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Protein

Transcription activator BRG1

Gene

Smarca4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1505 – 1506Required for binding to 'Lys-15'-acetylated histone 3By similarity2

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi779 – 786ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • aorta development Source: MGI
  • aortic smooth muscle cell differentiation Source: MGI
  • ATP-dependent chromatin remodeling Source: MGI
  • blastocyst growth Source: MGI
  • blastocyst hatching Source: MGI
  • blood vessel development Source: MGI
  • cell morphogenesis Source: MGI
  • chromatin remodeling Source: MGI
  • coronary vasculature development Source: MGI
  • definitive erythrocyte differentiation Source: MGI
  • DNA methylation on cytosine within a CG sequence Source: MGI
  • embryonic hindlimb morphogenesis Source: MGI
  • embryonic organ morphogenesis Source: MGI
  • epidermis morphogenesis Source: MGI
  • extracellular matrix organization Source: MGI
  • forebrain development Source: MGI
  • glial cell fate determination Source: MGI
  • heart development Source: MGI
  • heart trabecula formation Source: MGI
  • hindbrain development Source: MGI
  • histone H3 acetylation Source: MGI
  • in utero embryonic development Source: MGI
  • keratinocyte differentiation Source: MGI
  • lens fiber cell development Source: MGI
  • liver development Source: MGI
  • methylation-dependent chromatin silencing Source: MGI
  • negative regulation of androgen receptor signaling pathway Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of cell growth Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • nervous system development Source: UniProtKB
  • neurogenesis Source: MGI
  • nucleosome assembly Source: MGI
  • nucleosome disassembly Source: MGI
  • outflow tract morphogenesis Source: MGI
  • pharyngeal arch artery morphogenesis Source: MGI
  • positive regulation by host of viral transcription Source: MGI
  • positive regulation of cell differentiation Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of DNA binding Source: MGI
  • positive regulation of glucose mediated signaling pathway Source: MGI
  • positive regulation of pri-miRNA transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter Source: MGI
  • positive regulation of Wnt signaling pathway Source: BHF-UCL
  • regulation of cell migration Source: MGI
  • stem cell population maintenance Source: MGI
  • vasculogenesis Source: MGI
  • ventricular septum development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Helicase, Hydrolase, Repressor

Keywords - Biological processi

Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1266695. Interleukin-7 signaling.
R-MMU-201722. Formation of the beta-catenin:TCF transactivating complex.
R-MMU-3214858. RMTs methylate histone arginines.
R-MMU-3247509. Chromatin modifying enzymes.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription activator BRG1 (EC:3.6.4.-)
Alternative name(s):
ATP-dependent helicase SMARCA4
BRG1-associated factor 190A
Short name:
BAF190A
Protein brahma homolog 1
SNF2-beta
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
Gene namesi
Name:Smarca4
Synonyms:Baf190a, Brg1, Snf2b, Snf2l4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88192. Smarca4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • BAF-type complex Source: MGI
  • extracellular space Source: MGI
  • heterochromatin Source: MGI
  • membrane Source: MGI
  • nBAF complex Source: UniProtKB
  • npBAF complex Source: UniProtKB
  • nuclear chromatin Source: MGI
  • nuclear euchromatin Source: MGI
  • nucleus Source: MGI
  • perichromatin fibrils Source: MGI
  • protein complex Source: MGI
  • SWI/SNF complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003913431 – 1613Transcription activator BRG1Add BLAST1613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphothreonineBy similarity1
Modified residuei188N6-acetyllysineBy similarity1
Modified residuei353PhosphothreonineBy similarity1
Modified residuei609PhosphothreonineBy similarity1
Modified residuei610PhosphoserineCombined sources1
Modified residuei613PhosphoserineCombined sources1
Modified residuei695PhosphoserineCombined sources1
Modified residuei699PhosphoserineCombined sources1
Modified residuei1349PhosphoserineBy similarity1
Modified residuei1390PhosphothreonineCombined sources1
Modified residuei1419PhosphoserineBy similarity1
Modified residuei1536PhosphoserineCombined sources1
Modified residuei1541PhosphoserineCombined sources1
Modified residuei1552PhosphoserineCombined sources1
Modified residuei1593PhosphoserineBy similarity1
Modified residuei1597PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ3TKT4.
PaxDbiQ3TKT4.
PeptideAtlasiQ3TKT4.
PRIDEiQ3TKT4.

PTM databases

iPTMnetiQ3TKT4.
PhosphoSitePlusiQ3TKT4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032187.
ExpressionAtlasiQ3TKT4. baseline and differential.
GenevisibleiQ3TKT4. MM.

Interactioni

Subunit structurei

Interacts with NR3C1, PGR, SMARD1, TOPBP1 and ZMIM2/ZIMP7. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, IKFZ1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. Interacts directly with IKFZ1 in the BAF complex. In muscle cells, the BAF complex also contains DPF3. Component of the BAF53 complex, at least composed of BAF53A, RUVBL1, SMARCA4/BRG1/BAF190A, and TRRAP, which preferentially acetylates histone H4 (and H2A) within nucleosomes. Component of the CREST-BRG1 complex, at least composed of SMARCA4/BRG1/BAF190A, SS18L1/CREST, HDAC1, RB1 and SP1. Interacts with (via the bromodomain) with TERT; the interaction regulates Wnt-mediated signaling. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin. Interacts with ZEB1 (via N-terminus) (By similarity). Interacts with PHF10/BAF45A. Interacts with MYOG.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HnrnpuQ8VEK33EBI-1210244,EBI-529674
RB1P064004EBI-1210244,EBI-491274From a different organism.
Rb1P134053EBI-1210244,EBI-971782
Smarcc1P974966EBI-1210244,EBI-648047
Smarcd3Q6P9Z13EBI-1210244,EBI-7525857

GO - Molecular functioni

  • androgen receptor binding Source: MGI
  • DNA polymerase binding Source: BHF-UCL
  • lysine-acetylated histone binding Source: MGI
  • p53 binding Source: MGI
  • protein N-terminus binding Source: MGI
  • Tat protein binding Source: MGI
  • transcription factor binding Source: MGI

Protein-protein interaction databases

BioGridi203336. 73 interactors.
DIPiDIP-40650N.
DIP-59249N.
IntActiQ3TKT4. 28 interactors.
MINTiMINT-1958721.
STRINGi10090.ENSMUSP00000096547.

Structurei

3D structure databases

ProteinModelPortaliQ3TKT4.
SMRiQ3TKT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini171 – 206QLQPROSITE-ProRule annotationAdd BLAST36
Domaini460 – 532HSAPROSITE-ProRule annotationAdd BLAST73
Domaini766 – 931Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1084 – 1246Helicase C-terminalPROSITE-ProRule annotationAdd BLAST163
Domaini1443 – 1513BromoPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 282Necessary for interaction with SS18L1/CRESTBy similarityAdd BLAST282

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi881 – 884DEGH boxBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 344Pro-richAdd BLAST341
Compositional biasi663 – 672Poly-Glu10
Compositional biasi1252 – 1370Glu-richAdd BLAST119
Compositional biasi1531 – 1555Glu-richAdd BLAST25

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 HSA domain.PROSITE-ProRule annotation
Contains 1 QLQ domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain

Phylogenomic databases

eggNOGiKOG0386. Eukaryota.
COG0553. LUCA.
COG5076. LUCA.
GeneTreeiENSGT00550000074659.
HOGENOMiHOG000172363.
HOVERGENiHBG056636.
InParanoidiQ3TKT4.
KOiK11647.
PhylomeDBiQ3TKT4.
TreeFamiTF300785.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR030100. BRG1.
IPR006576. BRK_domain.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR014978. Gln-Leu-Gln_QLQ.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014012. HSA_dom.
IPR027417. P-loop_NTPase.
IPR029295. SnAC.
IPR000330. SNF2_N.
[Graphical view]
PANTHERiPTHR10799:SF76. PTHR10799:SF76. 3 hits.
PfamiPF07533. BRK. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF08880. QLQ. 1 hit.
PF14619. SnAC. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00592. BRK. 1 hit.
SM00297. BROMO. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00573. HSA. 1 hit.
SM00951. QLQ. 1 hit.
SM01314. SnAC. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
PS51666. QLQ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TKT4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTPDPPLGG TPRPGPSPGP GPSPGAMLGP SPGPSPGSAH SMMGPSPGPP
60 70 80 90 100
SAGHPMPTQG PGGYPQDNMH QMHKPMESMH EKGMPDDPRY NQMKGMGMRS
110 120 130 140 150
GAHTGMAPPP SPMDQHSQGY PSPLGGSEHA SSPVPASGPS SGPQMSSGPG
160 170 180 190 200
GAPLDGSDPQ ALGQQNRGPT PFNQNQLHQL RAQIMAYKML ARGQPLPDHL
210 220 230 240 250
QMAVQGKRPM PGMQQQMPTL PPPSVSATGP GPGPGPGPGP GPGPAPPNYS
260 270 280 290 300
RPHGMGGPNM PPPGPSGVPP GMPGQPPGGP PKPWPEGPMA NAAAPTSTPQ
310 320 330 340 350
KLIPPQPTGR PSPAPPAVPP AASPVMPPQT QSPGQPAQPA PLVPLHQKQS
360 370 380 390 400
RITPIQKPRG LDPVEILQER EYRLQARIAH RIQELENLPG SLAGDLRTKA
410 420 430 440 450
TIELKALRLL NFQRQLRQEV VVCMRRDTAL ETALNAKAYK RSKRQSLREA
460 470 480 490 500
RITEKLEKQQ KIEQERKRRQ KHQEYLNSIL QHAKDFREYH RSVTGKLQKL
510 520 530 540 550
TKAVATYHAN TEREQKKENE RIEKERMRRL MAEDEEGYRK LIDQKKDKRL
560 570 580 590 600
AYLLQQTDEY VANLTELVRQ HKAAQVAKEK KKKKKKKKAE NAEGQTPAIG
610 620 630 640 650
PDGEPLDETS QMSDLPVKVI HVESGKILTG TDAPKAGQLE AWLEMNPGYE
660 670 680 690 700
VAPRSDSEES GSEEEEEEEE EEQPQPAQPP TLPVEEKKKI PDPDSDDVSE
710 720 730 740 750
VDARHIIENA KQDVDDEYGV SQALARGLQS YYAVAHAVTE RVDKQSALMV
760 770 780 790 800
NGVLKQYQIK GLEWLVSLYN NNLNGILADE MGLGKTIQTI ALITYLMEHK
810 820 830 840 850
RINGPFLIIV PLSTLSNWAY EFDKWAPSVV KVSYKGSPAA RRAFVPQLRS
860 870 880 890 900
GKFNVLLTTY EYIIKDKHIL AKIRWKYMIV DEGHRMKNHH CKLTQVLNTH
910 920 930 940 950
YVAPRRLLLT GTPLQNKLPE LWALLNFLLP TIFKSCSTFE QWFNAPFAMT
960 970 980 990 1000
GEKVDLNEEE TILIIRRLHK VLRPFLLRRL KKEVEAQLPE KVEYVIKCDM
1010 1020 1030 1040 1050
SALQRVLYRH MQAKGVLLTD GSEKDKKGKG GTKTLMNTIM QLRKICNHPY
1060 1070 1080 1090 1100
MFQHIEESFS EHLGFTGGIV QGLDLYRASG KFELLDRILP KLRATNHKVL
1110 1120 1130 1140 1150
LFCQMTSLMT IMEDYFAYRG FKYLRLDGTT KAEDRGMLLK TFNEPGSEYF
1160 1170 1180 1190 1200
IFLLSTRAGG LGLNLQSADT VIIFDSDWNP HQDLQAQDRA HRIGQQNEVR
1210 1220 1230 1240 1250
VLRLCTVNSV EEKILAAAKY KLNVDQKVIQ AGMFDQKSSS HERRAFLQAI
1260 1270 1280 1290 1300
LEHEEQDEEE DEVPDDETVN QMIARHEEEF DLFMRMDLDR RREEARNPKR
1310 1320 1330 1340 1350
KPRLMEEDEL PSWIIKDDAE VERLTCEEEE EKMFGRGSRH RKEVDYSDSL
1360 1370 1380 1390 1400
TEKQWLKAIE EGTLEEIEEE VRQKKSSRKR KRDSEAGSST PTTSTRSRDK
1410 1420 1430 1440 1450
DEESKKQKKR GRPPAEKLSP NPPNLTKKMK KIVDAVIKYK DSSGRQLSEV
1460 1470 1480 1490 1500
FIQLPSRKEL PEYYELIRKP VDFKKIKERI RNHKYRSLND LEKDVMLLCQ
1510 1520 1530 1540 1550
NAQTFNLEGS LIYEDSIVLQ SVFTSVRQKI EKEDDSEGEE SEEEEEGEEE
1560 1570 1580 1590 1600
GSESESRSVK VKIKLGRKEK AQDRLKGGRR RPSRGSRAKP VVSDDDSEEE
1610
QEEDRSGSGS EED
Length:1,613
Mass (Da):181,427
Last modified:October 11, 2005 - v1
Checksum:iC23804ED858F98FE
GO
Isoform 2 (identifier: Q3TKT4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1441-1441: D → DS

Show »
Length:1,614
Mass (Da):181,514
Checksum:i1DC02672488F3BA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1355W → WLKT in BAE36034 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0386961441D → DS in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147285 mRNA. Translation: BAE27821.1.
AK160825 mRNA. Translation: BAE36034.1.
AK166837 mRNA. Translation: BAE39059.1.
BC079560 mRNA. Translation: AAH79560.1.
CH466522 Genomic DNA. Translation: EDL25209.1.
CCDSiCCDS22909.1. [Q3TKT4-2]
CCDS57662.1. [Q3TKT4-1]
RefSeqiNP_001167549.1. NM_001174078.1.
NP_001167550.1. NM_001174079.1. [Q3TKT4-1]
NP_035547.2. NM_011417.3. [Q3TKT4-2]
XP_006510180.2. XM_006510117.2.
XP_006510182.2. XM_006510119.2. [Q3TKT4-2]
XP_006510183.2. XM_006510120.2. [Q3TKT4-1]
UniGeneiMm.286593.

Genome annotation databases

EnsembliENSMUST00000034707; ENSMUSP00000034707; ENSMUSG00000032187. [Q3TKT4-2]
ENSMUST00000174008; ENSMUSP00000133922; ENSMUSG00000032187. [Q3TKT4-1]
GeneIDi20586.
KEGGimmu:20586.
UCSCiuc009omd.2. mouse. [Q3TKT4-2]
uc009ome.2. mouse. [Q3TKT4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147285 mRNA. Translation: BAE27821.1.
AK160825 mRNA. Translation: BAE36034.1.
AK166837 mRNA. Translation: BAE39059.1.
BC079560 mRNA. Translation: AAH79560.1.
CH466522 Genomic DNA. Translation: EDL25209.1.
CCDSiCCDS22909.1. [Q3TKT4-2]
CCDS57662.1. [Q3TKT4-1]
RefSeqiNP_001167549.1. NM_001174078.1.
NP_001167550.1. NM_001174079.1. [Q3TKT4-1]
NP_035547.2. NM_011417.3. [Q3TKT4-2]
XP_006510180.2. XM_006510117.2.
XP_006510182.2. XM_006510119.2. [Q3TKT4-2]
XP_006510183.2. XM_006510120.2. [Q3TKT4-1]
UniGeneiMm.286593.

3D structure databases

ProteinModelPortaliQ3TKT4.
SMRiQ3TKT4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203336. 73 interactors.
DIPiDIP-40650N.
DIP-59249N.
IntActiQ3TKT4. 28 interactors.
MINTiMINT-1958721.
STRINGi10090.ENSMUSP00000096547.

PTM databases

iPTMnetiQ3TKT4.
PhosphoSitePlusiQ3TKT4.

Proteomic databases

MaxQBiQ3TKT4.
PaxDbiQ3TKT4.
PeptideAtlasiQ3TKT4.
PRIDEiQ3TKT4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034707; ENSMUSP00000034707; ENSMUSG00000032187. [Q3TKT4-2]
ENSMUST00000174008; ENSMUSP00000133922; ENSMUSG00000032187. [Q3TKT4-1]
GeneIDi20586.
KEGGimmu:20586.
UCSCiuc009omd.2. mouse. [Q3TKT4-2]
uc009ome.2. mouse. [Q3TKT4-1]

Organism-specific databases

CTDi6597.
MGIiMGI:88192. Smarca4.

Phylogenomic databases

eggNOGiKOG0386. Eukaryota.
COG0553. LUCA.
COG5076. LUCA.
GeneTreeiENSGT00550000074659.
HOGENOMiHOG000172363.
HOVERGENiHBG056636.
InParanoidiQ3TKT4.
KOiK11647.
PhylomeDBiQ3TKT4.
TreeFamiTF300785.

Enzyme and pathway databases

ReactomeiR-MMU-1266695. Interleukin-7 signaling.
R-MMU-201722. Formation of the beta-catenin:TCF transactivating complex.
R-MMU-3214858. RMTs methylate histone arginines.
R-MMU-3247509. Chromatin modifying enzymes.

Miscellaneous databases

ChiTaRSiSmarca4. mouse.
PROiQ3TKT4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032187.
ExpressionAtlasiQ3TKT4. baseline and differential.
GenevisibleiQ3TKT4. MM.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR030100. BRG1.
IPR006576. BRK_domain.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR014978. Gln-Leu-Gln_QLQ.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014012. HSA_dom.
IPR027417. P-loop_NTPase.
IPR029295. SnAC.
IPR000330. SNF2_N.
[Graphical view]
PANTHERiPTHR10799:SF76. PTHR10799:SF76. 3 hits.
PfamiPF07533. BRK. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF08880. QLQ. 1 hit.
PF14619. SnAC. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00592. BRK. 1 hit.
SM00297. BROMO. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00573. HSA. 1 hit.
SM00951. QLQ. 1 hit.
SM01314. SnAC. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
PS51666. QLQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMCA4_MOUSE
AccessioniPrimary (citable) accession number: Q3TKT4
Secondary accession number(s): Q3TUD7, Q6AXG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.