L → P in BAE38393 (PubMed:16141072).Curated1
Sequence conflicti276G → S in ABS17665 (Ref. 2) Curated1
Sequence conflicti276G → S in BAE34290 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB261158 mRNA Translation: BAF62541.1
EF988666 mRNA Translation: ABS17665.1
AK157969 mRNA Translation: BAE34290.1
AK165818 mRNA Translation: BAE38393.1
BC014728 mRNA Translation: AAH14728.1
BC024788 mRNA Translation: AAH24788.1
CCDSiCCDS22417.1
RefSeqiNP_653117.1, NM_144534.1
UniGeneiMm.212927

Genome annotation databases

EnsembliENSMUST00000034244; ENSMUSP00000034244; ENSMUSG00000031791
GeneIDi74166
KEGGimmu:74166
UCSCiuc009mgi.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTM38A_MOUSE
AccessioniPrimary (citable) accession number: Q3TMP8
Secondary accession number(s): A5A6S4
, A7LBB7, Q3TZB9, Q91WL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: March 28, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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