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Protein

Minor histocompatibility protein HA-1

Gene

Hmha1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases.Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri699 – 74446Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Minor histocompatibility protein HA-1
Gene namesi
Name:Hmha1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1917969. Hmha1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11161116Minor histocompatibility protein HA-1PRO_0000330314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231PhosphoserineCombined sources
Modified residuei72 – 721PhosphoserineBy similarity
Modified residuei92 – 921PhosphoserineBy similarity
Modified residuei98 – 981PhosphoserineBy similarity
Modified residuei568 – 5681PhosphoserineCombined sources
Modified residuei577 – 5771PhosphoserineCombined sources
Modified residuei591 – 5911PhosphoserineCombined sources
Modified residuei618 – 6181PhosphoserineCombined sources
Modified residuei946 – 9461PhosphoserineBy similarity
Modified residuei1017 – 10171PhosphoserineCombined sources
Modified residuei1020 – 10201PhosphoserineCombined sources
Modified residuei1022 – 10221PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3TBD2.
MaxQBiQ3TBD2.
PaxDbiQ3TBD2.
PeptideAtlasiQ3TBD2.
PRIDEiQ3TBD2.

PTM databases

iPTMnetiQ3TBD2.
PhosphoSiteiQ3TBD2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035697.
ExpressionAtlasiQ3TBD2. baseline and differential.
GenevisibleiQ3TBD2. MM.

Interactioni

Protein-protein interaction databases

IntActiQ3TBD2. 2 interactions.
STRINGi10090.ENSMUSP00000097100.

Structurei

3D structure databases

ProteinModelPortaliQ3TBD2.
SMRiQ3TBD2. Positions 268-546, 683-971.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini268 – 538271F-BARPROSITE-ProRule annotationAdd
BLAST
Domaini758 – 971214Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili375 – 498124Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 F-BAR domain.PROSITE-ProRule annotation
Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri699 – 74446Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1453. Eukaryota.
ENOG410YM3I. LUCA.
GeneTreeiENSGT00840000129703.
HOVERGENiHBG107979.
InParanoidiQ3TBD2.
PhylomeDBiQ3TBD2.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR002219. PE/DAG-bd.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00055. FCH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS50238. RHOGAP. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TBD2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSRKKRELM KTPSISKKNR AGSPNPQSSS GELPRKDWTE APGLEPPATS
60 70 80 90 100
LSTVAKGTGT LKRPTSLSRH ASAAGFPLSG TATWTLVRGY RSPLSAASPA
110 120 130 140 150
ELPTEGAFPD GVEDISTLLA DVARFAEGLE KLKECVLQDD LLEARRPLAH
160 170 180 190 200
ECLGEALRVM RQVISRYPLL NTVETLTAAG TLIAKVKAFH YECNNESDKR
210 220 230 240 250
EFEKALETIA VSFSCTVSEF LLGEVDSSTL LAVPPGDPSQ SMENLYGAGT
260 270 280 290 300
EGPPHNVEEC EEGCLPPEEV DMLLQRCEGG VDAALQYAKD MARYMKDLIS
310 320 330 340 350
YLEKRTTLEM EFAKGLQKVV HNCRQSVTHE PHMPLLSIYS LALEQDLEFG
360 370 380 390 400
HGMVQAAGTL QTQTFMQPLT LRRLEHERRR KEIKESWHRA QRKLQEAEAN
410 420 430 440 450
LRKAKQGYKQ RCEDHDKARL QVAKAEEEQQ GTGPGAGTAA SKALDKRRRL
460 470 480 490 500
EEEAKNKAEE AMATYRTCVA DAKTQKQELE DTKVTALRQI QEVIRQSDQT
510 520 530 540 550
IKSATISYYQ LMHMQTAPLP VNFQMLCESS KLYDPGQQYA SHVRQLQRGE
560 570 580 590 600
EPDVRYDFEP YVSNNSWSPI MRTRKGSFNP GDASGPEAAG SPPEEGGTSE
610 620 630 640 650
AAPNKDHRGG RGHQVHKSWP ISISDTEVGL DTSSGDLKKF DRTSSSGTMS
660 670 680 690 700
SSEELGDQEA GLVASAFDSA DLNGMDPELP VAMPSGPFRH VGLSKAARTH
710 720 730 740 750
RLRKLRTPAK CRECNSYVYF QGAECEECCL ACHKKCLETL AIQCGHKKLQ
760 770 780 790 800
GRLQLFGQDF SQAALSTPDG VPFIVKKCVC EIERRALHTK GIYRVNGVKT
810 820 830 840 850
RVEKLCQAFE NGKELVELSQ ASPHDISNVL KLYLRQLPEP LISFRFYHEL
860 870 880 890 900
VGLAKDSLKA EAEAKAASRG RQGGSESEAA TLAMVGRLRE LMQDLPAENR
910 920 930 940 950
ATLLYLLKHL RRIVEMEQDN KMTPGNLGIV FGPTLLRPRP TDATVSLSSL
960 970 980 990 1000
VDYPHQARVI ETLIVHYGLV FEEEPEEAPG SQEGASTQCG QLESAEGIVF
1010 1020 1030 1040 1050
PLQEEAEDGS RESHAASNDS DSELEDASDP LSSSDASALH RLSFLEQTEA
1060 1070 1080 1090 1100
GLEEGPQSHS GSEEQLEGED GAPGPWLCHF NTNQSNNTSR APLPTMRLRG
1110
GQITGGTSQE RQPQFV
Length:1,116
Mass (Da):122,902
Last modified:April 29, 2008 - v2
Checksum:iE3F52D0364F19E96
GO
Isoform 2 (identifier: Q3TBD2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     117-139: TLLADVARFAEGLEKLKECVLQD → MCVCGTLHPALDHDPLCCQTRAR

Show »
Length:1,000
Mass (Da):110,690
Checksum:i2E8F552F6F0D55E3
GO
Isoform 3 (identifier: Q3TBD2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-309: Missing.

Show »
Length:807
Mass (Da):89,341
Checksum:i21C2C7C28239509A
GO
Isoform 4 (identifier: Q3TBD2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-461: Missing.

Show »
Length:655
Mass (Da):71,921
Checksum:i19CB353B6752CCBC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871V → G in BAE34889 (PubMed:16141072).Curated
Sequence conflicti87 – 871V → G in BAE41670 (PubMed:16141072).Curated
Sequence conflicti587 – 5871E → K in BAE21986 (PubMed:16141072).Curated
Sequence conflicti710 – 7101K → E in BAE34889 (PubMed:16141072).Curated
Sequence conflicti979 – 9791P → H in BAB31085 (PubMed:16141072).Curated
Sequence conflicti1047 – 10471Q → R in BAE41670 (PubMed:16141072).Curated
Sequence conflicti1047 – 10471Q → R in BAE42381 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 461461Missing in isoform 4. 1 PublicationVSP_033029Add
BLAST
Alternative sequencei1 – 309309Missing in isoform 3. 1 PublicationVSP_033030Add
BLAST
Alternative sequencei1 – 116116Missing in isoform 2. 2 PublicationsVSP_033031Add
BLAST
Alternative sequencei117 – 13923TLLAD…CVLQD → MCVCGTLHPALDHDPLCCQT RAR in isoform 2. 2 PublicationsVSP_033032Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018130 mRNA. Translation: BAB31085.1.
AK044860 mRNA. Translation: BAC32124.1.
AK134029 mRNA. Translation: BAE21986.1.
AK159194 mRNA. Translation: BAE34889.1.
AK161766 mRNA. Translation: BAE36565.1.
AK170262 mRNA. Translation: BAE41670.1.
AK171304 mRNA. Translation: BAE42381.1.
BC053750 mRNA. Translation: AAH53750.1.
CCDSiCCDS24005.1. [Q3TBD2-2]
CCDS48624.1. [Q3TBD2-1]
RefSeqiNP_001136173.1. NM_001142701.1.
NP_081797.1. NM_027521.3. [Q3TBD2-2]
UniGeneiMm.243954.

Genome annotation databases

EnsembliENSMUST00000043311; ENSMUSP00000041019; ENSMUSG00000035697. [Q3TBD2-2]
GeneIDi70719.
KEGGimmu:70719.
UCSCiuc007gbe.2. mouse. [Q3TBD2-1]
uc007gbg.2. mouse. [Q3TBD2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018130 mRNA. Translation: BAB31085.1.
AK044860 mRNA. Translation: BAC32124.1.
AK134029 mRNA. Translation: BAE21986.1.
AK159194 mRNA. Translation: BAE34889.1.
AK161766 mRNA. Translation: BAE36565.1.
AK170262 mRNA. Translation: BAE41670.1.
AK171304 mRNA. Translation: BAE42381.1.
BC053750 mRNA. Translation: AAH53750.1.
CCDSiCCDS24005.1. [Q3TBD2-2]
CCDS48624.1. [Q3TBD2-1]
RefSeqiNP_001136173.1. NM_001142701.1.
NP_081797.1. NM_027521.3. [Q3TBD2-2]
UniGeneiMm.243954.

3D structure databases

ProteinModelPortaliQ3TBD2.
SMRiQ3TBD2. Positions 268-546, 683-971.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3TBD2. 2 interactions.
STRINGi10090.ENSMUSP00000097100.

PTM databases

iPTMnetiQ3TBD2.
PhosphoSiteiQ3TBD2.

Proteomic databases

EPDiQ3TBD2.
MaxQBiQ3TBD2.
PaxDbiQ3TBD2.
PeptideAtlasiQ3TBD2.
PRIDEiQ3TBD2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043311; ENSMUSP00000041019; ENSMUSG00000035697. [Q3TBD2-2]
GeneIDi70719.
KEGGimmu:70719.
UCSCiuc007gbe.2. mouse. [Q3TBD2-1]
uc007gbg.2. mouse. [Q3TBD2-2]

Organism-specific databases

CTDi23526.
MGIiMGI:1917969. Hmha1.

Phylogenomic databases

eggNOGiKOG1453. Eukaryota.
ENOG410YM3I. LUCA.
GeneTreeiENSGT00840000129703.
HOVERGENiHBG107979.
InParanoidiQ3TBD2.
PhylomeDBiQ3TBD2.

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Miscellaneous databases

PROiQ3TBD2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035697.
ExpressionAtlasiQ3TBD2. baseline and differential.
GenevisibleiQ3TBD2. MM.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR002219. PE/DAG-bd.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00055. FCH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS50238. RHOGAP. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMHA1_MOUSE
AccessioniPrimary (citable) accession number: Q3TBD2
Secondary accession number(s): Q3TDD2
, Q3TSW0, Q3TXM6, Q3UZ72, Q8BI83, Q9CU46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: September 7, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.