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Protein
Submitted name:

Cytochrome P450, family 11, subfamily b, polypeptide 1

Gene

Cyp11b1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. corticosterone 18-monooxygenase activity Source: MGI
  2. heme binding Source: MGI
  3. iron ion binding Source: InterPro
  4. steroid 11-beta-monooxygenase activity Source: MGI

GO - Biological processi

  1. aldosterone biosynthetic process Source: MGI
  2. C21-steroid hormone biosynthetic process Source: MGI
  3. glucocorticoid biosynthetic process Source: MGI
  4. potassium ion homeostasis Source: MGI
  5. regulation of blood volume by renal aldosterone Source: MGI
  6. sodium ion homeostasis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_281686. Endogenous sterols.
REACT_295803. Mineralocorticoid biosynthesis.
REACT_297756. Glucocorticoid biosynthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome P450, family 11, subfamily b, polypeptide 1Imported
Submitted name:
Protein Cyp11b1Imported
Gene namesi
Name:Cyp11b1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:88583. Cyp11b1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiQ3TG86.
PRIDEiQ3TG86.

Expressioni

Gene expression databases

BgeeiQ3TG86.
GenevestigatoriQ3TG86.

Structurei

3D structure databases

SMRiQ3TG86. Positions 36-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000119243.
HOGENOMiHOG000013161.
HOVERGENiHBG051098.
InParanoidiQ3TG86.
KOiK07433.
OMAiMELIAGS.
OrthoDBiEOG783MVN.
PhylomeDBiQ3TG86.
TreeFamiTF105094.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00408. MITP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TG86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMALRVTTD VWLARPWQCL HRTRALGTTA TLAPKTLQPF EAIPQYSRNK
60 70 80 90 100
WLKMIQILRE QGQENLHLEM HQVFRELGPI FRHSVGKTQI VFVTLPEDVE
110 120 130 140 150
KLYQVESTHP CRMPLESWIV HRELRGLGRG VFLLNGPEWY FNRLQLNPNV
160 170 180 190 200
LSPKAVQKFV PLVDGIARDF VDNLKKKMLE SVHGSFSMDF QSSVFNYTIE
210 220 230 240 250
ASHFVLFGER LGLIGRDLSP DSLKFLHTLH SMFKTTTQLL YLPRSLTRWT
260 270 280 290 300
STRVWKENLE SWDFISEYVT KCIKNVYREL AEGRPQSWSV TAELVAERTL
310 320 330 340 350
SMDAIQANSM ELIAGSTDTT STPLVMTFFE LARNPDVQQA LRQESLAAEA
360 370 380 390 400
SIAANPQKAM SDLPLLRAAL KETLRLYPVG TFLERILSSD LVLQNYHVPA
410 420 430 440 450
GTVLNVNLYS MGRNPAVFPR PERYMPQRWL ERKRSFKHLA FGFGVRQCLG
460 470 480 490 500
RRLAEAEMML LLHHVLKSFH VETQEKEDVR MAYRFVLMPS SSPLLTFRPV

N
Length:501
Mass (Da):57,747
Last modified:October 11, 2005 - v1
Checksum:i9E1F5386BF18FBA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139671 Genomic DNA. No translation available.
BC139248 mRNA. Translation: AAI39249.1.
BC139250 mRNA. Translation: AAI39251.1.
AK168839 mRNA. Translation: BAE40662.1.
RefSeqiNP_001028401.2. NM_001033229.3.
UniGeneiMm.322606.

Genome annotation databases

EnsembliENSMUST00000170259; ENSMUSP00000127888; ENSMUSG00000075604.
GeneIDi110115.
KEGGimmu:110115.
UCSCiuc007wge.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139671 Genomic DNA. No translation available.
BC139248 mRNA. Translation: AAI39249.1.
BC139250 mRNA. Translation: AAI39251.1.
AK168839 mRNA. Translation: BAE40662.1.
RefSeqiNP_001028401.2. NM_001033229.3.
UniGeneiMm.322606.

3D structure databases

SMRiQ3TG86. Positions 36-501.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ3TG86.
PRIDEiQ3TG86.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000170259; ENSMUSP00000127888; ENSMUSG00000075604.
GeneIDi110115.
KEGGimmu:110115.
UCSCiuc007wge.2. mouse.

Organism-specific databases

CTDi1584.
MGIiMGI:88583. Cyp11b1.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000119243.
HOGENOMiHOG000013161.
HOVERGENiHBG051098.
InParanoidiQ3TG86.
KOiK07433.
OMAiMELIAGS.
OrthoDBiEOG783MVN.
PhylomeDBiQ3TG86.
TreeFamiTF105094.

Enzyme and pathway databases

ReactomeiREACT_281686. Endogenous sterols.
REACT_295803. Mineralocorticoid biosynthesis.
REACT_297756. Glucocorticoid biosynthesis.

Miscellaneous databases

NextBioi363353.
SOURCEiSearch...

Gene expression databases

BgeeiQ3TG86.
GenevestigatoriQ3TG86.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00408. MITP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2000)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  11. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3TG86_MOUSE
AccessioniPrimary (citable) accession number: Q3TG86
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 1, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.