Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

U4/U6.U5 tri-snRNP-associated protein 2

Gene

Usp39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity, but could be a competitor of ubiquitin C-terminal hydrolases (UCHs) (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri121 – 18262UBP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Protein family/group databases

MEROPSiC19.972.

Names & Taxonomyi

Protein namesi
Recommended name:
U4/U6.U5 tri-snRNP-associated protein 2
Alternative name(s):
Inactive ubiquitin-specific peptidase 39
Gene namesi
Name:Usp39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107622. Usp39.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564U4/U6.U5 tri-snRNP-associated protein 2PRO_0000223963Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461PhosphoserineBy similarity
Modified residuei81 – 811PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3TIX9.
MaxQBiQ3TIX9.
PaxDbiQ3TIX9.
PeptideAtlasiQ3TIX9.
PRIDEiQ3TIX9.

PTM databases

iPTMnetiQ3TIX9.
PhosphoSiteiQ3TIX9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000056305.
CleanExiMM_USP39.
GenevisibleiQ3TIX9. MM.

Interactioni

Subunit structurei

Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39.By similarity

Protein-protein interaction databases

BioGridi205726. 2 interactions.
IntActiQ3TIX9. 3 interactions.
MINTiMINT-4113699.
STRINGi10090.ENSMUSP00000064515.

Structurei

3D structure databases

ProteinModelPortaliQ3TIX9.
SMRiQ3TIX9. Positions 106-555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini224 – 554331USPAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 10299Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 UBP-type zinc finger.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri121 – 18262UBP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2026. Eukaryota.
ENOG410XS41. LUCA.
GeneTreeiENSGT00390000007992.
HOGENOMiHOG000188754.
HOVERGENiHBG079718.
InParanoidiQ3TIX9.
KOiK12847.
OMAiELMRKMW.
OrthoDBiEOG091G06U0.
PhylomeDBiQ3TIX9.
TreeFamiTF300610.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001394. Peptidase_C19_UCH.
IPR028889. USP_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
SMARTiSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEiPS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TIX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRSKRQSH GSTRGKRESE SRGSSGRIKK ERDREKEPEA ASSRGSPVRV
60 70 80 90 100
KREAEPAARE VPAPALPVVR VKREREADED SEPEREVRAK NGRVDSEDRR
110 120 130 140 150
SRHCPYLDTI NRSVLDFDFE KLCSISLSHI NAYACLVCGK YFQGRGLKSH
160 170 180 190 200
AYIHSVQFSH HVFLNLHTLK FYCLPDNYEI IDSSLEDITY VLKPTFTKQQ
210 220 230 240 250
IANLDKQAKL SRAYDGTTYL PGIVGLNNIK ANDYANAVLQ ALSNVPPLRN
260 270 280 290 300
YFLEEDNYKN IKRPPGDIMF LLVQRFGELM RKLWNPRNFK AHVSPHEMLQ
310 320 330 340 350
AVVLCSKKTF QITKQGDGVD FLSWFLNALH SALGGTKKKK KTIVNDVFQG
360 370 380 390 400
SMRIFTKKLP HPDLPAEEKE QLLHNDEYQE TMVESTFMYL TLDLPTAPLY
410 420 430 440 450
KDEKEQLIIP QVPLFNILAK FNGITEKEYK TYKENFLKRF QLTKLPPYLI
460 470 480 490 500
FCIKRFTKNN FFVEKNPTIV NFPITNVDLR EYLSEEVQAV HKNTTYDLIA
510 520 530 540 550
NIVHDGKPSE GSYRIHVLHH GTGKWYELQD LQVTDILPQM ITLSEAYIQI
560
WKRRDNDETN QQGA
Length:564
Mass (Da):65,146
Last modified:February 21, 2006 - v2
Checksum:i67A84B80FEE5AB71
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31S → T in BAC32203 (PubMed:16141072).Curated
Sequence conflicti14 – 141R → S in BAE39991 (PubMed:16141072).Curated
Sequence conflicti334 – 3341G → V in BAC28153 (PubMed:16141072).Curated
Sequence conflicti465 – 4651K → E in AAH26983 (PubMed:16141072).Curated
Sequence conflicti465 – 4651K → E in BAE39717 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010443 mRNA. Translation: BAB26944.1.
AK018595 mRNA. Translation: BAB31299.1.
AK033105 mRNA. Translation: BAC28153.1.
AK045062 mRNA. Translation: BAC32203.1.
AK167668 mRNA. Translation: BAE39717.1.
AK165625 mRNA. Translation: BAE38302.1.
AK168003 mRNA. Translation: BAE39991.1.
AK088354 mRNA. Translation: BAC40299.1.
BC026983 mRNA. Translation: AAH26983.1.
CCDSiCCDS20238.1.
RefSeqiNP_613058.1. NM_138592.4.
UniGeneiMm.281900.

Genome annotation databases

EnsembliENSMUST00000070345; ENSMUSP00000064515; ENSMUSG00000056305.
ENSMUST00000193449; ENSMUSP00000141203; ENSMUSG00000104250.
GeneIDi28035.
KEGGimmu:28035.
UCSCiuc009cif.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010443 mRNA. Translation: BAB26944.1.
AK018595 mRNA. Translation: BAB31299.1.
AK033105 mRNA. Translation: BAC28153.1.
AK045062 mRNA. Translation: BAC32203.1.
AK167668 mRNA. Translation: BAE39717.1.
AK165625 mRNA. Translation: BAE38302.1.
AK168003 mRNA. Translation: BAE39991.1.
AK088354 mRNA. Translation: BAC40299.1.
BC026983 mRNA. Translation: AAH26983.1.
CCDSiCCDS20238.1.
RefSeqiNP_613058.1. NM_138592.4.
UniGeneiMm.281900.

3D structure databases

ProteinModelPortaliQ3TIX9.
SMRiQ3TIX9. Positions 106-555.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205726. 2 interactions.
IntActiQ3TIX9. 3 interactions.
MINTiMINT-4113699.
STRINGi10090.ENSMUSP00000064515.

Protein family/group databases

MEROPSiC19.972.

PTM databases

iPTMnetiQ3TIX9.
PhosphoSiteiQ3TIX9.

Proteomic databases

EPDiQ3TIX9.
MaxQBiQ3TIX9.
PaxDbiQ3TIX9.
PeptideAtlasiQ3TIX9.
PRIDEiQ3TIX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070345; ENSMUSP00000064515; ENSMUSG00000056305.
ENSMUST00000193449; ENSMUSP00000141203; ENSMUSG00000104250.
GeneIDi28035.
KEGGimmu:28035.
UCSCiuc009cif.1. mouse.

Organism-specific databases

CTDi10713.
MGIiMGI:107622. Usp39.

Phylogenomic databases

eggNOGiKOG2026. Eukaryota.
ENOG410XS41. LUCA.
GeneTreeiENSGT00390000007992.
HOGENOMiHOG000188754.
HOVERGENiHBG079718.
InParanoidiQ3TIX9.
KOiK12847.
OMAiELMRKMW.
OrthoDBiEOG091G06U0.
PhylomeDBiQ3TIX9.
TreeFamiTF300610.

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiQ3TIX9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056305.
CleanExiMM_USP39.
GenevisibleiQ3TIX9. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001394. Peptidase_C19_UCH.
IPR028889. USP_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
SMARTiSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEiPS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNUT2_MOUSE
AccessioniPrimary (citable) accession number: Q3TIX9
Secondary accession number(s): Q3TI55
, Q8BLI5, Q8BZZ5, Q9CQR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 21, 2006
Last modified: September 7, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.