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Protein

SPRY domain-containing protein 7

Gene

Spryd7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SPRY domain-containing protein 7
Alternative name(s):
Chronic lymphocytic leukemia deletion region gene 6 protein homolog
Short name:
CLL deletion region gene 6 protein homolog
Gene namesi
Name:Spryd7
Synonyms:Clld6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1913924. Spryd7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 196195SPRY domain-containing protein 7PRO_0000243926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ3TFQ1.
PaxDbiQ3TFQ1.
PRIDEiQ3TFQ1.

PTM databases

PhosphoSiteiQ3TFQ1.

Expressioni

Gene expression databases

BgeeiQ3TFQ1.
CleanExiMM_6330409N04RIK.
ExpressionAtlasiQ3TFQ1. baseline and differential.
GenevestigatoriQ3TFQ1.

Structurei

3D structure databases

ProteinModelPortaliQ3TFQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 184183B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG291635.
GeneTreeiENSGT00390000011048.
HOVERGENiHBG056533.
InParanoidiQ3TFQ1.
OMAiALYYNNE.
OrthoDBiEOG7J447S.
PhylomeDBiQ3TFQ1.
TreeFamiTF314996.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3TFQ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAASAWCCLR CCRDGGTGHI PLKEMPAVQL DTQHMGTDVV IVKNGRRICG
60 70 80 90 100
TGGCLASAPL HQNKSYFEFK IQSTGIWGIG VATQKVNLNQ IPLGRDMHSL
110 120 130 140 150
VMRNDGALYH NNEEKNRLPA NSLPQEGDVV GITYDHVELN VYLNGKNMHC
160 170 180 190
PASGIRGTVY PVVYVDDSAI LDCQFSEFYH TPPPGFEKIL FEQQIF
Length:196
Mass (Da):21,681
Last modified:June 27, 2006 - v2
Checksum:i238C69FC296A4C57
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71C → S in BAB31148. (PubMed:16141072)Curated
Sequence conflicti174 – 1741Q → E in BAB31049. (PubMed:16141072)Curated
Sequence conflicti179 – 1791Y → H in BAB31148. (PubMed:16141072)Curated
Sequence conflicti186 – 1861F → V in BAB31049. (PubMed:16141072)Curated
Sequence conflicti194 – 1941Q → R in BAE40847. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018044 mRNA. Translation: BAB31049.1.
AK018153 mRNA. Translation: BAB31097.2.
AK018290 mRNA. Translation: BAB31148.1.
AK137685 mRNA. Translation: BAE23460.1.
AK167306 mRNA. Translation: BAE39410.1.
AK169059 mRNA. Translation: BAE40847.1.
BC037015 mRNA. Translation: AAH37015.1.
CCDSiCCDS27185.1.
RefSeqiNP_079973.1. NM_025697.3.
UniGeneiMm.282706.

Genome annotation databases

EnsembliENSMUST00000022497; ENSMUSP00000022497; ENSMUSG00000021930.
GeneIDi66674.
KEGGimmu:66674.
UCSCiuc007ufx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018044 mRNA. Translation: BAB31049.1.
AK018153 mRNA. Translation: BAB31097.2.
AK018290 mRNA. Translation: BAB31148.1.
AK137685 mRNA. Translation: BAE23460.1.
AK167306 mRNA. Translation: BAE39410.1.
AK169059 mRNA. Translation: BAE40847.1.
BC037015 mRNA. Translation: AAH37015.1.
CCDSiCCDS27185.1.
RefSeqiNP_079973.1. NM_025697.3.
UniGeneiMm.282706.

3D structure databases

ProteinModelPortaliQ3TFQ1.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ3TFQ1.

Proteomic databases

MaxQBiQ3TFQ1.
PaxDbiQ3TFQ1.
PRIDEiQ3TFQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022497; ENSMUSP00000022497; ENSMUSG00000021930.
GeneIDi66674.
KEGGimmu:66674.
UCSCiuc007ufx.1. mouse.

Organism-specific databases

CTDi57213.
MGIiMGI:1913924. Spryd7.

Phylogenomic databases

eggNOGiNOG291635.
GeneTreeiENSGT00390000011048.
HOVERGENiHBG056533.
InParanoidiQ3TFQ1.
OMAiALYYNNE.
OrthoDBiEOG7J447S.
PhylomeDBiQ3TFQ1.
TreeFamiTF314996.

Miscellaneous databases

NextBioi322341.
PROiQ3TFQ1.
SOURCEiSearch...

Gene expression databases

BgeeiQ3TFQ1.
CleanExiMM_6330409N04RIK.
ExpressionAtlasiQ3TFQ1. baseline and differential.
GenevestigatoriQ3TFQ1.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney, Medulla oblongata, Olfactory bulb, Placenta, Thymus and Vagina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiSPRY7_MOUSE
AccessioniPrimary (citable) accession number: Q3TFQ1
Secondary accession number(s): Q8K1Y1
, Q9CU44, Q9D368, Q9D3D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: January 7, 2015
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.