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Q3TLS3

- GDPP1_MOUSE

UniProt

Q3TLS3 - GDPP1_MOUSE

Protein

GDP-D-glucose phosphorylase 1

Gene

Gdpgp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.By similarity

    Catalytic activityi

    GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei219 – 2191Tele-GMP-histidine intermediateBy similarity

    GO - Molecular functioni

    1. GDP-D-glucose phosphorylase activity Source: UniProtKB
    2. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
    3. hydrolase activity Source: UniProtKB-KW
    4. nucleotide binding Source: UniProtKB-KW
    5. nucleotidyltransferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. glucose metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor, Hydrolase, Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GDP-D-glucose phosphorylase 1 (EC:2.7.7.78)
    Gene namesi
    Name:Gdpgp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2443429. Gdpgp1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 386386GDP-D-glucose phosphorylase 1PRO_0000336752Add
    BLAST

    Proteomic databases

    PaxDbiQ3TLS3.
    PRIDEiQ3TLS3.

    Expressioni

    Tissue specificityi

    Highly expressed in the nervous and male reproductive systems compared to kidney, liver and heart.1 Publication

    Gene expression databases

    BgeeiQ3TLS3.
    GenevestigatoriQ3TLS3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3TLS3.
    SMRiQ3TLS3. Positions 151-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GDPGP1 family.Curated

    Phylogenomic databases

    eggNOGiNOG307761.
    GeneTreeiENSGT00390000016718.
    HOVERGENiHBG106673.
    InParanoidiQ3TLS3.
    KOiK15630.
    OMAiGIQWPRN.
    OrthoDBiEOG7M98H0.
    PhylomeDBiQ3TLS3.
    TreeFamiTF313615.

    Family and domain databases

    InterProiIPR026506. GDPGP.
    [Graphical view]
    PANTHERiPTHR20884. PTHR20884. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3TLS3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVPHHLQET SYLLPPDPED WEKQGIPDFV YGQEDLVGKE VQWPRDSPSA    50
    VDTVPLSRFD SALRSAWRQR LELGLFRYRL EDLQTQILPG SVGFVAQLNI 100
    ERGIQRRRPQ NIRSVRQEFD PEQFNFNKIR PGEVLFRMQR EPKGPATPKQ 150
    EDDVLVVINV SPLEWGHVLL VPAPAQGLPQ RLLPGVLRVG LEAVLLSLHP 200
    GFRVGFNSLG GLASVNHLHL HCYYLAHPLP VEGAPSTPLD PKGCIHLLQA 250
    LPAPGFLFYT SGPGPDLEVL ISRVCRATDY LSDREIAHNL FVTRGAPPGP 300
    TSSTSDLSGI RVILWARKSS FGIKESGAFN VALCELAGHL PVKTSQDFSS 350
    LTEAAAVALI QDCLLPETQA GEVRAALVAL MAQEEL 386
    Length:386
    Mass (Da):42,515
    Last modified:May 20, 2008 - v2
    Checksum:iB69E1EECF9D719A0
    GO

    Sequence cautioni

    The sequence BAC39476.1 differs from that shown. Reason: Frameshift at positions 186, 265 and 355.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71L → S in BAE38719. (PubMed:16141072)Curated
    Sequence conflicti7 – 71L → S in AAH37479. (PubMed:15489334)Curated
    Sequence conflicti8 – 81Q → L in AAH37479. (PubMed:15489334)Curated
    Sequence conflicti44 – 441P → S in BAE25508. (PubMed:16141072)Curated
    Sequence conflicti81 – 811E → K in BAC39476. (PubMed:16141072)Curated
    Sequence conflicti95 – 951V → L in BAC39476. (PubMed:16141072)Curated
    Sequence conflicti101 – 1011E → D in AAH37479. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK084531 mRNA. Translation: BAC39213.1.
    AK085577 mRNA. Translation: BAC39476.1. Frameshift.
    AK143704 mRNA. Translation: BAE25508.1.
    AK166345 mRNA. Translation: BAE38719.1.
    BC037479 mRNA. Translation: AAH37479.1.
    CCDSiCCDS39995.1.
    RefSeqiNP_848867.2. NM_178752.3.
    UniGeneiMm.187733.

    Genome annotation databases

    EnsembliENSMUST00000062915; ENSMUSP00000061808; ENSMUSG00000050973.
    GeneIDi269952.
    KEGGimmu:269952.
    UCSCiuc009hzu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK084531 mRNA. Translation: BAC39213.1 .
    AK085577 mRNA. Translation: BAC39476.1 . Frameshift.
    AK143704 mRNA. Translation: BAE25508.1 .
    AK166345 mRNA. Translation: BAE38719.1 .
    BC037479 mRNA. Translation: AAH37479.1 .
    CCDSi CCDS39995.1.
    RefSeqi NP_848867.2. NM_178752.3.
    UniGenei Mm.187733.

    3D structure databases

    ProteinModelPortali Q3TLS3.
    SMRi Q3TLS3. Positions 151-224.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q3TLS3.
    PRIDEi Q3TLS3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000062915 ; ENSMUSP00000061808 ; ENSMUSG00000050973 .
    GeneIDi 269952.
    KEGGi mmu:269952.
    UCSCi uc009hzu.1. mouse.

    Organism-specific databases

    CTDi 390637.
    MGIi MGI:2443429. Gdpgp1.

    Phylogenomic databases

    eggNOGi NOG307761.
    GeneTreei ENSGT00390000016718.
    HOVERGENi HBG106673.
    InParanoidi Q3TLS3.
    KOi K15630.
    OMAi GIQWPRN.
    OrthoDBi EOG7M98H0.
    PhylomeDBi Q3TLS3.
    TreeFami TF313615.

    Miscellaneous databases

    NextBioi 393115.
    PROi Q3TLS3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3TLS3.
    Genevestigatori Q3TLS3.

    Family and domain databases

    InterProi IPR026506. GDPGP.
    [Graphical view ]
    PANTHERi PTHR20884. PTHR20884. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Heart, Kidney, Mammary gland and Spleen.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. "A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals."
      Adler L.N., Gomez T.A., Clarke S.G., Linster C.L.
      J. Biol. Chem. 286:21511-21523(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiGDPP1_MOUSE
    AccessioniPrimary (citable) accession number: Q3TLS3
    Secondary accession number(s): Q3UP89
    , Q8C3L2, Q8C3Y3, Q8CI49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 60 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The orthologs in A.thaliana are GDP-L-galactose phosphorylases catalyzing the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3