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Protein

Sugar phosphate exchanger 3

Gene

Slc37a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar phosphate exchanger 3
Alternative name(s):
Solute carrier family 37 member 3
Gene namesi
Name:Slc37a3
Synonyms:Spx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1919394. Slc37a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003092791 – 494Sugar phosphate exchanger 3Add BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3TIT8.
PRIDEiQ3TIT8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029924.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087709.

Structurei

3D structure databases

ProteinModelPortaliQ3TIT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP3Z. Eukaryota.
COG2271. LUCA.
HOGENOMiHOG000230522.
HOVERGENiHBG005851.
InParanoidiQ3TIT8.
KOiK03447.
PhylomeDBiQ3TIT8.
TreeFamiTF314991.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TIT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWPRFLQRG ALLTSFSHHH LAVFLLTFFS YSLLHASRKT FSNVKVSISK
60 70 80 90 100
QWTPNAFNTS LDLPAEIWSS NHLFPSTEEA TLFLGTLDTV FLFSYAVGLF
110 120 130 140 150
ISGIIGDRLN LRWVLSFGMC SSAFVVFVFG TLTEWLHFYN KWFYCGLWIV
160 170 180 190 200
NGLLQSTGWP CVVAVMGNWF GKAGRGVVFG LWSACASVGN ILGAFLASSV
210 220 230 240 250
LQYGYEYAFL VTASVQFAGG IIIFFGLLVS PEEIGLPSIG AEESSEEDSQ
260 270 280 290 300
RPLIDGAENE DDYEPNYSIQ EDRAVVQVKA ISFHQACCLP GVIPYSLAYA
310 320 330 340 350
CLKLVNYSFF FWLPFYLSNN FGWKEAEADK LSIWYDVGGI IGGTLLGFIS
360 370 380 390 400
DVLQKRAPVL ALSLFLAVWS LVGYSRSPNN KSINALLMTI TGFFIGGPSN
410 420 430 440 450
MVSSAISADL GRQELIQGNS EALATVTGIV DGTGSIGAAV GQYLVSLIQD
460 470 480 490
NLGWMWVFYF FILMTSCTIL FILPLIVREV FSLVQRRQAH SLNE
Length:494
Mass (Da):54,553
Last modified:October 11, 2005 - v1
Checksum:i1343CBFC34C192F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197A → T in AAH99673 (PubMed:15489334).Curated1
Sequence conflicti237P → L in AAH99673 (PubMed:15489334).Curated1
Sequence conflicti369W → G in BAC36258 (PubMed:16141072).Curated1
Sequence conflicti369W → G in AAH99673 (PubMed:15489334).Curated1
Sequence conflicti473L → S in AAH99673 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076213 mRNA. Translation: BAC36258.1.
AK167716 mRNA. Translation: BAE39758.1.
BC099673 mRNA. Translation: AAH99673.1.
CCDSiCCDS20020.1.
RefSeqiNP_082399.3. NM_028123.3.
XP_017177246.1. XM_017321757.1.
XP_017177247.1. XM_017321758.1.
XP_017177248.1. XM_017321759.1.
UniGeneiMm.482167.

Genome annotation databases

GeneIDi72144.
KEGGimmu:72144.
UCSCiuc009bll.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076213 mRNA. Translation: BAC36258.1.
AK167716 mRNA. Translation: BAE39758.1.
BC099673 mRNA. Translation: AAH99673.1.
CCDSiCCDS20020.1.
RefSeqiNP_082399.3. NM_028123.3.
XP_017177246.1. XM_017321757.1.
XP_017177247.1. XM_017321758.1.
XP_017177248.1. XM_017321759.1.
UniGeneiMm.482167.

3D structure databases

ProteinModelPortaliQ3TIT8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087709.

Proteomic databases

PaxDbiQ3TIT8.
PRIDEiQ3TIT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi72144.
KEGGimmu:72144.
UCSCiuc009bll.2. mouse.

Organism-specific databases

CTDi84255.
MGIiMGI:1919394. Slc37a3.

Phylogenomic databases

eggNOGiENOG410IP3Z. Eukaryota.
COG2271. LUCA.
HOGENOMiHOG000230522.
HOVERGENiHBG005851.
InParanoidiQ3TIT8.
KOiK03447.
PhylomeDBiQ3TIT8.
TreeFamiTF314991.

Miscellaneous databases

ChiTaRSiSlc37a3. mouse.
PROiQ3TIT8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029924.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR000849. Sugar_P_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PIRSFiPIRSF002808. Hexose_phosphate_transp. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPX3_MOUSE
AccessioniPrimary (citable) accession number: Q3TIT8
Secondary accession number(s): Q4FZD9, Q8BVX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.