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Protein

Potassium channel subfamily K member

Gene

Kcnk6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • negative regulation of systemic arterial blood pressure Source: MGI
  • potassium ion transmembrane transport Source: GO_Central
  • regulation of resting membrane potential Source: MGI
  • regulation of systemic arterial blood pressure Source: MGI
  • stabilization of membrane potential Source: GO_Central

Keywordsi

Molecular functionIon channel, Potassium channelUniRule annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
R-MMU-5576886 Phase 4 - resting membrane potential

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K memberUniRule annotation
Gene namesi
Name:Kcnk6Imported
ORF Names:mCG_22939Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1891291 Kcnk6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei93 – 112HelicalSequence analysisAdd BLAST20
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Transmembranei169 – 194HelicalSequence analysisAdd BLAST26
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagineUniRule annotation1

Expressioni

Gene expression databases

BgeeiENSMUSG00000046410

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082975

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 145Ion_trans_2InterPro annotationAdd BLAST56
Domaini180 – 258Ion_trans_2InterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118858
HOGENOMiHOG000286014
HOVERGENiHBG052237
KOiK04917
OMAiSHTDYAS
OrthoDBiEOG091G0DIX
TreeFamiTF313947

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR005408 2pore_dom_K_chnl_TWIK
IPR005409 2pore_dom_K_chnl_TWIK2
IPR013099 K_chnl_dom
PANTHERiPTHR11003:SF28 PTHR11003:SF28, 1 hit
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PIRSFiPIRSF038061 K_channel_subfamily_K_type, 1 hit
PRINTSiPR01333 2POREKCHANEL
PR01587 TWIK2CHANNEL
PR01586 TWIKCHANNEL

Sequencei

Sequence statusi: Complete.

Q3TBV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGALLASA LAAYAGYLAL GALLVARLER PHEARLRAEL GTLREQLLQH
60 70 80 90 100
SPCVAAHALD AFVERVLAAG RLGRAALANA SGAANASDPA WDFASALFFA
110 120 130 140 150
STLVTTVGYG YTTPLTDAGK AFSIVFALLG VPITMLLLTA SAQRLSLLLT
160 170 180 190 200
HAPLSWLSLH WGWPPQRAAR WHLVALLMVI VAIFFLVPAA VFAYLEEAWS
210 220 230 240 250
FLDAFYFCFI SLSTIGLGDY VPGEAPGQPY RALYKVLVTA YLFLGLVAMV
260 270 280 290 300
LVLQTFRRVS DLHGLTELIL LPDPDPASLS QDEDDQVAVL DARTDLHQHL
310
SAASHADYAS IPR
Length:313
Mass (Da):33,807
Last modified:October 11, 2005 - v1
Checksum:iB0C2335FB4F44F38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164564 Genomic DNA No translation available.
DQ185135 mRNA Translation: ABA28316.1
AK171038 mRNA Translation: BAE42203.1
CH466593 Genomic DNA Translation: EDL24076.1
RefSeqiNP_001028697.2, NM_001033525.3
UniGeneiMm.24877

Genome annotation databases

EnsembliENSMUST00000085818; ENSMUSP00000082975; ENSMUSG00000046410
GeneIDi52150
KEGGimmu:52150
UCSCiuc009gbg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ3TBV4_MOUSE
AccessioniPrimary (citable) accession number: Q3TBV4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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