Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-selectin

Gene

Sell

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Biological processi

Keywordsi

Biological processCell adhesionUniRule annotation
LigandCalciumUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
L-selectinUniRule annotation
Gene namesi
Name:SellImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98279 Sell

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei298 – 319HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_501458634439 – 336L-selectinSequence analysisAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 155UniRule annotation
Disulfide bondi128 ↔ 147UniRule annotation
Disulfide bondi161 ↔ 205UniRule annotation
Disulfide bondi191 ↔ 218UniRule annotation
Disulfide bondi223 ↔ 267UniRule annotation
Disulfide bondi253 ↔ 280UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000026581

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 156C-type lectinInterPro annotationAdd BLAST123
Domaini159 – 220SushiInterPro annotationAdd BLAST62
Domaini221 – 282SushiInterPro annotationAdd BLAST62

Sequence similaritiesi

Belongs to the selectin/LECAM family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00910000143999
HOGENOMiHOG000236254
HOVERGENiHBG052375

Family and domain databases

CDDicd00033 CCP, 2 hits
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR016348 L-selectin
IPR002396 Selectin_superfamily
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 2 hits
PIRSFiPIRSF002421 L-selectin, 2 hits
PRINTSiPR00343 SELECTIN
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS50923 SUSHI, 2 hits

Sequencei

Sequence statusi: Complete.

Q3TCF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFPWRCEGT YWGSRNILKL WVWTLLCCDF LIHHGTHCWT YHYSEKPMNW
60 70 80 90 100
ENARKFCKQN YTDLVAIQNK REIEYLENTL PKSPYYYWIG IRKIGKMWTW
110 120 130 140 150
VGTNKTLTKE AENWGAGEPN NKKSKEDCVE IYIKRERDSG KWNDDACHKR
160 170 180 190 200
KAALCYTVVQ CEPLEAPELG TMDCIHPLGN FSFQSKCAFN CSEGRELLGT
210 220 230 240 250
AETQCGASGN WSSPEPICQV VQCEPLEAPE LGTMDCIHPL GNFSFQSKCA
260 270 280 290 300
FNCSEGRELL GTAETQCGAS GNWSSPEPIC QETNRSFSKI KEGDYNPLFI
310 320 330
PVAVMVTAFS GLAFLIWLAR RLKKGKKSQE RMDDPY
Length:336
Mass (Da):38,463
Last modified:October 11, 2005 - v1
Checksum:i60FFD09756963C66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110499 Genomic DNA No translation available.
AK170753 mRNA Translation: BAE42004.1
RefSeqiNP_001157531.1, NM_001164059.1
UniGeneiMm.1461

Genome annotation databases

EnsembliENSMUST00000192047; ENSMUSP00000142237; ENSMUSG00000026581
GeneIDi20343
UCSCiuc011wuv.1 mouse

Entry informationi

Entry nameiQ3TCF3_MOUSE
AccessioniPrimary (citable) accession number: Q3TCF3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health