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Protein

Transcription activator BRG1

Gene

Smarca4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role in regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (By similarity). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (PubMed:26138476). Binds to RNA in a promiscuous manner (PubMed:26138476). Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities (PubMed:26138476).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1505 – 1506Required for binding to 'Lys-15'-acetylated histone 3By similarity2

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi779 – 786ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • aorta development Source: MGI
  • aortic smooth muscle cell differentiation Source: MGI
  • ATP-dependent chromatin remodeling Source: InterPro
  • blastocyst growth Source: MGI
  • blastocyst hatching Source: MGI
  • blood vessel development Source: MGI
  • cell morphogenesis Source: MGI
  • chromatin remodeling Source: MGI
  • coronary vasculature development Source: MGI
  • definitive erythrocyte differentiation Source: MGI
  • DNA methylation on cytosine within a CG sequence Source: MGI
  • embryonic hindlimb morphogenesis Source: MGI
  • embryonic organ morphogenesis Source: MGI
  • epidermis morphogenesis Source: MGI
  • extracellular matrix organization Source: MGI
  • forebrain development Source: MGI
  • glial cell fate determination Source: MGI
  • heart development Source: MGI
  • heart trabecula formation Source: MGI
  • hindbrain development Source: MGI
  • histone H3 acetylation Source: MGI
  • in utero embryonic development Source: MGI
  • keratinocyte differentiation Source: MGI
  • lens fiber cell development Source: MGI
  • liver development Source: MGI
  • methylation-dependent chromatin silencing Source: MGI
  • negative regulation of androgen receptor signaling pathway Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of cell growth Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • nervous system development Source: UniProtKB
  • neurogenesis Source: MGI
  • nucleosome assembly Source: MGI
  • nucleosome disassembly Source: MGI
  • outflow tract morphogenesis Source: MGI
  • pharyngeal arch artery morphogenesis Source: MGI
  • positive regulation by host of viral transcription Source: MGI
  • positive regulation of cell differentiation Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of DNA binding Source: MGI
  • positive regulation of DNA binding transcription factor activity Source: MGI
  • positive regulation of glucose mediated signaling pathway Source: MGI
  • positive regulation of pri-miRNA transcription by RNA polymerase II Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • positive regulation of transcription of nucleolar large rRNA by RNA polymerase I Source: MGI
  • positive regulation of Wnt signaling pathway Source: BHF-UCL
  • regulation of cell migration Source: MGI
  • stem cell population maintenance Source: MGI
  • vasculogenesis Source: MGI
  • ventricular septum development Source: MGI

Keywordsi

Molecular functionActivator, Chromatin regulator, Helicase, Hydrolase, Repressor, RNA-binding
Biological processNeurogenesis, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1266695 Interleukin-7 signaling
R-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-3214858 RMTs methylate histone arginines
R-MMU-3247509 Chromatin modifying enzymes
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription activator BRG1 (EC:3.6.4.-)
Alternative name(s):
ATP-dependent helicase SMARCA4
BRG1-associated factor 190A
Short name:
BAF190A
Protein brahma homolog 1
SNF2-beta
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
Gene namesi
Name:Smarca4
Synonyms:Baf190a, Brg1, Snf2b, Snf2l4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88192 Smarca4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003913431 – 1613Transcription activator BRG1Add BLAST1613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphothreonineBy similarity1
Modified residuei188N6-acetyllysineBy similarity1
Modified residuei353PhosphothreonineBy similarity1
Modified residuei609PhosphothreonineBy similarity1
Modified residuei610PhosphoserineCombined sources1
Modified residuei613PhosphoserineCombined sources1
Modified residuei695PhosphoserineCombined sources1
Modified residuei699PhosphoserineCombined sources1
Modified residuei1027N6-acetyllysineBy similarity1
Modified residuei1029N6-acetyllysineBy similarity1
Cross-linki1332Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1349PhosphoserineBy similarity1
Modified residuei1390PhosphothreonineCombined sources1
Modified residuei1419PhosphoserineBy similarity1
Modified residuei1536PhosphoserineCombined sources1
Modified residuei1541PhosphoserineCombined sources1
Modified residuei1552PhosphoserineCombined sources1
Modified residuei1593PhosphoserineBy similarity1
Modified residuei1597PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ3TKT4
PaxDbiQ3TKT4
PeptideAtlasiQ3TKT4
PRIDEiQ3TKT4

PTM databases

iPTMnetiQ3TKT4
PhosphoSitePlusiQ3TKT4

Expressioni

Gene expression databases

BgeeiENSMUSG00000032187
ExpressionAtlasiQ3TKT4 baseline and differential
GenevisibleiQ3TKT4 MM

Interactioni

Subunit structurei

Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible developmental- and tissue-specific combinations (Probable). Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (PubMed:17640523). Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin. Component of the BAF53 complex, at least composed of BAF53A, RUVBL1, SMARCA4/BRG1/BAF190A, and TRRAP, which preferentially acetylates histone H4 (and H2A) within nucleosomes (By similarity). Component of the CREST-BRG1 complex, at least composed of SMARCA4/BRG1/BAF190A, SS18L1/CREST, HDAC1, RB1 and SP1 (By similarity). Interacts with PHF10/BAF45A (PubMed:17640523). Interacts with MYOG (PubMed:16424906). Interacts directly with IKFZ1; the interaction associates IKFZ1 with the BAF complex. Interacts with ZEB1 (via N-terminus). Interacts with NR3C1, PGR, SMARD1, TOPBP1 and ZMIM2/ZIMP7. Interacts with (via the bromodomain) with TERT; the interaction regulates Wnt-mediated signaling (By similarity). Interacts with KDM6A and KDM6B (PubMed:21095589). Interacts with TBX21 in a KDM6B-dependent manner (PubMed:21095589). Interacts with HNRNPU; this interaction occurs in embryonic stem cells and stimulates global Pol II-mediated transcription (PubMed:22162999). Interacts with ACTL6A (By similarity). Interacts with DLX1 (PubMed:26138476).2 PublicationsBy similarity5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • androgen receptor binding Source: MGI
  • DNA polymerase binding Source: BHF-UCL
  • lysine-acetylated histone binding Source: MGI
  • p53 binding Source: MGI
  • protein N-terminus binding Source: MGI
  • Tat protein binding Source: MGI
  • transcription factor binding Source: MGI

Protein-protein interaction databases

BioGridi20333676 interactors.
CORUMiQ3TKT4
DIPiDIP-40650N
DIP-59249N
IntActiQ3TKT4 48 interactors.
MINTiQ3TKT4
STRINGi10090.ENSMUSP00000096547

Structurei

3D structure databases

ProteinModelPortaliQ3TKT4
SMRiQ3TKT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini171 – 206QLQPROSITE-ProRule annotationAdd BLAST36
Domaini460 – 532HSAPROSITE-ProRule annotationAdd BLAST73
Domaini766 – 931Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1084 – 1246Helicase C-terminalPROSITE-ProRule annotationAdd BLAST163
Domaini1443 – 1513BromoPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 282Necessary for interaction with SS18L1/CRESTBy similarityAdd BLAST282
Regioni462 – 728RNA-binding region which is sufficient for binding to lncRNA Evf21 PublicationAdd BLAST267
Regioni837 – 916Sufficient for interaction with DLX11 PublicationAdd BLAST80
Regioni1247 – 1413Sufficient for interaction with DLX11 PublicationAdd BLAST167

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi881 – 884DEGH boxBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 344Pro-richAdd BLAST341
Compositional biasi663 – 672Poly-Glu10
Compositional biasi1252 – 1370Glu-richAdd BLAST119
Compositional biasi1531 – 1555Glu-richAdd BLAST25

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domaini

Bromodomain

Phylogenomic databases

eggNOGiKOG0386 Eukaryota
COG0553 LUCA
COG5076 LUCA
GeneTreeiENSGT00550000074659
HOGENOMiHOG000172363
HOVERGENiHBG056636
InParanoidiQ3TKT4
KOiK11647
PhylomeDBiQ3TKT4
TreeFamiTF300785

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di1.20.920.101 hit
2.20.28.1301 hit
3.40.50.108102 hits
InterProiView protein in InterPro
IPR030100 BRG1
IPR006576 BRK_domain
IPR037259 BRK_sf
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR014978 Gln-Leu-Gln_QLQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR029295 SnAC
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PANTHERiPTHR10799:SF76 PTHR10799:SF76, 1 hit
PfamiView protein in Pfam
PF07533 BRK, 1 hit
PF00439 Bromodomain, 1 hit
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF08880 QLQ, 1 hit
PF14619 SnAC, 1 hit
PF00176 SNF2_N, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00592 BRK, 1 hit
SM00297 BROMO, 1 hit
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00573 HSA, 1 hit
SM00951 QLQ, 1 hit
SM01314 SnAC, 1 hit
SUPFAMiSSF160481 SSF160481, 1 hit
SSF47370 SSF47370, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit
PS51666 QLQ, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TKT4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTPDPPLGG TPRPGPSPGP GPSPGAMLGP SPGPSPGSAH SMMGPSPGPP
60 70 80 90 100
SAGHPMPTQG PGGYPQDNMH QMHKPMESMH EKGMPDDPRY NQMKGMGMRS
110 120 130 140 150
GAHTGMAPPP SPMDQHSQGY PSPLGGSEHA SSPVPASGPS SGPQMSSGPG
160 170 180 190 200
GAPLDGSDPQ ALGQQNRGPT PFNQNQLHQL RAQIMAYKML ARGQPLPDHL
210 220 230 240 250
QMAVQGKRPM PGMQQQMPTL PPPSVSATGP GPGPGPGPGP GPGPAPPNYS
260 270 280 290 300
RPHGMGGPNM PPPGPSGVPP GMPGQPPGGP PKPWPEGPMA NAAAPTSTPQ
310 320 330 340 350
KLIPPQPTGR PSPAPPAVPP AASPVMPPQT QSPGQPAQPA PLVPLHQKQS
360 370 380 390 400
RITPIQKPRG LDPVEILQER EYRLQARIAH RIQELENLPG SLAGDLRTKA
410 420 430 440 450
TIELKALRLL NFQRQLRQEV VVCMRRDTAL ETALNAKAYK RSKRQSLREA
460 470 480 490 500
RITEKLEKQQ KIEQERKRRQ KHQEYLNSIL QHAKDFREYH RSVTGKLQKL
510 520 530 540 550
TKAVATYHAN TEREQKKENE RIEKERMRRL MAEDEEGYRK LIDQKKDKRL
560 570 580 590 600
AYLLQQTDEY VANLTELVRQ HKAAQVAKEK KKKKKKKKAE NAEGQTPAIG
610 620 630 640 650
PDGEPLDETS QMSDLPVKVI HVESGKILTG TDAPKAGQLE AWLEMNPGYE
660 670 680 690 700
VAPRSDSEES GSEEEEEEEE EEQPQPAQPP TLPVEEKKKI PDPDSDDVSE
710 720 730 740 750
VDARHIIENA KQDVDDEYGV SQALARGLQS YYAVAHAVTE RVDKQSALMV
760 770 780 790 800
NGVLKQYQIK GLEWLVSLYN NNLNGILADE MGLGKTIQTI ALITYLMEHK
810 820 830 840 850
RINGPFLIIV PLSTLSNWAY EFDKWAPSVV KVSYKGSPAA RRAFVPQLRS
860 870 880 890 900
GKFNVLLTTY EYIIKDKHIL AKIRWKYMIV DEGHRMKNHH CKLTQVLNTH
910 920 930 940 950
YVAPRRLLLT GTPLQNKLPE LWALLNFLLP TIFKSCSTFE QWFNAPFAMT
960 970 980 990 1000
GEKVDLNEEE TILIIRRLHK VLRPFLLRRL KKEVEAQLPE KVEYVIKCDM
1010 1020 1030 1040 1050
SALQRVLYRH MQAKGVLLTD GSEKDKKGKG GTKTLMNTIM QLRKICNHPY
1060 1070 1080 1090 1100
MFQHIEESFS EHLGFTGGIV QGLDLYRASG KFELLDRILP KLRATNHKVL
1110 1120 1130 1140 1150
LFCQMTSLMT IMEDYFAYRG FKYLRLDGTT KAEDRGMLLK TFNEPGSEYF
1160 1170 1180 1190 1200
IFLLSTRAGG LGLNLQSADT VIIFDSDWNP HQDLQAQDRA HRIGQQNEVR
1210 1220 1230 1240 1250
VLRLCTVNSV EEKILAAAKY KLNVDQKVIQ AGMFDQKSSS HERRAFLQAI
1260 1270 1280 1290 1300
LEHEEQDEEE DEVPDDETVN QMIARHEEEF DLFMRMDLDR RREEARNPKR
1310 1320 1330 1340 1350
KPRLMEEDEL PSWIIKDDAE VERLTCEEEE EKMFGRGSRH RKEVDYSDSL
1360 1370 1380 1390 1400
TEKQWLKAIE EGTLEEIEEE VRQKKSSRKR KRDSEAGSST PTTSTRSRDK
1410 1420 1430 1440 1450
DEESKKQKKR GRPPAEKLSP NPPNLTKKMK KIVDAVIKYK DSSGRQLSEV
1460 1470 1480 1490 1500
FIQLPSRKEL PEYYELIRKP VDFKKIKERI RNHKYRSLND LEKDVMLLCQ
1510 1520 1530 1540 1550
NAQTFNLEGS LIYEDSIVLQ SVFTSVRQKI EKEDDSEGEE SEEEEEGEEE
1560 1570 1580 1590 1600
GSESESRSVK VKIKLGRKEK AQDRLKGGRR RPSRGSRAKP VVSDDDSEEE
1610
QEEDRSGSGS EED
Length:1,613
Mass (Da):181,427
Last modified:October 11, 2005 - v1
Checksum:iC23804ED858F98FE
GO
Isoform 2 (identifier: Q3TKT4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1441-1441: D → DS

Show »
Length:1,614
Mass (Da):181,514
Checksum:i1DC02672488F3BA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1355W → WLKT in BAE36034 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0386961441D → DS in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147285 mRNA Translation: BAE27821.1
AK160825 mRNA Translation: BAE36034.1
AK166837 mRNA Translation: BAE39059.1
BC079560 mRNA Translation: AAH79560.1
CH466522 Genomic DNA Translation: EDL25209.1
CCDSiCCDS22909.1 [Q3TKT4-2]
CCDS57662.1 [Q3TKT4-1]
RefSeqiNP_001167549.1, NM_001174078.1
NP_001167550.1, NM_001174079.1 [Q3TKT4-1]
NP_035547.2, NM_011417.3 [Q3TKT4-2]
XP_006510180.2, XM_006510117.2
XP_006510182.2, XM_006510119.2 [Q3TKT4-2]
XP_006510183.2, XM_006510120.2 [Q3TKT4-1]
UniGeneiMm.286593

Genome annotation databases

EnsembliENSMUST00000034707; ENSMUSP00000034707; ENSMUSG00000032187 [Q3TKT4-2]
ENSMUST00000174008; ENSMUSP00000133922; ENSMUSG00000032187 [Q3TKT4-1]
GeneIDi20586
KEGGimmu:20586
UCSCiuc009omd.2 mouse [Q3TKT4-2]
uc009ome.2 mouse [Q3TKT4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSMCA4_MOUSE
AccessioniPrimary (citable) accession number: Q3TKT4
Secondary accession number(s): Q3TUD7, Q6AXG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: October 11, 2005
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome