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Protein

Protein rogdi homolog

Gene

Rogdi

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a positive regulator of cell proliferation.

GO - Biological processi

  • brain development Source: MGI
  • hemopoiesis Source: MGI
  • neurogenesis Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • positive regulation of cell proliferation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein rogdi homolog
Alternative name(s):
Leucine-zipper-containing LZF
Gene namesi
Name:Rogdi
Synonyms:Lzf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1913299. Rogdi.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003156652 – 287Protein rogdi homologAdd BLAST286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ3TDK6.
PeptideAtlasiQ3TDK6.
PRIDEiQ3TDK6.

PTM databases

iPTMnetiQ3TDK6.
PhosphoSitePlusiQ3TDK6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022540.
CleanExiMM_ROGDI.
ExpressionAtlasiQ3TDK6. baseline and differential.
GenevisibleiQ3TDK6. MM.

Interactioni

Protein-protein interaction databases

BioGridi211177. 2 interactors.
IntActiQ3TDK6. 3 interactors.
MINTiMINT-4122850.

Structurei

3D structure databases

ProteinModelPortaliQ3TDK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the rogdi family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000007164.
HOGENOMiHOG000008516.
HOVERGENiHBG087014.
InParanoidiQ3TDK6.
OMAiTKNFKPA.
OrthoDBiEOG091G0GOX.
PhylomeDBiQ3TDK6.
TreeFamiTF105859.

Family and domain databases

InterProiIPR028241. RAVE2/Rogdi.
[Graphical view]
PANTHERiPTHR13618:SF1. PTHR13618:SF1. 1 hit.
PfamiPF10259. Rogdi_lz. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TDK6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATAMAASAA ERAVLEEEFR WLLHAEVHAV LRQLQDILKE ASLRFTLPGP
60 70 80 90 100
STEGPAKQEN FILGSCGTDQ VKGTLTLQGD ALSQADVNLK MPRNNQLLHL
110 120 130 140 150
AFREDKQWKL QQIQDARNHV SQAIYLLANR DESYQFKTGA EVLKLMDAVM
160 170 180 190 200
LQLTRARSRL TTPATLTLPE IAASGLTRMF APTLPSDLLV NVYINLNKLC
210 220 230 240 250
LTVYQLHALQ PTSTKNFRPA GGAVLHSPGA MFEWGSQRLE VSHVHKVECV
260 270 280
IPWLNDALVY FTVSLQLCQQ LKDKIAVFSS YWSSRPF
Length:287
Mass (Da):32,100
Last modified:January 15, 2008 - v2
Checksum:i5F47C4A8073B1A04
GO
Isoform 2 (identifier: Q3TDK6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-85: A → ALPPGWLRRLGPQPSPHCIAGSQ

Note: No experimental confirmation available.
Show »
Length:309
Mass (Da):34,450
Checksum:iABCB5C70AB9E45EA
GO
Isoform 3 (identifier: Q3TDK6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-287: QLHALQPTST...FSSYWSSRPF → HLFCDPTHL

Note: No experimental confirmation available.
Show »
Length:213
Mass (Da):23,796
Checksum:i3A2750088A5DE029
GO

Sequence cautioni

The sequence AAK71345 differs from that shown. Reason: Frameshift at positions 3, 158 and 167.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158S → N in AAK71345 (PubMed:11740862).Curated1
Sequence conflicti164A → T in AAK71345 (PubMed:11740862).Curated1
Sequence conflicti193Y → H in BAE41595 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03060085A → ALPPGWLRRLGPQPSPHCIA GSQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_030601205 – 287QLHAL…SSRPF → HLFCDPTHL in isoform 3. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY036117 mRNA. Translation: AAK71345.1. Frameshift.
AK046477 mRNA. Translation: BAC32748.1.
AK170144 mRNA. Translation: BAE41595.1.
BC006914 mRNA. Translation: AAH06914.1.
CCDSiCCDS79419.1. [Q3TDK6-1]
RefSeqiNP_573448.2. NM_133185.2. [Q3TDK6-1]
UniGeneiMm.27792.

Genome annotation databases

EnsembliENSMUST00000023191; ENSMUSP00000023191; ENSMUSG00000022540. [Q3TDK6-2]
ENSMUST00000090453; ENSMUSP00000087938; ENSMUSG00000022540. [Q3TDK6-3]
ENSMUST00000202281; ENSMUSP00000144481; ENSMUSG00000022540. [Q3TDK6-1]
GeneIDi66049.
KEGGimmu:66049.
UCSCiuc007ybj.1. mouse. [Q3TDK6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY036117 mRNA. Translation: AAK71345.1. Frameshift.
AK046477 mRNA. Translation: BAC32748.1.
AK170144 mRNA. Translation: BAE41595.1.
BC006914 mRNA. Translation: AAH06914.1.
CCDSiCCDS79419.1. [Q3TDK6-1]
RefSeqiNP_573448.2. NM_133185.2. [Q3TDK6-1]
UniGeneiMm.27792.

3D structure databases

ProteinModelPortaliQ3TDK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211177. 2 interactors.
IntActiQ3TDK6. 3 interactors.
MINTiMINT-4122850.

PTM databases

iPTMnetiQ3TDK6.
PhosphoSitePlusiQ3TDK6.

Proteomic databases

MaxQBiQ3TDK6.
PeptideAtlasiQ3TDK6.
PRIDEiQ3TDK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023191; ENSMUSP00000023191; ENSMUSG00000022540. [Q3TDK6-2]
ENSMUST00000090453; ENSMUSP00000087938; ENSMUSG00000022540. [Q3TDK6-3]
ENSMUST00000202281; ENSMUSP00000144481; ENSMUSG00000022540. [Q3TDK6-1]
GeneIDi66049.
KEGGimmu:66049.
UCSCiuc007ybj.1. mouse. [Q3TDK6-1]

Organism-specific databases

CTDi79641.
MGIiMGI:1913299. Rogdi.

Phylogenomic databases

GeneTreeiENSGT00390000007164.
HOGENOMiHOG000008516.
HOVERGENiHBG087014.
InParanoidiQ3TDK6.
OMAiTKNFKPA.
OrthoDBiEOG091G0GOX.
PhylomeDBiQ3TDK6.
TreeFamiTF105859.

Miscellaneous databases

ChiTaRSiRogdi. mouse.
PROiQ3TDK6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022540.
CleanExiMM_ROGDI.
ExpressionAtlasiQ3TDK6. baseline and differential.
GenevisibleiQ3TDK6. MM.

Family and domain databases

InterProiIPR028241. RAVE2/Rogdi.
[Graphical view]
PANTHERiPTHR13618:SF1. PTHR13618:SF1. 1 hit.
PfamiPF10259. Rogdi_lz. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiROGDI_MOUSE
AccessioniPrimary (citable) accession number: Q3TDK6
Secondary accession number(s): Q8BL37, Q922N4, Q923H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.