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Protein

RING finger protein 157

Gene

Rnf157

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri276 – 315RING-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 157
Gene namesi
Name:Rnf157
Synonyms:Kiaa1917
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2442484. Rnf157.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002616152 – 685RING finger protein 157Add BLAST684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiQ3TEL6.
PaxDbiQ3TEL6.
PRIDEiQ3TEL6.

PTM databases

iPTMnetiQ3TEL6.
PhosphoSitePlusiQ3TEL6.

Expressioni

Gene expression databases

CleanExiMM_RNF157.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097776.

Structurei

3D structure databases

ProteinModelPortaliQ3TEL6.
SMRiQ3TEL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi431 – 537Ser-richAdd BLAST107

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri276 – 315RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4265. Eukaryota.
ENOG410XRAE. LUCA.
HOGENOMiHOG000231196.
HOVERGENiHBG061762.
InParanoidiQ3TEL6.
PhylomeDBiQ3TEL6.

Family and domain databases

InterProiView protein in InterPro
IPR001841. Znf_RING.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS50089. ZF_RING_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TEL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGALTSRQHA GVEEVDIPSN SVYRYPPKSG SYFASHFIMG GEKFDSTHPE
60 70 80 90 100
GYLFGENSDL NFLGNRPVAF PYAAPPPQEP VKTLRSLINI RKDTLRLVKC
110 120 130 140 150
AEEVKSHGEE AGKAKVHYNV EFTFDTDARV AITIYYQATE EFQNGIASYI
160 170 180 190 200
PKDNSLQSET VHYKRGVFQQ FCLPSHTVDP SEWAEEELGF DLDREVYPLV
210 220 230 240 250
VHAVVDEGDE YFGHCHVLLG TFEKHPDGTF CVKPLKQKQV VDGVSYLLQE
260 270 280 290 300
IYGIENKYNT QDSKVAEDDV SDNSAECVVC LSDVRDTLIL PCRHLCLCNT
310 320 330 340 350
CADTLRYQAN NCPICRLPFR ALLQIRAMRK KLGPLSPSSF NPIISSQTSD
360 370 380 390 400
SEEHSSSENI PPGYEVVSLL EALNGPLTSS PAVPPLHVLG DGHLSGMLPS
410 420 430 440 450
YGSDGYLPPV RTLSPLDRLS DCNNQGLKLK KSLSKSISQN SSVLHEEEDE
460 470 480 490 500
RSCSESDTQL SQRLSVQHPE EGPDVTPESE NLTLSSSGAV DQSSCTGTPL
510 520 530 540 550
SSTISSPEDP ASSSLAQSVM SMASSQISTD TVSSMSGSYI APGTEEEGEA
560 570 580 590 600
LPSPRAASRA PSEGEETPAE SPDSNFAGLP AGEQDAEGND IIEEEDRSPV
610 620 630 640 650
REDGQRTCAF LGMECDNNND FDVASVKALD NKLCSEVCLP GEWQCAEHEL
660 670 680
GGRRPSARPR SPRGGLGKEA SAFRIETVAL PGTYV
Length:685
Mass (Da):74,534
Last modified:November 28, 2006 - v2
Checksum:i22B9382ECBA0E334
GO
Isoform 2 (identifier: Q3TEL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     592-592: I → V
     642-685: EWQCAEHELG...ETVALPGTYV → TWQHEDNTVN...RPCVWDPMAV

Note: No experimental confirmation available.
Show »
Length:681
Mass (Da):74,506
Checksum:i3AD25161D25034B9
GO

Sequence cautioni

The sequence BAE41232 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021736592I → V in isoform 2. 1 Publication1
Alternative sequenceiVSP_021737642 – 685EWQCA…PGTYV → TWQHEDNTVNCRHTQRRRLS SSSLEDPEENRPCVWDPMAV in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645861 Genomic DNA. No translation available.
AK169566 mRNA. Translation: BAE41232.1. Different initiation.
AK122571 mRNA. Translation: BAC65853.1.
CCDSiCCDS48984.1. [Q3TEL6-2]
UniGeneiMm.426344.

Genome annotation databases

UCSCiuc007mkz.1. mouse. [Q3TEL6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRN157_MOUSE
AccessioniPrimary (citable) accession number: Q3TEL6
Secondary accession number(s): Q80T75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: August 30, 2017
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot