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Protein

HCLS1-binding protein 3

Gene

Hs1bp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a modulator of IL-2 signaling.

GO - Molecular functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: MGI
  • regulation of apoptotic process Source: MGI
  • T cell differentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
HCLS1-binding protein 3
Alternative name(s):
HS1-binding protein 3
Short name:
HSP1BP-3
Gene namesi
Name:Hs1bp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1913224. Hs1bp3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395HCLS1-binding protein 3PRO_0000313803Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei3 – 31PhosphoserineBy similarity
Modified residuei191 – 1911PhosphoserineBy similarity
Modified residuei254 – 2541PhosphoserineBy similarity
Modified residuei341 – 3411N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3TC93.
MaxQBiQ3TC93.
PaxDbiQ3TC93.
PRIDEiQ3TC93.

PTM databases

iPTMnetiQ3TC93.
PhosphoSiteiQ3TC93.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ3TC93.
CleanExiMM_HS1BP3.
GenevisibleiQ3TC93. MM.

Interactioni

Subunit structurei

Binds HCLS1. Interacts with the SH3 domain of HCLS1 in vitro.1 Publication

Protein-protein interaction databases

BioGridi208412. 2 interactions.
IntActiQ3TC93. 2 interactions.
MINTiMINT-112163.
STRINGi10090.ENSMUSP00000020927.

Structurei

3D structure databases

ProteinModelPortaliQ3TC93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 142124PXPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi195 – 20410Poly-Glu
Compositional biasi217 – 23115Pro-richAdd
BLAST
Compositional biasi273 – 30028Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGRU. Eukaryota.
ENOG41121IK. LUCA.
GeneTreeiENSGT00390000013092.
HOGENOMiHOG000112839.
HOVERGENiHBG098900.
InParanoidiQ3TC93.
OMAiIRDHDTP.
OrthoDBiEOG79GT6R.
TreeFamiTF335484.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3TC93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSPAVLRTS RQVQNAHTGL DLSVPQHQEV RGKMMSGHVE YQILVVTRLA
60 70 80 90 100
VFKSAKHRPE DVVQFLVSKK YSEIEEFYQK LYSCYPAASL PPLPRKVLFV
110 120 130 140 150
GESDIRERRA MFDEILRCVS KDAQLAGSPE LLEFLGTRAP GATGLATRDP
160 170 180 190 200
SVLDDTASQP GDSDEAFDFF EQQDEVQPPT LGLSSKDVEK SLVGEEEEEE
210 220 230 240 250
EEEEVLDPLG IMRSKKPKKR PEVAVRPKPA PRLTIFDEEV DPDAGLFSSD
260 270 280 290 300
KKVSETRRPL ETTQDSLKLF DDPDLGGAVS LGDPLLLPAA SESRGPTSRP
310 320 330 340 350
EHGDASKELF RVEEDLDLIL NLGSEPKPKP QTKPKPLVPA KPALPRKPTL
360 370 380 390
PASVGPSEPG SGPQKQQQIQ AMDEMDILQY IRDHDTLAQD SPSLF
Length:395
Mass (Da):43,691
Last modified:July 27, 2011 - v2
Checksum:i5FB38580320FF456
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti299 – 2991R → S in BAE42064 (PubMed:16141072).Curated
Sequence conflicti392 – 3954PSLF → SGFQC in CAA10600 (PubMed:10590261).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132192 mRNA. Translation: CAA10600.1.
AK170838 mRNA. Translation: BAE42064.1.
AC122860 Genomic DNA. No translation available.
CCDSiCCDS49024.1.
RefSeqiNP_067404.2. NM_021429.3.
UniGeneiMm.309954.

Genome annotation databases

EnsembliENSMUST00000020927; ENSMUSP00000020927; ENSMUSG00000020605.
GeneIDi58240.
KEGGimmu:58240.
UCSCiuc007mzo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132192 mRNA. Translation: CAA10600.1.
AK170838 mRNA. Translation: BAE42064.1.
AC122860 Genomic DNA. No translation available.
CCDSiCCDS49024.1.
RefSeqiNP_067404.2. NM_021429.3.
UniGeneiMm.309954.

3D structure databases

ProteinModelPortaliQ3TC93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208412. 2 interactions.
IntActiQ3TC93. 2 interactions.
MINTiMINT-112163.
STRINGi10090.ENSMUSP00000020927.

PTM databases

iPTMnetiQ3TC93.
PhosphoSiteiQ3TC93.

Proteomic databases

EPDiQ3TC93.
MaxQBiQ3TC93.
PaxDbiQ3TC93.
PRIDEiQ3TC93.

Protocols and materials databases

DNASUi58240.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020927; ENSMUSP00000020927; ENSMUSG00000020605.
GeneIDi58240.
KEGGimmu:58240.
UCSCiuc007mzo.2. mouse.

Organism-specific databases

CTDi64342.
MGIiMGI:1913224. Hs1bp3.

Phylogenomic databases

eggNOGiENOG410IGRU. Eukaryota.
ENOG41121IK. LUCA.
GeneTreeiENSGT00390000013092.
HOGENOMiHOG000112839.
HOVERGENiHBG098900.
InParanoidiQ3TC93.
OMAiIRDHDTP.
OrthoDBiEOG79GT6R.
TreeFamiTF335484.

Miscellaneous databases

ChiTaRSiHs1bp3. mouse.
NextBioi314285.
PROiQ3TC93.
SOURCEiSearch...

Gene expression databases

BgeeiQ3TC93.
CleanExiMM_HS1BP3.
GenevisibleiQ3TC93. MM.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3."
    Takemoto Y., Furuta M., Sato M., Kubo M., Hashimoto Y.
    Int. Immunol. 11:1957-1964(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH HCLS1, POSSIBLE FUNCTION, TISSUE SPECIFICITY.
    Strain: BALB/cJ.
    Tissue: Lymphocyte.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Lung, Pancreas and Spleen.

Entry informationi

Entry nameiH1BP3_MOUSE
AccessioniPrimary (citable) accession number: Q3TC93
Secondary accession number(s): E9QLQ4, Q9Z1K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.