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Protein

FAS-associated factor 2

Gene

Faf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUnfolded protein response

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
FAS-associated factor 2
Alternative name(s):
UBX domain-containing protein 8
Gene namesi
Name:Faf2
Synonyms:Kiaa0887, Ubxd8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1923827 Faf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Lipid droplet

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002440652 – 445FAS-associated factor 2Add BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei167N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ3TDN2
MaxQBiQ3TDN2
PaxDbiQ3TDN2
PeptideAtlasiQ3TDN2
PRIDEiQ3TDN2

PTM databases

iPTMnetiQ3TDN2
PhosphoSitePlusiQ3TDN2
SwissPalmiQ3TDN2

Expressioni

Gene expression databases

BgeeiENSMUSG00000025873
ExpressionAtlasiQ3TDN2 baseline and differential
GenevisibleiQ3TDN2 MM

Interactioni

Subunit structurei

Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with YOD1. Interacts (via N-terminus) with UBQLN2 (via C-terminus). Interacts with PNPLA2 and UBAC2 (By similarity). Interacts with ZFAND2B; probably through VCP (PubMed:24160817).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218186, 2 interactors
STRINGi10090.ENSMUSP00000121182

Structurei

3D structure databases

ProteinModelPortaliQ3TDN2
SMRiQ3TDN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 48UBAAdd BLAST37
Domaini357 – 439UBXPROSITE-ProRule annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili275 – 350Sequence analysisAdd BLAST76

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1363 Eukaryota
ENOG410XSFS LUCA
GeneTreeiENSGT00530000063422
HOGENOMiHOG000007539
HOVERGENiHBG101311
InParanoidiQ3TDN2
KOiK18726
OMAiSLRCTKF
OrthoDBiEOG091G07IN
PhylomeDBiQ3TDN2
TreeFamiTF314172

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR006577 UAS
IPR009060 UBA-like_sf
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00594 UAS, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF52833 SSF52833, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50033 UBX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TDN2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPEEQDLT QEQTEKLLQF QDLTGIESME QCRLALEQHN WNMEAAVQDR
60 70 80 90 100
LNEQEGVPSV FNPPPARPLQ VNTADHRIYS YVVSRPQPRG LLGWGYYLIM
110 120 130 140 150
LPFRFTYYTI LDIFRFALRF IRPDPRSRVT DPVGDIVSFM HSFEEKYGRA
160 170 180 190 200
HPVFYQGTYS QALNDAKREL RFLLVYLHGD DHQDSDEFCR NALCAPEVIS
210 220 230 240 250
LINSRMLFWA CSTNKPEGYR VSQALRENTY PFLAMIMLKD RRMTVVGRLE
260 270 280 290 300
GLIQPDDLIN QLTFIMDANQ TYLVSERLER EERNQTQVLR QQQDEAYLAS
310 320 330 340 350
LRADQEKERK KREEKERKRR KEEEVQQQKL AEERRRQNLQ EEKERKLECL
360 370 380 390 400
PPEPSPDDPE SVKIIFKLPN DSRVERRFHF SQSLTVIHDF LFSLKESPEK
410 420 430 440
FQIEANFPRR VLPCVPSEEW PNPPTLQEAG LSHTEVLFVQ DLTDE
Length:445
Mass (Da):52,471
Last modified:June 27, 2006 - v2
Checksum:iF0FD0FC631148AE7
GO
Isoform 2 (identifier: Q3TDN2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-89: Missing.

Note: No experimental confirmation available.
Show »
Length:426
Mass (Da):50,231
Checksum:iEFA71B09CB52A7D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72Missing in AAH46817 (PubMed:15489334).Curated1
Sequence conflicti430 – 434GLSHT → DSATQ in BAE41569 (PubMed:16141072).Curated5

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01950471 – 89Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK151617 mRNA Translation: BAE30554.1
AK170111 mRNA Translation: BAE41569.1
BC046817 mRNA Translation: AAH46817.1
AK122394 mRNA Translation: BAC65676.1
CCDSiCCDS36668.1 [Q3TDN2-1]
RefSeqiNP_848484.2, NM_178397.3 [Q3TDN2-1]
UniGeneiMm.194459

Genome annotation databases

EnsembliENSMUST00000026991; ENSMUSP00000026991; ENSMUSG00000025873 [Q3TDN2-2]
ENSMUST00000126071; ENSMUSP00000121182; ENSMUSG00000025873 [Q3TDN2-1]
GeneIDi76577
KEGGimmu:76577
UCSCiuc007qoq.2 mouse [Q3TDN2-1]
uc007qor.2 mouse [Q3TDN2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFAF2_MOUSE
AccessioniPrimary (citable) accession number: Q3TDN2
Secondary accession number(s): Q3U9W2, Q80TP7, Q80W42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: May 23, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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