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Q3TEA8

- HP1B3_MOUSE

UniProt

Q3TEA8 - HP1B3_MOUSE

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Protein

Heterochromatin protein 1-binding protein 3

Gene

Hp1bp3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Component of heterochromatin, may be involved in chromatin structure and function.1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. nucleosome assembly Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heterochromatin protein 1-binding protein 3
Gene namesi
Name:Hp1bp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:109369. Hp1bp3.

Subcellular locationi

Nucleus PROSITE-ProRule annotation. Chromosome PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleosome Source: InterPro
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 554553Heterochromatin protein 1-binding protein 3PRO_0000339643Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei6 – 61PhosphoserineBy similarity
Modified residuei144 – 1441PhosphoserineBy similarity
Modified residuei157 – 1571PhosphoserineBy similarity
Modified residuei158 – 1581PhosphoserineBy similarity
Modified residuei192 – 1921N6-acetyllysine1 Publication
Modified residuei249 – 2491PhosphoserineBy similarity
Modified residuei443 – 4431PhosphoserineBy similarity
Modified residuei444 – 4441PhosphoserineBy similarity
Modified residuei447 – 4471PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ3TEA8.
PaxDbiQ3TEA8.
PRIDEiQ3TEA8.

PTM databases

PhosphoSiteiQ3TEA8.

Expressioni

Gene expression databases

BgeeiQ3TEA8.
ExpressionAtlasiQ3TEA8. baseline and differential.
GenevestigatoriQ3TEA8.

Interactioni

Subunit structurei

Interacts with CBX5.1 Publication

Protein-protein interaction databases

BioGridi200401. 4 interactions.
IntActiQ3TEA8. 2 interactions.
MINTiMINT-4128252.

Structurei

3D structure databases

ProteinModelPortaliQ3TEA8.
SMRiQ3TEA8. Positions 155-237, 248-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini159 – 23476H15 1PROSITE-ProRule annotationAdd
BLAST
Domaini255 – 33076H15 2PROSITE-ProRule annotationAdd
BLAST
Domaini337 – 41377H15 3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 12870Glu-richAdd
BLAST
Compositional biasi432 – 44110Poly-Asp
Compositional biasi455 – 554100Lys-richAdd
BLAST

Sequence similaritiesi

Contains 3 H15 (linker histone H1/H5 globular) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG285312.
GeneTreeiENSGT00510000047652.
HOVERGENiHBG097678.
InParanoidiQ3TEA8.
OrthoDBiEOG75QR72.
PhylomeDBiQ3TEA8.
TreeFamiTF106395.

Family and domain databases

Gene3Di1.10.10.10. 3 hits.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 3 hits.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 3 hits.
[Graphical view]
PROSITEiPS51504. H15. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3TEA8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATDMSQGEL IHPKALPLIV GAQLIHADKL GEKAEDTTMP IRRAVNSTRE
60 70 80 90 100
TPPKSKLAEG EEEKPEPDGS SEESISTVEE QENETPPATS SEAEQPKGEP
110 120 130 140 150
ESGEKEENNN KSAEEPKKDE KDQSKEKEKK VKKTIPAWAT LSASQLARAQ
160 170 180 190 200
RQTPMASSPR PKMDAILTEA IKACFQKTGA SVVAIRKYII HKYPSLGLER
210 220 230 240 250
RGYLLKQALK RELNRGVIRQ VKGKGASGSF VVVQKSKPPQ KSKNRKKGSA
260 270 280 290 300
LDPEPQVKLE DVLPLAFTRL CEPKEASYSL IRKYVSQYYP KLRVDIRPQL
310 320 330 340 350
LKNALQRAVE RGQLEQITGK GASGTFQLKK SGEKPLLGGS LMEYAILSAI
360 370 380 390 400
AAMNEPKTCS TTALKKYVLE NHPGANSNYQ MHLLKKTLQK CEKNGWLEQI
410 420 430 440 450
SGKGFSGTFQ LSFPYYPSPG VLFPKKESGG SDDEDEDDDD DESSEDSEDE
460 470 480 490 500
EPPPKRSLQK KTPAKSQGKT ASMKQRGSKP ARKVPAAQRG KVRPLPKKAP
510 520 530 540 550
PKAKTPARKA RPSPSVIKKP SGSSSRKPIA SARKEAKLPG KGKSAMKKSF

KTKK
Length:554
Mass (Da):60,867
Last modified:October 11, 2005 - v1
Checksum:iA49C4F7C42D1BE64
GO
Isoform 2 (identifier: Q3TEA8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-79: Missing.

Show »
Length:541
Mass (Da):59,548
Checksum:i2F19451E819E2EB7
GO
Isoform 3 (identifier: Q3TEA8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Show »
Length:516
Mass (Da):56,841
Checksum:i95FCF9348F2868BE
GO

Sequence cautioni

The sequence BAC35912.1 differs from that shown. Reason: Frameshift at positions 13 and 313. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681D → N in BAE36164. (PubMed:16141072)Curated
Sequence conflicti110 – 1101N → S in CAA67961. (PubMed:8978696)Curated
Sequence conflicti110 – 1101N → S in AAH20024. (PubMed:15489334)Curated
Sequence conflicti111 – 1111K → E in BAB23683. (PubMed:16141072)Curated
Sequence conflicti174 – 1741C → S in CAM18860. (PubMed:19468303)Curated
Sequence conflicti174 – 1741C → S in CAM18863. (PubMed:19468303)Curated
Sequence conflicti197 – 1971G → D in CAA67961. (PubMed:8978696)Curated
Sequence conflicti197 – 1971G → D in AAH04053. (PubMed:15489334)Curated
Sequence conflicti197 – 1971G → D in AAH20024. (PubMed:15489334)Curated
Sequence conflicti219 – 2191R → K in CAA67961. (PubMed:8978696)Curated
Sequence conflicti219 – 2191R → K in AAH04053. (PubMed:15489334)Curated
Sequence conflicti219 – 2191R → K in AAH20024. (PubMed:15489334)Curated
Sequence conflicti247 – 2471Missing in BAC25794. (PubMed:16141072)Curated
Sequence conflicti403 – 4031K → R in BAE38604. (PubMed:16141072)Curated
Sequence conflicti436 – 4361E → D in AAH04053. (PubMed:15489334)Curated
Sequence conflicti436 – 4361E → D in AAH20024. (PubMed:15489334)Curated
Sequence conflicti440 – 4412Missing in AAH04053. (PubMed:15489334)Curated
Sequence conflicti547 – 5471K → E in BAE36164. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3838Missing in isoform 3. 1 PublicationVSP_034174Add
BLAST
Alternative sequencei67 – 7913Missing in isoform 2. 1 PublicationVSP_034175Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004938 mRNA. Translation: BAB23683.1.
AK028181 mRNA. Translation: BAC25794.1.
AK043260 mRNA. Translation: BAC31507.1.
AK075725 mRNA. Translation: BAC35912.1. Frameshift.
AK161041 mRNA. Translation: BAE36164.1.
AK166161 mRNA. Translation: BAE38604.1.
AK169740 mRNA. Translation: BAE41340.1.
AL807249 Genomic DNA. Translation: CAM18860.1.
AL807249 Genomic DNA. Translation: CAM18863.1.
BC004053 mRNA. Translation: AAH04053.1.
BC020024 mRNA. Translation: AAH20024.1.
X99642 mRNA. Translation: CAA67961.1.
CCDSiCCDS38927.1. [Q3TEA8-1]
RefSeqiNP_001116368.1. NM_001122896.2.
NP_001116369.1. NM_001122897.2. [Q3TEA8-1]
NP_001272407.1. NM_001285478.1. [Q3TEA8-1]
NP_001272408.1. NM_001285479.1.
NP_001272409.1. NM_001285480.1.
NP_001272410.1. NM_001285481.1. [Q3TEA8-2]
NP_034600.2. NM_010470.3. [Q3TEA8-1]
XP_006538631.1. XM_006538568.1. [Q3TEA8-1]
XP_006538632.1. XM_006538569.1.
XP_006538633.1. XM_006538570.1.
UniGeneiMm.348429.
Mm.399941.

Genome annotation databases

EnsembliENSMUST00000030541; ENSMUSP00000030541; ENSMUSG00000028759. [Q3TEA8-1]
ENSMUST00000097836; ENSMUSP00000095447; ENSMUSG00000028759.
ENSMUST00000165861; ENSMUSP00000132614; ENSMUSG00000028759. [Q3TEA8-1]
GeneIDi15441.
KEGGimmu:15441.
UCSCiuc008vkg.2. mouse. [Q3TEA8-1]
uc008vki.2. mouse. [Q3TEA8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004938 mRNA. Translation: BAB23683.1 .
AK028181 mRNA. Translation: BAC25794.1 .
AK043260 mRNA. Translation: BAC31507.1 .
AK075725 mRNA. Translation: BAC35912.1 . Frameshift.
AK161041 mRNA. Translation: BAE36164.1 .
AK166161 mRNA. Translation: BAE38604.1 .
AK169740 mRNA. Translation: BAE41340.1 .
AL807249 Genomic DNA. Translation: CAM18860.1 .
AL807249 Genomic DNA. Translation: CAM18863.1 .
BC004053 mRNA. Translation: AAH04053.1 .
BC020024 mRNA. Translation: AAH20024.1 .
X99642 mRNA. Translation: CAA67961.1 .
CCDSi CCDS38927.1. [Q3TEA8-1 ]
RefSeqi NP_001116368.1. NM_001122896.2.
NP_001116369.1. NM_001122897.2. [Q3TEA8-1 ]
NP_001272407.1. NM_001285478.1. [Q3TEA8-1 ]
NP_001272408.1. NM_001285479.1.
NP_001272409.1. NM_001285480.1.
NP_001272410.1. NM_001285481.1. [Q3TEA8-2 ]
NP_034600.2. NM_010470.3. [Q3TEA8-1 ]
XP_006538631.1. XM_006538568.1. [Q3TEA8-1 ]
XP_006538632.1. XM_006538569.1.
XP_006538633.1. XM_006538570.1.
UniGenei Mm.348429.
Mm.399941.

3D structure databases

ProteinModelPortali Q3TEA8.
SMRi Q3TEA8. Positions 155-237, 248-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200401. 4 interactions.
IntActi Q3TEA8. 2 interactions.
MINTi MINT-4128252.

PTM databases

PhosphoSitei Q3TEA8.

Proteomic databases

MaxQBi Q3TEA8.
PaxDbi Q3TEA8.
PRIDEi Q3TEA8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030541 ; ENSMUSP00000030541 ; ENSMUSG00000028759 . [Q3TEA8-1 ]
ENSMUST00000097836 ; ENSMUSP00000095447 ; ENSMUSG00000028759 .
ENSMUST00000165861 ; ENSMUSP00000132614 ; ENSMUSG00000028759 . [Q3TEA8-1 ]
GeneIDi 15441.
KEGGi mmu:15441.
UCSCi uc008vkg.2. mouse. [Q3TEA8-1 ]
uc008vki.2. mouse. [Q3TEA8-2 ]

Organism-specific databases

CTDi 50809.
MGIi MGI:109369. Hp1bp3.

Phylogenomic databases

eggNOGi NOG285312.
GeneTreei ENSGT00510000047652.
HOVERGENi HBG097678.
InParanoidi Q3TEA8.
OrthoDBi EOG75QR72.
PhylomeDBi Q3TEA8.
TreeFami TF106395.

Miscellaneous databases

ChiTaRSi Hp1bp3. mouse.
NextBioi 288226.
PROi Q3TEA8.
SOURCEi Search...

Gene expression databases

Bgeei Q3TEA8.
ExpressionAtlasi Q3TEA8. baseline and differential.
Genevestigatori Q3TEA8.

Family and domain databases

Gene3Di 1.10.10.10. 3 hits.
InterProi IPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00538. Linker_histone. 3 hits.
[Graphical view ]
PRINTSi PR00624. HISTONEH5.
SMARTi SM00526. H15. 3 hits.
[Graphical view ]
PROSITEi PS51504. H15. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Strain: C57BL/6J and NOD.
    Tissue: Cerebellum, Liver, Lung, Skin and Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors."
    le Douarin B., Nielsen A.L., Garnier J.-M., Ichinose H., Jeanmougin F., Losson R., Chambon P.
    EMBO J. 15:6701-6715(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 43-324, FUNCTION, INTERACTION WITH CBX5.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-192, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiHP1B3_MOUSE
AccessioniPrimary (citable) accession number: Q3TEA8
Secondary accession number(s): A2AM64
, A2AM68, Q3TM38, Q3TU07, Q61688, Q8BT17, Q8C6H2, Q8C911, Q8VE06, Q99KR0, Q9DBI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 11, 2005
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3