Q3TLH4 (PRC2C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein PRRC2C

Alternative name(s):
BAT2 domain-containing protein 1
HLA-B-associated transcript 2-like 2
Proline-rich and coiled-coil-containing protein 2C

Gene names

Name:	Prrc2c
Synonyms:	Bat2d, Bat2d1, Bat2l2, Kiaa1096

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2846 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence caution

The sequence AAH06723.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAH21412.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAH37745.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAH80672.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAH99612.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence BAC25414.1 differs from that shown. Reason: Frameshift at positions 199, 239, 376 and 379. The sequence BAC65723.1 differs from that shown. Reason: Frameshift at position 1877. The sequence BAE22468.1 differs from that shown. Reason: Probable cloning artifact.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q3TLH4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 5 (identifier: Q3TLH4-5)

The sequence of this isoform differs from the canonical sequence as follows:
     2684-2762: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2846	2846	Protein PRRC2C		PRO_0000349240
Regions
	Coiled coil	995 – 1026	32	Potential
	Coiled coil	1655 – 1681	27	Potential
	Compositional bias	381 – 440	60	Pro-rich
	Compositional bias	468 – 627	160	Glu-rich
	Compositional bias	530 – 679	150	Gln-rich
	Compositional bias	673 – 745	73	Pro-rich
	Compositional bias	1033 – 1062	30	Pro-rich
	Compositional bias	1314 – 1416	103	Arg-rich
	Compositional bias	1716 – 1913	198	Pro-rich
	Compositional bias	1732 – 1739	8	Poly-Ala
	Compositional bias	1790 – 1793	4	Poly-Ser
	Compositional bias	2297 – 2586	290	Gln-rich
Amino acid modifications
	Modified residue	27	1	N6-acetyllysine By similarity
	Modified residue	102	1	Phosphoserine Ref.7
	Modified residue	189	1	Phosphoserine By similarity
	Modified residue	192	1	Phosphoserine By similarity
	Modified residue	393	1	N6-acetyllysine By similarity
	Modified residue	501	1	Phosphoserine By similarity
	Modified residue	755	1	Phosphoserine By similarity
	Modified residue	777	1	Phosphoserine By similarity
	Modified residue	853	1	Phosphoserine Ref.6 Ref.7
	Modified residue	899	1	Phosphoserine Ref.6
	Modified residue	1219	1	Phosphoserine Ref.6
	Modified residue	1221	1	Phosphoserine By similarity
	Modified residue	1236	1	Phosphoserine By similarity
	Modified residue	1238	1	Phosphothreonine By similarity
	Modified residue	1240	1	Phosphothreonine By similarity
	Modified residue	1917	1	Phosphothreonine By similarity
	Modified residue	1935	1	Phosphoserine Ref.5
	Modified residue	1965	1	Phosphoserine By similarity
	Modified residue	2057	1	Phosphoserine By similarity
	Modified residue	2095	1	Phosphoserine By similarity
	Modified residue	2625	1	Phosphothreonine Ref.6 Ref.7 Ref.8
	Modified residue	2634	1	Phosphothreonine By similarity
	Modified residue	2638	1	Phosphoserine By similarity
	Modified residue	2646	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	2684 – 2762	79	Missing in isoform 5.		VSP_035255
Experimental info
	Sequence conflict	38 – 39	2	Missing in AAH80672. Ref.2
	Sequence conflict	38 – 39	2	Missing in BAC25414. Ref.2
	Sequence conflict	38 – 39	2	Missing in BAE38818. Ref.2
	Sequence conflict	38 – 39	2	Missing in BAE39192. Ref.2
	Sequence conflict	186	1	S → C in BAE38818. Ref.2
	Sequence conflict	264	1	G → V in BAC25414. Ref.2
	Sequence conflict	347	1	K → E in BAC25414. Ref.2
	Sequence conflict	376 – 378	3	SSS → IIF in BAC25414. Ref.2
	Sequence conflict	382	1	A → T in BAE38818. Ref.2
	Sequence conflict	563	1	E → K in AAH64009. Ref.3
	Sequence conflict	846	1	E → G in BAE38818. Ref.2
	Sequence conflict	1362	1	E → G in BAC65723. Ref.4
	Sequence conflict	1491	1	K → M in BAC65723. Ref.4
	Sequence conflict	1686	1	N → K in AAH50871. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 9, 2013. Version 3. Checksum: 2AEFFE844FBC60C8	FASTA	2,846	310,892
	10 20 30 40 50 60 MSEKSGQSTK AKDGKKYATL SLFNTYKGKS LETQKTTVAA RHGLQSLGKV GISRRMPPPA 70 80 90 100 110 120 NLPSLKAENK GNDPNVNIVP KDGTGWASKQ EQHEEEKAPE VSPAQPKPGV AAPPEVAPAP 130 140 150 160 170 180 KSWASNKQGG QGDGIQVNSQ FQQEFPSLQA AGDQEKKEKE ANDENYGPGP SLRPPNVACW 190 200 210 220 230 240 RDGGKSAGSP SSDQDEKQLG QDESTAITSE QNDILKVVEK RIACGPPQAK LNGQQPALAS 250 260 270 280 290 300 QYRAMMPPYM FQQYPRMAYP PLHGPMRFPP SLSEANKSLR GRGPPPSWAS EPERPSILSA 310 320 330 340 350 360 SELKELDKFD NLDAEADEGW AGAQMEVDYT EQLNFSDDDE QGSTSPKESS SEDQTAKTPE 370 380 390 400 410 420 STENRKEVDE ASSTKSSSQI PAQPPVTKSP YGKGPPFNQE RGPSSHLPPP PKLLAQQHPP 430 440 450 460 470 480 PPDRQIPGRQ GPFPSKPPVP DNDEIWKQRR KQQSEISAAV ERARKRREEE ERRMEEQRKA 490 500 510 520 530 540 ACAEKLKQLD EKLGIIEKQP SPEELRERER EKERERELEK EKERELEKEQ EKQREMERAR 550 560 570 580 590 600 QQEKELEQQR EKEQELQRLR EQEKEGEPKE QEKEEKVEPQ EPVVEPATEN QESENNCKKE 610 620 630 640 650 660 EEPIFTRQDS NRSEKETTQV VQEAEPESGA QPRPGYFKQF QKSLPPRFQR QQEQMKQQQW 670 680 690 700 710 720 QQQQQQQQQG VLPQTVPSQP SNGSVPPPPH RPLYQPMQPH PQHLASMGFD PRWLMMQSYM 730 740 750 760 770 780 DPRMISGRPA MDIPPIHPGM IPPKPLIRRD QMEGSPNSSE SFEHIARSAR DHGISLSEPR 790 800 810 820 830 840 MMWGSDPYHA EPQQAATPKS AEETGDARPE TAMDHEHMTA AYPVEHSQLE THSKTDVARD 850 860 870 880 890 900 STETEEQKFL SRSLEDVKPR HVDTNTQSAC FDVIDQKSLP TSAEERISAL ESQPARKRSV 910 920 930 940 950 960 SHGSNHAQNA EEQRNEPSVS IPKVINRCMD SKETVEKPEE KPRKDGFLRS SEGPKPEKVY 970 980 990 1000 1010 1020 KSKSETRWGP RPSSNRREEG NDRPVRRSGP IKKPVLRDMK EEREQRKEKE GEKLEKVTEK 1030 1040 1050 1060 1070 1080 VVKAEKPEKK DLPLPLPPPA PAQPQPQPLV SPPVQPEPEK PPSTETSTLT QKPSQDEKPL 1090 1100 1110 1120 1130 1140 EPVGSVQVEP VVKTVNQQSV AAPTVKEEKP PEKVINKDVG IERSRPDSRL AVKKDSSLPT 1150 1160 1170 1180 1190 1200 RTYWKEARDR DWFPDQGYRG RGRGEYYSRG RSYRGSYGGR GRGGRGHTRE YPQYRDNKPR 1210 1220 1230 1240 1250 1260 TEHVPSGPLR QREESETRSE SSDFEVVPKR RRQRGSETDT DSEVHESASD KDSVSKGKLP 1270 1280 1290 1300 1310 1320 KREERPENKK PVKPQSSFKP ENHVRIDNRP LEKPYIREED KSKPGFLPKG EPTRRGRGGT 1330 1340 1350 1360 1370 1380 FRRGGRDPGG RPSRPATLRR PAYRDNQWNT RQAEPPKPED GEPPRRHEQF MPIPADKRPP 1390 1400 1410 1420 1430 1440 KFERKFDPAR ERPRRQRPTR PPRQDKPPRF RRLREREAAS KTSEVLVPSN GTANNVVQEP 1450 1460 1470 1480 1490 1500 VNPPADISGN KTPDLSNQNS SDQANEEWET ASESSDFNER RERDEKKNAD KSSQAVVKAG 1510 1520 1530 1540 1550 1560 ESVLPPKREI AKRSFSSQRP GVDRQNRRGN NGPPKSGRNF SGPRNERRNG PPSKGGKRGP 1570 1580 1590 1600 1610 1620 FDDQASGTAG ADPVSGNSAH HQEGVPNGAG QKNSKDAAGK KREDTKPGPK KPKEKVDALS 1630 1640 1650 1660 1670 1680 QFDLNNYASV VIIDDHPEVT VIEDPQSNLN DDGFTEVVSK KQQKRLQDEE RRKKEEQVVQ 1690 1700 1710 1720 1730 1740 VWSKKNIGEK GRSQTSKLPP RFAKKQATGT QQIQAPPSAP VPVSSSAPGL TAPAAAAPAS 1750 1760 1770 1780 1790 1800 TPAPVPILAS ATALVPVSTP APVLTSCPAP VPTSASAPVP ASTSSPVTAS SSSQPSVPAP 1810 1820 1830 1840 1850 1860 TPVLASASTT VSVPILTSAS IPILASALAP ATVSSPTPVV SATAVPSIST PAVPASAPTA 1870 1880 1890 1900 1910 1920 SVPLAPASAA STVPPPASTV QTQTQTQTHK PVQSPLPPSA PSSKQPPPSI RLPSAQTSNG 1930 1940 1950 1960 1970 1980 TDFVAAGKSM PTSQSHGSLT AELWDSKVAA PAVLNDISKK LGPISPPQPP SVSAWNKPLT 1990 2000 2010 2020 2030 2040 SFGSATSSEG TRNGQESGVE IGIDTIQFGA PASNGNENEV VPVLSEKATD KVPEPKEQRQ 2050 2060 2070 2080 2090 2100 KQPRAGPIKA QKLPDLSLVE NKEHKPGPIG KERSLKNRKV KDAQQVEPEG QEKPSPAVVR 2110 2120 2130 2140 2150 2160 STDPETAKET KAVSEMSAEI GAMISVSSAE YGSDAKESVT DYTTPSSSLP NTVATNNAKM 2170 2180 2190 2200 2210 2220 EDTLVNNVPL PNTLPLPKRE TIQQSSSLTS VPPTTFSLTF KMESARKAWE NSPNLREKGS 2230 2240 2250 2260 2270 2280 PVTSTAPPIV SGVSSSASGP STANYSSFSS ASMPQIPVAS VTPTASLSGA GTYTTSSLST 2290 2300 2310 2320 2330 2340 KSTTTSDPPN ICKVKPQQLQ TSSLPSASHF SQLSCMPSLI AQQQQSPQVY VSQSAAAQIP 2350 2360 2370 2380 2390 2400 AFYMDTSHLF NTQHARLAPP SLAQQQGFQP GLSQPTSVQQ IPIPIYAPLQ GQHQAQLSLG 2410 2420 2430 2440 2450 2460 AGPAVSQAQE LFSSSIQPYR SQPAFMQSSL SQPSVVLSGT AIHNFPAVQH QELAKAQSGL 2470 2480 2490 2500 2510 2520 AFQQTSNPQP IPILYDHQLG QASGLGSSQL IDTHLLQARA NLTQASNLYS GQVQQPGQTN 2530 2540 2550 2560 2570 2580 FYNTAQSPSA LQQVTVPLPA SQLSLTNFGS TGQPLIALPQ TLQPQLQHTT PQAQAQSLSR 2590 2600 2610 2620 2630 2640 PAQVSQPFRG LIPAGTQHSM MATTGKMSEM ELKAFGSGID IKPGTPPIGG RSTTPTSSPF 2650 2660 2670 2680 2690 2700 RATSTSPNSQ SSKMNSVVYQ KQFQSAPATV RMAQPFPAQF APQILSQPNL VPPLVRAPHT 2710 2720 2730 2740 2750 2760 NTFPAPVQRP PMALASQMPP PLTTGLMSHA RLPHVARGPC GSLSGVRGNQ AQAALKAEQD 2770 2780 2790 2800 2810 2820 LKAKQRAEVL QSTQRFFSEQ QQNKQIGGKT QRVDSDTSNP ETLSDPPGTC PEKVEEKPPP 2830 2840 APTITTKPVR TGPIKPQAIK TEETKS
	Isoform 5 [UniParc]. Checksum: A23A9945F3F383F2	FASTA	2,767	302,606
	10 20 30 40 50 60 MSEKSGQSTK AKDGKKYATL SLFNTYKGKS LETQKTTVAA RHGLQSLGKV GISRRMPPPA 70 80 90 100 110 120 NLPSLKAENK GNDPNVNIVP KDGTGWASKQ EQHEEEKAPE VSPAQPKPGV AAPPEVAPAP 130 140 150 160 170 180 KSWASNKQGG QGDGIQVNSQ FQQEFPSLQA AGDQEKKEKE ANDENYGPGP SLRPPNVACW 190 200 210 220 230 240 RDGGKSAGSP SSDQDEKQLG QDESTAITSE QNDILKVVEK RIACGPPQAK LNGQQPALAS 250 260 270 280 290 300 QYRAMMPPYM FQQYPRMAYP PLHGPMRFPP SLSEANKSLR GRGPPPSWAS EPERPSILSA 310 320 330 340 350 360 SELKELDKFD NLDAEADEGW AGAQMEVDYT EQLNFSDDDE QGSTSPKESS SEDQTAKTPE 370 380 390 400 410 420 STENRKEVDE ASSTKSSSQI PAQPPVTKSP YGKGPPFNQE RGPSSHLPPP PKLLAQQHPP 430 440 450 460 470 480 PPDRQIPGRQ GPFPSKPPVP DNDEIWKQRR KQQSEISAAV ERARKRREEE ERRMEEQRKA 490 500 510 520 530 540 ACAEKLKQLD EKLGIIEKQP SPEELRERER EKERERELEK EKERELEKEQ EKQREMERAR 550 560 570 580 590 600 QQEKELEQQR EKEQELQRLR EQEKEGEPKE QEKEEKVEPQ EPVVEPATEN QESENNCKKE 610 620 630 640 650 660 EEPIFTRQDS NRSEKETTQV VQEAEPESGA QPRPGYFKQF QKSLPPRFQR QQEQMKQQQW 670 680 690 700 710 720 QQQQQQQQQG VLPQTVPSQP SNGSVPPPPH RPLYQPMQPH PQHLASMGFD PRWLMMQSYM 730 740 750 760 770 780 DPRMISGRPA MDIPPIHPGM IPPKPLIRRD QMEGSPNSSE SFEHIARSAR DHGISLSEPR 790 800 810 820 830 840 MMWGSDPYHA EPQQAATPKS AEETGDARPE TAMDHEHMTA AYPVEHSQLE THSKTDVARD 850 860 870 880 890 900 STETEEQKFL SRSLEDVKPR HVDTNTQSAC FDVIDQKSLP TSAEERISAL ESQPARKRSV 910 920 930 940 950 960 SHGSNHAQNA EEQRNEPSVS IPKVINRCMD SKETVEKPEE KPRKDGFLRS SEGPKPEKVY 970 980 990 1000 1010 1020 KSKSETRWGP RPSSNRREEG NDRPVRRSGP IKKPVLRDMK EEREQRKEKE GEKLEKVTEK 1030 1040 1050 1060 1070 1080 VVKAEKPEKK DLPLPLPPPA PAQPQPQPLV SPPVQPEPEK PPSTETSTLT QKPSQDEKPL 1090 1100 1110 1120 1130 1140 EPVGSVQVEP VVKTVNQQSV AAPTVKEEKP PEKVINKDVG IERSRPDSRL AVKKDSSLPT 1150 1160 1170 1180 1190 1200 RTYWKEARDR DWFPDQGYRG RGRGEYYSRG RSYRGSYGGR GRGGRGHTRE YPQYRDNKPR 1210 1220 1230 1240 1250 1260 TEHVPSGPLR QREESETRSE SSDFEVVPKR RRQRGSETDT DSEVHESASD KDSVSKGKLP 1270 1280 1290 1300 1310 1320 KREERPENKK PVKPQSSFKP ENHVRIDNRP LEKPYIREED KSKPGFLPKG EPTRRGRGGT 1330 1340 1350 1360 1370 1380 FRRGGRDPGG RPSRPATLRR PAYRDNQWNT RQAEPPKPED GEPPRRHEQF MPIPADKRPP 1390 1400 1410 1420 1430 1440 KFERKFDPAR ERPRRQRPTR PPRQDKPPRF RRLREREAAS KTSEVLVPSN GTANNVVQEP 1450 1460 1470 1480 1490 1500 VNPPADISGN KTPDLSNQNS SDQANEEWET ASESSDFNER RERDEKKNAD KSSQAVVKAG 1510 1520 1530 1540 1550 1560 ESVLPPKREI AKRSFSSQRP GVDRQNRRGN NGPPKSGRNF SGPRNERRNG PPSKGGKRGP 1570 1580 1590 1600 1610 1620 FDDQASGTAG ADPVSGNSAH HQEGVPNGAG QKNSKDAAGK KREDTKPGPK KPKEKVDALS 1630 1640 1650 1660 1670 1680 QFDLNNYASV VIIDDHPEVT VIEDPQSNLN DDGFTEVVSK KQQKRLQDEE RRKKEEQVVQ 1690 1700 1710 1720 1730 1740 VWSKKNIGEK GRSQTSKLPP RFAKKQATGT QQIQAPPSAP VPVSSSAPGL TAPAAAAPAS 1750 1760 1770 1780 1790 1800 TPAPVPILAS ATALVPVSTP APVLTSCPAP VPTSASAPVP ASTSSPVTAS SSSQPSVPAP 1810 1820 1830 1840 1850 1860 TPVLASASTT VSVPILTSAS IPILASALAP ATVSSPTPVV SATAVPSIST PAVPASAPTA 1870 1880 1890 1900 1910 1920 SVPLAPASAA STVPPPASTV QTQTQTQTHK PVQSPLPPSA PSSKQPPPSI RLPSAQTSNG 1930 1940 1950 1960 1970 1980 TDFVAAGKSM PTSQSHGSLT AELWDSKVAA PAVLNDISKK LGPISPPQPP SVSAWNKPLT 1990 2000 2010 2020 2030 2040 SFGSATSSEG TRNGQESGVE IGIDTIQFGA PASNGNENEV VPVLSEKATD KVPEPKEQRQ 2050 2060 2070 2080 2090 2100 KQPRAGPIKA QKLPDLSLVE NKEHKPGPIG KERSLKNRKV KDAQQVEPEG QEKPSPAVVR 2110 2120 2130 2140 2150 2160 STDPETAKET KAVSEMSAEI GAMISVSSAE YGSDAKESVT DYTTPSSSLP NTVATNNAKM 2170 2180 2190 2200 2210 2220 EDTLVNNVPL PNTLPLPKRE TIQQSSSLTS VPPTTFSLTF KMESARKAWE NSPNLREKGS 2230 2240 2250 2260 2270 2280 PVTSTAPPIV SGVSSSASGP STANYSSFSS ASMPQIPVAS VTPTASLSGA GTYTTSSLST 2290 2300 2310 2320 2330 2340 KSTTTSDPPN ICKVKPQQLQ TSSLPSASHF SQLSCMPSLI AQQQQSPQVY VSQSAAAQIP 2350 2360 2370 2380 2390 2400 AFYMDTSHLF NTQHARLAPP SLAQQQGFQP GLSQPTSVQQ IPIPIYAPLQ GQHQAQLSLG 2410 2420 2430 2440 2450 2460 AGPAVSQAQE LFSSSIQPYR SQPAFMQSSL SQPSVVLSGT AIHNFPAVQH QELAKAQSGL 2470 2480 2490 2500 2510 2520 AFQQTSNPQP IPILYDHQLG QASGLGSSQL IDTHLLQARA NLTQASNLYS GQVQQPGQTN 2530 2540 2550 2560 2570 2580 FYNTAQSPSA LQQVTVPLPA SQLSLTNFGS TGQPLIALPQ TLQPQLQHTT PQAQAQSLSR 2590 2600 2610 2620 2630 2640 PAQVSQPFRG LIPAGTQHSM MATTGKMSEM ELKAFGSGID IKPGTPPIGG RSTTPTSSPF 2650 2660 2670 2680 2690 2700 RATSTSPNSQ SSKMNSVVYQ KQFQSAPATV RMAQPFPAQF APQAKQRAEV LQSTQRFFSE 2710 2720 2730 2740 2750 2760 QQQNKQIGGK TQRVDSDTSN PETLSDPPGT CPEKVEEKPP PAPTITTKPV RTGPIKPQAI KTEETKS

References

[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1105 (ISOFORM 1). Strain: C57BL/6J. Tissue: Hippocampus, Mammary gland and Wolffian duct.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-591 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1285-1687, NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2540-2811 (ISOFORM 5). Strain: C57BL/6J, Czech II and FVB/N. Tissue: Embryo, Jaw, Limb, Lung, Mammary tumor and Thymus.
[4]	"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H. DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 906-2074. Tissue: Brain.
[5]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1935, MASS SPECTROMETRY. Tissue: Liver.
[6]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-853; SER-899; SER-1219 AND THR-2625, MASS SPECTROMETRY. Tissue: Melanoma.
[7]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102; SER-853 AND THR-2625, MASS SPECTROMETRY. Tissue: Macrophage.
[8]	"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry." Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J. Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2625, MASS SPECTROMETRY. Tissue: Embryonic fibroblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC118643 Genomic DNA. No translation available. AC132867 Genomic DNA. No translation available. AK013732 mRNA. Translation: BAC25414.1. Frameshift. AK030766 mRNA. Translation: BAC27127.1. AK135245 mRNA. Translation: BAE22468.1. Sequence problems. AK166509 mRNA. Translation: BAE38818.1. AK167018 mRNA. Translation: BAE39192.1. BC006723 mRNA. Translation: AAH06723.1. Sequence problems. BC021412 mRNA. Translation: AAH21412.1. Sequence problems. BC037745 mRNA. Translation: AAH37745.1. Sequence problems. BC050871 mRNA. Translation: AAH50871.1. BC064009 mRNA. Translation: AAH64009.1. BC080672 mRNA. Translation: AAH80672.1. Sequence problems. BC099612 mRNA. Translation: AAH99612.1. Sequence problems. AK122441 Transcribed RNA. Translation: BAC65723.1. Frameshift.
IPI	IPI00330171. IPI00659535. IPI00831515. IPI00903422. IPI01007925.
RefSeq	NP_001074759.1. NM_001081290.1.
UniGene	Mm.245446.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4111556.
Proteomic databases
PaxDb	Q3TLH4.
PRIDE	Q3TLH4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000028016; ENSMUSP00000028016; ENSMUSG00000040225.
GeneID	226562.
KEGG	mmu:226562.
UCSC	uc007dgr.1. mouse. uc007dgu.1. mouse.
Organism-specific databases
CTD	23215.
MGI	MGI:1913754. Prrc2c.
Rouge	Search...
Phylogenomic databases
eggNOG	NOG271062.
GeneTree	ENSGT00530000063496.
HOVERGEN	HBG107491.
InParanoid	Q3TLH4.
OMA	IWKQRRR.
OrthoDB	EOG43BMPT.
Gene expression databases
Genevestigator	Q3TLH4.
Family and domain databases
InterPro	IPR009738. BAT2_N. [Graphical view]
Pfam	PF07001. BAT2_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PRRC2C. mouse.
NextBio	378234.
SOURCE	Search...

Entry information

Entry name

PRC2C_MOUSE

Accession

Primary (citable) accession number: Q3TLH4
Secondary accession number(s): E9QKG5 , Q05CS4, Q05DM5, Q3TKF3, Q3UXU5, Q4FZE4, Q66K03, Q6P3F4, Q80TK3, Q80YR0, Q8BMJ4, Q8C1K7, Q8CGH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	January 9, 2013
Last modified:	May 29, 2013
This is version 54 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program