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Q3TG86

- Q3TG86_MOUSE

UniProt

Q3TG86 - Q3TG86_MOUSE

Protein
Submitted name:

Cytochrome P450, family 11, subfamily b, polypeptide 1

Gene

Cyp11b1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. corticosterone 18-monooxygenase activity Source: MGI
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. glucocorticoid biosynthetic process Source: MGI

    Keywords - Molecular functioni

    MonooxygenaseUniRule annotation, Oxidoreductase

    Keywords - Ligandi

    HemeUniRule annotation, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_204887. Mineralocorticoid biosynthesis.
    REACT_207160. Glucocorticoid biosynthesis.
    REACT_227038. Endogenous sterols.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cytochrome P450, family 11, subfamily b, polypeptide 1Imported
    Submitted name:
    Protein Cyp11b1Imported
    Gene namesi
    Name:Cyp11b1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:88583. Cyp11b1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ3TG86.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00750000117408.
    HOGENOMiHOG000013161.
    HOVERGENiHBG051098.
    InParanoidiQ3TG86.
    KOiK07433.
    OMAiMELIAGS.
    OrthoDBiEOG783MVN.
    TreeFamiTF105094.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002399. Cyt_P450_mitochondrial.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00408. MITP450.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3TG86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMALRVTTD VWLARPWQCL HRTRALGTTA TLAPKTLQPF EAIPQYSRNK    50
    WLKMIQILRE QGQENLHLEM HQVFRELGPI FRHSVGKTQI VFVTLPEDVE 100
    KLYQVESTHP CRMPLESWIV HRELRGLGRG VFLLNGPEWY FNRLQLNPNV 150
    LSPKAVQKFV PLVDGIARDF VDNLKKKMLE SVHGSFSMDF QSSVFNYTIE 200
    ASHFVLFGER LGLIGRDLSP DSLKFLHTLH SMFKTTTQLL YLPRSLTRWT 250
    STRVWKENLE SWDFISEYVT KCIKNVYREL AEGRPQSWSV TAELVAERTL 300
    SMDAIQANSM ELIAGSTDTT STPLVMTFFE LARNPDVQQA LRQESLAAEA 350
    SIAANPQKAM SDLPLLRAAL KETLRLYPVG TFLERILSSD LVLQNYHVPA 400
    GTVLNVNLYS MGRNPAVFPR PERYMPQRWL ERKRSFKHLA FGFGVRQCLG 450
    RRLAEAEMML LLHHVLKSFH VETQEKEDVR MAYRFVLMPS SSPLLTFRPV 500
    N 501
    Length:501
    Mass (Da):57,747
    Last modified:October 11, 2005 - v1
    Checksum:i9E1F5386BF18FBA1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC139671 Genomic DNA. No translation available.
    BC139248 mRNA. Translation: AAI39249.1.
    BC139250 mRNA. Translation: AAI39251.1.
    AK168839 mRNA. Translation: BAE40662.1.
    RefSeqiNP_001028401.2. NM_001033229.3.
    UniGeneiMm.322606.

    Genome annotation databases

    EnsembliENSMUST00000170259; ENSMUSP00000127888; ENSMUSG00000075604.
    GeneIDi110115.
    KEGGimmu:110115.
    UCSCiuc007wge.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC139671 Genomic DNA. No translation available.
    BC139248 mRNA. Translation: AAI39249.1 .
    BC139250 mRNA. Translation: AAI39251.1 .
    AK168839 mRNA. Translation: BAE40662.1 .
    RefSeqi NP_001028401.2. NM_001033229.3.
    UniGenei Mm.322606.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000170259 ; ENSMUSP00000127888 ; ENSMUSG00000075604 .
    GeneIDi 110115.
    KEGGi mmu:110115.
    UCSCi uc007wge.2. mouse.

    Organism-specific databases

    CTDi 1584.
    MGIi MGI:88583. Cyp11b1.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00750000117408.
    HOGENOMi HOG000013161.
    HOVERGENi HBG051098.
    InParanoidi Q3TG86.
    KOi K07433.
    OMAi MELIAGS.
    OrthoDBi EOG783MVN.
    TreeFami TF105094.

    Enzyme and pathway databases

    Reactomei REACT_204887. Mineralocorticoid biosynthesis.
    REACT_207160. Glucocorticoid biosynthesis.
    REACT_227038. Endogenous sterols.

    Miscellaneous databases

    NextBioi 363353.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3TG86.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002399. Cyt_P450_mitochondrial.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00408. MITP450.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    8. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: KidneyImported.
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    11. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ3TG86_MOUSE
    AccessioniPrimary (citable) accession number: Q3TG86
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3