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Protein

Minor histocompatibility protein HA-1

Gene

Hmha1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri699 – 744Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST46

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Minor histocompatibility protein HA-1
Gene namesi
Name:Hmha1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1917969. Hmha1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003303141 – 1116Minor histocompatibility protein HA-1Add BLAST1116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineCombined sources1
Modified residuei72PhosphoserineBy similarity1
Modified residuei92PhosphoserineBy similarity1
Modified residuei98PhosphoserineBy similarity1
Modified residuei568PhosphoserineCombined sources1
Modified residuei577PhosphoserineCombined sources1
Modified residuei591PhosphoserineCombined sources1
Modified residuei618PhosphoserineCombined sources1
Modified residuei946PhosphoserineBy similarity1
Modified residuei1017PhosphoserineCombined sources1
Modified residuei1020PhosphoserineCombined sources1
Modified residuei1022PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3TBD2.
MaxQBiQ3TBD2.
PaxDbiQ3TBD2.
PeptideAtlasiQ3TBD2.
PRIDEiQ3TBD2.

PTM databases

iPTMnetiQ3TBD2.
PhosphoSitePlusiQ3TBD2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035697.
ExpressionAtlasiQ3TBD2. baseline and differential.
GenevisibleiQ3TBD2. MM.

Interactioni

Protein-protein interaction databases

IntActiQ3TBD2. 2 interactors.
STRINGi10090.ENSMUSP00000097100.

Structurei

3D structure databases

ProteinModelPortaliQ3TBD2.
SMRiQ3TBD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 538F-BARPROSITE-ProRule annotationAdd BLAST271
Domaini758 – 971Rho-GAPPROSITE-ProRule annotationAdd BLAST214

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili375 – 498Sequence analysisAdd BLAST124

Sequence similaritiesi

Contains 1 F-BAR domain.PROSITE-ProRule annotation
Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri699 – 744Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST46

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1453. Eukaryota.
ENOG410YM3I. LUCA.
GeneTreeiENSGT00860000133689.
HOVERGENiHBG107979.
InParanoidiQ3TBD2.
KOiK20644.
PhylomeDBiQ3TBD2.

Family and domain databases

CDDicd00029. C1. 1 hit.
Gene3Di1.10.555.10. 1 hit.
InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR002219. PE/DAG-bd.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00055. FCH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS50238. RHOGAP. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TBD2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSRKKRELM KTPSISKKNR AGSPNPQSSS GELPRKDWTE APGLEPPATS
60 70 80 90 100
LSTVAKGTGT LKRPTSLSRH ASAAGFPLSG TATWTLVRGY RSPLSAASPA
110 120 130 140 150
ELPTEGAFPD GVEDISTLLA DVARFAEGLE KLKECVLQDD LLEARRPLAH
160 170 180 190 200
ECLGEALRVM RQVISRYPLL NTVETLTAAG TLIAKVKAFH YECNNESDKR
210 220 230 240 250
EFEKALETIA VSFSCTVSEF LLGEVDSSTL LAVPPGDPSQ SMENLYGAGT
260 270 280 290 300
EGPPHNVEEC EEGCLPPEEV DMLLQRCEGG VDAALQYAKD MARYMKDLIS
310 320 330 340 350
YLEKRTTLEM EFAKGLQKVV HNCRQSVTHE PHMPLLSIYS LALEQDLEFG
360 370 380 390 400
HGMVQAAGTL QTQTFMQPLT LRRLEHERRR KEIKESWHRA QRKLQEAEAN
410 420 430 440 450
LRKAKQGYKQ RCEDHDKARL QVAKAEEEQQ GTGPGAGTAA SKALDKRRRL
460 470 480 490 500
EEEAKNKAEE AMATYRTCVA DAKTQKQELE DTKVTALRQI QEVIRQSDQT
510 520 530 540 550
IKSATISYYQ LMHMQTAPLP VNFQMLCESS KLYDPGQQYA SHVRQLQRGE
560 570 580 590 600
EPDVRYDFEP YVSNNSWSPI MRTRKGSFNP GDASGPEAAG SPPEEGGTSE
610 620 630 640 650
AAPNKDHRGG RGHQVHKSWP ISISDTEVGL DTSSGDLKKF DRTSSSGTMS
660 670 680 690 700
SSEELGDQEA GLVASAFDSA DLNGMDPELP VAMPSGPFRH VGLSKAARTH
710 720 730 740 750
RLRKLRTPAK CRECNSYVYF QGAECEECCL ACHKKCLETL AIQCGHKKLQ
760 770 780 790 800
GRLQLFGQDF SQAALSTPDG VPFIVKKCVC EIERRALHTK GIYRVNGVKT
810 820 830 840 850
RVEKLCQAFE NGKELVELSQ ASPHDISNVL KLYLRQLPEP LISFRFYHEL
860 870 880 890 900
VGLAKDSLKA EAEAKAASRG RQGGSESEAA TLAMVGRLRE LMQDLPAENR
910 920 930 940 950
ATLLYLLKHL RRIVEMEQDN KMTPGNLGIV FGPTLLRPRP TDATVSLSSL
960 970 980 990 1000
VDYPHQARVI ETLIVHYGLV FEEEPEEAPG SQEGASTQCG QLESAEGIVF
1010 1020 1030 1040 1050
PLQEEAEDGS RESHAASNDS DSELEDASDP LSSSDASALH RLSFLEQTEA
1060 1070 1080 1090 1100
GLEEGPQSHS GSEEQLEGED GAPGPWLCHF NTNQSNNTSR APLPTMRLRG
1110
GQITGGTSQE RQPQFV
Length:1,116
Mass (Da):122,902
Last modified:April 29, 2008 - v2
Checksum:iE3F52D0364F19E96
GO
Isoform 2 (identifier: Q3TBD2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     117-139: TLLADVARFAEGLEKLKECVLQD → MCVCGTLHPALDHDPLCCQTRAR

Show »
Length:1,000
Mass (Da):110,690
Checksum:i2E8F552F6F0D55E3
GO
Isoform 3 (identifier: Q3TBD2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-309: Missing.

Show »
Length:807
Mass (Da):89,341
Checksum:i21C2C7C28239509A
GO
Isoform 4 (identifier: Q3TBD2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-461: Missing.

Show »
Length:655
Mass (Da):71,921
Checksum:i19CB353B6752CCBC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87V → G in BAE34889 (PubMed:16141072).Curated1
Sequence conflicti87V → G in BAE41670 (PubMed:16141072).Curated1
Sequence conflicti587E → K in BAE21986 (PubMed:16141072).Curated1
Sequence conflicti710K → E in BAE34889 (PubMed:16141072).Curated1
Sequence conflicti979P → H in BAB31085 (PubMed:16141072).Curated1
Sequence conflicti1047Q → R in BAE41670 (PubMed:16141072).Curated1
Sequence conflicti1047Q → R in BAE42381 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0330291 – 461Missing in isoform 4. 1 PublicationAdd BLAST461
Alternative sequenceiVSP_0330301 – 309Missing in isoform 3. 1 PublicationAdd BLAST309
Alternative sequenceiVSP_0330311 – 116Missing in isoform 2. 2 PublicationsAdd BLAST116
Alternative sequenceiVSP_033032117 – 139TLLAD…CVLQD → MCVCGTLHPALDHDPLCCQT RAR in isoform 2. 2 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018130 mRNA. Translation: BAB31085.1.
AK044860 mRNA. Translation: BAC32124.1.
AK134029 mRNA. Translation: BAE21986.1.
AK159194 mRNA. Translation: BAE34889.1.
AK161766 mRNA. Translation: BAE36565.1.
AK170262 mRNA. Translation: BAE41670.1.
AK171304 mRNA. Translation: BAE42381.1.
BC053750 mRNA. Translation: AAH53750.1.
CCDSiCCDS24005.1. [Q3TBD2-2]
CCDS48624.1. [Q3TBD2-1]
RefSeqiNP_001136173.1. NM_001142701.1.
NP_081797.1. NM_027521.3. [Q3TBD2-2]
UniGeneiMm.243954.

Genome annotation databases

EnsembliENSMUST00000043311; ENSMUSP00000041019; ENSMUSG00000035697. [Q3TBD2-2]
GeneIDi70719.
KEGGimmu:70719.
UCSCiuc007gbe.2. mouse. [Q3TBD2-1]
uc007gbg.2. mouse. [Q3TBD2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018130 mRNA. Translation: BAB31085.1.
AK044860 mRNA. Translation: BAC32124.1.
AK134029 mRNA. Translation: BAE21986.1.
AK159194 mRNA. Translation: BAE34889.1.
AK161766 mRNA. Translation: BAE36565.1.
AK170262 mRNA. Translation: BAE41670.1.
AK171304 mRNA. Translation: BAE42381.1.
BC053750 mRNA. Translation: AAH53750.1.
CCDSiCCDS24005.1. [Q3TBD2-2]
CCDS48624.1. [Q3TBD2-1]
RefSeqiNP_001136173.1. NM_001142701.1.
NP_081797.1. NM_027521.3. [Q3TBD2-2]
UniGeneiMm.243954.

3D structure databases

ProteinModelPortaliQ3TBD2.
SMRiQ3TBD2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3TBD2. 2 interactors.
STRINGi10090.ENSMUSP00000097100.

PTM databases

iPTMnetiQ3TBD2.
PhosphoSitePlusiQ3TBD2.

Proteomic databases

EPDiQ3TBD2.
MaxQBiQ3TBD2.
PaxDbiQ3TBD2.
PeptideAtlasiQ3TBD2.
PRIDEiQ3TBD2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043311; ENSMUSP00000041019; ENSMUSG00000035697. [Q3TBD2-2]
GeneIDi70719.
KEGGimmu:70719.
UCSCiuc007gbe.2. mouse. [Q3TBD2-1]
uc007gbg.2. mouse. [Q3TBD2-2]

Organism-specific databases

CTDi70719.
MGIiMGI:1917969. Hmha1.

Phylogenomic databases

eggNOGiKOG1453. Eukaryota.
ENOG410YM3I. LUCA.
GeneTreeiENSGT00860000133689.
HOVERGENiHBG107979.
InParanoidiQ3TBD2.
KOiK20644.
PhylomeDBiQ3TBD2.

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ3TBD2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035697.
ExpressionAtlasiQ3TBD2. baseline and differential.
GenevisibleiQ3TBD2. MM.

Family and domain databases

CDDicd00029. C1. 1 hit.
Gene3Di1.10.555.10. 1 hit.
InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR002219. PE/DAG-bd.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00055. FCH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS50238. RHOGAP. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMHA1_MOUSE
AccessioniPrimary (citable) accession number: Q3TBD2
Secondary accession number(s): Q3TDD2
, Q3TSW0, Q3TXM6, Q3UZ72, Q8BI83, Q9CU46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 30, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.