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Protein

Ectonucleoside triphosphate diphosphohydrolase 7

Gene

Entpd7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Preferentially hydrolyzes nucleoside 5'-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP (By similarity).By similarity

Cofactori

Ca2+By similarity, Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei217 – 2171Proton acceptorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.6.1.5. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Ectonucleoside triphosphate diphosphohydrolase 7 (EC:3.6.1.-)
Short name:
NTPDase 7
Alternative name(s):
Lysosomal apyrase-like protein 1
Gene namesi
Name:Entpd7
Synonyms:Kiaa4066, Lalp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2135885. Entpd7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828CytoplasmicSequence analysisAdd
BLAST
Transmembranei29 – 4921HelicalSequence analysisAdd
BLAST
Topological domaini50 – 548499VesicularSequence analysisAdd
BLAST
Transmembranei549 – 56921HelicalSequence analysisAdd
BLAST
Topological domaini570 – 60637CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 606606Ectonucleoside triphosphate diphosphohydrolase 7PRO_0000274420Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence analysis
Disulfide bondi448 ↔ 477By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ3TCT4.
PaxDbiQ3TCT4.
PeptideAtlasiQ3TCT4.
PRIDEiQ3TCT4.

PTM databases

PhosphoSiteiQ3TCT4.

Expressioni

Tissue specificityi

Widely expressed. Expressed at high level in brain, kidney, liver and testis. Weakly expressed in lung, thymus and heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000025192.
CleanExiMM_ENTPD7.
GenevisibleiQ3TCT4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079864.

Structurei

3D structure databases

ProteinModelPortaliQ3TCT4.
SMRiQ3TCT4. Positions 82-526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1386. Eukaryota.
COG5371. LUCA.
GeneTreeiENSGT00550000074435.
HOGENOMiHOG000090205.
HOVERGENiHBG006789.
InParanoidiQ3TCT4.
KOiK14643.
OMAiIHHRQTR.
OrthoDBiEOG091G04IV.
PhylomeDBiQ3TCT4.
TreeFamiTF354343.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 2 hits.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TCT4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARISFSYLC PASWYFTVPT VSPFLRQRVA FLGLFFIPCV LLLLLIMDLR
60 70 80 90 100
HWATSLPRDR QYERYLARVG DLEATNTEDP NLNYGLVVDC GSSGSRIFVY
110 120 130 140 150
FWPRHNGNPH DLLDIKQMRD RNSQPVVKKI KPGISAMADT PEHASDYLRP
160 170 180 190 200
LLSFAAAHVP VKKHRETPLY ILCTAGMRLL PERQQLAILA DLVKDLPLEF
210 220 230 240 250
DFLFSQSQAE VISGKQEGVY AWIGINFVLG RFDHEDESDS DTSVDSAAGR
260 270 280 290 300
RRTVGILDMG GASLQIAYEV PTSASDLPPK QEEAAKILLA EFNLGCDVQH
310 320 330 340 350
TEHVYRVYVT TFLGFGGNFA RQRYEDLVLN ETLNKNRLLG QKTGLSPDNP
360 370 380 390 400
FLDPCLPVGL TDMVKRNNQV LHFRGKGDWA SCRTLLSPLL ARSNTSQASL
410 420 430 440 450
NGIYQSPIDF NNSEFYGFSE FFYCTEDVLR IGGHYHGPTF AKAAQDYCGM
460 470 480 490 500
AWPVLAQRFK NGLFSSHADE HRLKYQCFKS AWMYEVLHEG FHFPYDYPNL
510 520 530 540 550
QTAQLVYDRE VQWTLGAILY KTRFLPLRDL RQGQGGVRPA HGSWLRLSFV
560 570 580 590 600
YNHYLFFACT LVVLLAIVLY LLRIHRIHRR QTRASAPLDL LWIEQVVPMI

GVQVGP
Length:606
Mass (Da):68,974
Last modified:October 11, 2005 - v1
Checksum:iFD574C72FAA7848A
GO
Isoform 2 (identifier: Q3TCT4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     338-354: LLGQKTGLSPDNPFLDP → YNVARLQPLGRNSSTQL
     355-606: Missing.

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):40,002
Checksum:iA15E7E3D5604563D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221S → R in AAG01009 (PubMed:11278936).Curated
Sequence conflicti116 – 1161K → R in BAE38638 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei338 – 35417LLGQK…PFLDP → YNVARLQPLGRNSSTQL in isoform 2. 1 PublicationVSP_022743Add
BLAST
Alternative sequencei355 – 606252Missing in isoform 2. 1 PublicationVSP_022744Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288221 mRNA. Translation: AAG01009.1.
AK147401 mRNA. Translation: BAE27889.1.
AK166220 mRNA. Translation: BAE38638.1.
AK170546 mRNA. Translation: BAE41871.1.
BC137709 mRNA. Translation: AAI37710.1.
BC137717 mRNA. Translation: AAI37718.1.
AK220284 mRNA. Translation: BAD90209.1.
CCDSiCCDS29835.1. [Q3TCT4-1]
RefSeqiNP_444333.3. NM_053103.5. [Q3TCT4-1]
UniGeneiMm.248237.
Mm.296789.

Genome annotation databases

EnsembliENSMUST00000081079; ENSMUSP00000079864; ENSMUSG00000025192. [Q3TCT4-1]
GeneIDi93685.
KEGGimmu:93685.
UCSCiuc008hor.2. mouse. [Q3TCT4-2]
uc008hos.2. mouse. [Q3TCT4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288221 mRNA. Translation: AAG01009.1.
AK147401 mRNA. Translation: BAE27889.1.
AK166220 mRNA. Translation: BAE38638.1.
AK170546 mRNA. Translation: BAE41871.1.
BC137709 mRNA. Translation: AAI37710.1.
BC137717 mRNA. Translation: AAI37718.1.
AK220284 mRNA. Translation: BAD90209.1.
CCDSiCCDS29835.1. [Q3TCT4-1]
RefSeqiNP_444333.3. NM_053103.5. [Q3TCT4-1]
UniGeneiMm.248237.
Mm.296789.

3D structure databases

ProteinModelPortaliQ3TCT4.
SMRiQ3TCT4. Positions 82-526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079864.

PTM databases

PhosphoSiteiQ3TCT4.

Proteomic databases

MaxQBiQ3TCT4.
PaxDbiQ3TCT4.
PeptideAtlasiQ3TCT4.
PRIDEiQ3TCT4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081079; ENSMUSP00000079864; ENSMUSG00000025192. [Q3TCT4-1]
GeneIDi93685.
KEGGimmu:93685.
UCSCiuc008hor.2. mouse. [Q3TCT4-2]
uc008hos.2. mouse. [Q3TCT4-1]

Organism-specific databases

CTDi57089.
MGIiMGI:2135885. Entpd7.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1386. Eukaryota.
COG5371. LUCA.
GeneTreeiENSGT00550000074435.
HOGENOMiHOG000090205.
HOVERGENiHBG006789.
InParanoidiQ3TCT4.
KOiK14643.
OMAiIHHRQTR.
OrthoDBiEOG091G04IV.
PhylomeDBiQ3TCT4.
TreeFamiTF354343.

Enzyme and pathway databases

BRENDAi3.6.1.5. 3474.

Miscellaneous databases

PROiQ3TCT4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025192.
CleanExiMM_ENTPD7.
GenevisibleiQ3TCT4. MM.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 2 hits.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiENTP7_MOUSE
AccessioniPrimary (citable) accession number: Q3TCT4
Secondary accession number(s): B9EHD3
, Q3TM04, Q571A5, Q9ET10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.