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Protein

Trimeric intracellular cation channel type A

Gene

Tmem38a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.1 Publication

GO - Molecular functioni

  • calcium-activated potassium channel activity Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Protein family/group databases

TCDBi1.A.62.1.1. the homotrimeric cation channel (tric) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Trimeric intracellular cation channel type A
Short name:
TRIC-A
Short name:
TRICA
Alternative name(s):
27 kDa sarcoplasmic reticulum protein
Mitsugumin-33A
SPR-27
Transmembrane protein 38A
Gene namesi
Name:Tmem38a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1921416. Tmem38a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151LumenalSequence analysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence analysisAdd
BLAST
Topological domaini73 – 8513CytoplasmicSequence analysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST
Topological domaini107 – 14438CytoplasmicSequence analysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence analysisAdd
BLAST
Topological domaini166 – 20944LumenalSequence analysisAdd
BLAST
Transmembranei210 – 23021HelicalSequence analysisAdd
BLAST
Topological domaini231 – 29868CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus, Sarcoplasmic reticulum

Pathology & Biotechi

Disruption phenotypei

Mice are viable. Mice lacking Tmem38a and Tmem38b show a weak heartbeat at E9.5 followed by loss of cardiomyocyte viability and embryonic lethality around E10.5.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Trimeric intracellular cation channel type APRO_0000271069Add
BLAST

Proteomic databases

EPDiQ3TMP8.
MaxQBiQ3TMP8.
PaxDbiQ3TMP8.
PeptideAtlasiQ3TMP8.
PRIDEiQ3TMP8.

PTM databases

iPTMnetiQ3TMP8.
PhosphoSiteiQ3TMP8.

Expressioni

Tissue specificityi

Expressed at high levels in heart and striated muscle. Also detected in brain, lung and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000031791.
CleanExiMM_TMEM38A.
GenevisibleiQ3TMP8. MM.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034244.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi135 – 1439His-rich

Domaini

The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore.

Sequence similaritiesi

Belongs to the TMEM38 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3944. Eukaryota.
ENOG410XQ0P. LUCA.
GeneTreeiENSGT00390000018845.
HOGENOMiHOG000037929.
HOVERGENiHBG059853.
InParanoidiQ3TMP8.
OMAiYKCVSFL.
OrthoDBiEOG091G0GQP.
PhylomeDBiQ3TMP8.
TreeFamiTF313483.

Family and domain databases

InterProiIPR007866. TRIC_channel.
[Graphical view]
PANTHERiPTHR12454. PTHR12454. 1 hit.
PfamiPF05197. TRIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TMP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLMSALSLG ELALSFSRVP LFPVFDLSYF IVSIIYLKYE PGAVELSRRH
60 70 80 90 100
PVASWLCAML HCFGSYILAD LLLGEPIIDY FSNSSSILLA SGVWYLIFFC
110 120 130 140 150
PLDLFYKCVC FLPVKLIFVA MKEVVRVRKI AVGIHHAHHH YHHGWFIMIA
160 170 180 190 200
TGWVKGSGVA LLSNVEQLLR GVWKPETNEI LHMSFPTKAS LYGAILFTLQ
210 220 230 240 250
QTRWLPVSKA SLIFVFTMFM VSCKVFLTAT HSHSSPFDIL EGYICPVLFG
260 270 280 290
ATWGGDHHHD NHGAPHGMGL GTQHSGLPAK AKEELGEGSR KKKTKKAD
Length:298
Mass (Da):33,309
Last modified:January 9, 2007 - v2
Checksum:iF35559581DA80BD7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731L → P in BAE38393 (PubMed:16141072).Curated
Sequence conflicti276 – 2761G → S in ABS17665 (Ref. 2) Curated
Sequence conflicti276 – 2761G → S in BAE34290 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB261158 mRNA. Translation: BAF62541.1.
EF988666 mRNA. Translation: ABS17665.1.
AK157969 mRNA. Translation: BAE34290.1.
AK165818 mRNA. Translation: BAE38393.1.
BC014728 mRNA. Translation: AAH14728.1.
BC024788 mRNA. Translation: AAH24788.1.
CCDSiCCDS22417.1.
RefSeqiNP_653117.1. NM_144534.1.
UniGeneiMm.212927.

Genome annotation databases

EnsembliENSMUST00000034244; ENSMUSP00000034244; ENSMUSG00000031791.
GeneIDi74166.
KEGGimmu:74166.
UCSCiuc009mgi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB261158 mRNA. Translation: BAF62541.1.
EF988666 mRNA. Translation: ABS17665.1.
AK157969 mRNA. Translation: BAE34290.1.
AK165818 mRNA. Translation: BAE38393.1.
BC014728 mRNA. Translation: AAH14728.1.
BC024788 mRNA. Translation: AAH24788.1.
CCDSiCCDS22417.1.
RefSeqiNP_653117.1. NM_144534.1.
UniGeneiMm.212927.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034244.

Protein family/group databases

TCDBi1.A.62.1.1. the homotrimeric cation channel (tric) family.

PTM databases

iPTMnetiQ3TMP8.
PhosphoSiteiQ3TMP8.

Proteomic databases

EPDiQ3TMP8.
MaxQBiQ3TMP8.
PaxDbiQ3TMP8.
PeptideAtlasiQ3TMP8.
PRIDEiQ3TMP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034244; ENSMUSP00000034244; ENSMUSG00000031791.
GeneIDi74166.
KEGGimmu:74166.
UCSCiuc009mgi.2. mouse.

Organism-specific databases

CTDi79041.
MGIiMGI:1921416. Tmem38a.

Phylogenomic databases

eggNOGiKOG3944. Eukaryota.
ENOG410XQ0P. LUCA.
GeneTreeiENSGT00390000018845.
HOGENOMiHOG000037929.
HOVERGENiHBG059853.
InParanoidiQ3TMP8.
OMAiYKCVSFL.
OrthoDBiEOG091G0GQP.
PhylomeDBiQ3TMP8.
TreeFamiTF313483.

Miscellaneous databases

PROiQ3TMP8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031791.
CleanExiMM_TMEM38A.
GenevisibleiQ3TMP8. MM.

Family and domain databases

InterProiIPR007866. TRIC_channel.
[Graphical view]
PANTHERiPTHR12454. PTHR12454. 1 hit.
PfamiPF05197. TRIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM38A_MOUSE
AccessioniPrimary (citable) accession number: Q3TMP8
Secondary accession number(s): A5A6S4
, A7LBB7, Q3TZB9, Q91WL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.