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Protein

Schwannomin-interacting protein 1

Gene

Schip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • estrogen metabolic process Source: MGI
  • face morphogenesis Source: MGI
  • female gonad development Source: MGI
  • fibroblast migration Source: MGI
  • kidney development Source: MGI
  • luteinization Source: MGI
  • nitrogen compound metabolic process Source: MGI
  • palate development Source: MGI
  • platelet-derived growth factor receptor signaling pathway Source: MGI
  • post-embryonic development Source: MGI
  • skeletal system morphogenesis Source: MGI
  • smooth muscle tissue development Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Schwannomin-interacting protein 1
Short name:
SCHIP-1
Gene namesi
Name:Schip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1353557. Schip1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Schwannomin-interacting protein 1PRO_0000288928Add
BLAST

Proteomic databases

MaxQBiQ3TI53.
PaxDbiQ3TI53.
PeptideAtlasiQ3TI53.
PRIDEiQ3TI53.

PTM databases

iPTMnetiQ3TI53.
PhosphoSiteiQ3TI53.

Expressioni

Tissue specificityi

Isoform 7, but not isoforms 5 or 6, is highly enriched at AISs and NRs in the PNS and CNS of the adult brain (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000027777.
CleanExiMM_SCHIP1.
ExpressionAtlasiQ3TI53. baseline and differential.
GenevisibleiQ3TI53. MM.

Interactioni

Subunit structurei

Self-associates through its coiled coil domain. Interacts with NF2 isoforms (By similarity). Isoform 7 interacts (via C-terminal IQ motif) with calmodulin in the absence of Ca2+. Isoform 7 interacts (via C-terminus) with ANK3 (via N-terminal ANK repeats); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NF2P352402EBI-1397475,EBI-1014472From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi206029. 2 interactions.
IntActiQ3TI53. 1 interaction.
STRINGi10090.ENSMUSP00000029346.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili421 – 45535Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 6735Ser-richAdd
BLAST
Compositional biasi99 – 1046Poly-Glu

Sequence similaritiesi

Belongs to the SCHIP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4847. Eukaryota.
ENOG4111HYM. LUCA.
GeneTreeiENSGT00390000011127.
HOGENOMiHOG000063723.
HOVERGENiHBG054427.
InParanoidiQ3TI53.
OMAiPRRAIQK.
OrthoDBiEOG091G0K9X.
TreeFamiTF323326.

Family and domain databases

InterProiIPR015649. SCHIP_1.
[Graphical view]
PANTHERiPTHR13103. PTHR13103. 1 hit.
PfamiPF10148. SCHIP-1. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 5 (identifier: Q3TI53-5) [UniParc]FASTAAdd to basket
Also known as: SCHIP-1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERSEQRVRA AWDCDPGKQA DRDYREDGMD LGSDAGSSSS SRASSQSNST
60 70 80 90 100
KVTPCSECKS SSSPGGSLDL VSALEDYEEP FPVYQKKVID EWAPEEDGEE
110 120 130 140 150
EEEEDDRGYR DDGCPAREPG DVSARIGSSG SGSRSAATTM PSPMPNGNLH
160 170 180 190 200
PHDPQDLRHN GNVVVAGRPN ASRVPRRPIQ KTQPPGSRRG GRNRASGGLC
210 220 230 240 250
LQPPDGGTRV PEEPPAPPMD WEALEKHLAG LQFREQEVRN QGQARTNSTS
260 270 280 290 300
AQKNERESIR QKLALGSFFD DGPGIYTSCS KSGKPSLSAR LQSGMNLQIC
310 320 330 340 350
FVNDSGSDKD SDADDSKTET SLDTPLSPMS KQSSSYSDRD TTEEESESLD
360 370 380 390 400
DMDFLTRQKK LQAEAKMALA MAKPMAKMQV EVEKQNRKKS PVADLLPHMP
410 420 430 440 450
HISECLMKRS LKPTDLRDMT IGQLQVIVND LHSQIESLNE ELVQLLLIRD
460 470 480
ELHTEQDAML VDIEDLTRHA ESQQKHMAEK MPAK
Length:484
Mass (Da):53,306
Last modified:April 3, 2013 - v2
Checksum:iD6940356290904EC
GO
Isoform 1 (identifier: Q3TI53-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Show »
Length:456
Mass (Da):49,983
Checksum:iF4A0CECB79EDF3AC
GO
Isoform 3 (identifier: Q3TI53-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     241-250: QGQARTNSTS → MVHQENCSYQ

Show »
Length:244
Mass (Da):27,490
Checksum:i0E710D6280F10CB9
GO
Isoform 6 (identifier: Q3TI53-6) [UniParc]FASTAAdd to basket
Also known as: SCHIP-1B

The sequence of this isoform differs from the canonical sequence as follows:
     23-250: Missing.

Show »
Length:256
Mass (Da):28,857
Checksum:iA4654471898FE59C
GO
Isoform 7 (identifier: Q3TI53-7) [UniParc]FASTAAdd to basket
Also known as: IQCJ-SCHIP-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MERSEQRVRAAWDCDPGKQADR → MRLEELKRLQ...MNTFSDSSTP

Note: Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein.
Show »
Length:559
Mass (Da):61,917
Checksum:i72C5FB63AD80036D
GO

Sequence cautioni

The sequence AAH94348 differs from that shown.Aberrant splicing.Curated
The sequence AAH94348 differs from that shown. Reason: Frameshift at position 389. Curated
The sequence BAB32387 differs from that shown.Probable cloning artifact.Curated
The sequence BAB32387 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti166 – 1661A → V in AAF34244 (PubMed:10669747).Curated
Sequence conflicti384 – 3841K → R in BAB32387 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 240240Missing in isoform 3. 2 PublicationsVSP_025831Add
BLAST
Alternative sequencei1 – 2828Missing in isoform 1. 2 PublicationsVSP_046119Add
BLAST
Alternative sequencei1 – 2222MERSE…KQADR → MRLEELKRLQNPLEQVDDGK YLLENHQLAMDVENNIENYP LSLQPLESKVKIIQRAWREY LQRQDPLEKRSPSPPSVSSD KLSSSVSMNTFSDSSTP in isoform 7. 1 PublicationVSP_046120Add
BLAST
Alternative sequencei23 – 250228Missing in isoform 6. 1 PublicationVSP_046121Add
BLAST
Alternative sequencei241 – 25010QGQARTNSTS → MVHQENCSYQ in isoform 3. 2 PublicationsVSP_025834

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU163407 mRNA. Translation: ABW06760.1.
EU163408 mRNA. Translation: ABW06761.1.
EU163409 mRNA. Translation: ABW06762.1.
AK021361 mRNA. Translation: BAB32387.1. Sequence problems.
AK168005 mRNA. Translation: BAE39993.1.
AK146930 mRNA. Translation: BAE27541.1.
AC093360 Genomic DNA. No translation available.
AC114675 Genomic DNA. No translation available.
AC121306 Genomic DNA. No translation available.
AC122913 Genomic DNA. No translation available.
AC164401 Genomic DNA. No translation available.
BC060529 mRNA. Translation: AAH60529.1.
BC094348 mRNA. Translation: AAH94348.1. Sequence problems.
AF145716 mRNA. Translation: AAF34244.1.
CCDSiCCDS50926.1. [Q3TI53-5]
CCDS50927.1. [Q3TI53-6]
CCDS50929.1. [Q3TI53-3]
CCDS71249.1. [Q3TI53-1]
RefSeqiNP_001106890.1. NM_001113419.2. [Q3TI53-7]
NP_001106891.1. NM_001113420.1. [Q3TI53-6]
NP_001106892.1. NM_001113421.1. [Q3TI53-5]
NP_001268973.1. NM_001282044.1. [Q3TI53-1]
NP_001268974.1. NM_001282045.1. [Q3TI53-1]
NP_038956.2. NM_013928.5. [Q3TI53-3]
UniGeneiMm.331064.

Genome annotation databases

EnsembliENSMUST00000029346; ENSMUSP00000029346; ENSMUSG00000027777. [Q3TI53-5]
ENSMUST00000169909; ENSMUSP00000129152; ENSMUSG00000027777. [Q3TI53-6]
ENSMUST00000170788; ENSMUSP00000126443; ENSMUSG00000027777. [Q3TI53-3]
ENSMUST00000182006; ENSMUSP00000138212; ENSMUSG00000102422. [Q3TI53-7]
ENSMUST00000182532; ENSMUSP00000138245; ENSMUSG00000027777. [Q3TI53-1]
ENSMUST00000182719; ENSMUSP00000138207; ENSMUSG00000027777. [Q3TI53-1]
GeneIDi100505386.
30953.
KEGGimmu:100505386.
mmu:30953.
UCSCiuc008plr.3. mouse. [Q3TI53-5]
uc012cqg.1. mouse. [Q3TI53-7]
uc012cqi.1. mouse. [Q3TI53-6]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU163407 mRNA. Translation: ABW06760.1.
EU163408 mRNA. Translation: ABW06761.1.
EU163409 mRNA. Translation: ABW06762.1.
AK021361 mRNA. Translation: BAB32387.1. Sequence problems.
AK168005 mRNA. Translation: BAE39993.1.
AK146930 mRNA. Translation: BAE27541.1.
AC093360 Genomic DNA. No translation available.
AC114675 Genomic DNA. No translation available.
AC121306 Genomic DNA. No translation available.
AC122913 Genomic DNA. No translation available.
AC164401 Genomic DNA. No translation available.
BC060529 mRNA. Translation: AAH60529.1.
BC094348 mRNA. Translation: AAH94348.1. Sequence problems.
AF145716 mRNA. Translation: AAF34244.1.
CCDSiCCDS50926.1. [Q3TI53-5]
CCDS50927.1. [Q3TI53-6]
CCDS50929.1. [Q3TI53-3]
CCDS71249.1. [Q3TI53-1]
RefSeqiNP_001106890.1. NM_001113419.2. [Q3TI53-7]
NP_001106891.1. NM_001113420.1. [Q3TI53-6]
NP_001106892.1. NM_001113421.1. [Q3TI53-5]
NP_001268973.1. NM_001282044.1. [Q3TI53-1]
NP_001268974.1. NM_001282045.1. [Q3TI53-1]
NP_038956.2. NM_013928.5. [Q3TI53-3]
UniGeneiMm.331064.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206029. 2 interactions.
IntActiQ3TI53. 1 interaction.
STRINGi10090.ENSMUSP00000029346.

PTM databases

iPTMnetiQ3TI53.
PhosphoSiteiQ3TI53.

Proteomic databases

MaxQBiQ3TI53.
PaxDbiQ3TI53.
PeptideAtlasiQ3TI53.
PRIDEiQ3TI53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029346; ENSMUSP00000029346; ENSMUSG00000027777. [Q3TI53-5]
ENSMUST00000169909; ENSMUSP00000129152; ENSMUSG00000027777. [Q3TI53-6]
ENSMUST00000170788; ENSMUSP00000126443; ENSMUSG00000027777. [Q3TI53-3]
ENSMUST00000182006; ENSMUSP00000138212; ENSMUSG00000102422. [Q3TI53-7]
ENSMUST00000182532; ENSMUSP00000138245; ENSMUSG00000027777. [Q3TI53-1]
ENSMUST00000182719; ENSMUSP00000138207; ENSMUSG00000027777. [Q3TI53-1]
GeneIDi100505386.
30953.
KEGGimmu:100505386.
mmu:30953.
UCSCiuc008plr.3. mouse. [Q3TI53-5]
uc012cqg.1. mouse. [Q3TI53-7]
uc012cqi.1. mouse. [Q3TI53-6]

Organism-specific databases

CTDi29970.
MGIiMGI:1353557. Schip1.

Phylogenomic databases

eggNOGiKOG4847. Eukaryota.
ENOG4111HYM. LUCA.
GeneTreeiENSGT00390000011127.
HOGENOMiHOG000063723.
HOVERGENiHBG054427.
InParanoidiQ3TI53.
OMAiPRRAIQK.
OrthoDBiEOG091G0K9X.
TreeFamiTF323326.

Miscellaneous databases

PROiQ3TI53.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027777.
CleanExiMM_SCHIP1.
ExpressionAtlasiQ3TI53. baseline and differential.
GenevisibleiQ3TI53. MM.

Family and domain databases

InterProiIPR015649. SCHIP_1.
[Graphical view]
PANTHERiPTHR13103. PTHR13103. 1 hit.
PfamiPF10148. SCHIP-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCHI1_MOUSE
AccessioniPrimary (citable) accession number: Q3TI53
Secondary accession number(s): A8IJC6
, A8IJD0, A8IJD3, F6YL02, F8WI70, Q52KH1, Q6P9Y8, Q9CX07, Q9JLR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: April 3, 2013
Last modified: September 7, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.