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Protein

NLR family member X1

Gene

Nlrx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in antiviral signaling.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi166 – 1738ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • innate immune response Source: UniProtKB-KW
  • negative regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  • negative regulation of inflammatory response Source: MGI
  • negative regulation of innate immune response Source: MGI
  • negative regulation of interferon-beta production Source: MGI
  • negative regulation of interleukin-6 production Source: MGI
  • negative regulation of RIG-I signaling pathway Source: MGI
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity, Innate immunity

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-936440. Negative regulators of RIG-I/MDA5 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
NLR family member X1
Gene namesi
Name:Nlrx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2429611. Nlrx1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial outer membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 8686MitochondrionBy similarityAdd
BLAST
Chaini87 – 975889NLR family member X1By similarityPRO_0000296191Add
BLAST

Proteomic databases

EPDiQ3TL44.
MaxQBiQ3TL44.
PaxDbiQ3TL44.
PeptideAtlasiQ3TL44.
PRIDEiQ3TL44.

PTM databases

PhosphoSiteiQ3TL44.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032109.
CleanExiMM_NLRX1.
GenevisibleiQ3TL44. MM.

Interactioni

Subunit structurei

Homohexamer. Interacts with MAVS (By similarity).By similarity

Protein-protein interaction databases

BioGridi234769. 4 interactions.
STRINGi10090.ENSMUSP00000034621.

Structurei

3D structure databases

ProteinModelPortaliQ3TL44.
SMRiQ3TL44. Positions 157-183, 667-970.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini160 – 483324NACHTPROSITE-ProRule annotationAdd
BLAST
Domaini667 – 69428LRRNTAdd
BLAST
Repeati695 – 71824LRR 1Add
BLAST
Repeati724 – 74724LRR 2Add
BLAST
Repeati749 – 77729LRR 3Add
BLAST
Repeati778 – 80124LRR 4Add
BLAST
Repeati811 – 83424LRR 5Add
BLAST
Repeati835 – 85723LRR 6Add
BLAST
Repeati858 – 87720LRR 7Add
BLAST
Repeati878 – 89922LRR 8Add
BLAST
Domaini906 – 97065LRRCTAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni75 – 556482Required for interaction with MAVSBy similarityAdd
BLAST
Regioni556 – 974419Required for the repression of MAVS-induced interferon signalingBy similarityAdd
BLAST

Domaini

The LRRCT domain mediates homodimerization and LRRNT mediates trimerization of the dimers.By similarity

Sequence similaritiesi

Belongs to the NLRP family.Curated
Contains 8 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated
Contains 1 NACHT domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00840000129829.
HOGENOMiHOG000113797.
HOVERGENiHBG106320.
InParanoidiQ3TL44.
KOiK12653.
OMAiLHLYFNE.
OrthoDBiEOG091G01CG.
PhylomeDBiQ3TL44.
TreeFamiTF331068.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3TL44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWGCHLPRT SWGSGLGRTP QLPDEHISFL IQWSWPFKGV HPLRPPRAFI
60 70 80 90 100
RYHGNSADSA PPPGRHGQLF RSISATEAIQ RHRRNLTEWF SRLPREERQF
110 120 130 140 150
GPTFALDTVH VDPVIRESTP DELLRPSTEL ATGHQQTQAG LPPLALSQLF
160 170 180 190 200
DPDSCGRRVQ TVVLYGTVGT GKSTLVRKMV LDWCYGRLPA FELLIPFSCE
210 220 230 240 250
DLSSLGSTPA SLCQLVTQRY TPLKEVLPLM TAAGSRLLFV LHGLERLNLD
260 270 280 290 300
FRLAGTGLCS DPEEPGPPAA IIVNLLRKYM LPEASILVTT RPSTISRIPS
310 320 330 340 350
KYVGRYGEIC GFSDTNLQKL YFQLRLNQPD CGYGAGGASV SVTPAQRDNL
360 370 380 390 400
IQMLSRNLEG HHQIAAACFL PSYCWLVCAT LHFLHAPTPA GQTLTSIYTS
410 420 430 440 450
FLRLNFSGET LDSTHTSNLS LMSYAARTMG KLAYEGVSSR KTYFSEEDVR
460 470 480 490 500
GCLEAGIKTE EEFQLLQIFR RDALRFFLAP CVEPGHLGTF VFTVPAMQEY
510 520 530 540 550
LAALYIVLGL RKTALQRVGK EVVEFVGRVG EDVSLVLGIV AKLLPLRILP
560 570 580 590 600
LLFNLLKVVP RVFGRMVSKS REAVAQAMVL EMFREEDYYN DDVLDQMGAS
610 620 630 640 650
ILGVEGPRRH PDEPSEDEVF ELFPMFMGGL LSAHNRAVLA QLGCPIKNLD
660 670 680 690 700
ALENAQAIKK KLGKLGRQVL PPSELLDHLF FHYEFQNQRF SAEVLGSLRQ
710 720 730 740 750
LNLAGVRMTP LKCTVVASVL GSGRHPLDEV NLASCQLDPA GLHTLMPVLL
760 770 780 790 800
RARKLGLQLN NLGPEACRDL RDLLLHDQCQ ITTLRLSNNP LTAAGVGLLM
810 820 830 840 850
DGLAGNTSVT HLSLLHTDLG DEGLELLAAQ LDRNKQLQEL NVAYNGAGDT
860 870 880 890 900
VALALAKAAR EHPSLELLHL YFNELSSEGR QVLRDLGGSG EGGARVVASL
910 920 930 940 950
TEGTAVSEYW SVILSEVQRN VHSWDPLRVQ RHLKLLLRDL EDSRGATLNP
960 970
WRKAQLLRVE GEVKTLLEQL GGSGH
Length:975
Mass (Da):107,831
Last modified:October 11, 2005 - v1
Checksum:iB677729514B1A34F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti438 – 4381S → P in AAH50054 (PubMed:15489334).Curated
Sequence conflicti506 – 5061I → S in AAH50054 (PubMed:15489334).Curated
Sequence conflicti595 – 5951D → V in BAE26810 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089260 mRNA. Translation: BAC40818.1.
AK145988 mRNA. Translation: BAE26810.1.
AK166689 mRNA. Translation: BAE38948.1.
BC050054 mRNA. Translation: AAH50054.1.
CCDSiCCDS23100.1.
RefSeqiNP_001157214.1. NM_001163742.1.
NP_001157215.1. NM_001163743.1.
NP_848507.2. NM_178420.3.
UniGeneiMm.3957.

Genome annotation databases

EnsembliENSMUST00000034621; ENSMUSP00000034621; ENSMUSG00000032109.
ENSMUST00000168499; ENSMUSP00000127531; ENSMUSG00000032109.
ENSMUST00000169651; ENSMUSP00000126555; ENSMUSG00000032109.
GeneIDi270151.
KEGGimmu:270151.
UCSCiuc009pci.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089260 mRNA. Translation: BAC40818.1.
AK145988 mRNA. Translation: BAE26810.1.
AK166689 mRNA. Translation: BAE38948.1.
BC050054 mRNA. Translation: AAH50054.1.
CCDSiCCDS23100.1.
RefSeqiNP_001157214.1. NM_001163742.1.
NP_001157215.1. NM_001163743.1.
NP_848507.2. NM_178420.3.
UniGeneiMm.3957.

3D structure databases

ProteinModelPortaliQ3TL44.
SMRiQ3TL44. Positions 157-183, 667-970.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234769. 4 interactions.
STRINGi10090.ENSMUSP00000034621.

PTM databases

PhosphoSiteiQ3TL44.

Proteomic databases

EPDiQ3TL44.
MaxQBiQ3TL44.
PaxDbiQ3TL44.
PeptideAtlasiQ3TL44.
PRIDEiQ3TL44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034621; ENSMUSP00000034621; ENSMUSG00000032109.
ENSMUST00000168499; ENSMUSP00000127531; ENSMUSG00000032109.
ENSMUST00000169651; ENSMUSP00000126555; ENSMUSG00000032109.
GeneIDi270151.
KEGGimmu:270151.
UCSCiuc009pci.2. mouse.

Organism-specific databases

CTDi79671.
MGIiMGI:2429611. Nlrx1.

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00840000129829.
HOGENOMiHOG000113797.
HOVERGENiHBG106320.
InParanoidiQ3TL44.
KOiK12653.
OMAiLHLYFNE.
OrthoDBiEOG091G01CG.
PhylomeDBiQ3TL44.
TreeFamiTF331068.

Enzyme and pathway databases

ReactomeiR-MMU-936440. Negative regulators of RIG-I/MDA5 signaling.

Miscellaneous databases

PROiQ3TL44.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032109.
CleanExiMM_NLRX1.
GenevisibleiQ3TL44. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNLRX1_MOUSE
AccessioniPrimary (citable) accession number: Q3TL44
Secondary accession number(s): Q3UKJ1, Q80W30, Q8C249
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.