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Q3TB31 (Q3TB31_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Gsk3b MGI 1861437
OrganismMus musculus (Mouse) EMBL BAE42483.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length92 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processER overload response

Inferred from direct assay PubMed 14744935. Source: MGI

Wnt signaling pathway

Inferred from genetic interaction PubMed 16815997PubMed 23074275. Source: MGI

axonogenesis

Inferred from genetic interaction PubMed 18716223. Source: MGI

canonical Wnt signaling pathway

Inferred from direct assay PubMed 15282335. Source: MGI

cell migration

Inferred from genetic interaction PubMed 17986005. Source: MGI

cell proliferation

Traceable author statement PubMed 10894547. Source: MGI

cellular response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

epithelial to mesenchymal transition

Inferred from electronic annotation. Source: Ensembl

establishment of cell polarity

Inferred from electronic annotation. Source: Ensembl

fat cell differentiation

Inferred from direct assay PubMed 12502791. Source: MGI

glycogen metabolic process

Inferred from electronic annotation. Source: Ensembl

hippocampus development

Inferred from electronic annotation. Source: Ensembl

intracellular signal transduction

Inferred from sequence orthology PubMed 14749367. Source: MGI

myoblast fusion

Inferred from direct assay PubMed 15282335. Source: MGI

myotube differentiation

Inferred from genetic interaction PubMed 15282335. Source: MGI

negative regulation of MAP kinase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of NFAT protein import into nucleus

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 10894547. Source: MGI

negative regulation of cardiac muscle hypertrophy

Inferred from direct assay PubMed 11782539. Source: MGI

negative regulation of dendrite morphogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein binding

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein complex assembly

Inferred from electronic annotation. Source: Ensembl

organ morphogenesis

Inferred from mutant phenotype PubMed 10894547. Source: MGI

peptidyl-serine phosphorylation

Inferred from direct assay PubMed 17986005. Source: MGI

positive regulation of Rac GTPase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell-matrix adhesion

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-serine phosphorylation

Inferred from direct assay PubMed 17986005. Source: MGI

positive regulation of peptidyl-threonine phosphorylation

Inferred from direct assay PubMed 17986005. Source: MGI

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

Inferred from genetic interaction PubMed 22660580. Source: MGI

positive regulation of protein binding

Inferred from direct assay PubMed 19141611. Source: MGI

positive regulation of protein complex assembly

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein export from nucleus

Inferred from electronic annotation. Source: Ensembl

positive regulation of stem cell differentiation

Inferred from mutant phenotype PubMed 22064483. Source: MGI

protein export from nucleus

Inferred from direct assay PubMed 11782539. Source: MGI

protein localization to microtubule

Inferred from genetic interaction PubMed 18716223. Source: MGI

protein phosphorylation

Inferred from direct assay PubMed 12432063PubMed 12805290PubMed 14730361PubMed 17026964. Source: MGI

re-entry into mitotic cell cycle

Inferred from direct assay PubMed 12502791. Source: MGI

regulation of microtubule-based process

Inferred from electronic annotation. Source: Ensembl

regulation of neuronal synaptic plasticity

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to lithium ion

Inferred from electronic annotation. Source: Ensembl

superior temporal gyrus development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentbeta-catenin destruction complex

Inferred from direct assay PubMed 10318824. Source: MGI

centrosome

Inferred from electronic annotation. Source: Ensembl

cytosol

Inferred from direct assay PubMed 12502791. Source: MGI

dendritic shaft

Inferred from direct assay PubMed 12805290. Source: MGI

dendritic spine

Inferred from electronic annotation. Source: Ensembl

growth cone

Inferred from direct assay PubMed 12805290. Source: MGI

membrane raft

Inferred from electronic annotation. Source: Ensembl

membrane-bounded organelle

Inferred from direct assay PubMed 12805290. Source: MGI

neuronal cell body

Inferred from direct assay PubMed 12805290. Source: MGI

nucleus

Inferred from direct assay PubMed 12502791PubMed 22064483. Source: MGI

plasma membrane

Inferred from electronic annotation. Source: Ensembl

ribonucleoprotein complex

Inferred from direct assay PubMed 21709260. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: Ensembl

beta-catenin binding

Inferred from physical interaction PubMed 12874278. Source: MGI

protein binding

Inferred from physical interaction PubMed 12432063PubMed 12805290PubMed 16510873PubMed 18632848PubMed 19047045PubMed 21471969PubMed 22064483PubMed 9554852. Source: MGI

protein kinase activity

Inferred from direct assay PubMed 14730361. Source: MGI

protein serine/threonine kinase activity

Inferred from direct assay PubMed 12805290PubMed 17986005PubMed 22660580. Source: MGI

tau-protein kinase activity

Inferred from direct assay PubMed 15192701. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue921 EMBL BAE42483.1

Sequences

Sequence LengthMass (Da)Tools
Q3TB31 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: D3DFFB10661BD3C7

FASTA929,836
        10         20         30         40         50         60 
MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK 

        70         80         90 
VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KR 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE42483.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE42483.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE42483.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE42483.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE42483.1.
[6]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE42483.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE42483.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE42483.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK171482 mRNA. Translation: BAE42483.1.
UniGeneMm.394930.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ3TB31.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1861437. Gsk3b.

Phylogenomic databases

HOGENOMHOG000233017.
InParanoidQ3TB31.

Gene expression databases

ArrayExpressQ3TB31.
BgeeQ3TB31.
GenevestigatorQ3TB31.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGSK3B. mouse.
SOURCESearch...

Entry information

Entry nameQ3TB31_MOUSE
AccessionPrimary (citable) accession number: Q3TB31
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)