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Protein

Non-specific protein-tyrosine kinase

Gene

Lck

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

  1. ATPase binding Source: MGI
  2. ATP binding Source: UniProtKB-KW
  3. CD4 receptor binding Source: MGI
  4. CD8 receptor binding Source: MGI
  5. glycoprotein binding Source: MGI
  6. identical protein binding Source: MGI
  7. non-membrane spanning protein tyrosine kinase activity Source: GO_Central
  8. phosphatidylinositol 3-kinase binding Source: MGI
  9. protein C-terminus binding Source: MGI
  10. protein kinase binding Source: MGI
  11. protein phosphatase binding Source: MGI
  12. protein serine/threonine phosphatase activity Source: MGI
  13. protein tyrosine kinase activity Source: MGI
  14. receptor binding Source: GO_Central
  15. SH2 domain binding Source: MGI

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  2. B cell receptor signaling pathway Source: MGI
  3. cell surface receptor signaling pathway Source: MGI
  4. cellular response to peptide hormone stimulus Source: GO_Central
  5. dephosphorylation Source: MGI
  6. innate immune response Source: GO_Central
  7. peptidyl-tyrosine autophosphorylation Source: GO_Central
  8. peptidyl-tyrosine phosphorylation Source: MGI
  9. positive regulation of gamma-delta T cell differentiation Source: MGI
  10. positive regulation of gene expression Source: MGI
  11. positive regulation of intrinsic apoptotic signaling pathway Source: MGI
  12. positive regulation of T cell activation Source: MGI
  13. positive regulation of T cell receptor signaling pathway Source: GO_Central
  14. positive regulation of tyrosine phosphorylation of Stat5 protein Source: MGI
  15. protein autophosphorylation Source: MGI
  16. protein phosphorylation Source: MGI
  17. regulation of apoptotic process Source: GO_Central
  18. regulation of cell proliferation Source: GO_Central
  19. regulation of T cell receptor signaling pathway Source: MGI
  20. response to drug Source: MGI
  21. T cell differentiation Source: MGI
  22. transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific protein-tyrosine kinaseSAAS annotation (EC:2.7.10.2SAAS annotation)
Gene namesi
Name:LckImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96756. Lck.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
  4. immunological synapse Source: MGI
  5. membrane raft Source: MGI
  6. pericentriolar material Source: MGI
  7. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ3TLX4.

Structurei

3D structure databases

ProteinModelPortaliQ3TLX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG008761.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3TLX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AFSSSTSLLF PPPISNLSSG SFSLSVRDFD QNQGEVVKHY KIRNLDNGGF
60 70 80 90 100
YISPRITFPG LHDLVRHYTN ASDGLCTKLS RPCQTQKPQK PWWEDEWEVP
110 120 130 140 150
RETLKLVERL GAGQFGEVWM GYYNGHTKVA VKSLKQGSMS PDAFLAEANL
160 170 180 190 200
MKQLQHPRLV RLYAVVTQEP IYIITEYMEN GSLVDFLKTP SGIKLNVNKL
210 220 230 240 250
LDMAAQIAEG MAFIEEQNYI HRDLRAANIL VSDTLSCKIA DFGLARLIED
260 270 280 290 300
NEYTAREGAK FPIKWTAPEA INYGTFTIKS DVWSFGILLT EIVTHGRIPY
310 320 330 340 350
PGMTNPEVIQ NLERGYRMVR PDNCPEELYH LMMLCWKERP EDRPTFDYLR
360
SVLDDFFTAT EGQYQPQP
Length:368
Mass (Da):42,018
Last modified:October 11, 2005 - v1
Checksum:i7AB6AE53AF1A5059
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK166263 mRNA. Translation: BAE38668.1.
UniGeneiMm.293753.

Genome annotation databases

UCSCiuc008uxh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK166263 mRNA. Translation: BAE38668.1.
UniGeneiMm.293753.

3D structure databases

ProteinModelPortaliQ3TLX4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc008uxh.2. mouse.

Organism-specific databases

MGIiMGI:96756. Lck.

Phylogenomic databases

HOVERGENiHBG008761.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

GenevestigatoriQ3TLX4.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Mammary glandImported.

Entry informationi

Entry nameiQ3TLX4_MOUSE
AccessioniPrimary (citable) accession number: Q3TLX4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: March 4, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.