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Protein

Na(+)/H(+) exchange regulatory cofactor NHE-RF

Gene

Slc9a3r1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)/H(+) exchange regulatory cofactor NHE-RFUniRule annotation
Gene namesi
Name:Slc9a3r1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1349482. Slc9a3r1.

Subcellular locationi

  • Endomembrane system UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

MembraneUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiQ3TG37.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020733.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021077.

Structurei

3D structure databases

SMRiQ3TG37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 94PDZ (DHR)InterPro annotationAdd BLAST81
Domaini149 – 229PDZ (DHR)InterPro annotationAdd BLAST81

Phylogenomic databases

eggNOGiENOG410ITAB. Eukaryota.
ENOG4110SZZ. LUCA.
HOVERGENiHBG052616.
KOiK13365.
OMAiLCAMKKG.
OrthoDBiEOG091G086H.

Family and domain databases

InterProiView protein in InterPro
IPR015098. EBP50_C-term.
IPR031199. NHERF-1.
IPR017300. NHERF-1/NHERF-2.
IPR001478. PDZ.
PANTHERiPTHR14191:SF14. PTHR14191:SF14. 1 hit.
PfamiView protein in Pfam
PF09007. EBP50_C. 1 hit.
PF00595. PDZ. 2 hits.
PIRSFiPIRSF037866. EBP50. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD283022. EBP50_C-term. 1 hit.
SMARTiView protein in SMART
SM00228. PDZ. 2 hits.
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiView protein in PROSITE
PS50106. PDZ. 2 hits.

Sequencei

Sequence statusi: Complete.

Q3TG37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADAAAGEP LPRLCCLEKG PNGYGFHLHG EKGKVGQFIR LVEPGSPAEK
60 70 80 90 100
SGLLAGDRLV EVNGENVEKE THQQVVSRIR AALNAVRLLV VDPETDERLK
110 120 130 140 150
KLGVSIREEL LRPQEKSEQA EPPAAADTHE AGDQNEAEKS HLRELRPRLC
160 170 180 190 200
TMKKGPNGYG FNLHSDKSKP GQFIRAVDPD SPAEASGLRA QDRIVEVNGV
210 220 230 240 250
CMEGKQHGDV VSAIKGGGDE AKLLVVDKET DEFFKKCKVI PSQEHLDGPL
260 270 280 290 300
PEPFSNGEIQ KESSREALVE PASESPRPAL ARSASSDTSE ELNSQDSPKR
310 320 330 340 350
QVSTEPSSTS SSSSDPILDL NISLAVAKER AHQKRSSKRA PQMDWSKKNE

LFSNL
Length:355
Mass (Da):38,600
Last modified:October 11, 2005 - v1
Checksum:i331F6BEE31DA0A11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153558 mRNA. Translation: BAE32094.1.
AK168894 mRNA. Translation: BAE40711.1.
RefSeqiNP_036160.1. NM_012030.2.
UniGeneiMm.27842.

Genome annotation databases

GeneIDi26941.
KEGGimmu:26941.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153558 mRNA. Translation: BAE32094.1.
AK168894 mRNA. Translation: BAE40711.1.
RefSeqiNP_036160.1. NM_012030.2.
UniGeneiMm.27842.

3D structure databases

SMRiQ3TG37.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021077.

Proteomic databases

MaxQBiQ3TG37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi26941.
KEGGimmu:26941.

Organism-specific databases

CTDi9368.
MGIiMGI:1349482. Slc9a3r1.

Phylogenomic databases

eggNOGiENOG410ITAB. Eukaryota.
ENOG4110SZZ. LUCA.
HOVERGENiHBG052616.
KOiK13365.
OMAiLCAMKKG.
OrthoDBiEOG091G086H.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020733.

Family and domain databases

InterProiView protein in InterPro
IPR015098. EBP50_C-term.
IPR031199. NHERF-1.
IPR017300. NHERF-1/NHERF-2.
IPR001478. PDZ.
PANTHERiPTHR14191:SF14. PTHR14191:SF14. 1 hit.
PfamiView protein in Pfam
PF09007. EBP50_C. 1 hit.
PF00595. PDZ. 2 hits.
PIRSFiPIRSF037866. EBP50. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD283022. EBP50_C-term. 1 hit.
SMARTiView protein in SMART
SM00228. PDZ. 2 hits.
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiView protein in PROSITE
PS50106. PDZ. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ3TG37_MOUSE
AccessioniPrimary (citable) accession number: Q3TG37
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 7, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.