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Protein

Sodium/hydrogen exchanger

Gene

Slc9a2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • sodium:proton antiporter activity Source: MGI

GO - Biological processi

  • protein localization Source: MGI
  • regulation of pH Source: MGI
  • sodium ion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

AntiportUniRule annotationSAAS annotation, Ion transport, Sodium transportUniRule annotation, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-425986. Sodium/Proton exchangers.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchangerUniRule annotation
Gene namesi
Name:Slc9a2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:105075. Slc9a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei108 – 129HelicalSequence analysisAdd BLAST22
Transmembranei141 – 158HelicalSequence analysisAdd BLAST18
Transmembranei170 – 193HelicalSequence analysisAdd BLAST24
Transmembranei205 – 230HelicalSequence analysisAdd BLAST26
Transmembranei236 – 258HelicalSequence analysisAdd BLAST23
Transmembranei270 – 297HelicalSequence analysisAdd BLAST28
Transmembranei309 – 326HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

  • brush border Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_500878020535 – 336Sodium/hydrogen exchangerSequence analysisAdd BLAST302

Expressioni

Gene expression databases

BgeeiENSMUSG00000026062.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027231.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 336Na_H_ExchangerInterPro annotationAdd BLAST252

Sequence similaritiesi

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1966. Eukaryota.
COG0025. LUCA.
GeneTreeiENSGT00760000119074.
HOVERGENiHBG084586.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3TM63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPRGTAHSV RAPLSWLLLL LLSLQVAVPA GALAETLLDA PRARGASSNP
60 70 80 90 100
PSPASVVAPG TTPFEESRLP VFTLDYPHVQ IPFEITLWIL LASLAKIGFH
110 120 130 140 150
LYHKLPTIVP ESCLLIMVGL LLGGIIFGVD EKSPPAMKTD VFFLYLLPPI
160 170 180 190 200
VLDAGYFMPT RPFFENFGTI FWYAVVGTLW NSIGIGVSLF GICQIEAFGL
210 220 230 240 250
SDITLLQNLL FGSLISAVDP VAVLAVFENI HVNEQLYILV FGESLLNDAV
260 270 280 290 300
TVVLYNLFKS FCQMKTIQTV DVFAGIANFF VVGIGGVLIG ILLGFIAAFT
310 320 330
TRFTHNIRVI EPLFVFLYSY LSYITAEMFH LSGIMA
Length:336
Mass (Da):36,662
Last modified:October 11, 2005 - v1
Checksum:i55C1DC0901B79BB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154392 Genomic DNA. No translation available.
AK166114 mRNA. Translation: BAE38579.1.
UniGeneiMm.256414.

Genome annotation databases

EnsembliENSMUST00000192345; ENSMUSP00000142144; ENSMUSG00000026062.
UCSCiuc007aum.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154392 Genomic DNA. No translation available.
AK166114 mRNA. Translation: BAE38579.1.
UniGeneiMm.256414.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027231.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000192345; ENSMUSP00000142144; ENSMUSG00000026062.
UCSCiuc007aum.1. mouse.

Organism-specific databases

MGIiMGI:105075. Slc9a2.

Phylogenomic databases

eggNOGiKOG1966. Eukaryota.
COG0025. LUCA.
GeneTreeiENSGT00760000119074.
HOVERGENiHBG084586.

Enzyme and pathway databases

ReactomeiR-MMU-425986. Sodium/Proton exchangers.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026062.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ3TM63_MOUSE
AccessioniPrimary (citable) accession number: Q3TM63
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.