ID   Q3TFZ4_MOUSE            Unreviewed;       685 AA.
AC   Q3TFZ4;
DT   11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2005, sequence version 1.
DT   27-MAR-2024, entry version 165.
DE   SubName: Full=Zinc finger protein 7 {ECO:0000313|Ensembl:ENSMUSP00000023179.6};
GN   Name=Zfp7 {ECO:0000313|Ensembl:ENSMUSP00000023179.6,
GN   ECO:0000313|MGI:MGI:99208};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE40754.1};
RN   [1] {ECO:0000313|EMBL:BAE40754.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE40754.1};
RC   TISSUE=Heart {ECO:0000313|EMBL:BAE40754.1}, and Lung
RC   {ECO:0000313|EMBL:BAE26117.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2] {ECO:0000313|EMBL:BAE40754.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE40754.1};
RC   TISSUE=Heart {ECO:0000313|EMBL:BAE40754.1}, and Lung
RC   {ECO:0000313|EMBL:BAE26117.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT   full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [3] {ECO:0000313|EMBL:BAE40754.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE40754.1};
RC   TISSUE=Heart {ECO:0000313|EMBL:BAE40754.1}, and Lung
RC   {ECO:0000313|EMBL:BAE26117.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA   Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA   Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA   Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA   Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA   Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT   pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [4] {ECO:0000313|EMBL:BAE40754.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE40754.1};
RC   TISSUE=Heart {ECO:0000313|EMBL:BAE40754.1}, and Lung
RC   {ECO:0000313|EMBL:BAE26117.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [5] {ECO:0000313|EMBL:BAE40754.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE40754.1};
RC   TISSUE=Heart {ECO:0000313|EMBL:BAE40754.1}, and Lung
RC   {ECO:0000313|EMBL:BAE26117.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [6] {ECO:0000313|EMBL:BAE40754.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE40754.1};
RC   TISSUE=Heart {ECO:0000313|EMBL:BAE40754.1}, and Lung
RC   {ECO:0000313|EMBL:BAE26117.1};
RA   Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA   Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA   Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA   Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA   Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:BAE40754.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE40754.1};
RC   TISSUE=Heart {ECO:0000313|EMBL:BAE40754.1}, and Lung
RC   {ECO:0000313|EMBL:BAE26117.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [8] {ECO:0000313|EMBL:BAE40754.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE40754.1};
RC   TISSUE=Heart {ECO:0000313|EMBL:BAE40754.1}, and Lung
RC   {ECO:0000313|EMBL:BAE26117.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
RN   [9] {ECO:0000313|Ensembl:ENSMUSP00000023179.6, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000023179.6,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [10] {ECO:0000313|Ensembl:ENSMUSP00000023179.6}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000023179.6};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC       {ECO:0000256|ARBA:ARBA00003767}.
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DR   EMBL; AK144887; BAE26117.1; -; mRNA.
DR   EMBL; AK168948; BAE40754.1; -; mRNA.
DR   RefSeq; NP_666021.2; NM_145916.2.
DR   RefSeq; XP_006520858.1; XM_006520795.2.
DR   STRING; 10090.ENSMUSP00000155599; -.
DR   PaxDb; 10090-ENSMUSP00000023179; -.
DR   ProteomicsDB; 330868; -.
DR   Antibodypedia; 15006; 164 antibodies from 26 providers.
DR   DNASU; 223669; -.
DR   Ensembl; ENSMUST00000023179.7; ENSMUSP00000023179.6; ENSMUSG00000033669.9.
DR   Ensembl; ENSMUST00000230106.2; ENSMUSP00000155599.2; ENSMUSG00000033669.9.
DR   GeneID; 223669; -.
DR   UCSC; uc007wmo.2; mouse.
DR   AGR; MGI:99208; -.
DR   CTD; 223669; -.
DR   MGI; MGI:99208; Zfp7.
DR   VEuPathDB; HostDB:ENSMUSG00000033669; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000161563; -.
DR   HOGENOM; CLU_002678_44_5_1; -.
DR   OMA; QKPNRCQ; -.
DR   OrthoDB; 4591539at2759; -.
DR   TreeFam; TF341817; -.
DR   BioGRID-ORCS; 223669; 0 hits in 77 CRISPR screens.
DR   ChiTaRS; Zfp7; mouse.
DR   Proteomes; UP000000589; Chromosome 15.
DR   Bgee; ENSMUSG00000033669; Expressed in embryonic post-anal tail and 186 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   Gene3D; 6.10.140.140; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 16.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24404; ZINC FINGER PROTEIN; 1.
DR   PANTHER; PTHR24404:SF97; ZINC FINGER PROTEIN 501; 1.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 13.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 16.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 9.
DR   SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 16.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
PE   1: Evidence at protein level;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Proteomics identification {ECO:0007829|EPD:Q3TFZ4,
KW   ECO:0007829|ProteomicsDB:Q3TFZ4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00042}.
FT   DOMAIN          4..76
FT                   /note="KRAB"
FT                   /evidence="ECO:0000259|PROSITE:PS50805"
FT   DOMAIN          192..219
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          220..247
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          248..275
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          276..303
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          304..331
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          332..359
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          360..388
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          412..439
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          440..467
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          468..495
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          496..523
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          524..551
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          552..579
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          580..607
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          633..660
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          661..685
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
SQ   SEQUENCE   685 AA;  78762 MW;  6154FCAC21F308DD CRC64;
     MEAVTFGDVA VHFSREEWQC LDSGQRALYK EVMLENHSSV AGLAGFLVFK PELISRLEQG
     QEPWVLDLQG AEGTEAPRIC QTDSAIRTDR KQTCEYTSLL QRQIPGFGDN LDSKVWSENC
     PRSLGLSVSG SLFQKHRLNS EAVMPKNSTK DAVQERKELQ ATDVGYRPDD QRDHLSSKLI
     RRQSVPTGEN RYPCEECGKA FRWRSRLNQH KLSHTGEKSY QCNKCTKVFA SSSRLIRHQR
     AHTGEKPFKC DQCGKRFVLA SVLTQHQRIH TGERPFKCAE CGKGFHLSAK LVQHQRIHTG
     EKPYRCEECG KTFGQSSSLV HHQRIHTGER PFICQECGKA FCQRSQLSRH RRTHTGERPY
     SCQECGKAFC QRATLAQHQK MMHTAEKSQM PRASESPSLI ACQGNTTEEK PFKCEQCGKA
     FRWLSRLNQH QVVHSGEKPY QCNKCSKAFG CTSRLIRHQR THTGEKPFKC DECGKRFVQS
     SHLIQHQRIH TGEKPYVCDD CGRAFTQSSS LIYHQRIHKG EKPYKCSQCG KAFSMSTQLT
     SHQRTHTGER PYTCNECGKT FRQNSTLFQH QIIHVRVKPY ECNECGKAFS RSSYLIEHQR
     IHTRAQGGHE FGDTPESPTV LNHKKVHTVK KLYQCDDCDK VFRWRSYLII HQRIHTGERP
     YKCNACGKAF HQIAKLTQHQ KLHMR
//