Unreviewed, UniProtKB/TrEMBL Q3TLX4 (Q3TLX4_MOUSE)

Names and origin

Protein names

Submitted name:
    Putative uncharacterized protein EMBL BAE38668.1

Gene names

Name:

Lck MGI 96756

Organism

Mus musculus (Mouse) EMBL BAE38668.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	368 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Spearmint SPM020635
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304V2 Spearmint SPM020635 Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase RuleBase RU000307V5 Spearmint SPM020635
Gene Ontology (GO)
Biological process	B cell receptor signaling pathway Inferred from direct assay. Source: MGI aging Inferred from electronic annotation. Source: Compara apoptosis Inferred from electronic annotation. Source: Compara peptidyl-tyrosine phosphorylation Inferred from direct assay. Source: MGI positive regulation of gamma-delta T cell differentiation Inferred from mutant phenotype. Source: MGI protein amino acid autophosphorylation Inferred from direct assay. Source: MGI regulation of T cell receptor signaling pathway Inferred from direct assay. Source: MGI response to hydrogen peroxide Inferred from electronic annotation. Source: Compara response to zinc ion Inferred from electronic annotation. Source: Compara
Cellular component	endocytic vesicle Inferred from electronic annotation. Source: Compara
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein complex binding Inferred from electronic annotation. Source: Compara protein tyrosine kinase activity Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAE38668.1

Sequences

	Sequence		Length	Mass (Da)
	Q3TLX4-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 7AB6AE53AF1A5059	FASTA	368	42,018
	10 20 30 40 50 60 AFSSSTSLLF PPPISNLSSG SFSLSVRDFD QNQGEVVKHY KIRNLDNGGF YISPRITFPG 70 80 90 100 110 120 LHDLVRHYTN ASDGLCTKLS RPCQTQKPQK PWWEDEWEVP RETLKLVERL GAGQFGEVWM 130 140 150 160 170 180 GYYNGHTKVA VKSLKQGSMS PDAFLAEANL MKQLQHPRLV RLYAVVTQEP IYIITEYMEN 190 200 210 220 230 240 GSLVDFLKTP SGIKLNVNKL LDMAAQIAEG MAFIEEQNYI HRDLRAANIL VSDTLSCKIA 250 260 270 280 290 300 DFGLARLIED NEYTAREGAK FPIKWTAPEA INYGTFTIKS DVWSFGILLT EIVTHGRIPY 310 320 330 340 350 360 PGMTNPEVIQ NLERGYRMVR PDNCPEELYH LMMLCWKERP EDRPTFDYLR SVLDDFFTAT EGQYQPQP

References

[1]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland EMBL BAE38668.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK166263 mRNA. Translation: BAE38668.1.
IPI	IPI00555017.
UniGene	Mm.293753
3D structure databases
SMR	Q3TLX4. Positions 15-368.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3TLX4.
Genome annotation databases
Ensembl	ENSMUST00000067240; ENSMUSP00000066209; ENSMUSG00000000409; Mus musculus. [Genome view] ENSMUST00000102596; ENSMUSP00000099656; ENSMUSG00000000409; Mus musculus. [Genome view]
UCSC	uc008uxh.1. mouse.
Organism-specific databases
MGI	MGI:96756. Lck.
Phylogenomic databases
HOVERGEN	Q3TLX4.
InParanoid	Q3TLX4.
Gene expression databases
ArrayExpress	Q3TLX4.
Bgee	Q3TLX4.
Genevestigator	Q3TLX4.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR000980. SH2. IPR020749. Tyr_kinase_non-rcpt_Lck. IPR020635. Tyr_Pkinase_cat_dom. IPR020685. Tyr_prot_kinase. IPR008266. Tyr_prot_kinase_AS. [Graphical view]
Gene3D	G3DSA:3.30.505.10. SH2. 1 hit.
PANTHER	PTHR23256:SF260. Tyr_kinase_non-rcpt_Lck. 1 hit. PTHR23256. Tyr_prot_kinase. 1 hit.
Pfam	PF00017. SH2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN.
SMART	SM00252. SH2. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

Q3TLX4_MOUSE

Accession

Primary (citable) accession number: Q3TLX4

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	February 9, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)