Map2k1

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
MAP kinase kinase activity Source: Ensembl
protein C-terminus binding Source: Ensembl
protein N-terminus binding Source: Ensembl
protein serine/threonine kinase activator activity Source: Ensembl
protein serine/threonine kinase activity Source: UniProtKB-KW
signal transducer, downstream of receptor, with protein tyrosine phosphatase activity Source: Ensembl

GO - Biological processⁱ

Bergmann glial cell differentiation Source: Ensembl
cell cycle arrest Source: Ensembl
cell motility Source: Ensembl
cellular senescence Source: Ensembl
cerebellar cortex formation Source: Ensembl
epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
ERK1 and ERK2 cascade Source: Ensembl
face development Source: Ensembl
heart development Source: Ensembl
keratinocyte differentiation Source: Ensembl
labyrinthine layer development Source: Ensembl
negative regulation of cell proliferation Source: Ensembl
negative regulation of gene expression Source: Ensembl
neuron differentiation Source: Ensembl
placenta blood vessel development Source: Ensembl
positive regulation of axonogenesis Source: Ensembl
positive regulation of ERK1 and ERK2 cascade Source: Ensembl
positive regulation of production of miRNAs involved in gene silencing by miRNA Source: Ensembl
positive regulation of transcription, DNA-templated Source: Ensembl
regulation of axon regeneration Source: Ensembl
thymus development Source: Ensembl
thyroid gland development Source: Ensembl
trachea formation Source: Ensembl

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
Ligand	ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Mitogen activated protein kinase kinase 1Imported Submitted name: Putative uncharacterized proteinImported
Gene namesⁱ	Name:Map2k1Imported ORF Names:mCG_12792Imported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:1346866. Map2k1.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytosol Source: Ensembl
endoplasmic reticulum Source: Ensembl
extracellular exosome Source: Ensembl
plasma membrane Source: Ensembl

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3TMJ8.

MaxQBⁱ

Q3TMJ8.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000004936.
ExpressionAtlasⁱ	Q3TMJ8. baseline and differential.

Interactionⁱ

GO - Molecular functionⁱ

protein C-terminus binding Source: Ensembl
protein N-terminus binding Source: Ensembl

Complete GO annotation...

Structureⁱ

3D structure databases

SMRⁱ	Q3TMJ8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	68 – 361	Protein kinaseInterPro annotationAdd BLAST		294

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	23 – 50	Sequence analysisAdd BLAST		28

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily.UniRule annotation

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0581. Eukaryota. ENOG410XQ5A. LUCA.
HOVERGENⁱ	HBG108518.
KEGG Orthology (KO) More...KOⁱ	K04368.
OMAⁱ	ELMFGCP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DEC.

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069. Pkinase. 1 hit.
SMARTⁱ	View protein in SMART SM00220. S_TKc. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3TMJ8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL 
        60         70         80         90        100
EAFLTQKQKV GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH 
       110        120        130        140        150
LEIKPAIRNQ IIRELQVLHE CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS 
       160        170        180        190        200
LDQVLKKAGR IPEQILGKVS IAVIKGLTYL REKHKIMHRD VKPSNILVNS 
       210        220        230        240        250
RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY SVQSDIWSMG 
       260        270        280        290        300
LSLVEMAVGR YPIPPPDAKE LELLFGCHVE GDAAETPPRP RTPGRPLSSY 
       310        320        330        340        350
GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA 
       360        370        380        390 
DLKQLMVHAF IKRSDAEEVD FAGWLCSTIG LNQPSTPTHA ASI

Length:393

Mass (Da):43,474

Last modified:October 11, 2005 - v1

Checksum:ⁱ01D1D18572AE40E7

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY902345 Genomic DNA. Translation: AAY21055.1. AK146931 mRNA. Translation: BAE27542.1. AK165894 mRNA. Translation: BAE38443.1. AK167336 mRNA. Translation: BAE39437.1. CH466522 Genomic DNA. Translation: EDL26058.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_032953.1. NM_008927.3.
UniGeneⁱ	Mm.248907.

Genome annotation databases

GeneIDⁱ	26395.
KEGGⁱ	mmu:26395.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY902345 Genomic DNA. Translation: AAY21055.1. AK146931 mRNA. Translation: BAE27542.1. AK165894 mRNA. Translation: BAE38443.1. AK167336 mRNA. Translation: BAE39437.1. CH466522 Genomic DNA. Translation: EDL26058.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_032953.1. NM_008927.3.
UniGeneⁱ	Mm.248907.

3D structure databases

SMRⁱ	Q3TMJ8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3TMJ8.

MaxQBⁱ

Q3TMJ8.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	26395.
KEGGⁱ	mmu:26395.

Organism-specific databases

CTDⁱ	5604.
MGIⁱ	MGI:1346866. Map2k1.

Phylogenomic databases

eggNOGⁱ	KOG0581. Eukaryota. ENOG410XQ5A. LUCA.
HOVERGENⁱ	HBG108518.
KEGG Orthology (KO) More...KOⁱ	K04368.
OMAⁱ	ELMFGCP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DEC.

Miscellaneous databases

ChiTaRSⁱ	Map2k1. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000004936.
ExpressionAtlasⁱ	Q3TMJ8. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069. Pkinase. 1 hit.
SMARTⁱ	View protein in SMART SM00220. S_TKc. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q3TMJ8_MOUSE
Accessionⁱ	Q3TMJ8Primary (citable) accession number: Q3TMJ8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 11, 2005
	Last sequence update:	October 11, 2005
	Last modified:	July 5, 2017
	This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q3TMJ8 (Q3TMJ8_MOUSE)

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Mitogen activated protein kinase kinase 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ