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Protein

Ubiquitin carboxyl-terminal hydrolase

Gene

Uchl1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseUniRule annotation

Keywords - Biological processi

Ubl conjugation pathwayUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation)
Gene namesi
Name:Uchl1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:103149. Uchl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 225205Ubiquitin carboxyl-terminal hydrolaseSequence analysisPRO_5004229407Add
BLAST

Proteomic databases

PaxDbiQ3TCH2.
PeptideAtlasiQ3TCH2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031131.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 10217UCH_1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C12 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1415. Eukaryota.
ENOG4111HNA. LUCA.
HOGENOMiHOG000182400.
HOVERGENiHBG075483.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
IPR030297. UCHL1.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PTHR10589:SF19. PTHR10589:SF19. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.
PROSITEiPS00140. UCH_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3TCH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PLFVWLFRSG CPVFFLQVLA KLGVAGQWRF ADVLGLEEET LGSVPSPACA
60 70 80 90 100
LLLLFPLTAQ HENFRKKQIE ELKGQEVSPK VYFMKQTIGN SCGTIGLIHA
110 120 130 140 150
VANNQDKLEF EDGSVLKQFL SETEKLSPED RAKCFEKNEA IQAAHDSVAQ
160 170 180 190 200
EGQCRVDDKV NFHFILFNNV DGHLYELDGR MPFPVNHGAS SEDSLLQDAA
210 220
KVCREFTERE QGEVRFSAVA LCKAA
Length:225
Mass (Da):25,079
Last modified:October 11, 2005 - v1
Checksum:i7D5AD4179A9A81C2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK170728 mRNA. Translation: BAE41984.1.
UniGeneiMm.29807.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK170728 mRNA. Translation: BAE41984.1.
UniGeneiMm.29807.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031131.

Proteomic databases

PaxDbiQ3TCH2.
PeptideAtlasiQ3TCH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:103149. Uchl1.

Phylogenomic databases

eggNOGiKOG1415. Eukaryota.
ENOG4111HNA. LUCA.
HOGENOMiHOG000182400.
HOVERGENiHBG075483.

Miscellaneous databases

ChiTaRSiUchl1. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
IPR030297. UCHL1.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PTHR10589:SF19. PTHR10589:SF19. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.
PROSITEiPS00140. UCH_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3TCH2_MOUSE
AccessioniPrimary (citable) accession number: Q3TCH2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.