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Protein

Peptidyl-prolyl cis-trans isomerase CWC27 homolog

Gene

Cwc27

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins.By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CWC27 homolog (EC:5.2.1.8)
Short name:
PPIase CWC27
Gene namesi
Name:Cwc27
Synonyms:Sdccag10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1914535. Cwc27.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 469468Peptidyl-prolyl cis-trans isomerase CWC27 homologPRO_0000313649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ3TKY6.
MaxQBiQ3TKY6.
PaxDbiQ3TKY6.
PeptideAtlasiQ3TKY6.
PRIDEiQ3TKY6.

PTM databases

iPTMnetiQ3TKY6.
PhosphoSiteiQ3TKY6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021715.
CleanExiMM_SDCCAG10.
ExpressionAtlasiQ3TKY6. baseline and differential.
GenevisibleiQ3TKY6. MM.

Interactioni

Protein-protein interaction databases

IntActiQ3TKY6. 1 interaction.
MINTiMINT-4085044.
STRINGi10090.ENSMUSP00000022228.

Structurei

3D structure databases

ProteinModelPortaliQ3TKY6.
SMRiQ3TKY6. Positions 6-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 166156PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili206 – 22924Sequence analysisAdd
BLAST
Coiled coili309 – 37163Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0885. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000161443.
HOVERGENiHBG097993.
InParanoidiQ3TKY6.
KOiK12737.
OMAiANMQDED.
OrthoDBiEOG091G0BVF.
PhylomeDBiQ3TKY6.
TreeFamiTF105935.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3TKY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNIYIQEPP TNGKVLLKTT AGDIDIELWS KEAPKACRNF IQLCLEAYYD
60 70 80 90 100
NTIFHRVVPG FIVQGGDPTG TGTGGESIYG APFKDEFHSR LRFNRRGLVA
110 120 130 140 150
MANAGPHDNG SQFFFTLGRA DELNNKHTIF GKVTGDTVYN MLRLTEVDID
160 170 180 190 200
DEERPRNPHR IKSCEVLFNP FDDITPREIK KPKNEKPEEE VKKLKPKGTK
210 220 230 240 250
NFSLLSFGEE AEEEEEEVNR VSQSMKGRSK SSHDLLKDDP HLSSVPAVES
260 270 280 290 300
EKDDATGDLE DDGEDDSAER DEYMEDDEKN LMRERIAKRL KKDASASVKS
310 320 330 340 350
AGDGEKKPAS RSEELRKEAR QLKRELLAAK QKKETAIKVE EGREEEEAAP
360 370 380 390 400
DGAVAEYRRE KQKYEALRKQ QPKKGTSRED QTLALLSQFK SKLTQAITET
410 420 430 440 450
PENSVPEAEV EDDEGWMSHV LQFEDKTRKV KDASMQDSDT FEIYDPRNPV
460
NKRRREESKK LLREKKERR
Length:469
Mass (Da):53,543
Last modified:October 11, 2005 - v1
Checksum:iF0AF5A6E650BE7A3
GO

Sequence cautioni

The sequence AAH25437 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB29120 differs from that shown. Reason: Frameshift at position 90. Curated
The sequence BAC36042 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC37003 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti261 – 2611D → DLLQ in BAB29120 (PubMed:16141072).Curated
Sequence conflicti337 – 3371I → T in AAH25437 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014025 mRNA. Translation: BAB29120.1. Frameshift.
AK075902 mRNA. Translation: BAC36042.1. Different initiation.
AK077779 mRNA. Translation: BAC37003.1. Different initiation.
AK166770 mRNA. Translation: BAE39007.1.
BC025437 mRNA. Translation: AAH25437.1. Different initiation.
CCDSiCCDS26752.1.
RefSeqiNP_080348.1. NM_026072.1.
UniGeneiMm.235398.

Genome annotation databases

EnsembliENSMUST00000022228; ENSMUSP00000022228; ENSMUSG00000021715.
GeneIDi67285.
KEGGimmu:67285.
UCSCiuc007rtj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014025 mRNA. Translation: BAB29120.1. Frameshift.
AK075902 mRNA. Translation: BAC36042.1. Different initiation.
AK077779 mRNA. Translation: BAC37003.1. Different initiation.
AK166770 mRNA. Translation: BAE39007.1.
BC025437 mRNA. Translation: AAH25437.1. Different initiation.
CCDSiCCDS26752.1.
RefSeqiNP_080348.1. NM_026072.1.
UniGeneiMm.235398.

3D structure databases

ProteinModelPortaliQ3TKY6.
SMRiQ3TKY6. Positions 6-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3TKY6. 1 interaction.
MINTiMINT-4085044.
STRINGi10090.ENSMUSP00000022228.

PTM databases

iPTMnetiQ3TKY6.
PhosphoSiteiQ3TKY6.

Proteomic databases

EPDiQ3TKY6.
MaxQBiQ3TKY6.
PaxDbiQ3TKY6.
PeptideAtlasiQ3TKY6.
PRIDEiQ3TKY6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022228; ENSMUSP00000022228; ENSMUSG00000021715.
GeneIDi67285.
KEGGimmu:67285.
UCSCiuc007rtj.1. mouse.

Organism-specific databases

CTDi10283.
MGIiMGI:1914535. Cwc27.

Phylogenomic databases

eggNOGiKOG0885. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000161443.
HOVERGENiHBG097993.
InParanoidiQ3TKY6.
KOiK12737.
OMAiANMQDED.
OrthoDBiEOG091G0BVF.
PhylomeDBiQ3TKY6.
TreeFamiTF105935.

Miscellaneous databases

ChiTaRSiCwc27. mouse.
PROiQ3TKY6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021715.
CleanExiMM_SDCCAG10.
ExpressionAtlasiQ3TKY6. baseline and differential.
GenevisibleiQ3TKY6. MM.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCWC27_MOUSE
AccessioniPrimary (citable) accession number: Q3TKY6
Secondary accession number(s): Q8BG42, Q8R158, Q9CXT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.