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Protein

HCLS1-binding protein 3

Gene

Hs1bp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a modulator of IL-2 signaling.

GO - Molecular functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: MGI
  • regulation of apoptotic process Source: MGI
  • T cell differentiation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
HCLS1-binding protein 3
Alternative name(s):
HS1-binding protein 3
Short name:
HSP1BP-3
Gene namesi
Name:Hs1bp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1913224. Hs1bp3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003138031 – 395HCLS1-binding protein 3Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Modified residuei191PhosphoserineBy similarity1
Modified residuei254PhosphoserineBy similarity1
Modified residuei341N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3TC93.
MaxQBiQ3TC93.
PaxDbiQ3TC93.
PeptideAtlasiQ3TC93.
PRIDEiQ3TC93.

PTM databases

iPTMnetiQ3TC93.
PhosphoSitePlusiQ3TC93.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000020605.
CleanExiMM_HS1BP3.
GenevisibleiQ3TC93. MM.

Interactioni

Subunit structurei

Binds HCLS1. Interacts with the SH3 domain of HCLS1 in vitro.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Hcls1P497102EBI-7152397,EBI-924601

Protein-protein interaction databases

BioGridi208412. 2 interactors.
IntActiQ3TC93. 3 interactors.
MINTiMINT-112163.
STRINGi10090.ENSMUSP00000020927.

Structurei

3D structure databases

ProteinModelPortaliQ3TC93.
SMRiQ3TC93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 142PXPROSITE-ProRule annotationAdd BLAST124

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi195 – 204Poly-Glu10
Compositional biasi217 – 231Pro-richAdd BLAST15
Compositional biasi273 – 300Pro-richAdd BLAST28

Phylogenomic databases

eggNOGiENOG410IGRU. Eukaryota.
ENOG41121IK. LUCA.
GeneTreeiENSGT00390000013092.
HOGENOMiHOG000112839.
HOVERGENiHBG098900.
InParanoidiQ3TC93.
OMAiIRDHDTP.
OrthoDBiEOG091G12JB.
TreeFamiTF335484.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiView protein in InterPro
IPR001683. Phox.
PfamiView protein in Pfam
PF00787. PX. 1 hit.
SMARTiView protein in SMART
SM00312. PX. 1 hit.
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiView protein in PROSITE
PS50195. PX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3TC93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSPAVLRTS RQVQNAHTGL DLSVPQHQEV RGKMMSGHVE YQILVVTRLA
60 70 80 90 100
VFKSAKHRPE DVVQFLVSKK YSEIEEFYQK LYSCYPAASL PPLPRKVLFV
110 120 130 140 150
GESDIRERRA MFDEILRCVS KDAQLAGSPE LLEFLGTRAP GATGLATRDP
160 170 180 190 200
SVLDDTASQP GDSDEAFDFF EQQDEVQPPT LGLSSKDVEK SLVGEEEEEE
210 220 230 240 250
EEEEVLDPLG IMRSKKPKKR PEVAVRPKPA PRLTIFDEEV DPDAGLFSSD
260 270 280 290 300
KKVSETRRPL ETTQDSLKLF DDPDLGGAVS LGDPLLLPAA SESRGPTSRP
310 320 330 340 350
EHGDASKELF RVEEDLDLIL NLGSEPKPKP QTKPKPLVPA KPALPRKPTL
360 370 380 390
PASVGPSEPG SGPQKQQQIQ AMDEMDILQY IRDHDTLAQD SPSLF
Length:395
Mass (Da):43,691
Last modified:July 27, 2011 - v2
Checksum:i5FB38580320FF456
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299R → S in BAE42064 (PubMed:16141072).Curated1
Sequence conflicti392 – 395PSLF → SGFQC in CAA10600 (PubMed:10590261).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132192 mRNA. Translation: CAA10600.1.
AK170838 mRNA. Translation: BAE42064.1.
AC122860 Genomic DNA. No translation available.
CCDSiCCDS49024.1.
RefSeqiNP_067404.2. NM_021429.3.
UniGeneiMm.309954.

Genome annotation databases

EnsembliENSMUST00000020927; ENSMUSP00000020927; ENSMUSG00000020605.
GeneIDi58240.
KEGGimmu:58240.
UCSCiuc007mzo.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiH1BP3_MOUSE
AccessioniPrimary (citable) accession number: Q3TC93
Secondary accession number(s): E9QLQ4, Q9Z1K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 27, 2011
Last modified: September 27, 2017
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot