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Protein
Submitted name:

MCG22939

Gene

Kcnk6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • negative regulation of systemic arterial blood pressure Source: MGI
  • potassium ion transmembrane transport Source: GO_Central
  • regulation of resting membrane potential Source: MGI
  • regulation of systemic arterial blood pressure Source: MGI
  • stabilization of membrane potential Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1299308. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).
R-MMU-5576886. Phase 4 - resting membrane potential.

Names & Taxonomyi

Protein namesi
Submitted name:
MCG22939Imported
Submitted name:
Potassium channel subfamily K member 7Imported
Submitted name:
TWIK-2 two-pore-domain K+ channelImported
Gene namesi
Name:Kcnk6Imported
ORF Names:mCG_22939Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1891291. Kcnk6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST
Transmembranei93 – 11220HelicalSequence analysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence analysisAdd
BLAST
Transmembranei169 – 19426HelicalSequence analysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence analysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

PTM databases

PhosphoSiteiQ3TBV4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046410.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082975.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 14556Ion_trans_2InterPro annotationAdd
BLAST
Domaini180 – 25879Ion_trans_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.
KOiK04917.
OMAiPAVIFAH.
OrthoDBiEOG091G0DIX.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR005409. 2pore_dom_K_chnl_TWIK2.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01587. TWIK2CHANNEL.
PR01586. TWIKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q3TBV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGALLASA LAAYAGYLAL GALLVARLER PHEARLRAEL GTLREQLLQH
60 70 80 90 100
SPCVAAHALD AFVERVLAAG RLGRAALANA SGAANASDPA WDFASALFFA
110 120 130 140 150
STLVTTVGYG YTTPLTDAGK AFSIVFALLG VPITMLLLTA SAQRLSLLLT
160 170 180 190 200
HAPLSWLSLH WGWPPQRAAR WHLVALLMVI VAIFFLVPAA VFAYLEEAWS
210 220 230 240 250
FLDAFYFCFI SLSTIGLGDY VPGEAPGQPY RALYKVLVTA YLFLGLVAMV
260 270 280 290 300
LVLQTFRRVS DLHGLTELIL LPDPDPASLS QDEDDQVAVL DARTDLHQHL
310
SAASHADYAS IPR
Length:313
Mass (Da):33,807
Last modified:October 11, 2005 - v1
Checksum:iB0C2335FB4F44F38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164564 Genomic DNA. No translation available.
DQ185135 mRNA. Translation: ABA28316.1.
AK171038 mRNA. Translation: BAE42203.1.
CH466593 Genomic DNA. Translation: EDL24076.1.
RefSeqiNP_001028697.2. NM_001033525.3.
UniGeneiMm.24877.

Genome annotation databases

EnsembliENSMUST00000085818; ENSMUSP00000082975; ENSMUSG00000046410.
GeneIDi52150.
KEGGimmu:52150.
UCSCiuc009gbg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164564 Genomic DNA. No translation available.
DQ185135 mRNA. Translation: ABA28316.1.
AK171038 mRNA. Translation: BAE42203.1.
CH466593 Genomic DNA. Translation: EDL24076.1.
RefSeqiNP_001028697.2. NM_001033525.3.
UniGeneiMm.24877.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082975.

PTM databases

PhosphoSiteiQ3TBV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085818; ENSMUSP00000082975; ENSMUSG00000046410.
GeneIDi52150.
KEGGimmu:52150.
UCSCiuc009gbg.2. mouse.

Organism-specific databases

CTDi9424.
MGIiMGI:1891291. Kcnk6.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.
KOiK04917.
OMAiPAVIFAH.
OrthoDBiEOG091G0DIX.
TreeFamiTF313947.

Enzyme and pathway databases

ReactomeiR-MMU-1299308. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).
R-MMU-5576886. Phase 4 - resting membrane potential.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046410.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR005409. 2pore_dom_K_chnl_TWIK2.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01587. TWIK2CHANNEL.
PR01586. TWIKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiQ3TBV4_MOUSE
AccessioniPrimary (citable) accession number: Q3TBV4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.