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Protein

Sugar phosphate exchanger 3

Gene

Slc37a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar phosphate exchanger 3
Alternative name(s):
Solute carrier family 37 member 3
Gene namesi
Name:Slc37a3
Synonyms:Spx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1919394. Slc37a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalSequence analysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence analysisAdd
BLAST
Transmembranei177 – 19721HelicalSequence analysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence analysisAdd
BLAST
Transmembranei297 – 31721HelicalSequence analysisAdd
BLAST
Transmembranei333 – 35321HelicalSequence analysisAdd
BLAST
Transmembranei357 – 37721HelicalSequence analysisAdd
BLAST
Transmembranei386 – 40621HelicalSequence analysisAdd
BLAST
Transmembranei428 – 44821HelicalSequence analysisAdd
BLAST
Transmembranei457 – 47721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Sugar phosphate exchanger 3PRO_0000309279Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ3TIT8.
PaxDbiQ3TIT8.
PRIDEiQ3TIT8.

Expressioni

Gene expression databases

BgeeiQ3TIT8.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087709.

Structurei

3D structure databases

ProteinModelPortaliQ3TIT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP3Z. Eukaryota.
COG2271. LUCA.
HOGENOMiHOG000230522.
HOVERGENiHBG005851.
InParanoidiQ3TIT8.
KOiK03447.
OrthoDBiEOG7BZVS3.
PhylomeDBiQ3TIT8.
TreeFamiTF314991.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TIT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWPRFLQRG ALLTSFSHHH LAVFLLTFFS YSLLHASRKT FSNVKVSISK
60 70 80 90 100
QWTPNAFNTS LDLPAEIWSS NHLFPSTEEA TLFLGTLDTV FLFSYAVGLF
110 120 130 140 150
ISGIIGDRLN LRWVLSFGMC SSAFVVFVFG TLTEWLHFYN KWFYCGLWIV
160 170 180 190 200
NGLLQSTGWP CVVAVMGNWF GKAGRGVVFG LWSACASVGN ILGAFLASSV
210 220 230 240 250
LQYGYEYAFL VTASVQFAGG IIIFFGLLVS PEEIGLPSIG AEESSEEDSQ
260 270 280 290 300
RPLIDGAENE DDYEPNYSIQ EDRAVVQVKA ISFHQACCLP GVIPYSLAYA
310 320 330 340 350
CLKLVNYSFF FWLPFYLSNN FGWKEAEADK LSIWYDVGGI IGGTLLGFIS
360 370 380 390 400
DVLQKRAPVL ALSLFLAVWS LVGYSRSPNN KSINALLMTI TGFFIGGPSN
410 420 430 440 450
MVSSAISADL GRQELIQGNS EALATVTGIV DGTGSIGAAV GQYLVSLIQD
460 470 480 490
NLGWMWVFYF FILMTSCTIL FILPLIVREV FSLVQRRQAH SLNE
Length:494
Mass (Da):54,553
Last modified:October 11, 2005 - v1
Checksum:i1343CBFC34C192F5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti197 – 1971A → T in AAH99673 (PubMed:15489334).Curated
Sequence conflicti237 – 2371P → L in AAH99673 (PubMed:15489334).Curated
Sequence conflicti369 – 3691W → G in BAC36258 (PubMed:16141072).Curated
Sequence conflicti369 – 3691W → G in AAH99673 (PubMed:15489334).Curated
Sequence conflicti473 – 4731L → S in AAH99673 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076213 mRNA. Translation: BAC36258.1.
AK167716 mRNA. Translation: BAE39758.1.
BC099673 mRNA. Translation: AAH99673.1.
CCDSiCCDS20020.1.
RefSeqiNP_082399.3. NM_028123.3.
UniGeneiMm.482167.

Genome annotation databases

GeneIDi72144.
KEGGimmu:72144.
UCSCiuc009bll.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076213 mRNA. Translation: BAC36258.1.
AK167716 mRNA. Translation: BAE39758.1.
BC099673 mRNA. Translation: AAH99673.1.
CCDSiCCDS20020.1.
RefSeqiNP_082399.3. NM_028123.3.
UniGeneiMm.482167.

3D structure databases

ProteinModelPortaliQ3TIT8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087709.

Proteomic databases

MaxQBiQ3TIT8.
PaxDbiQ3TIT8.
PRIDEiQ3TIT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi72144.
KEGGimmu:72144.
UCSCiuc009bll.2. mouse.

Organism-specific databases

CTDi84255.
MGIiMGI:1919394. Slc37a3.

Phylogenomic databases

eggNOGiENOG410IP3Z. Eukaryota.
COG2271. LUCA.
HOGENOMiHOG000230522.
HOVERGENiHBG005851.
InParanoidiQ3TIT8.
KOiK03447.
OrthoDBiEOG7BZVS3.
PhylomeDBiQ3TIT8.
TreeFamiTF314991.

Miscellaneous databases

ChiTaRSiSlc37a3. mouse.
PROiQ3TIT8.
SOURCEiSearch...

Gene expression databases

BgeeiQ3TIT8.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head and Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NMRI.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiSPX3_MOUSE
AccessioniPrimary (citable) accession number: Q3TIT8
Secondary accession number(s): Q4FZD9, Q8BVX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.