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Q3TDT5

- Q3TDT5_MOUSE

UniProt

Q3TDT5 - Q3TDT5_MOUSE

Protein
Submitted name:

Interleukin-6 receptor subunit beta

Gene

Il6st

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. interleukin-6 receptor activity Source: Ensembl
    2. leukemia inhibitory factor receptor activity Source: Ensembl
    3. oncostatin-M receptor activity Source: Ensembl
    4. protein binding Source: MGI

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: MGI
    2. glycogen metabolic process Source: MGI
    3. interleukin-11-mediated signaling pathway Source: GOC
    4. interleukin-27-mediated signaling pathway Source: Ensembl
    5. negative regulation of interleukin-6-mediated signaling pathway Source: Ensembl
    6. positive regulation of astrocyte differentiation Source: MGI
    7. positive regulation of cell proliferation Source: MGI
    8. positive regulation of osteoblast differentiation Source: Ensembl
    9. positive regulation of T cell proliferation Source: Ensembl
    10. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
    11. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
    12. regulation of Notch signaling pathway Source: MGI
    13. signal transduction Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Interleukin-6 receptor subunit betaImported
    Gene namesi
    Name:Il6stImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:96560. Il6st.

    Subcellular locationi

    GO - Cellular componenti

    1. cell body Source: MGI
    2. ciliary neurotrophic factor receptor complex Source: Ensembl
    3. dendrite Source: MGI
    4. external side of plasma membrane Source: MGI
    5. extracellular space Source: Ensembl
    6. interleukin-6 receptor complex Source: Ensembl
    7. neuronal cell body Source: MGI
    8. oncostatin-M receptor complex Source: Ensembl

    Expressioni

    Gene expression databases

    BgeeiQ3TDT5.
    GenevestigatoriQ3TDT5.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00550000074436.
    InParanoidiQ3TDT5.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR010457. IgC2-like_lig-bd.
    IPR015321. IL-6_rcpt_alpha-bd.
    [Graphical view]
    PfamiPF09240. IL6Ra-bind. 1 hit.
    PF06328. Lep_receptor_Ig. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q3TDT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAPRIWLAQ ALLFFLTTES IGQLLEPCGY IYPEFPVVQR GSNFTAICVL    50
    KEACLQHYYV NASYIVWKTN HAAVPREQVT VINRTTSSVT FTDVVLPSVQ 100
    LTCNILSFGQ IEQNVYGVTM LSGFPPDKPT NLTCIVNEGK NMLCQWDPGR 150
    ETYLETNYTL KSEW 164
    Length:164
    Mass (Da):18,538
    Last modified:October 11, 2005 - v1
    Checksum:iCD2D736EB32CC0AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC159196 Genomic DNA. No translation available.
    AK170020 mRNA. Translation: BAE41514.1.
    UniGeneiMm.4364.

    Genome annotation databases

    EnsembliENSMUST00000183886; ENSMUSP00000138820; ENSMUSG00000021756.
    UCSCiuc007rwf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC159196 Genomic DNA. No translation available.
    AK170020 mRNA. Translation: BAE41514.1 .
    UniGenei Mm.4364.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000183886 ; ENSMUSP00000138820 ; ENSMUSG00000021756 .
    UCSCi uc007rwf.2. mouse.

    Organism-specific databases

    MGIi MGI:96560. Il6st.

    Phylogenomic databases

    GeneTreei ENSGT00550000074436.
    InParanoidi Q3TDT5.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Bgeei Q3TDT5.
    Genevestigatori Q3TDT5.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR010457. IgC2-like_lig-bd.
    IPR015321. IL-6_rcpt_alpha-bd.
    [Graphical view ]
    Pfami PF09240. IL6Ra-bind. 1 hit.
    PF06328. Lep_receptor_Ig. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    10. Ensembl
      Submitted (DEC-2013) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ3TDT5_MOUSE
    AccessioniPrimary (citable) accession number: Q3TDT5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3