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Q3TLS3 (GDPP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GDP-D-glucose phosphorylase 1

EC=2.7.7.78
Gene names
Name:Gdpgp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells By similarity.

Catalytic activity

GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Highly expressed in the nervous and male reproductive systems compared to kidney, liver and heart. Ref.3

Miscellaneous

The orthologs in A.thaliana are GDP-L-galactose phosphorylases catalyzing the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.

Sequence similarities

Belongs to the GDPGP1 family.

Sequence caution

The sequence BAC39476.1 differs from that shown. Reason: Frameshift at positions 186, 265 and 355.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 386386GDP-D-glucose phosphorylase 1
PRO_0000336752

Sites

Active site2191Tele-GMP-histidine intermediate By similarity

Experimental info

Sequence conflict71L → S in BAE38719. Ref.1
Sequence conflict71L → S in AAH37479. Ref.2
Sequence conflict81Q → L in AAH37479. Ref.2
Sequence conflict441P → S in BAE25508. Ref.1
Sequence conflict811E → K in BAC39476. Ref.1
Sequence conflict951V → L in BAC39476. Ref.1
Sequence conflict1011E → D in AAH37479. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q3TLS3 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: B69E1EECF9D719A0

FASTA38642,515
        10         20         30         40         50         60 
MAVPHHLQET SYLLPPDPED WEKQGIPDFV YGQEDLVGKE VQWPRDSPSA VDTVPLSRFD 

        70         80         90        100        110        120 
SALRSAWRQR LELGLFRYRL EDLQTQILPG SVGFVAQLNI ERGIQRRRPQ NIRSVRQEFD 

       130        140        150        160        170        180 
PEQFNFNKIR PGEVLFRMQR EPKGPATPKQ EDDVLVVINV SPLEWGHVLL VPAPAQGLPQ 

       190        200        210        220        230        240 
RLLPGVLRVG LEAVLLSLHP GFRVGFNSLG GLASVNHLHL HCYYLAHPLP VEGAPSTPLD 

       250        260        270        280        290        300 
PKGCIHLLQA LPAPGFLFYT SGPGPDLEVL ISRVCRATDY LSDREIAHNL FVTRGAPPGP 

       310        320        330        340        350        360 
TSSTSDLSGI RVILWARKSS FGIKESGAFN VALCELAGHL PVKTSQDFSS LTEAAAVALI 

       370        380 
QDCLLPETQA GEVRAALVAL MAQEEL 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Heart, Kidney, Mammary gland and Spleen.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[3]"A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals."
Adler L.N., Gomez T.A., Clarke S.G., Linster C.L.
J. Biol. Chem. 286:21511-21523(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK084531 mRNA. Translation: BAC39213.1.
AK085577 mRNA. Translation: BAC39476.1. Frameshift.
AK143704 mRNA. Translation: BAE25508.1.
AK166345 mRNA. Translation: BAE38719.1.
BC037479 mRNA. Translation: AAH37479.1.
CCDSCCDS39995.1.
RefSeqNP_848867.2. NM_178752.3.
UniGeneMm.187733.

3D structure databases

ProteinModelPortalQ3TLS3.
SMRQ3TLS3. Positions 151-224.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ3TLS3.
PRIDEQ3TLS3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000062915; ENSMUSP00000061808; ENSMUSG00000050973.
GeneID269952.
KEGGmmu:269952.
UCSCuc009hzu.1. mouse.

Organism-specific databases

CTD390637.
MGIMGI:2443429. Gdpgp1.

Phylogenomic databases

eggNOGNOG307761.
GeneTreeENSGT00390000016718.
HOVERGENHBG106673.
InParanoidQ3TLS3.
KOK15630.
OMAGIQWPRN.
OrthoDBEOG7M98H0.
PhylomeDBQ3TLS3.
TreeFamTF313615.

Gene expression databases

BgeeQ3TLS3.
GenevestigatorQ3TLS3.

Family and domain databases

InterProIPR026506. GDPGP.
[Graphical view]
PANTHERPTHR20884. PTHR20884. 1 hit.
ProtoNetSearch...

Other

NextBio393115.
PROQ3TLS3.
SOURCESearch...

Entry information

Entry nameGDPP1_MOUSE
AccessionPrimary (citable) accession number: Q3TLS3
Secondary accession number(s): Q3UP89 expand/collapse secondary AC list , Q8C3L2, Q8C3Y3, Q8CI49
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: July 9, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot