##gff-version 3 Q3TBT3 UniProtKB Chain 1 378 . . . ID=PRO_0000271117;Note=Stimulator of interferon genes protein Q3TBT3 UniProtKB Topological domain 1 17 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Transmembrane 18 34 . . . Note=Helical%3B Name%3D1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Topological domain 35 44 . . . Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Transmembrane 45 69 . . . Note=Helical%3B Name%3D2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Topological domain 70 91 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Transmembrane 92 106 . . . Note=Helical%3B Name%3D3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Topological domain 107 115 . . . Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Transmembrane 116 133 . . . Note=Helical%3B Name%3D4;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Topological domain 134 378 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Region 1 189 . . . Note=Mediates interaction with ZDHHC1 and ZDHHC11;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Region 152 339 . . . Note=Cyclic dinucleotide-binding domain (CBD);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23519410;Dbxref=PMID:23519410 Q3TBT3 UniProtKB Region 339 378 . . . Note=C-terminal tail (CTT);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Motif 362 365 . . . Note=PLxIS motif;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Binding site 165 165 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:23519410,ECO:0007744|PDB:4KBY;Dbxref=PMID:23519410 Q3TBT3 UniProtKB Binding site 166 166 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Binding site 166 166 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:23910378,ECO:0007744|PDB:4LOK;Dbxref=PMID:23910378 Q3TBT3 UniProtKB Binding site 237 240 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:23519410,ECO:0007744|PDB:4KBY;Dbxref=PMID:23519410 Q3TBT3 UniProtKB Binding site 237 237 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:23910378,ECO:0007744|PDB:4LOJ;Dbxref=PMID:23910378 Q3TBT3 UniProtKB Binding site 237 237 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Binding site 237 237 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:23910378,ECO:0007744|PDB:4LOK;Dbxref=PMID:23910378 Q3TBT3 UniProtKB Binding site 262 262 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:23910378,ECO:0007744|PDB:4LOJ;Dbxref=PMID:23910378 Q3TBT3 UniProtKB Binding site 262 262 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Binding site 262 262 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:23519410,ECO:0007744|PDB:4KBY;Dbxref=PMID:23519410 Q3TBT3 UniProtKB Modified residue 240 240 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Modified residue 354 354 . . . Note=Phosphoserine%3B by MAP3K7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37832545;Dbxref=PMID:37832545 Q3TBT3 UniProtKB Modified residue 357 357 . . . Note=Phosphoserine%3B by TBK1;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:25636800;Dbxref=PMID:25636800 Q3TBT3 UniProtKB Modified residue 365 365 . . . Note=Phosphoserine%3B by TBK1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25636800,ECO:0000269|PubMed:27637147;Dbxref=PMID:25636800,PMID:27637147 Q3TBT3 UniProtKB Lipidation 88 88 . . . Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27324217;Dbxref=PMID:27324217 Q3TBT3 UniProtKB Lipidation 91 91 . . . Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27324217;Dbxref=PMID:27324217 Q3TBT3 UniProtKB Cross-link 150 150 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Cross-link 235 235 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q86WV6 Q3TBT3 UniProtKB Cross-link 337 337 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27637147;Dbxref=PMID:27637147 Q3TBT3 UniProtKB Alternative sequence 1 1 . . . ID=VSP_022284;Note=In isoform 2. M->MIVESFGASGNPVGPCHFWSLYGVLLGVHWSVLHLGTFRGIRSAGLWLLM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16141072;Dbxref=PMID:16141072 Q3TBT3 UniProtKB Alternative sequence 76 116 . . . ID=VSP_022285;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16141072;Dbxref=PMID:16141072 Q3TBT3 UniProtKB Mutagenesis 64 65 . . . Note=Does not affect palmitoylation. CC->SS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27324217;Dbxref=PMID:27324217 Q3TBT3 UniProtKB Mutagenesis 88 91 . . . Note=Abolished palmitoylation. CLGC->SLGS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27324217;Dbxref=PMID:27324217 Q3TBT3 UniProtKB Mutagenesis 91 91 . . . Note=Abolished inhibition by nitrofuran derivatives C-178 and C-176%3B abolished palmitoylation. C->A%2CS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29973723;Dbxref=PMID:29973723 Q3TBT3 UniProtKB Mutagenesis 147 147 . . . Note=Does not affect palmitoylation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27324217;Dbxref=PMID:27324217 Q3TBT3 UniProtKB Mutagenesis 161 161 . . . Note=Decrease in cGAMP-binding. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23258412;Dbxref=PMID:23258412 Q3TBT3 UniProtKB Mutagenesis 205 205 . . . Note=Does not affect palmitoylation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27324217;Dbxref=PMID:27324217 Q3TBT3 UniProtKB Mutagenesis 229 229 . . . Note=Strongly decreases affinity for the synthetic compound 5%2C6-dimethylxanthenone 4-acetic acid (DMXAA). I->A%2CG%2CT;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26669264;Dbxref=PMID:26669264 Q3TBT3 UniProtKB Mutagenesis 239 239 . . . Note=Strong decrease in cGAMP-binding. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23258412;Dbxref=PMID:23258412 Q3TBT3 UniProtKB Mutagenesis 241 241 . . . Note=Strong decrease in cGAMP-binding. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23258412;Dbxref=PMID:23258412 Q3TBT3 UniProtKB Mutagenesis 256 256 . . . Note=Does not affect palmitoylation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27324217;Dbxref=PMID:27324217 Q3TBT3 UniProtKB Mutagenesis 291 291 . . . Note=Does not affect palmitoylation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27324217;Dbxref=PMID:27324217 Q3TBT3 UniProtKB Mutagenesis 308 308 . . . Note=Does not affect palmitoylation. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27324217;Dbxref=PMID:27324217 Q3TBT3 UniProtKB Mutagenesis 326 327 . . . Note=Decreased relocalization to autophagosomes and subsequent degradation. QE->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27637147;Dbxref=PMID:27637147 Q3TBT3 UniProtKB Mutagenesis 337 337 . . . Note=Abolished sumoylation by TRIM38%2C leading to decreased stability. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27637147;Dbxref=PMID:27637147 Q3TBT3 UniProtKB Mutagenesis 357 357 . . . Note=Induces a decrease in phosphorylation by TBK1%2C leading to reduced ability to activate IRF3. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25636800;Dbxref=PMID:25636800 Q3TBT3 UniProtKB Mutagenesis 365 365 . . . Note=Abolished ability to activate IRF3. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25636800;Dbxref=PMID:25636800 Q3TBT3 UniProtKB Sequence conflict 11 11 . . . Note=P->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q3TBT3 UniProtKB Sequence conflict 39 39 . . . Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q3TBT3 UniProtKB Sequence conflict 98 98 . . . Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q3TBT3 UniProtKB Sequence conflict 111 111 . . . Note=T->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q3TBT3 UniProtKB Sequence conflict 210 210 . . . Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q3TBT3 UniProtKB Sequence conflict 315 315 . . . Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q3TBT3 UniProtKB Helix 156 164 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Helix 167 170 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Turn 171 173 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOK Q3TBT3 UniProtKB Helix 174 184 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Turn 185 189 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Helix 192 194 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Beta strand 195 202 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Helix 211 213 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Beta strand 218 223 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Beta strand 227 231 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Beta strand 234 239 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Beta strand 242 248 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Beta strand 251 260 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Helix 262 272 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Turn 274 276 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Helix 280 298 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Helix 304 307 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Beta strand 308 313 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Beta strand 317 319 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ Q3TBT3 UniProtKB Helix 324 333 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4LOJ