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Protein

HCLS1-binding protein 3

Gene

Hs1bp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a modulator of IL-2 signaling.

GO - Molecular functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: MGI
  • regulation of apoptotic process Source: MGI
  • T cell differentiation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
HCLS1-binding protein 3
Alternative name(s):
HS1-binding protein 3
Short name:
HSP1BP-3
Gene namesi
Name:Hs1bp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1913224 Hs1bp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003138031 – 395HCLS1-binding protein 3Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Modified residuei191PhosphoserineBy similarity1
Modified residuei254PhosphoserineBy similarity1
Modified residuei341N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3TC93
MaxQBiQ3TC93
PaxDbiQ3TC93
PeptideAtlasiQ3TC93
PRIDEiQ3TC93

PTM databases

iPTMnetiQ3TC93
PhosphoSitePlusiQ3TC93

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000020605
CleanExiMM_HS1BP3
ExpressionAtlasiQ3TC93 baseline and differential
GenevisibleiQ3TC93 MM

Interactioni

Subunit structurei

Binds HCLS1. Interacts with the SH3 domain of HCLS1 in vitro.1 Publication

Protein-protein interaction databases

BioGridi208412, 2 interactors
IntActiQ3TC93, 2 interactors
MINTiQ3TC93
STRINGi10090.ENSMUSP00000020927

Structurei

3D structure databases

ProteinModelPortaliQ3TC93
SMRiQ3TC93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 142PXPROSITE-ProRule annotationAdd BLAST124

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi195 – 204Poly-Glu10
Compositional biasi217 – 231Pro-richAdd BLAST15
Compositional biasi273 – 300Pro-richAdd BLAST28

Phylogenomic databases

eggNOGiENOG410IGRU Eukaryota
ENOG41121IK LUCA
GeneTreeiENSGT00390000013092
HOGENOMiHOG000112839
HOVERGENiHBG098900
InParanoidiQ3TC93
OMAiIRDHDTP
OrthoDBiEOG091G12JB
TreeFamiTF335484

Family and domain databases

CDDicd06868 PX_HS1BP3, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR037901 HS1BP3_PX
IPR001683 Phox
IPR036871 PX_dom_sf
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

Q3TC93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSPAVLRTS RQVQNAHTGL DLSVPQHQEV RGKMMSGHVE YQILVVTRLA
60 70 80 90 100
VFKSAKHRPE DVVQFLVSKK YSEIEEFYQK LYSCYPAASL PPLPRKVLFV
110 120 130 140 150
GESDIRERRA MFDEILRCVS KDAQLAGSPE LLEFLGTRAP GATGLATRDP
160 170 180 190 200
SVLDDTASQP GDSDEAFDFF EQQDEVQPPT LGLSSKDVEK SLVGEEEEEE
210 220 230 240 250
EEEEVLDPLG IMRSKKPKKR PEVAVRPKPA PRLTIFDEEV DPDAGLFSSD
260 270 280 290 300
KKVSETRRPL ETTQDSLKLF DDPDLGGAVS LGDPLLLPAA SESRGPTSRP
310 320 330 340 350
EHGDASKELF RVEEDLDLIL NLGSEPKPKP QTKPKPLVPA KPALPRKPTL
360 370 380 390
PASVGPSEPG SGPQKQQQIQ AMDEMDILQY IRDHDTLAQD SPSLF
Length:395
Mass (Da):43,691
Last modified:July 27, 2011 - v2
Checksum:i5FB38580320FF456
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299R → S in BAE42064 (PubMed:16141072).Curated1
Sequence conflicti392 – 395PSLF → SGFQC in CAA10600 (PubMed:10590261).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132192 mRNA Translation: CAA10600.1
AK170838 mRNA Translation: BAE42064.1
AC122860 Genomic DNA No translation available.
CCDSiCCDS49024.1
RefSeqiNP_067404.2, NM_021429.3
UniGeneiMm.309954

Genome annotation databases

EnsembliENSMUST00000020927; ENSMUSP00000020927; ENSMUSG00000020605
GeneIDi58240
KEGGimmu:58240
UCSCiuc007mzo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiH1BP3_MOUSE
AccessioniPrimary (citable) accession number: Q3TC93
Secondary accession number(s): E9QLQ4, Q9Z1K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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