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Q3TEA8

- HP1B3_MOUSE

UniProt

Q3TEA8 - HP1B3_MOUSE

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Protein
Heterochromatin protein 1-binding protein 3
Gene
Hp1bp3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of heterochromatin, may be involved in chromatin structure and function.1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. nucleosome assembly Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heterochromatin protein 1-binding protein 3
Gene namesi
Name:Hp1bp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:109369. Hp1bp3.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. nucleosome Source: InterPro
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 554553Heterochromatin protein 1-binding protein 3
PRO_0000339643Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei6 – 61Phosphoserine By similarity
Modified residuei144 – 1441Phosphoserine By similarity
Modified residuei157 – 1571Phosphoserine By similarity
Modified residuei158 – 1581Phosphoserine By similarity
Modified residuei192 – 1921N6-acetyllysine1 Publication
Modified residuei249 – 2491Phosphoserine By similarity
Modified residuei443 – 4431Phosphoserine By similarity
Modified residuei444 – 4441Phosphoserine By similarity
Modified residuei447 – 4471Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ3TEA8.
PaxDbiQ3TEA8.
PRIDEiQ3TEA8.

PTM databases

PhosphoSiteiQ3TEA8.

Expressioni

Gene expression databases

ArrayExpressiQ3TEA8.
BgeeiQ3TEA8.
GenevestigatoriQ3TEA8.

Interactioni

Subunit structurei

Interacts with CBX5.1 Publication

Protein-protein interaction databases

BioGridi200401. 4 interactions.
IntActiQ3TEA8. 2 interactions.
MINTiMINT-4128252.

Structurei

3D structure databases

ProteinModelPortaliQ3TEA8.
SMRiQ3TEA8. Positions 155-237, 248-334.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini159 – 23476H15 1
Add
BLAST
Domaini255 – 33076H15 2
Add
BLAST
Domaini337 – 41377H15 3
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 12870Glu-rich
Add
BLAST
Compositional biasi432 – 44110Poly-Asp
Compositional biasi455 – 554100Lys-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG285312.
GeneTreeiENSGT00510000047652.
HOVERGENiHBG097678.
OrthoDBiEOG75QR72.
PhylomeDBiQ3TEA8.
TreeFamiTF106395.

Family and domain databases

Gene3Di1.10.10.10. 3 hits.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 3 hits.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 3 hits.
[Graphical view]
PROSITEiPS51504. H15. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3TEA8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATDMSQGEL IHPKALPLIV GAQLIHADKL GEKAEDTTMP IRRAVNSTRE    50
TPPKSKLAEG EEEKPEPDGS SEESISTVEE QENETPPATS SEAEQPKGEP 100
ESGEKEENNN KSAEEPKKDE KDQSKEKEKK VKKTIPAWAT LSASQLARAQ 150
RQTPMASSPR PKMDAILTEA IKACFQKTGA SVVAIRKYII HKYPSLGLER 200
RGYLLKQALK RELNRGVIRQ VKGKGASGSF VVVQKSKPPQ KSKNRKKGSA 250
LDPEPQVKLE DVLPLAFTRL CEPKEASYSL IRKYVSQYYP KLRVDIRPQL 300
LKNALQRAVE RGQLEQITGK GASGTFQLKK SGEKPLLGGS LMEYAILSAI 350
AAMNEPKTCS TTALKKYVLE NHPGANSNYQ MHLLKKTLQK CEKNGWLEQI 400
SGKGFSGTFQ LSFPYYPSPG VLFPKKESGG SDDEDEDDDD DESSEDSEDE 450
EPPPKRSLQK KTPAKSQGKT ASMKQRGSKP ARKVPAAQRG KVRPLPKKAP 500
PKAKTPARKA RPSPSVIKKP SGSSSRKPIA SARKEAKLPG KGKSAMKKSF 550
KTKK 554
Length:554
Mass (Da):60,867
Last modified:October 11, 2005 - v1
Checksum:iA49C4F7C42D1BE64
GO
Isoform 2 (identifier: Q3TEA8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-79: Missing.

Show »
Length:541
Mass (Da):59,548
Checksum:i2F19451E819E2EB7
GO
Isoform 3 (identifier: Q3TEA8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-38: Missing.

Show »
Length:517
Mass (Da):56,972
Checksum:i95FCF9349FACFC4E
GO

Sequence cautioni

The sequence BAC35912.1 differs from that shown. Reason: Frameshift at positions 13 and 313.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 3837Missing in isoform 3.
VSP_034174Add
BLAST
Alternative sequencei67 – 7913Missing in isoform 2.
VSP_034175Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681D → N in BAE36164. 1 Publication
Sequence conflicti110 – 1101N → S in CAA67961. 1 Publication
Sequence conflicti110 – 1101N → S in AAH20024. 1 Publication
Sequence conflicti111 – 1111K → E in BAB23683. 1 Publication
Sequence conflicti174 – 1741C → S in CAM18860. 1 Publication
Sequence conflicti174 – 1741C → S in CAM18863. 1 Publication
Sequence conflicti197 – 1971G → D in CAA67961. 1 Publication
Sequence conflicti197 – 1971G → D in AAH04053. 1 Publication
Sequence conflicti197 – 1971G → D in AAH20024. 1 Publication
Sequence conflicti219 – 2191R → K in CAA67961. 1 Publication
Sequence conflicti219 – 2191R → K in AAH04053. 1 Publication
Sequence conflicti219 – 2191R → K in AAH20024. 1 Publication
Sequence conflicti247 – 2471Missing in BAC25794. 1 Publication
Sequence conflicti403 – 4031K → R in BAE38604. 1 Publication
Sequence conflicti436 – 4361E → D in AAH04053. 1 Publication
Sequence conflicti436 – 4361E → D in AAH20024. 1 Publication
Sequence conflicti440 – 4412Missing in AAH04053. 1 Publication
Sequence conflicti547 – 5471K → E in BAE36164. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004938 mRNA. Translation: BAB23683.1.
AK028181 mRNA. Translation: BAC25794.1.
AK043260 mRNA. Translation: BAC31507.1.
AK075725 mRNA. Translation: BAC35912.1. Frameshift.
AK161041 mRNA. Translation: BAE36164.1.
AK166161 mRNA. Translation: BAE38604.1.
AK169740 mRNA. Translation: BAE41340.1.
AL807249 Genomic DNA. Translation: CAM18860.1.
AL807249 Genomic DNA. Translation: CAM18863.1.
BC004053 mRNA. Translation: AAH04053.1.
BC020024 mRNA. Translation: AAH20024.1.
X99642 mRNA. Translation: CAA67961.1.
CCDSiCCDS38927.1. [Q3TEA8-1]
RefSeqiNP_001116368.1. NM_001122896.2.
NP_001116369.1. NM_001122897.2. [Q3TEA8-1]
NP_001272407.1. NM_001285478.1. [Q3TEA8-1]
NP_001272408.1. NM_001285479.1.
NP_001272409.1. NM_001285480.1.
NP_001272410.1. NM_001285481.1. [Q3TEA8-2]
NP_034600.2. NM_010470.3. [Q3TEA8-1]
XP_006538631.1. XM_006538568.1. [Q3TEA8-1]
XP_006538632.1. XM_006538569.1.
XP_006538633.1. XM_006538570.1.
UniGeneiMm.348429.
Mm.399941.

Genome annotation databases

EnsembliENSMUST00000030541; ENSMUSP00000030541; ENSMUSG00000028759. [Q3TEA8-1]
ENSMUST00000097836; ENSMUSP00000095447; ENSMUSG00000028759.
ENSMUST00000165861; ENSMUSP00000132614; ENSMUSG00000028759. [Q3TEA8-1]
GeneIDi15441.
KEGGimmu:15441.
UCSCiuc008vkg.2. mouse. [Q3TEA8-1]
uc008vki.2. mouse. [Q3TEA8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004938 mRNA. Translation: BAB23683.1 .
AK028181 mRNA. Translation: BAC25794.1 .
AK043260 mRNA. Translation: BAC31507.1 .
AK075725 mRNA. Translation: BAC35912.1 . Frameshift.
AK161041 mRNA. Translation: BAE36164.1 .
AK166161 mRNA. Translation: BAE38604.1 .
AK169740 mRNA. Translation: BAE41340.1 .
AL807249 Genomic DNA. Translation: CAM18860.1 .
AL807249 Genomic DNA. Translation: CAM18863.1 .
BC004053 mRNA. Translation: AAH04053.1 .
BC020024 mRNA. Translation: AAH20024.1 .
X99642 mRNA. Translation: CAA67961.1 .
CCDSi CCDS38927.1. [Q3TEA8-1 ]
RefSeqi NP_001116368.1. NM_001122896.2.
NP_001116369.1. NM_001122897.2. [Q3TEA8-1 ]
NP_001272407.1. NM_001285478.1. [Q3TEA8-1 ]
NP_001272408.1. NM_001285479.1.
NP_001272409.1. NM_001285480.1.
NP_001272410.1. NM_001285481.1. [Q3TEA8-2 ]
NP_034600.2. NM_010470.3. [Q3TEA8-1 ]
XP_006538631.1. XM_006538568.1. [Q3TEA8-1 ]
XP_006538632.1. XM_006538569.1.
XP_006538633.1. XM_006538570.1.
UniGenei Mm.348429.
Mm.399941.

3D structure databases

ProteinModelPortali Q3TEA8.
SMRi Q3TEA8. Positions 155-237, 248-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200401. 4 interactions.
IntActi Q3TEA8. 2 interactions.
MINTi MINT-4128252.

PTM databases

PhosphoSitei Q3TEA8.

Proteomic databases

MaxQBi Q3TEA8.
PaxDbi Q3TEA8.
PRIDEi Q3TEA8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030541 ; ENSMUSP00000030541 ; ENSMUSG00000028759 . [Q3TEA8-1 ]
ENSMUST00000097836 ; ENSMUSP00000095447 ; ENSMUSG00000028759 .
ENSMUST00000165861 ; ENSMUSP00000132614 ; ENSMUSG00000028759 . [Q3TEA8-1 ]
GeneIDi 15441.
KEGGi mmu:15441.
UCSCi uc008vkg.2. mouse. [Q3TEA8-1 ]
uc008vki.2. mouse. [Q3TEA8-2 ]

Organism-specific databases

CTDi 50809.
MGIi MGI:109369. Hp1bp3.

Phylogenomic databases

eggNOGi NOG285312.
GeneTreei ENSGT00510000047652.
HOVERGENi HBG097678.
OrthoDBi EOG75QR72.
PhylomeDBi Q3TEA8.
TreeFami TF106395.

Miscellaneous databases

ChiTaRSi HP1BP3. mouse.
NextBioi 288226.
PROi Q3TEA8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3TEA8.
Bgeei Q3TEA8.
Genevestigatori Q3TEA8.

Family and domain databases

Gene3Di 1.10.10.10. 3 hits.
InterProi IPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00538. Linker_histone. 3 hits.
[Graphical view ]
PRINTSi PR00624. HISTONEH5.
SMARTi SM00526. H15. 3 hits.
[Graphical view ]
PROSITEi PS51504. H15. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Strain: C57BL/6J and NOD.
    Tissue: Cerebellum, Liver, Lung, Skin and Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors."
    le Douarin B., Nielsen A.L., Garnier J.-M., Ichinose H., Jeanmougin F., Losson R., Chambon P.
    EMBO J. 15:6701-6715(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 43-324, FUNCTION, INTERACTION WITH CBX5.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-192, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiHP1B3_MOUSE
AccessioniPrimary (citable) accession number: Q3TEA8
Secondary accession number(s): A2AM64
, A2AM68, Q3TM38, Q3TU07, Q61688, Q8BT17, Q8C6H2, Q8C911, Q8VE06, Q99KR0, Q9DBI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 11, 2005
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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