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Protein
Submitted name:

Putative uncharacterized protein

Gene

Gsk3b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • axonogenesis Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • cell migration Source: MGI
  • cell proliferation Source: MGI
  • cellular response to mechanical stimulus Source: Ensembl
  • epithelial to mesenchymal transition Source: MGI
  • ER overload response Source: MGI
  • establishment of cell polarity Source: Ensembl
  • fat cell differentiation Source: MGI
  • glycogen metabolic process Source: MGI
  • hippocampus development Source: MGI
  • intracellular signal transduction Source: MGI
  • myoblast fusion Source: MGI
  • myotube differentiation Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of cardiac muscle hypertrophy Source: MGI
  • negative regulation of dendrite morphogenesis Source: Ensembl
  • negative regulation of MAP kinase activity Source: Ensembl
  • negative regulation of neuron maturation Source: MGI
  • negative regulation of neuron projection development Source: MGI
  • negative regulation of NFAT protein import into nucleus Source: MGI
  • negative regulation of protein binding Source: MGI
  • negative regulation of protein complex assembly Source: MGI
  • organ morphogenesis Source: MGI
  • peptidyl-serine phosphorylation Source: MGI
  • positive regulation of apoptotic process Source: Ensembl
  • positive regulation of axon extension Source: MGI
  • positive regulation of cell-matrix adhesion Source: MGI
  • positive regulation of GTPase activity Source: MGI
  • positive regulation of peptidyl-serine phosphorylation Source: MGI
  • positive regulation of peptidyl-threonine phosphorylation Source: MGI
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  • positive regulation of protein binding Source: MGI
  • positive regulation of protein complex assembly Source: MGI
  • positive regulation of protein export from nucleus Source: MGI
  • positive regulation of stem cell differentiation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • protein autophosphorylation Source: MGI
  • protein export from nucleus Source: MGI
  • protein localization to microtubule Source: MGI
  • protein phosphorylation Source: MGI
  • re-entry into mitotic cell cycle Source: MGI
  • regulation of microtubule-based process Source: MGI
  • regulation of neuronal synaptic plasticity Source: Ensembl
  • regulation of neuron projection development Source: MGI
  • response to drug Source: Ensembl
  • response to lithium ion Source: Ensembl
  • superior temporal gyrus development Source: MGI
  • Wnt signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Gsk3bImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1861437. Gsk3b.

Subcellular locationi

GO - Cellular componenti

  • beta-catenin destruction complex Source: MGI
  • cell body Source: MGI
  • centrosome Source: MGI
  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • dendritic shaft Source: MGI
  • dendritic spine Source: Ensembl
  • growth cone Source: MGI
  • membrane-bounded organelle Source: MGI
  • membrane raft Source: Ensembl
  • neuronal cell body Source: MGI
  • neuronal postsynaptic density Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
  • ribonucleoprotein complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ3TB31.
ExpressionAtlasiQ3TB31. baseline and differential.
GenevestigatoriQ3TB31.

Interactioni

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000233017.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3TB31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR
60 70 80 90
PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KR
Length:92
Mass (Da):9,836
Last modified:October 11, 2005 - v1
Checksum:iD3DFFB10661BD3C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei92 – 921Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK171482 mRNA. Translation: BAE42483.1.
UniGeneiMm.394930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK171482 mRNA. Translation: BAE42483.1.
UniGeneiMm.394930.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ3TB31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1861437. Gsk3b.

Phylogenomic databases

HOGENOMiHOG000233017.

Miscellaneous databases

ChiTaRSiGsk3b. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ3TB31.
ExpressionAtlasiQ3TB31. baseline and differential.
GenevestigatoriQ3TB31.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3TB31_MOUSE
AccessioniPrimary (citable) accession number: Q3TB31
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 27, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.