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Protein

Probable RNA-binding protein EIF1AD

Gene

Eif1ad

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role into cellular response to oxidative stress. Decreases cell proliferation (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable RNA-binding protein EIF1AD
Alternative name(s):
Eukaryotic translation initiation factor 1A domain-containing protein
Gene namesi
Name:Eif1ad
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1917110. Eif1ad.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 170170Probable RNA-binding protein EIF1ADPRO_0000314153Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331PhosphothreonineBy similarity
Modified residuei131 – 1311PhosphoserineCombined sources
Modified residuei135 – 1351PhosphoserineBy similarity
Modified residuei136 – 1361PhosphoserineCombined sources
Modified residuei137 – 1371PhosphoserineBy similarity
Modified residuei155 – 1551PhosphoserineBy similarity
Modified residuei159 – 1591PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3THJ3.
MaxQBiQ3THJ3.
PaxDbiQ3THJ3.
PRIDEiQ3THJ3.

PTM databases

PhosphoSiteiQ3THJ3.

Expressioni

Gene expression databases

BgeeiQ3THJ3.
GenevisibleiQ3THJ3. MM.

Interactioni

Subunit structurei

Interacts with GAPDH and STAT1.By similarity

Protein-protein interaction databases

IntActiQ3THJ3. 2 interactions.
MINTiMINT-4116967.
STRINGi10090.ENSMUSP00000025759.

Structurei

3D structure databases

ProteinModelPortaliQ3THJ3.
SMRiQ3THJ3. Positions 16-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 8985S1-likePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi6 – 127Nuclear localization signalSequence analysis
Motifi56 – 6510Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi154 – 16815Poly-GluAdd
BLAST

Sequence similaritiesi

Belongs to the EIF1AD family.Curated
Contains 1 S1-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2925. Eukaryota.
ENOG4111N6Z. LUCA.
GeneTreeiENSGT00390000011180.
HOGENOMiHOG000007486.
HOVERGENiHBG097893.
InParanoidiQ3THJ3.
KOiK15025.
OMAiHRQYHES.
OrthoDBiEOG75J0Q8.
PhylomeDBiQ3THJ3.
TreeFamiTF314439.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR001253. TIF_eIF-1A.
[Graphical view]
PfamiPF01176. eIF-1a. 1 hit.
[Graphical view]
SMARTiSM00652. eIF1a. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS50832. S1_IF1_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3THJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQASKRKHV VQEVLGEHMV PSDHQQIVKV LRTPGNNLHE VETAQGQRFL
60 70 80 90 100
VSMPSKYRKN IWIKRGDFLI VDPIEEGEKV KAEISFVLCK NHVRSLQKEG
110 120 130 140 150
HWPEAFSEVA EKQNNMNRES QPELPAEPQL SGEGSSSEDD SDLFVNTNHR
160 170
QYHESEEESE EDEEEEEEAA
Length:170
Mass (Da):19,520
Last modified:January 15, 2008 - v2
Checksum:iDD70717832E439B5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 741I → V in BAB25440 (PubMed:16141072).Curated
Sequence conflicti103 – 1031P → R in BAE40073 (PubMed:16141072).Curated
Sequence conflicti103 – 1031P → R in BAE40203 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008070 mRNA. Translation: BAB25440.1.
AK153194 mRNA. Translation: BAE31794.1.
AK158977 mRNA. Translation: BAE34752.1.
AK168598 mRNA. Translation: BAE40465.1.
AK168102 mRNA. Translation: BAE40073.1.
AK168253 mRNA. Translation: BAE40203.1.
BC024640 mRNA. Translation: AAH24640.1.
CCDSiCCDS29459.1.
RefSeqiNP_081512.1. NM_027236.2.
UniGeneiMm.299167.

Genome annotation databases

EnsembliENSMUST00000025759; ENSMUSP00000025759; ENSMUSG00000024841.
GeneIDi69860.
KEGGimmu:69860.
UCSCiuc008gct.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008070 mRNA. Translation: BAB25440.1.
AK153194 mRNA. Translation: BAE31794.1.
AK158977 mRNA. Translation: BAE34752.1.
AK168598 mRNA. Translation: BAE40465.1.
AK168102 mRNA. Translation: BAE40073.1.
AK168253 mRNA. Translation: BAE40203.1.
BC024640 mRNA. Translation: AAH24640.1.
CCDSiCCDS29459.1.
RefSeqiNP_081512.1. NM_027236.2.
UniGeneiMm.299167.

3D structure databases

ProteinModelPortaliQ3THJ3.
SMRiQ3THJ3. Positions 16-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3THJ3. 2 interactions.
MINTiMINT-4116967.
STRINGi10090.ENSMUSP00000025759.

PTM databases

PhosphoSiteiQ3THJ3.

Proteomic databases

EPDiQ3THJ3.
MaxQBiQ3THJ3.
PaxDbiQ3THJ3.
PRIDEiQ3THJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025759; ENSMUSP00000025759; ENSMUSG00000024841.
GeneIDi69860.
KEGGimmu:69860.
UCSCiuc008gct.1. mouse.

Organism-specific databases

CTDi84285.
MGIiMGI:1917110. Eif1ad.

Phylogenomic databases

eggNOGiKOG2925. Eukaryota.
ENOG4111N6Z. LUCA.
GeneTreeiENSGT00390000011180.
HOGENOMiHOG000007486.
HOVERGENiHBG097893.
InParanoidiQ3THJ3.
KOiK15025.
OMAiHRQYHES.
OrthoDBiEOG75J0Q8.
PhylomeDBiQ3THJ3.
TreeFamiTF314439.

Miscellaneous databases

NextBioi330481.
PROiQ3THJ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ3THJ3.
GenevisibleiQ3THJ3. MM.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR001253. TIF_eIF-1A.
[Graphical view]
PfamiPF01176. eIF-1a. 1 hit.
[Graphical view]
SMARTiSM00652. eIF1a. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS50832. S1_IF1_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/cJ and C57BL/6J.
    Tissue: Bone marrow, Kidney, Small intestine and Visual cortex.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131; SER-136 AND SER-159, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiEIF1A_MOUSE
AccessioniPrimary (citable) accession number: Q3THJ3
Secondary accession number(s): Q8K1C2, Q9D8F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: March 16, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.