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Q3TLX4

- Q3TLX4_MOUSE

UniProt

Q3TLX4 - Q3TLX4_MOUSE

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Protein
Submitted name:

Putative uncharacterized protein

Gene

Lck

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein tyrosine kinase activity Source: MGI

GO - Biological processi

  1. B cell receptor signaling pathway Source: MGI
  2. cell surface receptor signaling pathway Source: MGI
  3. peptidyl-tyrosine phosphorylation Source: MGI
  4. positive regulation of gamma-delta T cell differentiation Source: MGI
  5. positive regulation of gene expression Source: MGI
  6. positive regulation of tyrosine phosphorylation of Stat5 protein Source: MGI
  7. protein autophosphorylation Source: MGI
  8. protein phosphorylation Source: MGI
  9. regulation of T cell receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:LckImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96756. Lck.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ3TLX4.

Structurei

3D structure databases

ProteinModelPortaliQ3TLX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG008761.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3TLX4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
AFSSSTSLLF PPPISNLSSG SFSLSVRDFD QNQGEVVKHY KIRNLDNGGF
60 70 80 90 100
YISPRITFPG LHDLVRHYTN ASDGLCTKLS RPCQTQKPQK PWWEDEWEVP
110 120 130 140 150
RETLKLVERL GAGQFGEVWM GYYNGHTKVA VKSLKQGSMS PDAFLAEANL
160 170 180 190 200
MKQLQHPRLV RLYAVVTQEP IYIITEYMEN GSLVDFLKTP SGIKLNVNKL
210 220 230 240 250
LDMAAQIAEG MAFIEEQNYI HRDLRAANIL VSDTLSCKIA DFGLARLIED
260 270 280 290 300
NEYTAREGAK FPIKWTAPEA INYGTFTIKS DVWSFGILLT EIVTHGRIPY
310 320 330 340 350
PGMTNPEVIQ NLERGYRMVR PDNCPEELYH LMMLCWKERP EDRPTFDYLR
360
SVLDDFFTAT EGQYQPQP
Length:368
Mass (Da):42,018
Last modified:October 11, 2005 - v1
Checksum:i7AB6AE53AF1A5059
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK166263 mRNA. Translation: BAE38668.1.
UniGeneiMm.293753.

Genome annotation databases

UCSCiuc008uxh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK166263 mRNA. Translation: BAE38668.1 .
UniGenei Mm.293753.

3D structure databases

ProteinModelPortali Q3TLX4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc008uxh.2. mouse.

Organism-specific databases

MGIi MGI:96756. Lck.

Phylogenomic databases

HOVERGENi HBG008761.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Genevestigatori Q3TLX4.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.

Entry informationi

Entry nameiQ3TLX4_MOUSE
AccessioniPrimary (citable) accession number: Q3TLX4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)