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Protein
Submitted name:

Tapasin

Gene

Tapbp

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Submitted name:
TapasinImported
Gene namesi
Name:TapbpImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1201689. Tapbp.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei417 – 44125HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 466443Sequence analysisPRO_5007702220Add
BLAST

Proteomic databases

PeptideAtlasiQ3TCU5.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025161.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini295 – 402108Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Keywords - Domaini

Immunoglobulin domainSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410II43. Eukaryota.
ENOG4111QPK. LUCA.
GeneTreeiENSGT00530000063758.
HOGENOMiHOG000231214.
HOVERGENiHBG005156.
OMAiYLATVHL.
TreeFamiTF334274.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR008056. Tapasin.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
PRINTSiPR01669. TAPASIN.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TCU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPLLLLVAV ALGLATVVSV VSAGPEAIEC WFVEDAGGGG LSKKPATLLL
60 70 80 90 100
RHGPRGPPPR PDLDPKLYFK VDDPAGMLLA AFRRYPAGAS APHCEMSRFI
110 120 130 140 150
PFPASAKWAR SLSPEQNCPR ALDGDWLLVS VSSTLFSLSS LLRPQPEPLR
160 170 180 190 200
EPVVITMATV VLTVLTHNPA PRVQLGKDAV LDLRFAYAPS ALEGSPSLDA
210 220 230 240 250
GPPPFGLEWR RQHRGKGHLL LAATPGLAGR MPPAQEKATA FAAWDDDEPW
260 270 280 290 300
GPWTGNGTFW LPAVKPSQEG VYLATVHLPY LQGQVSLELT VHKAPRVSLT
310 320 330 340 350
PAPVVWAAPG EAPPELLCLA SHFFPAEGLE VKWELRGGPG GSSRKVEGKT
360 370 380 390 400
WLSTIRHHSD GSVSQSGHLQ LPPVTAKQHG VHYVCRVYHS SLPASGRSAD
410 420 430 440 450
VTLEVAGFSG PSIEDGIGLF LSAFLLLGLL KVLGWLVAAY WTIPEVSKEK
460
ATAASLTIPR NSKKSQ
Length:466
Mass (Da):49,836
Last modified:October 11, 2005 - v1
Checksum:i0184756D434DB3CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974462 Genomic DNA. No translation available.
AK151807 mRNA. Translation: BAE30706.1.
AK170528 mRNA. Translation: BAE41860.1.
RefSeqiNP_001020484.1. NM_001025313.1.
UniGeneiMm.154457.

Genome annotation databases

EnsembliENSMUST00000025161; ENSMUSP00000025161; ENSMUSG00000024308.
GeneIDi21356.
UCSCiuc008caf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974462 Genomic DNA. No translation available.
AK151807 mRNA. Translation: BAE30706.1.
AK170528 mRNA. Translation: BAE41860.1.
RefSeqiNP_001020484.1. NM_001025313.1.
UniGeneiMm.154457.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025161.

Proteomic databases

PeptideAtlasiQ3TCU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025161; ENSMUSP00000025161; ENSMUSG00000024308.
GeneIDi21356.
UCSCiuc008caf.1. mouse.

Organism-specific databases

CTDi6892.
MGIiMGI:1201689. Tapbp.

Phylogenomic databases

eggNOGiENOG410II43. Eukaryota.
ENOG4111QPK. LUCA.
GeneTreeiENSGT00530000063758.
HOGENOMiHOG000231214.
HOVERGENiHBG005156.
OMAiYLATVHL.
TreeFamiTF334274.

Enzyme and pathway databases

ReactomeiR-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiTapbp. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR008056. Tapasin.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
PRINTSiPR01669. TAPASIN.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Bone marrowImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Bone marrowImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Bone marrowImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Bone marrowImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Bone marrowImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Bone marrowImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Bone marrowImported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3TCU5_MOUSE
AccessioniPrimary (citable) accession number: Q3TCU5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.