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Q3TB31

- Q3TB31_MOUSE

UniProt

Q3TB31 - Q3TB31_MOUSE

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Protein
Submitted name:

Putative uncharacterized protein

Gene

Gsk3b

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. beta-catenin binding Source: MGI
  3. protein kinase activity Source: MGI
  4. protein serine/threonine kinase activity Source: MGI
  5. tau-protein kinase activity Source: MGI

GO - Biological processi

  1. axonogenesis Source: MGI
  2. canonical Wnt signaling pathway Source: MGI
  3. cell migration Source: MGI
  4. cell proliferation Source: MGI
  5. cellular response to mechanical stimulus Source: Ensembl
  6. epithelial to mesenchymal transition Source: Ensembl
  7. ER overload response Source: MGI
  8. establishment of cell polarity Source: Ensembl
  9. fat cell differentiation Source: MGI
  10. glycogen metabolic process Source: Ensembl
  11. hippocampus development Source: Ensembl
  12. intracellular signal transduction Source: MGI
  13. myoblast fusion Source: MGI
  14. myotube differentiation Source: MGI
  15. negative regulation of apoptotic process Source: MGI
  16. negative regulation of cardiac muscle hypertrophy Source: MGI
  17. negative regulation of dendrite morphogenesis Source: Ensembl
  18. negative regulation of MAP kinase activity Source: Ensembl
  19. negative regulation of neuron maturation Source: MGI
  20. negative regulation of neuron projection development Source: MGI
  21. negative regulation of NFAT protein import into nucleus Source: Ensembl
  22. negative regulation of protein binding Source: Ensembl
  23. negative regulation of protein complex assembly Source: Ensembl
  24. organ morphogenesis Source: MGI
  25. peptidyl-serine phosphorylation Source: MGI
  26. positive regulation of apoptotic process Source: Ensembl
  27. positive regulation of axon extension Source: MGI
  28. positive regulation of cell-matrix adhesion Source: Ensembl
  29. positive regulation of peptidyl-serine phosphorylation Source: MGI
  30. positive regulation of peptidyl-threonine phosphorylation Source: MGI
  31. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  32. positive regulation of protein binding Source: MGI
  33. positive regulation of protein complex assembly Source: Ensembl
  34. positive regulation of protein export from nucleus Source: Ensembl
  35. positive regulation of Rac GTPase activity Source: Ensembl
  36. positive regulation of stem cell differentiation Source: MGI
  37. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  38. protein export from nucleus Source: MGI
  39. protein localization to microtubule Source: MGI
  40. protein phosphorylation Source: MGI
  41. re-entry into mitotic cell cycle Source: MGI
  42. regulation of microtubule-based process Source: Ensembl
  43. regulation of neuronal synaptic plasticity Source: Ensembl
  44. regulation of neuron projection development Source: MGI
  45. response to drug Source: Ensembl
  46. response to lithium ion Source: Ensembl
  47. superior temporal gyrus development Source: Ensembl
  48. Wnt signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Gsk3bImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1861437. Gsk3b.

Subcellular locationi

GO - Cellular componenti

  1. beta-catenin destruction complex Source: MGI
  2. cell body Source: MGI
  3. centrosome Source: Ensembl
  4. cytosol Source: MGI
  5. dendritic shaft Source: MGI
  6. dendritic spine Source: Ensembl
  7. growth cone Source: MGI
  8. membrane-bounded organelle Source: MGI
  9. membrane raft Source: Ensembl
  10. neuronal cell body Source: MGI
  11. nucleus Source: MGI
  12. plasma membrane Source: Ensembl
  13. ribonucleoprotein complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ3TB31.
ExpressionAtlasiQ3TB31. baseline and differential.
GenevestigatoriQ3TB31.

Interactioni

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000233017.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3TB31-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR
60 70 80 90
PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KR
Length:92
Mass (Da):9,836
Last modified:October 11, 2005 - v1
Checksum:iD3DFFB10661BD3C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei92 – 921Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK171482 mRNA. Translation: BAE42483.1.
UniGeneiMm.394930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK171482 mRNA. Translation: BAE42483.1 .
UniGenei Mm.394930.

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q3TB31.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1861437. Gsk3b.

Phylogenomic databases

HOGENOMi HOG000233017.

Miscellaneous databases

ChiTaRSi Gsk3b. mouse.
SOURCEi Search...

Gene expression databases

Bgeei Q3TB31.
ExpressionAtlasi Q3TB31. baseline and differential.
Genevestigatori Q3TB31.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3TB31_MOUSE
AccessioniPrimary (citable) accession number: Q3TB31
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)