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Protein

Histone H2A.V

Gene

H2afv

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-1221632. Meiotic synapsis.
R-MMU-1221633. Meiotic Synapsis.
R-MMU-427389. ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.
R-MMU-427413. NoRC negatively regulates rRNA expression.
R-MMU-5334118. DNA methylation.
R-MMU-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.
R-MMU-573389. NoRC negatively regulates rRNA expression.
R-MMU-912497. Meiotic Recombination.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A.V
Alternative name(s):
H2A.F/Z
Gene namesi
Name:H2afv
Synonyms:H2av
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1924855. H2afv.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128Histone H2A.VPRO_0000239069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51N6-acetyllysine1 Publication
Modified residuei8 – 81N6-acetyllysine1 Publication
Modified residuei12 – 121N6-acetyllysine1 Publication

Post-translational modificationi

Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.By similarity
Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.1 Publication

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

EPDiQ3THW5.
MaxQBiQ3THW5.
PaxDbiQ3THW5.
PRIDEiQ3THW5.

PTM databases

iPTMnetiQ3THW5.
PhosphoSiteiQ3THW5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041126.
CleanExiMM_H2AFV.
ExpressionAtlasiQ3THW5. baseline and differential.
GenevisibleiQ3THW5. MM.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFV forms a heterodimer with H2B (By similarity).By similarity

Protein-protein interaction databases

BioGridi218792. 1 interaction.
IntActiQ3THW5. 1 interaction.
STRINGi10090.ENSMUSP00000105359.

Structurei

3D structure databases

ProteinModelPortaliQ3THW5.
SMRiQ3THW5. Positions 15-121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1757. Eukaryota.
COG5262. LUCA.
GeneTreeiENSGT00710000106735.
HOGENOMiHOG000234652.
HOVERGENiHBG009342.
InParanoidiQ3THW5.
KOiK11251.
OMAiIHRYLMN.
OrthoDBiEOG091G0XGD.
PhylomeDBiQ3THW5.
TreeFamiTF354232.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3THW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGKAGKDS GKAKAKAVSR SQRAGLQFPV GRIHRHLKTR TTSHGRVGAT
60 70 80 90 100
AAVYSAAILE YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL
110 120
IKATIAGGGV IPHIHKSLIG KKGQQKTA
Length:128
Mass (Da):13,509
Last modified:January 23, 2007 - v3
Checksum:i1F3C388F6854041C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21A → VA in CAI26006 (PubMed:19468303).Curated
Sequence conflicti27 – 271Q → E in BAE40081 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021267 mRNA. Translation: BAB32354.1.
AK155105 mRNA. Translation: BAE33050.1.
AK168110 mRNA. Translation: BAE40081.1.
AL646020 Genomic DNA. Translation: CAI26006.1.
CCDSiCCDS48750.1.
RefSeqiNP_084214.1. NM_029938.1.
UniGeneiMm.27624.

Genome annotation databases

EnsembliENSMUST00000109737; ENSMUSP00000105359; ENSMUSG00000041126.
GeneIDi77605.
KEGGimmu:77605.
UCSCiuc007hyp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021267 mRNA. Translation: BAB32354.1.
AK155105 mRNA. Translation: BAE33050.1.
AK168110 mRNA. Translation: BAE40081.1.
AL646020 Genomic DNA. Translation: CAI26006.1.
CCDSiCCDS48750.1.
RefSeqiNP_084214.1. NM_029938.1.
UniGeneiMm.27624.

3D structure databases

ProteinModelPortaliQ3THW5.
SMRiQ3THW5. Positions 15-121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218792. 1 interaction.
IntActiQ3THW5. 1 interaction.
STRINGi10090.ENSMUSP00000105359.

PTM databases

iPTMnetiQ3THW5.
PhosphoSiteiQ3THW5.

Proteomic databases

EPDiQ3THW5.
MaxQBiQ3THW5.
PaxDbiQ3THW5.
PRIDEiQ3THW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109737; ENSMUSP00000105359; ENSMUSG00000041126.
GeneIDi77605.
KEGGimmu:77605.
UCSCiuc007hyp.2. mouse.

Organism-specific databases

CTDi94239.
MGIiMGI:1924855. H2afv.

Phylogenomic databases

eggNOGiKOG1757. Eukaryota.
COG5262. LUCA.
GeneTreeiENSGT00710000106735.
HOGENOMiHOG000234652.
HOVERGENiHBG009342.
InParanoidiQ3THW5.
KOiK11251.
OMAiIHRYLMN.
OrthoDBiEOG091G0XGD.
PhylomeDBiQ3THW5.
TreeFamiTF354232.

Enzyme and pathway databases

ReactomeiR-MMU-1221632. Meiotic synapsis.
R-MMU-1221633. Meiotic Synapsis.
R-MMU-427389. ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.
R-MMU-427413. NoRC negatively regulates rRNA expression.
R-MMU-5334118. DNA methylation.
R-MMU-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.
R-MMU-573389. NoRC negatively regulates rRNA expression.
R-MMU-912497. Meiotic Recombination.

Miscellaneous databases

ChiTaRSiH2afv. mouse.
PROiQ3THW5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041126.
CleanExiMM_H2AFV.
ExpressionAtlasiQ3THW5. baseline and differential.
GenevisibleiQ3THW5. MM.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH2AV_MOUSE
AccessioniPrimary (citable) accession number: Q3THW5
Secondary accession number(s): Q5NC92, Q6ZWU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.