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Q3TLX4

- Q3TLX4_MOUSE

UniProt

Q3TLX4 - Q3TLX4_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Lck

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: MGI
    3. protein tyrosine kinase activity Source: MGI

    GO - Biological processi

    1. B cell receptor signaling pathway Source: MGI
    2. cell surface receptor signaling pathway Source: MGI
    3. peptidyl-tyrosine phosphorylation Source: MGI
    4. positive regulation of gamma-delta T cell differentiation Source: MGI
    5. positive regulation of gene expression Source: MGI
    6. positive regulation of tyrosine phosphorylation of Stat5 protein Source: MGI
    7. protein autophosphorylation Source: MGI
    8. protein phosphorylation Source: MGI
    9. regulation of T cell receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:LckImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:96756. Lck.

    Subcellular locationi

    GO - Cellular componenti

    1. cell-cell junction Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ3TLX4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3TLX4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG008761.
    InParanoidiQ3TLX4.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00252. SH2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q3TLX4-1 [UniParc]FASTAAdd to Basket

    « Hide

    AFSSSTSLLF PPPISNLSSG SFSLSVRDFD QNQGEVVKHY KIRNLDNGGF    50
    YISPRITFPG LHDLVRHYTN ASDGLCTKLS RPCQTQKPQK PWWEDEWEVP 100
    RETLKLVERL GAGQFGEVWM GYYNGHTKVA VKSLKQGSMS PDAFLAEANL 150
    MKQLQHPRLV RLYAVVTQEP IYIITEYMEN GSLVDFLKTP SGIKLNVNKL 200
    LDMAAQIAEG MAFIEEQNYI HRDLRAANIL VSDTLSCKIA DFGLARLIED 250
    NEYTAREGAK FPIKWTAPEA INYGTFTIKS DVWSFGILLT EIVTHGRIPY 300
    PGMTNPEVIQ NLERGYRMVR PDNCPEELYH LMMLCWKERP EDRPTFDYLR 350
    SVLDDFFTAT EGQYQPQP 368
    Length:368
    Mass (Da):42,018
    Last modified:October 11, 2005 - v1
    Checksum:i7AB6AE53AF1A5059
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK166263 mRNA. Translation: BAE38668.1.
    UniGeneiMm.293753.

    Genome annotation databases

    UCSCiuc008uxh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK166263 mRNA. Translation: BAE38668.1 .
    UniGenei Mm.293753.

    3D structure databases

    ProteinModelPortali Q3TLX4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc008uxh.2. mouse.

    Organism-specific databases

    MGIi MGI:96756. Lck.

    Phylogenomic databases

    HOVERGENi HBG008761.
    InParanoidi Q3TLX4.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3TLX4.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00252. SH2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Mammary glandImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Mammary glandImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Mammary glandImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Mammary glandImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Mammary glandImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Mammary glandImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Mammary glandImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Mammary glandImported.

    Entry informationi

    Entry nameiQ3TLX4_MOUSE
    AccessioniPrimary (citable) accession number: Q3TLX4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)