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Protein

Coenzyme Q-binding protein COQ10 homolog B, mitochondrial

Gene

Coq10b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Coenzyme Q-binding protein COQ10 homolog B, mitochondrial
Gene namesi
Name:Coq10b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1915126. Coq10b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 39MitochondrionSequence analysisAdd BLAST39
ChainiPRO_000022864840 – 240Coenzyme Q-binding protein COQ10 homolog B, mitochondrialAdd BLAST201

Proteomic databases

MaxQBiQ3THF9.
PaxDbiQ3THF9.
PRIDEiQ3THF9.

PTM databases

PhosphoSitePlusiQ3THF9.

Expressioni

Gene expression databases

CleanExiMM_COQ10B.

Interactioni

Subunit structurei

Interacts with coenzyme Q.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027125.

Structurei

3D structure databases

ProteinModelPortaliQ3THF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COQ10 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3177. Eukaryota.
COG2867. LUCA.
HOGENOMiHOG000261732.
HOVERGENiHBG081329.
InParanoidiQ3THF9.
KOiK18588.
PhylomeDBiQ3THF9.
TreeFamiTF314447.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiView protein in InterPro
IPR005031. COQ10_START.
IPR023393. START-like_dom.
PfamiView protein in Pfam
PF03364. Polyketide_cyc. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3THF9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARTSQRAL ARVASGCHPK STTVTEATAR GSARDVRHLA ACGVLINRTL
60 70 80 90 100
PPCAAVLPKE ICARTFFRIS APLVNKRKEY SERRILGYSM QEMYDVVSGM
110 120 130 140 150
EDYQHFVPWC KKSDIISRRS GYCKTRLEVG FPPVLERYTS IVTLVKPHLV
160 170 180 190 200
KASCTDGKLF NHLETIWRFS PGLPGYPRTC TLDFSISFEF RSLLHSQLAT
210 220 230 240
LFFDEVVKQM VAAFERRACK LYGPETNIPR ELMLHEIHHT
Length:240
Mass (Da):27,269
Last modified:October 11, 2005 - v1
Checksum:iE31CF3DB36836A27
GO
Isoform 2 (identifier: Q3THF9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-87: Missing.

Note: No experimental confirmation available.
Show »
Length:190
Mass (Da):21,693
Checksum:i7D5C834A49B2BFF5
GO

Sequence cautioni

The sequence AAH62129 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB24648 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE22900 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE40661 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28T → P in BAE40237 (PubMed:16141072).Curated1
Sequence conflicti28T → P in BAE27020 (PubMed:16141072).Curated1
Sequence conflicti28T → P in BAB24648 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01768638 – 87Missing in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006551 mRNA. Translation: BAB24648.1. Different initiation.
AK136258 mRNA. Translation: BAE22900.1. Different initiation.
AK146260 mRNA. Translation: BAE27020.1.
AK168293 mRNA. Translation: BAE40237.1.
AK168837 mRNA. Translation: BAE40661.1. Different initiation.
BC062129 mRNA. Translation: AAH62129.1. Different initiation.
RefSeqiNP_001034799.1. NM_001039710.1.
NP_080700.3. NM_026424.3.
UniGeneiMm.281019.

Genome annotation databases

GeneIDi67876.
KEGGimmu:67876.
UCSCiuc007azz.1. mouse. [Q3THF9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCQ10B_MOUSE
AccessioniPrimary (citable) accession number: Q3THF9
Secondary accession number(s): Q6P6N0, Q9D9R6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 11, 2005
Last modified: August 30, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families