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Protein

Transmembrane protein 104

Gene

Tmem104

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 104
Gene namesi
Name:Tmem104
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2444222 Tmem104

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 36ExtracellularSequence analysis5
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 146CytoplasmicSequence analysisAdd BLAST89
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 204ExtracellularSequence analysisAdd BLAST37
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Topological domaini226 – 233CytoplasmicSequence analysis8
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 265ExtracellularSequence analysisAdd BLAST11
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 306CytoplasmicSequence analysisAdd BLAST20
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Topological domaini328 – 354ExtracellularSequence analysisAdd BLAST27
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 397CytoplasmicSequence analysisAdd BLAST22
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 421ExtracellularSequence analysis3
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Topological domaini443 – 470CytoplasmicSequence analysisAdd BLAST28
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21
Topological domaini492 – 496ExtracellularSequence analysis5

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002541791 – 496Transmembrane protein 104Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ3TB48
PaxDbiQ3TB48
PRIDEiQ3TB48

PTM databases

iPTMnetiQ3TB48
PhosphoSitePlusiQ3TB48

Expressioni

Gene expression databases

BgeeiENSMUSG00000045980
CleanExiMM_TMEM104
ExpressionAtlasiQ3TB48 baseline and differential
GenevisibleiQ3TB48 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056805

Structurei

3D structure databases

ProteinModelPortaliQ3TB48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM104 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3832 Eukaryota
ENOG410XP37 LUCA
GeneTreeiENSGT00390000001244
HOGENOMiHOG000231060
HOVERGENiHBG080085
InParanoidiQ3TB48
OMAiAFLVYHC
OrthoDBiEOG091G0E58
PhylomeDBiQ3TB48
TreeFamiTF314030

Family and domain databases

InterProiView protein in InterPro
IPR013057 AA_transpt_TM
PfamiView protein in Pfam
PF01490 Aa_trans, 2 hits

Sequencei

Sequence statusi: Complete.

Q3TB48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEITETGE LYSPYVGLVY MFNLIVGTGA LTMPKAFATA GWLVSLVLLV
60 70 80 90 100
FVGFMSFVTT TFAMEAMAAA NAQLRWKRME THKEEDDEDS STASDSDLLS
110 120 130 140 150
QDNYERAEKR PILSVQRRSS ANLFEITDRV EMGQMASMFF NKVGVNLFYF
160 170 180 190 200
CIITYLYGDL AIYAAAVPVS LMQVTCSVSG NDSCGVDTDA RYNDTDLCWG
210 220 230 240 250
PLRRVDVYRI YLAIFTVLLG PFTFFDVQKT KYLQILTSMM RWIAFAIMIV
260 270 280 290 300
LALVRIGKGQ GEGHPPLANF LGVQNLFGVC VYSFMCQHSL PSLITPISSK
310 320 330 340 350
RHITRLLFLD YALILAFYGL LSFTAIFCFR GDSLMDMYTL NFARCDVVGL
360 370 380 390 400
AAVRFFLGLF PVFTISTNFP IIAVTLRNNW KTLFHREGGT YPWVVDRVVF
410 420 430 440 450
PTITLVPPIL VAFCTHDLES LVAITGAYAG TGIQYVIPAF LVYLCRKDTQ
460 470 480 490
LTFGYGTVNK HRSPFRHTFW VAFVLLWAFS CFFFVTAYIV LKETQL
Length:496
Mass (Da):55,838
Last modified:October 11, 2005 - v1
Checksum:iAED11EE34AA01FBB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti434Q → R in BAE33008 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155041 mRNA Translation: BAE33008.1
AK171457 mRNA Translation: BAE42466.1
CCDSiCCDS25623.1
RefSeqiNP_001028565.1, NM_001033393.2
UniGeneiMm.260587

Genome annotation databases

EnsembliENSMUST00000061450; ENSMUSP00000056805; ENSMUSG00000045980
GeneIDi320534
KEGGimmu:320534
UCSCiuc007mgv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTM104_MOUSE
AccessioniPrimary (citable) accession number: Q3TB48
Secondary accession number(s): Q3U2Y2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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