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Protein

Ubiquitin carboxyl-terminal hydrolase

Gene

Uchl1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseUniRule annotation
Biological processUbl conjugation pathwayUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation)
Gene namesi
Name:Uchl1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:103149 Uchl1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500422940721 – 225Ubiquitin carboxyl-terminal hydrolaseSequence analysisAdd BLAST205

Proteomic databases

PeptideAtlasiQ3TCH2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 102UCH_1InterPro annotationAdd BLAST17

Sequence similaritiesi

Belongs to the peptidase C12 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1415 Eukaryota
ENOG4111HNA LUCA
HOGENOMiHOG000182400
HOVERGENiHBG075483

Family and domain databases

Gene3Di3.40.532.10, 1 hit
InterProiView protein in InterPro
IPR001578 Peptidase_C12_UCH
IPR036959 Peptidase_C12_UCH_sf
IPR030297 UCHL1
PANTHERiPTHR10589 PTHR10589, 1 hit
PTHR10589:SF19 PTHR10589:SF19, 1 hit
PfamiView protein in Pfam
PF01088 Peptidase_C12, 1 hit
PRINTSiPR00707 UBCTHYDRLASE
PROSITEiView protein in PROSITE
PS00140 UCH_1, 1 hit

Sequencei

Sequence statusi: Fragment.

Q3TCH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PLFVWLFRSG CPVFFLQVLA KLGVAGQWRF ADVLGLEEET LGSVPSPACA
60 70 80 90 100
LLLLFPLTAQ HENFRKKQIE ELKGQEVSPK VYFMKQTIGN SCGTIGLIHA
110 120 130 140 150
VANNQDKLEF EDGSVLKQFL SETEKLSPED RAKCFEKNEA IQAAHDSVAQ
160 170 180 190 200
EGQCRVDDKV NFHFILFNNV DGHLYELDGR MPFPVNHGAS SEDSLLQDAA
210 220
KVCREFTERE QGEVRFSAVA LCKAA
Length:225
Mass (Da):25,079
Last modified:October 11, 2005 - v1
Checksum:i7D5AD4179A9A81C2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK170728 mRNA Translation: BAE41984.1
UniGeneiMm.29807

Similar proteinsi

Entry informationi

Entry nameiQ3TCH2_MOUSE
AccessioniPrimary (citable) accession number: Q3TCH2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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