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Q3TKT4

- SMCA4_MOUSE

UniProt

Q3TKT4 - SMCA4_MOUSE

Protein

Transcription activator BRG1

Gene

Smarca4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP By similarity. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei1505 – 15062Required for binding to 'Lys-15'-acetylated histone 3By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi779 – 7868ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: MGI
    2. ATP binding Source: UniProtKB-KW
    3. chromatin binding Source: MGI
    4. DNA-dependent ATPase activity Source: Ensembl
    5. helicase activity Source: UniProtKB-KW
    6. protein binding Source: UniProtKB
    7. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
    8. RNA polymerase II transcription coactivator activity Source: Ensembl
    9. transcription corepressor activity Source: UniProtKB
    10. transcription factor binding Source: MGI

    GO - Biological processi

    1. aortic smooth muscle cell differentiation Source: MGI
    2. ATP catabolic process Source: GOC
    3. blastocyst growth Source: MGI
    4. blastocyst hatching Source: MGI
    5. cell morphogenesis Source: MGI
    6. chromatin remodeling Source: MGI
    7. definitive erythrocyte differentiation Source: MGI
    8. DNA methylation on cytosine within a CG sequence Source: MGI
    9. embryonic hindlimb morphogenesis Source: MGI
    10. embryonic organ morphogenesis Source: MGI
    11. epidermis morphogenesis Source: MGI
    12. extracellular matrix organization Source: MGI
    13. forebrain development Source: MGI
    14. glial cell fate determination Source: MGI
    15. heart development Source: MGI
    16. heart trabecula formation Source: MGI
    17. hindbrain development Source: MGI
    18. histone H3 acetylation Source: MGI
    19. in utero embryonic development Source: MGI
    20. keratinocyte differentiation Source: MGI
    21. lens fiber cell development Source: MGI
    22. liver development Source: MGI
    23. methylation-dependent chromatin silencing Source: MGI
    24. negative regulation of androgen receptor signaling pathway Source: Ensembl
    25. negative regulation of cell growth Source: Ensembl
    26. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    27. nervous system development Source: UniProtKB
    28. neural retina development Source: Ensembl
    29. neurogenesis Source: MGI
    30. nucleosome assembly Source: MGI
    31. nucleosome disassembly Source: Ensembl
    32. positive regulation by host of viral transcription Source: Ensembl
    33. positive regulation of DNA binding Source: MGI
    34. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    35. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    36. stem cell maintenance Source: MGI
    37. vasculogenesis Source: MGI

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Helicase, Hydrolase, Repressor

    Keywords - Biological processi

    Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_216539. formation of the beta-catenin:TCF transactivating complex.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription activator BRG1 (EC:3.6.4.-)
    Alternative name(s):
    ATP-dependent helicase SMARCA4
    BRG1-associated factor 190A
    Short name:
    BAF190A
    Protein brahma homolog 1
    SNF2-beta
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
    Gene namesi
    Name:Smarca4
    Synonyms:Baf190a, Brg1, Snf2b, Snf2l4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:88192. Smarca4.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. heterochromatin Source: MGI
    2. nBAF complex Source: UniProtKB
    3. npBAF complex Source: UniProtKB
    4. nuclear euchromatin Source: MGI
    5. nucleus Source: MGI
    6. perichromatin fibrils Source: MGI
    7. SWI/SNF complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16131613Transcription activator BRG1PRO_0000391343Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei11 – 111PhosphothreonineBy similarity
    Modified residuei188 – 1881N6-acetyllysineBy similarity
    Modified residuei353 – 3531PhosphothreonineBy similarity
    Modified residuei609 – 6091PhosphothreonineBy similarity
    Modified residuei610 – 6101Phosphoserine1 Publication
    Modified residuei613 – 6131Phosphoserine1 Publication
    Modified residuei695 – 6951PhosphoserineBy similarity
    Modified residuei699 – 6991PhosphoserineBy similarity
    Modified residuei1349 – 13491PhosphoserineBy similarity
    Modified residuei1419 – 14191PhosphoserineBy similarity
    Modified residuei1536 – 15361PhosphoserineBy similarity
    Modified residuei1541 – 15411PhosphoserineBy similarity
    Modified residuei1552 – 15521PhosphoserineBy similarity
    Modified residuei1593 – 15931PhosphoserineBy similarity
    Modified residuei1597 – 15971PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ3TKT4.
    PaxDbiQ3TKT4.
    PRIDEiQ3TKT4.

    PTM databases

    PhosphoSiteiQ3TKT4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3TKT4.
    BgeeiQ3TKT4.
    GenevestigatoriQ3TKT4.

    Interactioni

    Subunit structurei

    Interacts with NR3C1, PGR, SMARD1, TOPBP1 and ZMIM2/ZIMP7. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, IKFZ1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. Interacts directly with IKFZ1 in the BAF complex. In muscle cells, the BAF complex also contains DPF3. Component of the BAF53 complex, at least composed of BAF53A, RUVBL1, SMARCA4/BRG1/BAF190A, and TRRAP, which preferentially acetylates histone H4 (and H2A) within nucleosomes. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Component of the CREST-BRG1 complex, at least composed of SMARCA4/BRG1/BAF190A, SS18L1/CREST, HDAC1, RB1 and SP1. Interacts with (via the bromodomain) with TERT; the interaction regulates Wnt-mediated signaling. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin. Interacts with ZEB1 (via N-terminus) By similarity. Interacts with PHF10/BAF45A. Interacts with MYOG.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HnrnpuQ8VEK33EBI-1210244,EBI-529674
    RB1P064004EBI-1210244,EBI-491274From a different organism.
    Rb1P134053EBI-1210244,EBI-971782
    Smarcc1P974965EBI-1210244,EBI-648047
    Smarcd3Q6P9Z13EBI-1210244,EBI-7525857

    Protein-protein interaction databases

    BioGridi203336. 72 interactions.
    DIPiDIP-40650N.
    DIP-59249N.
    IntActiQ3TKT4. 28 interactions.
    MINTiMINT-1958721.
    STRINGi10090.ENSMUSP00000096547.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3TKT4.
    SMRiQ3TKT4. Positions 749-1221, 1416-1535.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini171 – 20636QLQPROSITE-ProRule annotationAdd
    BLAST
    Domaini460 – 53273HSAPROSITE-ProRule annotationAdd
    BLAST
    Domaini766 – 931166Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini1084 – 1246163Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini1443 – 151371BromoPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 282282Necessary for interaction with SS18L1/CRESTBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi881 – 8844DEGH boxBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4 – 344341Pro-richAdd
    BLAST
    Compositional biasi663 – 67210Poly-Glu
    Compositional biasi1252 – 1370119Glu-richAdd
    BLAST
    Compositional biasi1531 – 155525Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SNF2/RAD54 helicase family.Curated
    Contains 1 bromo domain.PROSITE-ProRule annotation
    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
    Contains 1 HSA domain.PROSITE-ProRule annotation
    Contains 1 QLQ domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Bromodomain

    Phylogenomic databases

    eggNOGiCOG0553.
    GeneTreeiENSGT00550000074659.
    HOGENOMiHOG000172363.
    HOVERGENiHBG056636.
    InParanoidiQ3TUD7.
    KOiK11647.
    OrthoDBiEOG771265.
    PhylomeDBiQ3TKT4.
    TreeFamiTF300785.

    Family and domain databases

    Gene3Di1.20.920.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR006576. BRK_domain.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR014978. Gln-Leu-Gln_QLQ.
    IPR013999. HAS_subgr.
    IPR014012. Helicase/SANT-assoc_DNA-bd.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR029295. SnAC.
    IPR000330. SNF2_N.
    [Graphical view]
    PfamiPF07533. BRK. 1 hit.
    PF00439. Bromodomain. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF07529. HSA. 1 hit.
    PF08880. QLQ. 1 hit.
    PF14619. SnAC. 1 hit.
    PF00176. SNF2_N. 1 hit.
    [Graphical view]
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00592. BRK. 1 hit.
    SM00297. BROMO. 1 hit.
    SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    SM00573. HSA. 1 hit.
    SM00951. QLQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 1 hit.
    SSF52540. SSF52540. 2 hits.
    PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51204. HSA. 1 hit.
    PS51666. QLQ. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3TKT4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSTPDPPLGG TPRPGPSPGP GPSPGAMLGP SPGPSPGSAH SMMGPSPGPP     50
    SAGHPMPTQG PGGYPQDNMH QMHKPMESMH EKGMPDDPRY NQMKGMGMRS 100
    GAHTGMAPPP SPMDQHSQGY PSPLGGSEHA SSPVPASGPS SGPQMSSGPG 150
    GAPLDGSDPQ ALGQQNRGPT PFNQNQLHQL RAQIMAYKML ARGQPLPDHL 200
    QMAVQGKRPM PGMQQQMPTL PPPSVSATGP GPGPGPGPGP GPGPAPPNYS 250
    RPHGMGGPNM PPPGPSGVPP GMPGQPPGGP PKPWPEGPMA NAAAPTSTPQ 300
    KLIPPQPTGR PSPAPPAVPP AASPVMPPQT QSPGQPAQPA PLVPLHQKQS 350
    RITPIQKPRG LDPVEILQER EYRLQARIAH RIQELENLPG SLAGDLRTKA 400
    TIELKALRLL NFQRQLRQEV VVCMRRDTAL ETALNAKAYK RSKRQSLREA 450
    RITEKLEKQQ KIEQERKRRQ KHQEYLNSIL QHAKDFREYH RSVTGKLQKL 500
    TKAVATYHAN TEREQKKENE RIEKERMRRL MAEDEEGYRK LIDQKKDKRL 550
    AYLLQQTDEY VANLTELVRQ HKAAQVAKEK KKKKKKKKAE NAEGQTPAIG 600
    PDGEPLDETS QMSDLPVKVI HVESGKILTG TDAPKAGQLE AWLEMNPGYE 650
    VAPRSDSEES GSEEEEEEEE EEQPQPAQPP TLPVEEKKKI PDPDSDDVSE 700
    VDARHIIENA KQDVDDEYGV SQALARGLQS YYAVAHAVTE RVDKQSALMV 750
    NGVLKQYQIK GLEWLVSLYN NNLNGILADE MGLGKTIQTI ALITYLMEHK 800
    RINGPFLIIV PLSTLSNWAY EFDKWAPSVV KVSYKGSPAA RRAFVPQLRS 850
    GKFNVLLTTY EYIIKDKHIL AKIRWKYMIV DEGHRMKNHH CKLTQVLNTH 900
    YVAPRRLLLT GTPLQNKLPE LWALLNFLLP TIFKSCSTFE QWFNAPFAMT 950
    GEKVDLNEEE TILIIRRLHK VLRPFLLRRL KKEVEAQLPE KVEYVIKCDM 1000
    SALQRVLYRH MQAKGVLLTD GSEKDKKGKG GTKTLMNTIM QLRKICNHPY 1050
    MFQHIEESFS EHLGFTGGIV QGLDLYRASG KFELLDRILP KLRATNHKVL 1100
    LFCQMTSLMT IMEDYFAYRG FKYLRLDGTT KAEDRGMLLK TFNEPGSEYF 1150
    IFLLSTRAGG LGLNLQSADT VIIFDSDWNP HQDLQAQDRA HRIGQQNEVR 1200
    VLRLCTVNSV EEKILAAAKY KLNVDQKVIQ AGMFDQKSSS HERRAFLQAI 1250
    LEHEEQDEEE DEVPDDETVN QMIARHEEEF DLFMRMDLDR RREEARNPKR 1300
    KPRLMEEDEL PSWIIKDDAE VERLTCEEEE EKMFGRGSRH RKEVDYSDSL 1350
    TEKQWLKAIE EGTLEEIEEE VRQKKSSRKR KRDSEAGSST PTTSTRSRDK 1400
    DEESKKQKKR GRPPAEKLSP NPPNLTKKMK KIVDAVIKYK DSSGRQLSEV 1450
    FIQLPSRKEL PEYYELIRKP VDFKKIKERI RNHKYRSLND LEKDVMLLCQ 1500
    NAQTFNLEGS LIYEDSIVLQ SVFTSVRQKI EKEDDSEGEE SEEEEEGEEE 1550
    GSESESRSVK VKIKLGRKEK AQDRLKGGRR RPSRGSRAKP VVSDDDSEEE 1600
    QEEDRSGSGS EED 1613
    Length:1,613
    Mass (Da):181,427
    Last modified:October 11, 2005 - v1
    Checksum:iC23804ED858F98FE
    GO
    Isoform 2 (identifier: Q3TKT4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1441-1441: D → DS

    Show »
    Length:1,614
    Mass (Da):181,514
    Checksum:i1DC02672488F3BA5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1355 – 13551W → WLKT in BAE36034. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1441 – 14411D → DS in isoform 2. 2 PublicationsVSP_038696

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK147285 mRNA. Translation: BAE27821.1.
    AK160825 mRNA. Translation: BAE36034.1.
    AK166837 mRNA. Translation: BAE39059.1.
    BC079560 mRNA. Translation: AAH79560.1.
    CH466522 Genomic DNA. Translation: EDL25209.1.
    CCDSiCCDS22909.1. [Q3TKT4-2]
    CCDS57662.1. [Q3TKT4-1]
    RefSeqiNP_001167549.1. NM_001174078.1.
    NP_001167550.1. NM_001174079.1. [Q3TKT4-1]
    NP_035547.2. NM_011417.3. [Q3TKT4-2]
    UniGeneiMm.286593.

    Genome annotation databases

    EnsembliENSMUST00000034707; ENSMUSP00000034707; ENSMUSG00000032187. [Q3TKT4-2]
    ENSMUST00000098948; ENSMUSP00000096547; ENSMUSG00000032187.
    ENSMUST00000174008; ENSMUSP00000133922; ENSMUSG00000032187. [Q3TKT4-1]
    GeneIDi20586.
    KEGGimmu:20586.
    UCSCiuc009omd.2. mouse. [Q3TKT4-2]
    uc009ome.2. mouse. [Q3TKT4-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK147285 mRNA. Translation: BAE27821.1 .
    AK160825 mRNA. Translation: BAE36034.1 .
    AK166837 mRNA. Translation: BAE39059.1 .
    BC079560 mRNA. Translation: AAH79560.1 .
    CH466522 Genomic DNA. Translation: EDL25209.1 .
    CCDSi CCDS22909.1. [Q3TKT4-2 ]
    CCDS57662.1. [Q3TKT4-1 ]
    RefSeqi NP_001167549.1. NM_001174078.1.
    NP_001167550.1. NM_001174079.1. [Q3TKT4-1 ]
    NP_035547.2. NM_011417.3. [Q3TKT4-2 ]
    UniGenei Mm.286593.

    3D structure databases

    ProteinModelPortali Q3TKT4.
    SMRi Q3TKT4. Positions 749-1221, 1416-1535.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203336. 72 interactions.
    DIPi DIP-40650N.
    DIP-59249N.
    IntActi Q3TKT4. 28 interactions.
    MINTi MINT-1958721.
    STRINGi 10090.ENSMUSP00000096547.

    PTM databases

    PhosphoSitei Q3TKT4.

    Proteomic databases

    MaxQBi Q3TKT4.
    PaxDbi Q3TKT4.
    PRIDEi Q3TKT4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034707 ; ENSMUSP00000034707 ; ENSMUSG00000032187 . [Q3TKT4-2 ]
    ENSMUST00000098948 ; ENSMUSP00000096547 ; ENSMUSG00000032187 .
    ENSMUST00000174008 ; ENSMUSP00000133922 ; ENSMUSG00000032187 . [Q3TKT4-1 ]
    GeneIDi 20586.
    KEGGi mmu:20586.
    UCSCi uc009omd.2. mouse. [Q3TKT4-2 ]
    uc009ome.2. mouse. [Q3TKT4-1 ]

    Organism-specific databases

    CTDi 6597.
    MGIi MGI:88192. Smarca4.

    Phylogenomic databases

    eggNOGi COG0553.
    GeneTreei ENSGT00550000074659.
    HOGENOMi HOG000172363.
    HOVERGENi HBG056636.
    InParanoidi Q3TUD7.
    KOi K11647.
    OrthoDBi EOG771265.
    PhylomeDBi Q3TKT4.
    TreeFami TF300785.

    Enzyme and pathway databases

    Reactomei REACT_216539. formation of the beta-catenin:TCF transactivating complex.

    Miscellaneous databases

    NextBioi 298883.
    PROi Q3TKT4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3TKT4.
    Bgeei Q3TKT4.
    Genevestigatori Q3TKT4.

    Family and domain databases

    Gene3Di 1.20.920.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR006576. BRK_domain.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR014978. Gln-Leu-Gln_QLQ.
    IPR013999. HAS_subgr.
    IPR014012. Helicase/SANT-assoc_DNA-bd.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR029295. SnAC.
    IPR000330. SNF2_N.
    [Graphical view ]
    Pfami PF07533. BRK. 1 hit.
    PF00439. Bromodomain. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF07529. HSA. 1 hit.
    PF08880. QLQ. 1 hit.
    PF14619. SnAC. 1 hit.
    PF00176. SNF2_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00592. BRK. 1 hit.
    SM00297. BROMO. 1 hit.
    SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    SM00573. HSA. 1 hit.
    SM00951. QLQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 1 hit.
    SSF52540. SSF52540. 2 hits.
    PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51204. HSA. 1 hit.
    PS51666. QLQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Placenta.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Brain.
    4. "An essential switch in subunit composition of a chromatin remodeling complex during neural development."
      Lessard J., Wu J.I., Ranish J.A., Wan M., Winslow M.M., Staahl B.T., Wu H., Aebersold R., Graef I.A., Crabtree G.R.
      Neuron 55:201-215(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, FUNCTION OF THE NBAF AND NPBAF COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE NBAF AND NPBAF COMPLEXES, INTERACTION WITH PHF10.
    5. "Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1."
      Ohkawa Y., Marfella C.G., Imbalzano A.N.
      EMBO J. 25:490-501(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MYOG.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-610 AND SER-613, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    7. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSMCA4_MOUSE
    AccessioniPrimary (citable) accession number: Q3TKT4
    Secondary accession number(s): Q3TUD7, Q6AXG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 9, 2010
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3