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Q3TEA8

- HP1B3_MOUSE

UniProt

Q3TEA8 - HP1B3_MOUSE

Protein

Heterochromatin protein 1-binding protein 3

Gene

Hp1bp3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Component of heterochromatin, may be involved in chromatin structure and function.1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. nucleosome assembly Source: InterPro

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heterochromatin protein 1-binding protein 3
    Gene namesi
    Name:Hp1bp3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:109369. Hp1bp3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation. Chromosome PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleosome Source: InterPro
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 554553Heterochromatin protein 1-binding protein 3PRO_0000339643Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei6 – 61PhosphoserineBy similarity
    Modified residuei144 – 1441PhosphoserineBy similarity
    Modified residuei157 – 1571PhosphoserineBy similarity
    Modified residuei158 – 1581PhosphoserineBy similarity
    Modified residuei192 – 1921N6-acetyllysine1 Publication
    Modified residuei249 – 2491PhosphoserineBy similarity
    Modified residuei443 – 4431PhosphoserineBy similarity
    Modified residuei444 – 4441PhosphoserineBy similarity
    Modified residuei447 – 4471PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ3TEA8.
    PaxDbiQ3TEA8.
    PRIDEiQ3TEA8.

    PTM databases

    PhosphoSiteiQ3TEA8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3TEA8.
    BgeeiQ3TEA8.
    GenevestigatoriQ3TEA8.

    Interactioni

    Subunit structurei

    Interacts with CBX5.1 Publication

    Protein-protein interaction databases

    BioGridi200401. 4 interactions.
    IntActiQ3TEA8. 2 interactions.
    MINTiMINT-4128252.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3TEA8.
    SMRiQ3TEA8. Positions 155-237, 248-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini159 – 23476H15 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini255 – 33076H15 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini337 – 41377H15 3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi59 – 12870Glu-richAdd
    BLAST
    Compositional biasi432 – 44110Poly-Asp
    Compositional biasi455 – 554100Lys-richAdd
    BLAST

    Sequence similaritiesi

    Contains 3 H15 (linker histone H1/H5 globular) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG285312.
    GeneTreeiENSGT00510000047652.
    HOVERGENiHBG097678.
    OrthoDBiEOG75QR72.
    PhylomeDBiQ3TEA8.
    TreeFamiTF106395.

    Family and domain databases

    Gene3Di1.10.10.10. 3 hits.
    InterProiIPR005818. Histone_H1/H5_H15.
    IPR005819. Histone_H5.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00538. Linker_histone. 3 hits.
    [Graphical view]
    PRINTSiPR00624. HISTONEH5.
    SMARTiSM00526. H15. 3 hits.
    [Graphical view]
    PROSITEiPS51504. H15. 3 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3TEA8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATDMSQGEL IHPKALPLIV GAQLIHADKL GEKAEDTTMP IRRAVNSTRE    50
    TPPKSKLAEG EEEKPEPDGS SEESISTVEE QENETPPATS SEAEQPKGEP 100
    ESGEKEENNN KSAEEPKKDE KDQSKEKEKK VKKTIPAWAT LSASQLARAQ 150
    RQTPMASSPR PKMDAILTEA IKACFQKTGA SVVAIRKYII HKYPSLGLER 200
    RGYLLKQALK RELNRGVIRQ VKGKGASGSF VVVQKSKPPQ KSKNRKKGSA 250
    LDPEPQVKLE DVLPLAFTRL CEPKEASYSL IRKYVSQYYP KLRVDIRPQL 300
    LKNALQRAVE RGQLEQITGK GASGTFQLKK SGEKPLLGGS LMEYAILSAI 350
    AAMNEPKTCS TTALKKYVLE NHPGANSNYQ MHLLKKTLQK CEKNGWLEQI 400
    SGKGFSGTFQ LSFPYYPSPG VLFPKKESGG SDDEDEDDDD DESSEDSEDE 450
    EPPPKRSLQK KTPAKSQGKT ASMKQRGSKP ARKVPAAQRG KVRPLPKKAP 500
    PKAKTPARKA RPSPSVIKKP SGSSSRKPIA SARKEAKLPG KGKSAMKKSF 550
    KTKK 554
    Length:554
    Mass (Da):60,867
    Last modified:October 11, 2005 - v1
    Checksum:iA49C4F7C42D1BE64
    GO
    Isoform 2 (identifier: Q3TEA8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         67-79: Missing.

    Show »
    Length:541
    Mass (Da):59,548
    Checksum:i2F19451E819E2EB7
    GO
    Isoform 3 (identifier: Q3TEA8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-38: Missing.

    Show »
    Length:517
    Mass (Da):56,972
    Checksum:i95FCF9349FACFC4E
    GO

    Sequence cautioni

    The sequence BAC35912.1 differs from that shown. Reason: Frameshift at positions 13 and 313.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti68 – 681D → N in BAE36164. (PubMed:16141072)Curated
    Sequence conflicti110 – 1101N → S in CAA67961. (PubMed:8978696)Curated
    Sequence conflicti110 – 1101N → S in AAH20024. (PubMed:15489334)Curated
    Sequence conflicti111 – 1111K → E in BAB23683. (PubMed:16141072)Curated
    Sequence conflicti174 – 1741C → S in CAM18860. (PubMed:19468303)Curated
    Sequence conflicti174 – 1741C → S in CAM18863. (PubMed:19468303)Curated
    Sequence conflicti197 – 1971G → D in CAA67961. (PubMed:8978696)Curated
    Sequence conflicti197 – 1971G → D in AAH04053. (PubMed:15489334)Curated
    Sequence conflicti197 – 1971G → D in AAH20024. (PubMed:15489334)Curated
    Sequence conflicti219 – 2191R → K in CAA67961. (PubMed:8978696)Curated
    Sequence conflicti219 – 2191R → K in AAH04053. (PubMed:15489334)Curated
    Sequence conflicti219 – 2191R → K in AAH20024. (PubMed:15489334)Curated
    Sequence conflicti247 – 2471Missing in BAC25794. (PubMed:16141072)Curated
    Sequence conflicti403 – 4031K → R in BAE38604. (PubMed:16141072)Curated
    Sequence conflicti436 – 4361E → D in AAH04053. (PubMed:15489334)Curated
    Sequence conflicti436 – 4361E → D in AAH20024. (PubMed:15489334)Curated
    Sequence conflicti440 – 4412Missing in AAH04053. (PubMed:15489334)Curated
    Sequence conflicti547 – 5471K → E in BAE36164. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 3837Missing in isoform 3. 1 PublicationVSP_034174Add
    BLAST
    Alternative sequencei67 – 7913Missing in isoform 2. 1 PublicationVSP_034175Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004938 mRNA. Translation: BAB23683.1.
    AK028181 mRNA. Translation: BAC25794.1.
    AK043260 mRNA. Translation: BAC31507.1.
    AK075725 mRNA. Translation: BAC35912.1. Frameshift.
    AK161041 mRNA. Translation: BAE36164.1.
    AK166161 mRNA. Translation: BAE38604.1.
    AK169740 mRNA. Translation: BAE41340.1.
    AL807249 Genomic DNA. Translation: CAM18860.1.
    AL807249 Genomic DNA. Translation: CAM18863.1.
    BC004053 mRNA. Translation: AAH04053.1.
    BC020024 mRNA. Translation: AAH20024.1.
    X99642 mRNA. Translation: CAA67961.1.
    CCDSiCCDS38927.1. [Q3TEA8-1]
    RefSeqiNP_001116368.1. NM_001122896.2.
    NP_001116369.1. NM_001122897.2. [Q3TEA8-1]
    NP_001272407.1. NM_001285478.1. [Q3TEA8-1]
    NP_001272408.1. NM_001285479.1.
    NP_001272409.1. NM_001285480.1.
    NP_001272410.1. NM_001285481.1. [Q3TEA8-2]
    NP_034600.2. NM_010470.3. [Q3TEA8-1]
    XP_006538631.1. XM_006538568.1. [Q3TEA8-1]
    XP_006538632.1. XM_006538569.1.
    XP_006538633.1. XM_006538570.1.
    UniGeneiMm.348429.
    Mm.399941.

    Genome annotation databases

    EnsembliENSMUST00000030541; ENSMUSP00000030541; ENSMUSG00000028759. [Q3TEA8-1]
    ENSMUST00000097836; ENSMUSP00000095447; ENSMUSG00000028759.
    ENSMUST00000165861; ENSMUSP00000132614; ENSMUSG00000028759. [Q3TEA8-1]
    GeneIDi15441.
    KEGGimmu:15441.
    UCSCiuc008vkg.2. mouse. [Q3TEA8-1]
    uc008vki.2. mouse. [Q3TEA8-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004938 mRNA. Translation: BAB23683.1 .
    AK028181 mRNA. Translation: BAC25794.1 .
    AK043260 mRNA. Translation: BAC31507.1 .
    AK075725 mRNA. Translation: BAC35912.1 . Frameshift.
    AK161041 mRNA. Translation: BAE36164.1 .
    AK166161 mRNA. Translation: BAE38604.1 .
    AK169740 mRNA. Translation: BAE41340.1 .
    AL807249 Genomic DNA. Translation: CAM18860.1 .
    AL807249 Genomic DNA. Translation: CAM18863.1 .
    BC004053 mRNA. Translation: AAH04053.1 .
    BC020024 mRNA. Translation: AAH20024.1 .
    X99642 mRNA. Translation: CAA67961.1 .
    CCDSi CCDS38927.1. [Q3TEA8-1 ]
    RefSeqi NP_001116368.1. NM_001122896.2.
    NP_001116369.1. NM_001122897.2. [Q3TEA8-1 ]
    NP_001272407.1. NM_001285478.1. [Q3TEA8-1 ]
    NP_001272408.1. NM_001285479.1.
    NP_001272409.1. NM_001285480.1.
    NP_001272410.1. NM_001285481.1. [Q3TEA8-2 ]
    NP_034600.2. NM_010470.3. [Q3TEA8-1 ]
    XP_006538631.1. XM_006538568.1. [Q3TEA8-1 ]
    XP_006538632.1. XM_006538569.1.
    XP_006538633.1. XM_006538570.1.
    UniGenei Mm.348429.
    Mm.399941.

    3D structure databases

    ProteinModelPortali Q3TEA8.
    SMRi Q3TEA8. Positions 155-237, 248-334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200401. 4 interactions.
    IntActi Q3TEA8. 2 interactions.
    MINTi MINT-4128252.

    PTM databases

    PhosphoSitei Q3TEA8.

    Proteomic databases

    MaxQBi Q3TEA8.
    PaxDbi Q3TEA8.
    PRIDEi Q3TEA8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030541 ; ENSMUSP00000030541 ; ENSMUSG00000028759 . [Q3TEA8-1 ]
    ENSMUST00000097836 ; ENSMUSP00000095447 ; ENSMUSG00000028759 .
    ENSMUST00000165861 ; ENSMUSP00000132614 ; ENSMUSG00000028759 . [Q3TEA8-1 ]
    GeneIDi 15441.
    KEGGi mmu:15441.
    UCSCi uc008vkg.2. mouse. [Q3TEA8-1 ]
    uc008vki.2. mouse. [Q3TEA8-2 ]

    Organism-specific databases

    CTDi 50809.
    MGIi MGI:109369. Hp1bp3.

    Phylogenomic databases

    eggNOGi NOG285312.
    GeneTreei ENSGT00510000047652.
    HOVERGENi HBG097678.
    OrthoDBi EOG75QR72.
    PhylomeDBi Q3TEA8.
    TreeFami TF106395.

    Miscellaneous databases

    ChiTaRSi HP1BP3. mouse.
    NextBioi 288226.
    PROi Q3TEA8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3TEA8.
    Bgeei Q3TEA8.
    Genevestigatori Q3TEA8.

    Family and domain databases

    Gene3Di 1.10.10.10. 3 hits.
    InterProi IPR005818. Histone_H1/H5_H15.
    IPR005819. Histone_H5.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00538. Linker_histone. 3 hits.
    [Graphical view ]
    PRINTSi PR00624. HISTONEH5.
    SMARTi SM00526. H15. 3 hits.
    [Graphical view ]
    PROSITEi PS51504. H15. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Strain: C57BL/6J and NOD.
      Tissue: Cerebellum, Liver, Lung, Skin and Thymus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. "A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors."
      le Douarin B., Nielsen A.L., Garnier J.-M., Ichinose H., Jeanmougin F., Losson R., Chambon P.
      EMBO J. 15:6701-6715(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 43-324, FUNCTION, INTERACTION WITH CBX5.
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-192, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiHP1B3_MOUSE
    AccessioniPrimary (citable) accession number: Q3TEA8
    Secondary accession number(s): A2AM64
    , A2AM68, Q3TM38, Q3TU07, Q61688, Q8BT17, Q8C6H2, Q8C911, Q8VE06, Q99KR0, Q9DBI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3