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Q3TKT4

- SMCA4_MOUSE

UniProt

Q3TKT4 - SMCA4_MOUSE

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Protein

Transcription activator BRG1

Gene

Smarca4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei1505 – 15062Required for binding to 'Lys-15'-acetylated histone 3By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi779 – 7868ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: MGI
  2. ATP binding Source: UniProtKB-KW
  3. chromatin binding Source: MGI
  4. DNA-dependent ATPase activity Source: Ensembl
  5. helicase activity Source: UniProtKB-KW
  6. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  7. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
  8. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  9. RNA polymerase II transcription coactivator activity Source: Ensembl
  10. transcription corepressor activity Source: UniProtKB
  11. transcription factor binding Source: MGI

GO - Biological processi

  1. aortic smooth muscle cell differentiation Source: MGI
  2. ATP-dependent chromatin remodeling Source: Ensembl
  3. blastocyst growth Source: MGI
  4. blastocyst hatching Source: MGI
  5. cell morphogenesis Source: MGI
  6. chromatin remodeling Source: MGI
  7. definitive erythrocyte differentiation Source: MGI
  8. DNA methylation on cytosine within a CG sequence Source: MGI
  9. embryonic hindlimb morphogenesis Source: MGI
  10. embryonic organ morphogenesis Source: MGI
  11. epidermis morphogenesis Source: MGI
  12. extracellular matrix organization Source: MGI
  13. forebrain development Source: MGI
  14. glial cell fate determination Source: MGI
  15. heart development Source: MGI
  16. heart trabecula formation Source: MGI
  17. hindbrain development Source: MGI
  18. histone H3 acetylation Source: MGI
  19. in utero embryonic development Source: MGI
  20. keratinocyte differentiation Source: MGI
  21. lens fiber cell development Source: MGI
  22. liver development Source: MGI
  23. methylation-dependent chromatin silencing Source: MGI
  24. negative regulation of androgen receptor signaling pathway Source: Ensembl
  25. negative regulation of cell growth Source: Ensembl
  26. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  27. nervous system development Source: UniProtKB
  28. neural retina development Source: Ensembl
  29. neurogenesis Source: MGI
  30. nucleosome assembly Source: MGI
  31. nucleosome disassembly Source: Ensembl
  32. positive regulation by host of viral transcription Source: Ensembl
  33. positive regulation of DNA binding Source: MGI
  34. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  35. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  36. stem cell maintenance Source: MGI
  37. vasculogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Helicase, Hydrolase, Repressor

Keywords - Biological processi

Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_216539. formation of the beta-catenin:TCF transactivating complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription activator BRG1 (EC:3.6.4.-)
Alternative name(s):
ATP-dependent helicase SMARCA4
BRG1-associated factor 190A
Short name:
BAF190A
Protein brahma homolog 1
SNF2-beta
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
Gene namesi
Name:Smarca4
Synonyms:Baf190a, Brg1, Snf2b, Snf2l4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:88192. Smarca4.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. heterochromatin Source: MGI
  3. nBAF complex Source: UniProtKB
  4. npBAF complex Source: UniProtKB
  5. nuclear euchromatin Source: MGI
  6. nucleus Source: MGI
  7. perichromatin fibrils Source: MGI
  8. SWI/SNF complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16131613Transcription activator BRG1PRO_0000391343Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111PhosphothreonineBy similarity
Modified residuei188 – 1881N6-acetyllysineBy similarity
Modified residuei353 – 3531PhosphothreonineBy similarity
Modified residuei609 – 6091PhosphothreonineBy similarity
Modified residuei610 – 6101Phosphoserine1 Publication
Modified residuei613 – 6131Phosphoserine1 Publication
Modified residuei695 – 6951PhosphoserineBy similarity
Modified residuei699 – 6991PhosphoserineBy similarity
Modified residuei1349 – 13491PhosphoserineBy similarity
Modified residuei1419 – 14191PhosphoserineBy similarity
Modified residuei1536 – 15361PhosphoserineBy similarity
Modified residuei1541 – 15411PhosphoserineBy similarity
Modified residuei1552 – 15521PhosphoserineBy similarity
Modified residuei1593 – 15931PhosphoserineBy similarity
Modified residuei1597 – 15971PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ3TKT4.
PaxDbiQ3TKT4.
PRIDEiQ3TKT4.

PTM databases

PhosphoSiteiQ3TKT4.

Expressioni

Gene expression databases

BgeeiQ3TKT4.
ExpressionAtlasiQ3TKT4. baseline and differential.
GenevestigatoriQ3TKT4.

Interactioni

Subunit structurei

Interacts with NR3C1, PGR, SMARD1, TOPBP1 and ZMIM2/ZIMP7. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, IKFZ1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. Interacts directly with IKFZ1 in the BAF complex. In muscle cells, the BAF complex also contains DPF3. Component of the BAF53 complex, at least composed of BAF53A, RUVBL1, SMARCA4/BRG1/BAF190A, and TRRAP, which preferentially acetylates histone H4 (and H2A) within nucleosomes. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Component of the CREST-BRG1 complex, at least composed of SMARCA4/BRG1/BAF190A, SS18L1/CREST, HDAC1, RB1 and SP1. Interacts with (via the bromodomain) with TERT; the interaction regulates Wnt-mediated signaling. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin. Interacts with ZEB1 (via N-terminus) (By similarity). Interacts with PHF10/BAF45A. Interacts with MYOG.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HnrnpuQ8VEK33EBI-1210244,EBI-529674
RB1P064004EBI-1210244,EBI-491274From a different organism.
Rb1P134053EBI-1210244,EBI-971782
Smarcc1P974965EBI-1210244,EBI-648047
Smarcd3Q6P9Z13EBI-1210244,EBI-7525857

Protein-protein interaction databases

BioGridi203336. 72 interactions.
DIPiDIP-40650N.
DIP-59249N.
IntActiQ3TKT4. 28 interactions.
MINTiMINT-1958721.
STRINGi10090.ENSMUSP00000096547.

Structurei

3D structure databases

ProteinModelPortaliQ3TKT4.
SMRiQ3TKT4. Positions 749-1221, 1416-1535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini171 – 20636QLQPROSITE-ProRule annotationAdd
BLAST
Domaini460 – 53273HSAPROSITE-ProRule annotationAdd
BLAST
Domaini766 – 931166Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1084 – 1246163Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini1443 – 151371BromoPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 282282Necessary for interaction with SS18L1/CRESTBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi881 – 8844DEGH boxBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 344341Pro-richAdd
BLAST
Compositional biasi663 – 67210Poly-Glu
Compositional biasi1252 – 1370119Glu-richAdd
BLAST
Compositional biasi1531 – 155525Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 HSA domain.PROSITE-ProRule annotation
Contains 1 QLQ domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain

Phylogenomic databases

eggNOGiCOG0553.
GeneTreeiENSGT00550000074659.
HOGENOMiHOG000172363.
HOVERGENiHBG056636.
InParanoidiQ3TKT4.
KOiK11647.
OrthoDBiEOG771265.
PhylomeDBiQ3TKT4.
TreeFamiTF300785.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR006576. BRK_domain.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR014978. Gln-Leu-Gln_QLQ.
IPR013999. HAS_subgr.
IPR014012. Helicase/SANT-assoc_DNA-bd.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR029295. SnAC.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF07533. BRK. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF08880. QLQ. 1 hit.
PF14619. SnAC. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00592. BRK. 1 hit.
SM00297. BROMO. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00573. HSA. 1 hit.
SM00951. QLQ. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
PS51666. QLQ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3TKT4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTPDPPLGG TPRPGPSPGP GPSPGAMLGP SPGPSPGSAH SMMGPSPGPP
60 70 80 90 100
SAGHPMPTQG PGGYPQDNMH QMHKPMESMH EKGMPDDPRY NQMKGMGMRS
110 120 130 140 150
GAHTGMAPPP SPMDQHSQGY PSPLGGSEHA SSPVPASGPS SGPQMSSGPG
160 170 180 190 200
GAPLDGSDPQ ALGQQNRGPT PFNQNQLHQL RAQIMAYKML ARGQPLPDHL
210 220 230 240 250
QMAVQGKRPM PGMQQQMPTL PPPSVSATGP GPGPGPGPGP GPGPAPPNYS
260 270 280 290 300
RPHGMGGPNM PPPGPSGVPP GMPGQPPGGP PKPWPEGPMA NAAAPTSTPQ
310 320 330 340 350
KLIPPQPTGR PSPAPPAVPP AASPVMPPQT QSPGQPAQPA PLVPLHQKQS
360 370 380 390 400
RITPIQKPRG LDPVEILQER EYRLQARIAH RIQELENLPG SLAGDLRTKA
410 420 430 440 450
TIELKALRLL NFQRQLRQEV VVCMRRDTAL ETALNAKAYK RSKRQSLREA
460 470 480 490 500
RITEKLEKQQ KIEQERKRRQ KHQEYLNSIL QHAKDFREYH RSVTGKLQKL
510 520 530 540 550
TKAVATYHAN TEREQKKENE RIEKERMRRL MAEDEEGYRK LIDQKKDKRL
560 570 580 590 600
AYLLQQTDEY VANLTELVRQ HKAAQVAKEK KKKKKKKKAE NAEGQTPAIG
610 620 630 640 650
PDGEPLDETS QMSDLPVKVI HVESGKILTG TDAPKAGQLE AWLEMNPGYE
660 670 680 690 700
VAPRSDSEES GSEEEEEEEE EEQPQPAQPP TLPVEEKKKI PDPDSDDVSE
710 720 730 740 750
VDARHIIENA KQDVDDEYGV SQALARGLQS YYAVAHAVTE RVDKQSALMV
760 770 780 790 800
NGVLKQYQIK GLEWLVSLYN NNLNGILADE MGLGKTIQTI ALITYLMEHK
810 820 830 840 850
RINGPFLIIV PLSTLSNWAY EFDKWAPSVV KVSYKGSPAA RRAFVPQLRS
860 870 880 890 900
GKFNVLLTTY EYIIKDKHIL AKIRWKYMIV DEGHRMKNHH CKLTQVLNTH
910 920 930 940 950
YVAPRRLLLT GTPLQNKLPE LWALLNFLLP TIFKSCSTFE QWFNAPFAMT
960 970 980 990 1000
GEKVDLNEEE TILIIRRLHK VLRPFLLRRL KKEVEAQLPE KVEYVIKCDM
1010 1020 1030 1040 1050
SALQRVLYRH MQAKGVLLTD GSEKDKKGKG GTKTLMNTIM QLRKICNHPY
1060 1070 1080 1090 1100
MFQHIEESFS EHLGFTGGIV QGLDLYRASG KFELLDRILP KLRATNHKVL
1110 1120 1130 1140 1150
LFCQMTSLMT IMEDYFAYRG FKYLRLDGTT KAEDRGMLLK TFNEPGSEYF
1160 1170 1180 1190 1200
IFLLSTRAGG LGLNLQSADT VIIFDSDWNP HQDLQAQDRA HRIGQQNEVR
1210 1220 1230 1240 1250
VLRLCTVNSV EEKILAAAKY KLNVDQKVIQ AGMFDQKSSS HERRAFLQAI
1260 1270 1280 1290 1300
LEHEEQDEEE DEVPDDETVN QMIARHEEEF DLFMRMDLDR RREEARNPKR
1310 1320 1330 1340 1350
KPRLMEEDEL PSWIIKDDAE VERLTCEEEE EKMFGRGSRH RKEVDYSDSL
1360 1370 1380 1390 1400
TEKQWLKAIE EGTLEEIEEE VRQKKSSRKR KRDSEAGSST PTTSTRSRDK
1410 1420 1430 1440 1450
DEESKKQKKR GRPPAEKLSP NPPNLTKKMK KIVDAVIKYK DSSGRQLSEV
1460 1470 1480 1490 1500
FIQLPSRKEL PEYYELIRKP VDFKKIKERI RNHKYRSLND LEKDVMLLCQ
1510 1520 1530 1540 1550
NAQTFNLEGS LIYEDSIVLQ SVFTSVRQKI EKEDDSEGEE SEEEEEGEEE
1560 1570 1580 1590 1600
GSESESRSVK VKIKLGRKEK AQDRLKGGRR RPSRGSRAKP VVSDDDSEEE
1610
QEEDRSGSGS EED
Length:1,613
Mass (Da):181,427
Last modified:October 11, 2005 - v1
Checksum:iC23804ED858F98FE
GO
Isoform 2 (identifier: Q3TKT4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1441-1441: D → DS

Show »
Length:1,614
Mass (Da):181,514
Checksum:i1DC02672488F3BA5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1355 – 13551W → WLKT in BAE36034. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1441 – 14411D → DS in isoform 2. 2 PublicationsVSP_038696

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK147285 mRNA. Translation: BAE27821.1.
AK160825 mRNA. Translation: BAE36034.1.
AK166837 mRNA. Translation: BAE39059.1.
BC079560 mRNA. Translation: AAH79560.1.
CH466522 Genomic DNA. Translation: EDL25209.1.
CCDSiCCDS22909.1. [Q3TKT4-2]
CCDS57662.1. [Q3TKT4-1]
RefSeqiNP_001167549.1. NM_001174078.1.
NP_001167550.1. NM_001174079.1. [Q3TKT4-1]
NP_035547.2. NM_011417.3. [Q3TKT4-2]
UniGeneiMm.286593.

Genome annotation databases

EnsembliENSMUST00000034707; ENSMUSP00000034707; ENSMUSG00000032187. [Q3TKT4-2]
ENSMUST00000098948; ENSMUSP00000096547; ENSMUSG00000032187.
ENSMUST00000174008; ENSMUSP00000133922; ENSMUSG00000032187. [Q3TKT4-1]
GeneIDi20586.
KEGGimmu:20586.
UCSCiuc009omd.2. mouse. [Q3TKT4-2]
uc009ome.2. mouse. [Q3TKT4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK147285 mRNA. Translation: BAE27821.1 .
AK160825 mRNA. Translation: BAE36034.1 .
AK166837 mRNA. Translation: BAE39059.1 .
BC079560 mRNA. Translation: AAH79560.1 .
CH466522 Genomic DNA. Translation: EDL25209.1 .
CCDSi CCDS22909.1. [Q3TKT4-2 ]
CCDS57662.1. [Q3TKT4-1 ]
RefSeqi NP_001167549.1. NM_001174078.1.
NP_001167550.1. NM_001174079.1. [Q3TKT4-1 ]
NP_035547.2. NM_011417.3. [Q3TKT4-2 ]
UniGenei Mm.286593.

3D structure databases

ProteinModelPortali Q3TKT4.
SMRi Q3TKT4. Positions 749-1221, 1416-1535.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203336. 72 interactions.
DIPi DIP-40650N.
DIP-59249N.
IntActi Q3TKT4. 28 interactions.
MINTi MINT-1958721.
STRINGi 10090.ENSMUSP00000096547.

PTM databases

PhosphoSitei Q3TKT4.

Proteomic databases

MaxQBi Q3TKT4.
PaxDbi Q3TKT4.
PRIDEi Q3TKT4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034707 ; ENSMUSP00000034707 ; ENSMUSG00000032187 . [Q3TKT4-2 ]
ENSMUST00000098948 ; ENSMUSP00000096547 ; ENSMUSG00000032187 .
ENSMUST00000174008 ; ENSMUSP00000133922 ; ENSMUSG00000032187 . [Q3TKT4-1 ]
GeneIDi 20586.
KEGGi mmu:20586.
UCSCi uc009omd.2. mouse. [Q3TKT4-2 ]
uc009ome.2. mouse. [Q3TKT4-1 ]

Organism-specific databases

CTDi 6597.
MGIi MGI:88192. Smarca4.

Phylogenomic databases

eggNOGi COG0553.
GeneTreei ENSGT00550000074659.
HOGENOMi HOG000172363.
HOVERGENi HBG056636.
InParanoidi Q3TKT4.
KOi K11647.
OrthoDBi EOG771265.
PhylomeDBi Q3TKT4.
TreeFami TF300785.

Enzyme and pathway databases

Reactomei REACT_216539. formation of the beta-catenin:TCF transactivating complex.

Miscellaneous databases

NextBioi 298883.
PROi Q3TKT4.
SOURCEi Search...

Gene expression databases

Bgeei Q3TKT4.
ExpressionAtlasi Q3TKT4. baseline and differential.
Genevestigatori Q3TKT4.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR006576. BRK_domain.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR014978. Gln-Leu-Gln_QLQ.
IPR013999. HAS_subgr.
IPR014012. Helicase/SANT-assoc_DNA-bd.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR029295. SnAC.
IPR000330. SNF2_N.
[Graphical view ]
Pfami PF07533. BRK. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF08880. QLQ. 1 hit.
PF14619. SnAC. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00592. BRK. 1 hit.
SM00297. BROMO. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00573. HSA. 1 hit.
SM00951. QLQ. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
PS51666. QLQ. 1 hit.
[Graphical view ]
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Publicationsi

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  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Placenta.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain.
  4. "An essential switch in subunit composition of a chromatin remodeling complex during neural development."
    Lessard J., Wu J.I., Ranish J.A., Wan M., Winslow M.M., Staahl B.T., Wu H., Aebersold R., Graef I.A., Crabtree G.R.
    Neuron 55:201-215(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, FUNCTION OF THE NBAF AND NPBAF COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE NBAF AND NPBAF COMPLEXES, INTERACTION WITH PHF10.
  5. "Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1."
    Ohkawa Y., Marfella C.G., Imbalzano A.N.
    EMBO J. 25:490-501(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYOG.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-610 AND SER-613, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSMCA4_MOUSE
AccessioniPrimary (citable) accession number: Q3TKT4
Secondary accession number(s): Q3TUD7, Q6AXG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

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