ID   Q3TDA4_MOUSE            Unreviewed;       354 AA.
AC   Q3TDA4;
DT   11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2005, sequence version 1.
DT   03-NOV-2009, entry version 41.
DE   SubName: Full=Putative uncharacterized protein;
DE   SubName: Full=Ccr5 protein;
GN   Name=Ccr5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD;
RX   MEDLINE=99279253; PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD;
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group
RG   (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD;
RX   MEDLINE=22354683; PubMed=12466851; DOI=10.1038/nature01266;
RA   Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S.,
RA   Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H.,
RA   Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T.,
RA   Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J.,
RA   Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W.,
RA   Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S.,
RA   Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S.,
RA   Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J.,
RA   Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D.,
RA   Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L.,
RA   Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A.,
RA   Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H.,
RA   Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G.,
RA   Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S.,
RA   Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M.,
RA   Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K.,
RA   Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M.,
RA   Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C.,
RA   Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L.,
RA   Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N.,
RA   Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K.,
RA   Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S.,
RA   Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I.,
RA   Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A.,
RA   Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J.,
RA   Birney E., Hayashizaki Y.;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD;
RX   MEDLINE=21085660; PubMed=11217851; DOI=10.1038/35055500;
RA   Kawai J., Shinagawa A., Shibata K., Yoshino M., Itoh M., Ishii Y.,
RA   Arakawa T., Hara A., Fukunishi Y., Konno H., Adachi J., Fukuda S.,
RA   Aizawa K., Izawa M., Nishi K., Kiyosawa H., Kondo S., Yamanaka I.,
RA   Saito T., Okazaki Y., Gojobori T., Bono H., Kasukawa T., Saito R.,
RA   Kadota K., Matsuda H.A., Ashburner M., Batalov S., Casavant T.,
RA   Fleischmann W., Gaasterland T., Gissi C., King B., Kochiwa H.,
RA   Kuehl P., Lewis S., Matsuo Y., Nikaido I., Pesole G., Quackenbush J.,
RA   Schriml L.M., Staubli F., Suzuki R., Tomita M., Wagner L., Washio T.,
RA   Sakai K., Okido T., Furuno M., Aono H., Baldarelli R., Barsh G.,
RA   Blake J., Boffelli D., Bojunga N., Carninci P., de Bonaldo M.F.,
RA   Brownstein M.J., Bult C., Fletcher C., Fujita M., Gariboldi M.,
RA   Gustincich S., Hill D., Hofmann M., Hume D.A., Kamiya M., Lee N.H.,
RA   Lyons P., Marchionni L., Mashima J., Mazzarelli J., Mombaerts P.,
RA   Nordone P., Ring B., Ringwald M., Rodriguez I., Sakamoto N.,
RA   Sasaki H., Sato K., Schoenbach C., Seya T., Shibata Y., Storch K.-F.,
RA   Suzuki H., Toyo-oka K., Wang K.H., Weitz C., Whittaker C., Wilming L.,
RA   Wynshaw-Boris A., Yoshida K., Hasegawa Y., Kawaji H., Kohtsuki S.,
RA   Hayashizaki Y.;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [6]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD;
RX   MEDLINE=20499374; PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to
RT   prepare full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [7]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD;
RX   MEDLINE=20530913; PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M.,
RA   Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A.,
RA   Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K.,
RA   Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M.,
RA   Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J.,
RA   Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format
RT   sequencing pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [8]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NOD;
RA   Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K.,
RA   Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S.,
RA   Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N.,
RA   Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D.,
RA   Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A.,
RA   Muramatsu M., Hayashizaki Y.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PCR rescued clones;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (By similarity).
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
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DR   EMBL; BC105643; AAI05644.1; -; mRNA.
DR   EMBL; AK170303; BAE41700.1; -; mRNA.
DR   IPI; IPI00653496; -.
DR   UniGene; Mm.14302; -.
DR   STRING; Q3TDA4; -.
DR   Ensembl; ENSMUST00000111442; ENSMUSP00000107069; ENSMUSG00000079227; Mus musculus.
DR   MGI; MGI:107182; Ccr5.
DR   HOVERGEN; Q3TDA4; -.
DR   ArrayExpress; Q3TDA4; -.
DR   Bgee; Q3TDA4; -.
DR   Genevestigator; Q3TDA4; -.
DR   GO; GO:0005768; C:endosome; IEA:Compara.
DR   GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016493; F:C-C chemokine receptor activity; IDA:MGI.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:Compara.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signalin...; IEA:UniProtKB-KW.
DR   GO; GO:0002437; P:inflammatory response to antigenic stimulus; IEA:Compara.
DR   InterPro; IPR000276; 7TM_GPCR_Rhodpsn.
DR   InterPro; IPR002240; CC_5_rcpt.
DR   InterPro; IPR000355; Chmkine_rcpt.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   PANTHER; PTHR19264:SF204; CC_5_rcpt; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00657; CCCHEMOKINER.
DR   PRINTS; PR01110; CHEMOKINER5.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW   Transducer; Transmembrane.
SQ   SEQUENCE   354 AA;  40837 MW;  C4F3AAFD1A6F3BE8 CRC64;
     MDFQGSVPTY IYDIDYGMSA PCQKINVKQI AAQLLPPLYS LVFIFGFVGN MMVFLILISC
     KRLKSMTDIY LLNLAISDLL FLLTLPFWAH YAANEWVFGN IMCKVFTGVY HIGYFGGIFF
     IILLTIDRYL AIVHAVFALK VRTVNFGVIT SVVTWVVAVS ASLPEIIFTR SQKEGFHYTC
     SPHFLHTQYH FWKSFQTLKM VILSLILPLL VMIICYSGIL HTLFRCRNEK KRHRAVRLIF
     AIMIVYFLFW TPYNIVLLLT TFQEFFGLNN CSSSNRLDQA MQATETLGMT HCCLNPVIYA
     FVGEKFRSYL SVFFRKHIVK RFCKRCSIFQ QDNPDRASSV YTRSTGEHEV STGL
//