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Protein

Peptidyl-prolyl cis-trans isomerase CWC27 homolog

Gene

Cwc27

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins.By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CWC27 homolog (EC:5.2.1.8)
Short name:
PPIase CWC27
Gene namesi
Name:Cwc27
Synonyms:Sdccag10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1914535. Cwc27.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

Knockout mice manifest significant embryonic lethality. Growth retardation, lack of neural tube closure, and absence of limb buds are observed at embryonic day 12.5. Surviving mice show growth retardation and retinal dystrophic changes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003136492 – 469Peptidyl-prolyl cis-trans isomerase CWC27 homologAdd BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ3TKY6.
MaxQBiQ3TKY6.
PaxDbiQ3TKY6.
PeptideAtlasiQ3TKY6.
PRIDEiQ3TKY6.

PTM databases

iPTMnetiQ3TKY6.
PhosphoSitePlusiQ3TKY6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021715.
CleanExiMM_SDCCAG10.
ExpressionAtlasiQ3TKY6. baseline and differential.
GenevisibleiQ3TKY6. MM.

Interactioni

Protein-protein interaction databases

IntActiQ3TKY6. 1 interactor.
MINTiMINT-4085044.
STRINGi10090.ENSMUSP00000022228.

Structurei

3D structure databases

ProteinModelPortaliQ3TKY6.
SMRiQ3TKY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 166PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST156

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili206 – 229Sequence analysisAdd BLAST24
Coiled coili309 – 371Sequence analysisAdd BLAST63

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0885. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000161443.
HOVERGENiHBG097993.
InParanoidiQ3TKY6.
KOiK12737.
OMAiSENHYIN.
OrthoDBiEOG091G0BVF.
PhylomeDBiQ3TKY6.
TreeFamiTF105935.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiView protein in InterPro
IPR029000. Cyclophilin-like_dom_sf.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
PANTHERiPTHR11071. PTHR11071. 2 hits.
PfamiView protein in Pfam
PF00160. Pro_isomerase. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiView protein in PROSITE
PS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3TKY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNIYIQEPP TNGKVLLKTT AGDIDIELWS KEAPKACRNF IQLCLEAYYD
60 70 80 90 100
NTIFHRVVPG FIVQGGDPTG TGTGGESIYG APFKDEFHSR LRFNRRGLVA
110 120 130 140 150
MANAGPHDNG SQFFFTLGRA DELNNKHTIF GKVTGDTVYN MLRLTEVDID
160 170 180 190 200
DEERPRNPHR IKSCEVLFNP FDDITPREIK KPKNEKPEEE VKKLKPKGTK
210 220 230 240 250
NFSLLSFGEE AEEEEEEVNR VSQSMKGRSK SSHDLLKDDP HLSSVPAVES
260 270 280 290 300
EKDDATGDLE DDGEDDSAER DEYMEDDEKN LMRERIAKRL KKDASASVKS
310 320 330 340 350
AGDGEKKPAS RSEELRKEAR QLKRELLAAK QKKETAIKVE EGREEEEAAP
360 370 380 390 400
DGAVAEYRRE KQKYEALRKQ QPKKGTSRED QTLALLSQFK SKLTQAITET
410 420 430 440 450
PENSVPEAEV EDDEGWMSHV LQFEDKTRKV KDASMQDSDT FEIYDPRNPV
460
NKRRREESKK LLREKKERR
Length:469
Mass (Da):53,543
Last modified:October 11, 2005 - v1
Checksum:iF0AF5A6E650BE7A3
GO

Sequence cautioni

The sequence AAH25437 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB29120 differs from that shown. Reason: Frameshift at position 90.Curated
The sequence BAC36042 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC37003 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti261D → DLLQ in BAB29120 (PubMed:16141072).Curated1
Sequence conflicti337I → T in AAH25437 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014025 mRNA. Translation: BAB29120.1. Frameshift.
AK075902 mRNA. Translation: BAC36042.1. Different initiation.
AK077779 mRNA. Translation: BAC37003.1. Different initiation.
AK166770 mRNA. Translation: BAE39007.1.
BC025437 mRNA. Translation: AAH25437.1. Different initiation.
CCDSiCCDS26752.1.
RefSeqiNP_080348.1. NM_026072.1.
UniGeneiMm.235398.

Genome annotation databases

EnsembliENSMUST00000022228; ENSMUSP00000022228; ENSMUSG00000021715.
GeneIDi67285.
KEGGimmu:67285.
UCSCiuc007rtj.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCWC27_MOUSE
AccessioniPrimary (citable) accession number: Q3TKY6
Secondary accession number(s): Q8BG42, Q8R158, Q9CXT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: November 22, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families