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Q3TLS3

- GDPP1_MOUSE

UniProt

Q3TLS3 - GDPP1_MOUSE

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Protein

GDP-D-glucose phosphorylase 1

Gene

Gdpgp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.By similarity

Catalytic activityi

GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei219 – 2191Tele-GMP-histidine intermediateBy similarity

GO - Molecular functioni

  1. GDP-D-glucose phosphorylase activity Source: UniProtKB
  2. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
  3. hydrolase activity Source: UniProtKB-KW
  4. nucleotide binding Source: UniProtKB-KW
  5. nucleotidyltransferase activity Source: UniProtKB-KW

GO - Biological processi

  1. glucose metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor, Hydrolase, Nucleotidyltransferase, Transferase

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-D-glucose phosphorylase 1 (EC:2.7.7.78)
Gene namesi
Name:Gdpgp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2443429. Gdpgp1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386GDP-D-glucose phosphorylase 1PRO_0000336752Add
BLAST

Proteomic databases

MaxQBiQ3TLS3.
PaxDbiQ3TLS3.
PRIDEiQ3TLS3.

Expressioni

Tissue specificityi

Highly expressed in the nervous and male reproductive systems compared to kidney, liver and heart.1 Publication

Gene expression databases

BgeeiQ3TLS3.
GenevestigatoriQ3TLS3.

Structurei

3D structure databases

ProteinModelPortaliQ3TLS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDPGP1 family.Curated

Phylogenomic databases

eggNOGiNOG307761.
GeneTreeiENSGT00390000016718.
HOVERGENiHBG106673.
InParanoidiQ3TLS3.
KOiK15630.
OMAiGIQWPRN.
OrthoDBiEOG7M98H0.
PhylomeDBiQ3TLS3.
TreeFamiTF313615.

Family and domain databases

InterProiIPR026506. GDPGP.
[Graphical view]
PANTHERiPTHR20884. PTHR20884. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3TLS3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVPHHLQET SYLLPPDPED WEKQGIPDFV YGQEDLVGKE VQWPRDSPSA
60 70 80 90 100
VDTVPLSRFD SALRSAWRQR LELGLFRYRL EDLQTQILPG SVGFVAQLNI
110 120 130 140 150
ERGIQRRRPQ NIRSVRQEFD PEQFNFNKIR PGEVLFRMQR EPKGPATPKQ
160 170 180 190 200
EDDVLVVINV SPLEWGHVLL VPAPAQGLPQ RLLPGVLRVG LEAVLLSLHP
210 220 230 240 250
GFRVGFNSLG GLASVNHLHL HCYYLAHPLP VEGAPSTPLD PKGCIHLLQA
260 270 280 290 300
LPAPGFLFYT SGPGPDLEVL ISRVCRATDY LSDREIAHNL FVTRGAPPGP
310 320 330 340 350
TSSTSDLSGI RVILWARKSS FGIKESGAFN VALCELAGHL PVKTSQDFSS
360 370 380
LTEAAAVALI QDCLLPETQA GEVRAALVAL MAQEEL
Length:386
Mass (Da):42,515
Last modified:May 20, 2008 - v2
Checksum:iB69E1EECF9D719A0
GO

Sequence cautioni

The sequence BAC39476.1 differs from that shown. Reason: Frameshift at positions 186, 265 and 355. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71L → S in BAE38719. (PubMed:16141072)Curated
Sequence conflicti7 – 71L → S in AAH37479. (PubMed:15489334)Curated
Sequence conflicti8 – 81Q → L in AAH37479. (PubMed:15489334)Curated
Sequence conflicti44 – 441P → S in BAE25508. (PubMed:16141072)Curated
Sequence conflicti81 – 811E → K in BAC39476. (PubMed:16141072)Curated
Sequence conflicti95 – 951V → L in BAC39476. (PubMed:16141072)Curated
Sequence conflicti101 – 1011E → D in AAH37479. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084531 mRNA. Translation: BAC39213.1.
AK085577 mRNA. Translation: BAC39476.1. Frameshift.
AK143704 mRNA. Translation: BAE25508.1.
AK166345 mRNA. Translation: BAE38719.1.
BC037479 mRNA. Translation: AAH37479.1.
CCDSiCCDS39995.1.
RefSeqiNP_848867.2. NM_178752.3.
UniGeneiMm.187733.

Genome annotation databases

EnsembliENSMUST00000062915; ENSMUSP00000061808; ENSMUSG00000050973.
GeneIDi269952.
KEGGimmu:269952.
UCSCiuc009hzu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084531 mRNA. Translation: BAC39213.1 .
AK085577 mRNA. Translation: BAC39476.1 . Frameshift.
AK143704 mRNA. Translation: BAE25508.1 .
AK166345 mRNA. Translation: BAE38719.1 .
BC037479 mRNA. Translation: AAH37479.1 .
CCDSi CCDS39995.1.
RefSeqi NP_848867.2. NM_178752.3.
UniGenei Mm.187733.

3D structure databases

ProteinModelPortali Q3TLS3.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi Q3TLS3.
PaxDbi Q3TLS3.
PRIDEi Q3TLS3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000062915 ; ENSMUSP00000061808 ; ENSMUSG00000050973 .
GeneIDi 269952.
KEGGi mmu:269952.
UCSCi uc009hzu.1. mouse.

Organism-specific databases

CTDi 390637.
MGIi MGI:2443429. Gdpgp1.

Phylogenomic databases

eggNOGi NOG307761.
GeneTreei ENSGT00390000016718.
HOVERGENi HBG106673.
InParanoidi Q3TLS3.
KOi K15630.
OMAi GIQWPRN.
OrthoDBi EOG7M98H0.
PhylomeDBi Q3TLS3.
TreeFami TF313615.

Miscellaneous databases

NextBioi 393115.
PROi Q3TLS3.
SOURCEi Search...

Gene expression databases

Bgeei Q3TLS3.
Genevestigatori Q3TLS3.

Family and domain databases

InterProi IPR026506. GDPGP.
[Graphical view ]
PANTHERi PTHR20884. PTHR20884. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart, Kidney, Mammary gland and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals."
    Adler L.N., Gomez T.A., Clarke S.G., Linster C.L.
    J. Biol. Chem. 286:21511-21523(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiGDPP1_MOUSE
AccessioniPrimary (citable) accession number: Q3TLS3
Secondary accession number(s): Q3UP89
, Q8C3L2, Q8C3Y3, Q8CI49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The orthologs in A.thaliana are GDP-L-galactose phosphorylases catalyzing the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3