Q3TBN1 (CG042_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: UPF0458 protein C7orf42 homolog
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the UPF0458 family.
Sequence caution	The sequence BAB21996.1 differs from that shown. Reason: Frameshift at position 312.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	UPF0458 protein C7orf42 homolog		PRO_0000295127
Regions
	Transmembrane	21 – 41	21	Helical; Potential
	Transmembrane	179 – 199	21	Helical; Potential
	Transmembrane	236 – 258	23	Helical; Potential
	Transmembrane	270 – 290	21	Helical; Potential
Experimental info
	Sequence conflict	63	1	N → D in AAH33455. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q3TBN1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: FC21A7434BA1C2EF	FASTA	314	35,041
	10 20 30 40 50 60 MFSINPLENL KLYISSRPPL VVFMISVSAM AIAFLTLGYF FKIKEIKSPE MAEDWNTFLL 70 80 90 100 110 120 RFNDLDLCVS ENETLKHLSN DTTTPESTMT VGQARSSTQP PQSLEESGPI NISVAITLTL 130 140 150 160 170 180 DPLKPFGGYS RNVTHLYSTI LGHQIGLSGR EAHEEINITF TLPAAWNADD CALHGHCEQA 190 200 210 220 230 240 VFTACMTLTA APGVFPVTVQ PPHCIPDTYS NATLWYKIFT TARDANTKYA QDYNPFWCYK 250 260 270 280 290 300 GAIGKVYHAL NPKLTVVVPD DDRSLINLHL MHTSYFLFVM VITMFCYAVI KGRPSKLRQS 310 NPEFCPEKVA LADA

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Dendritic cell, Heart and Kidney.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Czech II. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK002297 mRNA. Translation: BAB21996.1. Frameshift. AK142176 mRNA. Translation: BAE24962.1. AK171152 mRNA. Translation: BAE42278.1. BC033455 mRNA. Translation: AAH33455.1.
IPI	IPI00876306.
RefSeq	NP_001074863.1. NM_001081394.1. NP_082130.1. NM_027854.1.
UniGene	Mm.258508.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3TBN1.
Proteomic databases
PRIDE	Q3TBN1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000065329; ENSMUSP00000067501; ENSMUSG00000053094. ENSMUST00000111298; ENSMUSP00000106929; ENSMUSG00000053094.
GeneID	71667.
KEGG	mmu:71667.
UCSC	uc008zuh.1. mouse.
Organism-specific databases
MGI	MGI:1918917. 0610007L01Rik.
Phylogenomic databases
eggNOG	roNOG10348.
GeneTree	ENSGT00390000005624.
HOVERGEN	HBG055060.
Gene expression databases
ArrayExpress	Q3TBN1.
Bgee	Q3TBN1.
CleanEx	MM_0610007L01RIK.
Genevestigator	Q3TBN1.
Family and domain databases
ProtoNet	Search...
Other
NextBio	334187.

Entry information

Entry name

CG042_MOUSE

Accession

Primary (citable) accession number: Q3TBN1
Secondary accession number(s): Q8CIB2, Q9DD07

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	October 11, 2005
Last modified:	September 21, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program