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Protein

Solute carrier organic anion transporter family member

Gene

Slco2a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family memberUniRule annotation
Gene namesi
Name:Slco2a1Imported
ORF Names:mCG_1040582Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1346021. Slco2a1.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei71 – 91HelicalUniRule annotationAdd BLAST21
Transmembranei103 – 121HelicalUniRule annotationAdd BLAST19
Transmembranei169 – 194HelicalUniRule annotationAdd BLAST26
Transmembranei206 – 234HelicalUniRule annotationAdd BLAST29
Transmembranei254 – 278HelicalUniRule annotationAdd BLAST25
Transmembranei317 – 341HelicalUniRule annotationAdd BLAST25
Transmembranei361 – 386HelicalUniRule annotationAdd BLAST26
Transmembranei398 – 417HelicalUniRule annotationAdd BLAST20
Transmembranei513 – 537HelicalUniRule annotationAdd BLAST25
Transmembranei549 – 567HelicalUniRule annotationAdd BLAST19
Transmembranei605 – 625HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000032548.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035148.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 628MFSInterPro annotationAdd BLAST628
Domaini437 – 495Kazal-likeInterPro annotationAdd BLAST59

Sequence similaritiesi

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]UniRule annotation
Contains 1 Kazal-like domain.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOVERGENiHBG108345.
KOiK14345.
OMAiIYLNCSC.
OrthoDBiEOG091G08QD.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TED0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLPKPGAR QGSGTSSVPA RRCSRSVFNN IKVFVLCHGL LQLCQLLYSA
60 70 80 90 100
YFKSSLTTIE KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVNRPRM
110 120 130 140 150
IGIGGLLLAA GAFVLTLPHF LSEPYQYAST TAGNSSHFQT DLCQKHLPGL
160 170 180 190 200
LPSKCHSTVP DTQKETSSMW SLMVVAQLLA GVGTVPIQPF GISYVDDFAE
210 220 230 240 250
PTNSPLYISI LFAIAVFGPA FGYLLGSVML RIFVDYGRVD TATVNLSPGD
260 270 280 290 300
PRWIGAWWLG LLISSGFLIV TSLPFFFFPR AMSRGAERSV IAEETMKMEE
310 320 330 340 350
DKSRGSLMDF IKRFPRIFLR LLMNPLFMLV VLSQCTFSSV IAGLSTFLNK
360 370 380 390 400
FLEKQYDASA AYANLLIGAV NLPAAALGML FGGILMKRFV FPLQTIPRVA
410 420 430 440 450
ATIMTISIIL CAPLFFMGCS TPAVAEVYPP STPSSIHPQP PACRRDCLCP
460 470 480 490 500
DSVFHPVCGD NGVEYLSPCH AGCSSLNVSS AASKQPIYLN CSCVTGGSAS
510 520 530 540 550
AKTGSCPTSC AQLLLPSIFL ISFVALIACV SHNPLYMMVL RVVNQDEKSF
560 570 580 590 600
AIGVQFLLMR LLAWLPSPSL YGLLIDSSCI RWNYLCSGRR GACAYYDNDA
610 620 630 640
LRNRYLGLQV IYKVLGTLLL FFISWRVKKN REYSLQENAS GLI
Length:643
Mass (Da):70,147
Last modified:October 11, 2005 - v1
Checksum:iAC487386F847D9D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK166724 mRNA. Translation: BAE38971.1.
AK169706 mRNA. Translation: BAE41318.1.
CH466560 Genomic DNA. Translation: EDL21061.1.
CH466560 Genomic DNA. Translation: EDL21063.1.
RefSeqiNP_201571.2. NM_033314.3.
UniGeneiMm.207106.
Mm.412758.

Genome annotation databases

GeneIDi24059.
KEGGimmu:24059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK166724 mRNA. Translation: BAE38971.1.
AK169706 mRNA. Translation: BAE41318.1.
CH466560 Genomic DNA. Translation: EDL21061.1.
CH466560 Genomic DNA. Translation: EDL21063.1.
RefSeqiNP_201571.2. NM_033314.3.
UniGeneiMm.207106.
Mm.412758.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035148.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24059.
KEGGimmu:24059.

Organism-specific databases

CTDi6578.
MGIiMGI:1346021. Slco2a1.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOVERGENiHBG108345.
KOiK14345.
OMAiIYLNCSC.
OrthoDBiEOG091G08QD.

Miscellaneous databases

ChiTaRSiSlco2a1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032548.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3TED0_MOUSE
AccessioniPrimary (citable) accession number: Q3TED0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.