SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3TJM4

- CENPT_MOUSE

UniProt

Q3TJM4 - CENPT_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Centromere protein T

Gene
Cenpt
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis By similarity.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. chromosome organization Source: UniProtKB
  2. chromosome segregation Source: UniProtKB
  3. kinetochore assembly Source: UniProtKB
  4. mitotic cell cycle Source: UniProtKB
  5. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein T
Short name:
CENP-T
Gene namesi
Name:Cenpt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2443939. Cenpt.

Subcellular locationi

Nucleus By similarity. Chromosomecentromere By similarity. Chromosomecentromerekinetochore By similarity
Note: Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. Localizes to the inner kinetochore, and may connect it to the outer kinetochore via its N-terminus By similarity.

GO - Cellular componenti

  1. chromosome, centromeric region Source: UniProtKB
  2. condensed chromosome kinetochore Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Centromere protein TPRO_0000249516Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei86 – 861Phosphothreonine By similarity
Modified residuei333 – 3331Phosphoserine By similarity
Modified residuei345 – 3451Phosphoserine By similarity
Modified residuei346 – 3461Phosphoserine By similarity
Modified residuei357 – 3571Phosphoserine By similarity

Post-translational modificationi

Dynamically phosphorylated during the cell cycle. Phosphorylated during G2 phase, metaphase and anaphase, but not during telophase or G1 phase.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ3TJM4.

Expressioni

Gene expression databases

BgeeiQ3TJM4.
CleanExiMM_CENPT.
GenevestigatoriQ3TJM4.

Interactioni

Subunit structurei

Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Part of a centromere complex consisting of CENPA, CENPT and CENPW. Part of a centromere complex consisting of histone H3, CENPT and CENPW. Interacts (via N-terminus) with the NDC80 complex By similarity. Component of a heterotetrameric CENP-T-W-S-X complex composed of APITD1/CENPS, STRA13/CENPX, CENPT and CENPW. Interacts directly with CENPW. Binds DNA By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ3TJM4.
SMRiQ3TJM4. Positions 419-505.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 375282Flexible stalk domain By similarityAdd
BLAST

Domaini

The largest part of the sequence forms an elongated and flexible stalk structure that is connected to a C-terminal globular domain with a histone-type fold By similarity.

Phylogenomic databases

eggNOGiNOG26624.
GeneTreeiENSGT00390000003044.
HOGENOMiHOG000111545.
HOVERGENiHBG081089.
InParanoidiQ3TJM4.
KOiK11512.
OMAiFSFYAKM.
OrthoDBiEOG7TQV2Z.
PhylomeDBiQ3TJM4.
TreeFamiTF332946.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR028255. CENP-T.
IPR009072. Histone-fold.
[Graphical view]
PANTHERiPTHR14857. PTHR14857. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3TJM4-1 [UniParc]FASTAAdd to Basket

« Hide

MADLSFSDGD PTVRTLLRRV LETADSRTPM RRRSTRINAQ RRRSQTPYSN    50
RQGSQTKTSA RKQSHGARSV GRSTRVQGRG RLEEQTPRTL LRNILLTAPE 100
SSTVMPDPVV KPAQVPEVAR SSRRESSRGS LELHLPELEP PSTLAPGLTA 150
PGKRKQKLRL SVFQQEVDQG LPLSQEPRRS RSADVSSLAS SFNLTFVLPG 200
QPETVERPGL ARRRPIRQLV NAGALLQDLE DNSLASALPG DSHRTPVAAL 250
PMDVGLEDTQ PFSQSLAAFS LSGKHSLPSP SRPGVEDVER VMGPPSSGTR 300
LQSRMSRSGP AASPSPFLEP QPPPAEPREA VGSNEAAEPK DQEGSSGYEE 350
TSARPASGEL SSSTHDSLPA EQPPPSPGVA VLSSEPLESV TAKCPSRTQT 400
AGPRRRQDPH KAGLSPYVKF FSFCTKMPVE KTALEIVEKC LDKYFQHLCN 450
DLEVFASHAG RKIVKPEDLL LLMRRQGLVT DQVSQHVLVE RYLPLEYRQQ 500
LIPCAFSGNS VFPAQ 515
Length:515
Mass (Da):56,242
Last modified:October 3, 2006 - v2
Checksum:iC736E7FA30E6206B
GO

Sequence cautioni

The sequence BAC40776.1 differs from that shown. Reason: Frameshift at position 303.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51S → V in BAE25464. 1 Publication
Sequence conflicti157 – 1571K → R in BAE39471. 1 Publication
Sequence conflicti302 – 3032QS → KG in BAC40776. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK089172 mRNA. Translation: BAC40776.1. Frameshift.
AK090340 mRNA. Translation: BAC41176.1.
AK143613 mRNA. Translation: BAE25464.1.
AK164039 mRNA. Translation: BAE37599.1.
AK167376 mRNA. Translation: BAE39471.1.
BC022690 mRNA. Translation: AAH22690.1.
BC121824 mRNA. Translation: AAI21825.1.
CCDSiCCDS22615.1.
RefSeqiNP_796124.1. NM_177150.2.
UniGeneiMm.334775.

Genome annotation databases

EnsembliENSMUST00000040776; ENSMUSP00000038188; ENSMUSG00000036672.
GeneIDi320394.
KEGGimmu:320394.
UCSCiuc009nef.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK089172 mRNA. Translation: BAC40776.1 . Frameshift.
AK090340 mRNA. Translation: BAC41176.1 .
AK143613 mRNA. Translation: BAE25464.1 .
AK164039 mRNA. Translation: BAE37599.1 .
AK167376 mRNA. Translation: BAE39471.1 .
BC022690 mRNA. Translation: AAH22690.1 .
BC121824 mRNA. Translation: AAI21825.1 .
CCDSi CCDS22615.1.
RefSeqi NP_796124.1. NM_177150.2.
UniGenei Mm.334775.

3D structure databases

ProteinModelPortali Q3TJM4.
SMRi Q3TJM4. Positions 419-505.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q3TJM4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040776 ; ENSMUSP00000038188 ; ENSMUSG00000036672 .
GeneIDi 320394.
KEGGi mmu:320394.
UCSCi uc009nef.1. mouse.

Organism-specific databases

CTDi 80152.
MGIi MGI:2443939. Cenpt.

Phylogenomic databases

eggNOGi NOG26624.
GeneTreei ENSGT00390000003044.
HOGENOMi HOG000111545.
HOVERGENi HBG081089.
InParanoidi Q3TJM4.
KOi K11512.
OMAi FSFYAKM.
OrthoDBi EOG7TQV2Z.
PhylomeDBi Q3TJM4.
TreeFami TF332946.

Enzyme and pathway databases

Reactomei REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Miscellaneous databases

NextBioi 396642.
PROi Q3TJM4.
SOURCEi Search...

Gene expression databases

Bgeei Q3TJM4.
CleanExi MM_CENPT.
Genevestigatori Q3TJM4.

Family and domain databases

Gene3Di 1.10.20.10. 1 hit.
InterProi IPR028255. CENP-T.
IPR009072. Histone-fold.
[Graphical view ]
PANTHERi PTHR14857. PTHR14857. 1 hit.
SUPFAMi SSF47113. SSF47113. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung, Placenta and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCENPT_MOUSE
AccessioniPrimary (citable) accession number: Q3TJM4
Secondary accession number(s): Q3TPY6
, Q3UPD2, Q8BTH0, Q8BTP2, Q8R5E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: September 3, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi